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The map label for this gene is moeA [C]

Identifier: 156936957

GI number: 156936957

Start: 145622

End: 147376

Strand: Direct

Name: moeA [C]

Synonym: Igni_0162

Alternate gene names: 156936957

Gene position: 145622-147376 (Clockwise)

Preceding gene: 156936956

Following gene: 156936958

Centisome position: 11.22

GC content: 61.14

Gene sequence:

>1755_bases
TTGAAGAAGGAGAGGAAGGTGTTCAAAGAGCTCTTGCCTCCGGACGAGGCTATGAGGAGGTTAGAGGAAAGGGTCCCCCC
TACCCCTCCGGAGGCGGAAGAGGTACCTATAGAAGAGGCCTTGGGCTTCTACCTCGCGGAAGACGTGAAGTCCCCAATAA
ACTTACCTCCCTACCCCCGCTCGGCTGCCGACGGGTACGCGGTTAGGGCCCGCTCCACTTGGGGCGCTTCAGAGGACGAG
CCCGTGGAGCTGAGGGTTGTGGGAGAGGTGAGGGTCGGCGAGGCGCCGGGCTTTGAGCTGAAGGAGGGCGAGGCGGCCGA
GGTCGACACGGGCTCGGCCCTCCCCCCGGGCGCCGACGCGGTAGTCATGATAGAGTACGTGAAGGAGGTCGGGGACAAGA
TATTGGTTTACAAGTCCGTAGTCCCCGGCGAGAACGTCCTCTGGCCCGCCACCGACGTCTACTCCGGGCAGCCCCTCTGG
AAGAGGGGCACCAGGGTGGACTCCAGAGTAATAGCCTCCTTGGCCTCCGTGGGCATAAGGAAGGTGAGGGTCTGGAGGCC
TAAGGTTTATCTAATATCCACGGGCTCCGAGCTCGTGGAGCCCGGTAAGCCCTTAGAGACTGGTAAAATATACGACGTCA
ACACTTACTCCTTGCAAGCGCGCTTACGGGAAGAGGGCTTTGTCCCAATAGTCCACGGCGTGGTGCCGGACGACAAGGAG
GAGATAAAGAAGGCCATCTTAGAGGGCGTCGAGAAGGCCGACGTAGTGGTTACTACGGGCTCCACCTCCGCCGGCCCTGC
GGACTTCGTGTACCGCGCGGTAGGCGAGGTAGGGGAGGTGCTAGTCCACGGCTTGGCCTTCAAGCCCGGCAAGCCCGTCA
TGCTGGGCGTAGTGAAGGGCAAACCGGTCTTCGGCCTGGCCGGCCACCCCGACTCCGCATACTTCAACTTGGAACGCTTG
GTAATACCATATTTGAGGAAAATGGTTAAGGCCGACGAGAGGTCCCAGAGCTCTACGAAAGCCGTAGCGGCGACCAGCTT
CGTGGGGGCTAAGGGGAGGAGGACCCACGTCCCCGTGAGCTTGTTGACGGACGGCTCGAGGTGGTTCGCCTTCCCGGCGT
CCCACTCGGACCACGCGATGGTCAGCTACTCCAAGGCGGACGGCTACATAGTGATACCGGAGACTAGGAGGGCCCCGGTG
GAGCCCGGCGAGGAGGTGGAGGTTTGGCTGTTCAAGGACCCTAGCTACAAGGGAGCTATAGTAGGCGATACCGACGTAGC
CGTGGACGCCGTCGTTGAGAGGCTTGACTATCCCCCGAAAATGTTACCCTTGGGTAGCTACAGCGGCGCCTACGCCTCTA
AGATGTCGTTGCGTTCCGTCTGGATTTCGCCGGAGGCGGTCGGGAAAGAGGTAGAGGTGGAAGTGGTGGCCGTGGGGAGG
GGAGAGCGCGTCGGAGTGCCCCACAAGTCGTCCTTCTTGTATCCCTTCTTCTCCAAGTTCTTGGAGGTGGAGGGTATAAG
TAGGGAGGAGCTCCAGAAGAGGTTCGTGAGGGTTACCATGCCGACCCCTCAAGCCTTGGCGTCCGCCGTGGCCAGCGGGG
AGGTGGACGCGGCGATAACCACTAGGAACGCGGCAGAAGCATTGGGCTTGGACTGGAGGCCCTTGAGTAAGGCTAAGCTA
TACATAGGCTGGACGGAAGACCACGCCGAGCTGGGGAGGGAGGTGCTCAATGAGTTCCTACGCCGCGGAGGTTAG

