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The map label for this gene is mptN [H]

Identifier: 156936963

GI number: 156936963

Start: 151589

End: 152470

Strand: Direct

Name: mptN [H]

Synonym: Igni_0168

Alternate gene names: 156936963

Gene position: 151589-152470 (Clockwise)

Preceding gene: 156936962

Following gene: 156936966

Centisome position: 11.68

GC content: 55.22

Gene sequence:

>882_bases
ATGAGGAGGGCTGGTATTGGTGAGCGCGGCGATGAACGCGGATGCCAGGGCCGAGTCCCCCGCTTGCTCGTACTCTATCC
TCAGAGGAAGATGCCTCGTTCGGTCCTCATCTTAGGAGCTTATTTGACCAAGCTAGGCGCGATAACTTCCTTGAAGTCCT
ACGAGGAGCTCAGTTGCCGCGACTTGGAACGCTTCGACCTGGTCGTCGCTAGGGGTTTGCCGTACTACTACGACTCCGTG
AGGATGCTCTCCTTGATAGAGTGCTTAAGAACAGCGAGGAAGGTGATAAACGACCCGCAAGCCACGCTCGTAGCGCGCAA
CAAGTACGTTTCTATGAAAGTGCTCGAATCAAACGGCGTACCGGTACCGAAGACCTTTCTAGTGAGGACTAGGTTCGAAT
TGCTAGAAAAGGTAAAGGAGCTAGGCGAAGTCGTCGTAAAGCCTCTCTCCAACAGCCTCGGCTTGGGGGTCAACAGAGTT
GACGAGAGGTCCATCCACTACCTAATCCCCCTGTTGCCTTATACCTTCGACTTGGTCATTCAAGAGTACGTGGAGAAGGT
CCGAGACGTCCGGTCCTTCGTGATAGGGAACAGAGCAGTAGCTTCTATGTATAGAATATCGCCTTTCAAGTTCGCCACTA
ACTACGCCCAAGGCTCTGACGTAGACCCGGCGCCTCTCGAAGAGTACTCGGAGATCTCGGTGAAGGCCGTAAGGGCGTTG
GGGCTGAGCTACGGCGGCGTGGACTTGGTGGAGAGCCCCGAGGGCCCCAAGGTAATAGAAGTTAACCCGTCCCCCCTCTG
GTTCGGGGTCTCGAGGGCTTGTAACGTCGACGTTGGGTTCGAGCTGGCGAAGTTCTTGTTTGAGGAGGCCTGTGAGGACT
AG

Upstream 100 bases:

>100_bases
GCGATCACGAGCCGCTGGTGGAGGAAGCGGCCAAAGCCCTTCTCTACGATTACCACAAGGGCAAAATACCGTTCTACGTG
CCGCCCGGTGAGTATTGGAG

Downstream 100 bases:

>100_bases
ACGGGACCCGATCGGTGAGGAGCAGGCTAGGATCCGAGGCACAAAGTTTATTAAAGGTTCGTGGCTCCCATGCCCCGGAG
CCGGGGTCGCCTAGCCTGGC

Product: SSU ribosomal protein S6P modification protein

Products: NA

Alternate protein names: H(4)MPT:alpha-L-glutamate ligase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MRRAGIGERGDERGCQGRVPRLLVLYPQRKMPRSVLILGAYLTKLGAITSLKSYEELSCRDLERFDLVVARGLPYYYDSV
RMLSLIECLRTARKVINDPQATLVARNKYVSMKVLESNGVPVPKTFLVRTRFELLEKVKELGEVVVKPLSNSLGLGVNRV
DERSIHYLIPLLPYTFDLVIQEYVEKVRDVRSFVIGNRAVASMYRISPFKFATNYAQGSDVDPAPLEEYSEISVKAVRAL
GLSYGGVDLVESPEGPKVIEVNPSPLWFGVSRACNVDVGFELAKFLFEEACED

Sequences:

>Translated_293_residues
MRRAGIGERGDERGCQGRVPRLLVLYPQRKMPRSVLILGAYLTKLGAITSLKSYEELSCRDLERFDLVVARGLPYYYDSV
RMLSLIECLRTARKVINDPQATLVARNKYVSMKVLESNGVPVPKTFLVRTRFELLEKVKELGEVVVKPLSNSLGLGVNRV
DERSIHYLIPLLPYTFDLVIQEYVEKVRDVRSFVIGNRAVASMYRISPFKFATNYAQGSDVDPAPLEEYSEISVKAVRAL
GLSYGGVDLVESPEGPKVIEVNPSPLWFGVSRACNVDVGFELAKFLFEEACED
>Mature_293_residues
MRRAGIGERGDERGCQGRVPRLLVLYPQRKMPRSVLILGAYLTKLGAITSLKSYEELSCRDLERFDLVVARGLPYYYDSV
RMLSLIECLRTARKVINDPQATLVARNKYVSMKVLESNGVPVPKTFLVRTRFELLEKVKELGEVVVKPLSNSLGLGVNRV
DERSIHYLIPLLPYTFDLVIQEYVEKVRDVRSFVIGNRAVASMYRISPFKFATNYAQGSDVDPAPLEEYSEISVKAVRAL
GLSYGGVDLVESPEGPKVIEVNPSPLWFGVSRACNVDVGFELAKFLFEEACED

Specific function: Catalyzes the ATP or GTP-dependent addition of one L- glutamate molecule to tetrahydromethanopterin, producing tetrahydrosarcinapterin [H]

COG id: COG0189

COG function: function code HJ; Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI164663810, Length=267, Percent_Identity=27.7153558052434, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787076, Length=243, Percent_Identity=25.9259259259259, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013651
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR004666 [H]

Pfam domain/function: PF08443 RimK [H]

EC number: NA

Molecular weight: Translated: 32933; Mature: 32933

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRAGIGERGDERGCQGRVPRLLVLYPQRKMPRSVLILGAYLTKLGAITSLKSYEELSCR
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLERFDLVVARGLPYYYDSVRMLSLIECLRTARKVINDPQATLVARNKYVSMKVLESNGV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEEEECCCC
PVPKTFLVRTRFELLEKVKELGEVVVKPLSNSLGLGVNRVDERSIHYLIPLLPYTFDLVI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QEYVEKVRDVRSFVIGNRAVASMYRISPFKFATNYAQGSDVDPAPLEEYSEISVKAVRAL
HHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
GLSYGGVDLVESPEGPKVIEVNPSPLWFGVSRACNVDVGFELAKFLFEEACED
HCCCCCCEECCCCCCCEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRAGIGERGDERGCQGRVPRLLVLYPQRKMPRSVLILGAYLTKLGAITSLKSYEELSCR
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLERFDLVVARGLPYYYDSVRMLSLIECLRTARKVINDPQATLVARNKYVSMKVLESNGV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEEEECCCC
PVPKTFLVRTRFELLEKVKELGEVVVKPLSNSLGLGVNRVDERSIHYLIPLLPYTFDLVI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QEYVEKVRDVRSFVIGNRAVASMYRISPFKFATNYAQGSDVDPAPLEEYSEISVKAVRAL
HHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
GLSYGGVDLVESPEGPKVIEVNPSPLWFGVSRACNVDVGFELAKFLFEEACED
HCCCCCCEECCCCCCCEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Glu; Ribosomal protein S6 [C]

Specific reaction: Catalyzes the addition of glutamic acids to the carboxyl end of ribosomal protein S6 [C]

General reaction: Ligases; Forming Carbon-Nitrogen Bonds; Acid-D-Amino-Acid Ligases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]