Upstream 100 bases:

>100_bases
CGACGAGAGGGTAGTCTCCTTAGCGTAAGCTTGTACAAGTTTACAAAAGCCGGATACGCGTAAAATGAGGCCAACGGGCT
GTAGTTTACGGGGGCGAAGC

Downstream 100 bases:

>100_bases
GGACGTGTGGAAGGTCTACGCGGCCGGAGGCTCCTCCTACCCGGCGTTGAGAGGAGTTACCTTGAAGATACCCAAGGGGA
GCTTCGTGGTCGTCTTGGGT

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MKKERKVFKELLPPDEAMRRLEERVPPTPPEAEEVPIEEALGFYLAEDVKSPINLPPYPRSAADGYAVRARSTWGASEDE
PVELRVVGEVRVGEAPGFELKEGEAAEVDTGSALPPGADAVVMIEYVKEVGDKILVYKSVVPGENVLWPATDVYSGQPLW
KRGTRVDSRVIASLASVGIRKVRVWRPKVYLISTGSELVEPGKPLETGKIYDVNTYSLQARLREEGFVPIVHGVVPDDKE
EIKKAILEGVEKADVVVTTGSTSAGPADFVYRAVGEVGEVLVHGLAFKPGKPVMLGVVKGKPVFGLAGHPDSAYFNLERL
VIPYLRKMVKADERSQSSTKAVAATSFVGAKGRRTHVPVSLLTDGSRWFAFPASHSDHAMVSYSKADGYIVIPETRRAPV
EPGEEVEVWLFKDPSYKGAIVGDTDVAVDAVVERLDYPPKMLPLGSYSGAYASKMSLRSVWISPEAVGKEVEVEVVAVGR
GERVGVPHKSSFLYPFFSKFLEVEGISREELQKRFVRVTMPTPQALASAVASGEVDAAITTRNAAEALGLDWRPLSKAKL
YIGWTEDHAELGREVLNEFLRRGG

Sequences:

>Translated_584_residues
MKKERKVFKELLPPDEAMRRLEERVPPTPPEAEEVPIEEALGFYLAEDVKSPINLPPYPRSAADGYAVRARSTWGASEDE
PVELRVVGEVRVGEAPGFELKEGEAAEVDTGSALPPGADAVVMIEYVKEVGDKILVYKSVVPGENVLWPATDVYSGQPLW
KRGTRVDSRVIASLASVGIRKVRVWRPKVYLISTGSELVEPGKPLETGKIYDVNTYSLQARLREEGFVPIVHGVVPDDKE
EIKKAILEGVEKADVVVTTGSTSAGPADFVYRAVGEVGEVLVHGLAFKPGKPVMLGVVKGKPVFGLAGHPDSAYFNLERL
VIPYLRKMVKADERSQSSTKAVAATSFVGAKGRRTHVPVSLLTDGSRWFAFPASHSDHAMVSYSKADGYIVIPETRRAPV
EPGEEVEVWLFKDPSYKGAIVGDTDVAVDAVVERLDYPPKMLPLGSYSGAYASKMSLRSVWISPEAVGKEVEVEVVAVGR
GERVGVPHKSSFLYPFFSKFLEVEGISREELQKRFVRVTMPTPQALASAVASGEVDAAITTRNAAEALGLDWRPLSKAKL
YIGWTEDHAELGREVLNEFLRRGG
>Mature_584_residues
MKKERKVFKELLPPDEAMRRLEERVPPTPPEAEEVPIEEALGFYLAEDVKSPINLPPYPRSAADGYAVRARSTWGASEDE
PVELRVVGEVRVGEAPGFELKEGEAAEVDTGSALPPGADAVVMIEYVKEVGDKILVYKSVVPGENVLWPATDVYSGQPLW
KRGTRVDSRVIASLASVGIRKVRVWRPKVYLISTGSELVEPGKPLETGKIYDVNTYSLQARLREEGFVPIVHGVVPDDKE
EIKKAILEGVEKADVVVTTGSTSAGPADFVYRAVGEVGEVLVHGLAFKPGKPVMLGVVKGKPVFGLAGHPDSAYFNLERL
VIPYLRKMVKADERSQSSTKAVAATSFVGAKGRRTHVPVSLLTDGSRWFAFPASHSDHAMVSYSKADGYIVIPETRRAPV
EPGEEVEVWLFKDPSYKGAIVGDTDVAVDAVVERLDYPPKMLPLGSYSGAYASKMSLRSVWISPEAVGKEVEVEVVAVGR
GERVGVPHKSSFLYPFFSKFLEVEGISREELQKRFVRVTMPTPQALASAVASGEVDAAITTRNAAEALGLDWRPLSKAKL
YIGWTEDHAELGREVLNEFLRRGG

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=314, Percent_Identity=34.7133757961783, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI10880983, Length=314, Percent_Identity=34.7133757961783, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1787049, Length=390, Percent_Identity=31.2820512820513, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25147659, Length=339, Percent_Identity=33.3333333333333, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=258, Percent_Identity=27.1317829457364, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17136978, Length=289, Percent_Identity=33.5640138408304, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24638841, Length=289, Percent_Identity=33.5640138408304, Blast_Score=130, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 63760; Mature: 63760

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKERKVFKELLPPDEAMRRLEERVPPTPPEAEEVPIEEALGFYLAEDVKSPINLPPYPR
CCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
SAADGYAVRARSTWGASEDEPVELRVVGEVRVGEAPGFELKEGEAAEVDTGSALPPGADA
CCCCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCH
VVMIEYVKEVGDKILVYKSVVPGENVLWPATDVYSGQPLWKRGTRVDSRVIASLASVGIR
HHHHHHHHHHCCEEEEEEEECCCCCEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCE
KVRVWRPKVYLISTGSELVEPGKPLETGKIYDVNTYSLQARLREEGFVPIVHGVVPDDKE
EEEEECCEEEEEECCHHHHCCCCCCCCCEEEECCHHEEHHHHHHCCCEEEEECCCCCCHH
EIKKAILEGVEKADVVVTTGSTSAGPADFVYRAVGEVGEVLVHGLAFKPGKPVMLGVVKG
HHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
KPVFGLAGHPDSAYFNLERLVIPYLRKMVKADERSQSSTKAVAATSFVGAKGRRTHVPVS
CCEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEECCEE
LLTDGSRWFAFPASHSDHAMVSYSKADGYIVIPETRRAPVEPGEEVEVWLFKDPSYKGAI
EEECCCEEEEECCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCEE
VGDTDVAVDAVVERLDYPPKMLPLGSYSGAYASKMSLRSVWISPEAVGKEVEVEVVAVGR
ECCCHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHEEEEECHHHCCCEEEEEEEEECC
GERVGVPHKSSFLYPFFSKFLEVEGISREELQKRFVRVTMPTPQALASAVASGEVDAAIT
CCCCCCCCCCCEEHHHHHHHHHHCCCCHHHHHHHEEEEECCCHHHHHHHHHCCCCCEEEE
TRNAAEALGLDWRPLSKAKLYIGWTEDHAELGREVLNEFLRRGG
ECCHHHHHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKERKVFKELLPPDEAMRRLEERVPPTPPEAEEVPIEEALGFYLAEDVKSPINLPPYPR
CCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
SAADGYAVRARSTWGASEDEPVELRVVGEVRVGEAPGFELKEGEAAEVDTGSALPPGADA
CCCCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCH
VVMIEYVKEVGDKILVYKSVVPGENVLWPATDVYSGQPLWKRGTRVDSRVIASLASVGIR
HHHHHHHHHHCCEEEEEEEECCCCCEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCE
KVRVWRPKVYLISTGSELVEPGKPLETGKIYDVNTYSLQARLREEGFVPIVHGVVPDDKE
EEEEECCEEEEEECCHHHHCCCCCCCCCEEEECCHHEEHHHHHHCCCEEEEECCCCCCHH
EIKKAILEGVEKADVVVTTGSTSAGPADFVYRAVGEVGEVLVHGLAFKPGKPVMLGVVKG
HHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
KPVFGLAGHPDSAYFNLERLVIPYLRKMVKADERSQSSTKAVAATSFVGAKGRRTHVPVS
CCEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEECCEE
LLTDGSRWFAFPASHSDHAMVSYSKADGYIVIPETRRAPVEPGEEVEVWLFKDPSYKGAI
EEECCCEEEEECCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCEE
VGDTDVAVDAVVERLDYPPKMLPLGSYSGAYASKMSLRSVWISPEAVGKEVEVEVVAVGR
ECCCHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHEEEEECHHHCCCEEEEEEEEECC
GERVGVPHKSSFLYPFFSKFLEVEGISREELQKRFVRVTMPTPQALASAVASGEVDAAIT
CCCCCCCCCCCEEHHHHHHHHHHCCCCHHHHHHHEEEEECCCHHHHHHHHHCCCCCEEEE
TRNAAEALGLDWRPLSKAKLYIGWTEDHAELGREVLNEFLRRGG
ECCHHHHHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]