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The map label for this gene is pncB [H]

Identifier: 156936816

GI number: 156936816

Start: 22014

End: 23168

Strand: Direct

Name: pncB [H]

Synonym: Igni_0021

Alternate gene names: 156936816

Gene position: 22014-23168 (Clockwise)

Preceding gene: 156936815

Following gene: 156936818

Centisome position: 1.7

GC content: 57.66

Gene sequence:

>1155_bases
ATGAGGCTTTACGTAGCGTCCGAAGAAGACATACTCTCCGGCAACGCGACAGACATATACTTCAAGAGGACCGTCGAAGT
AGTCAAGAAGTCCGGAAAAGACAAGAAAGTCAGAATGGAATTTCACGCCTACAGCCTCCCGAAGGGGTACGAGTGGGGAG
TTTTCGCCGGCCTGGAAGAGGCGCTATACGTCCTAAGGGGGAGGGACGTCACGGTCTACTCACTGCCAGAGGGAACGCTG
TTCTTCCGAAAGGAACCCATCATGGTGATCGAGGGCAAGTACTCGGAGTTTGGCGAGCTGGAGACCGCGCTCTTGGGAAT
AATAAGGCACTCTACCTCGATAGCCACCAAGGCCGCTAGAATAAAGCTGGCCGCCGGAGACAAGAAGGTTTTGTTCTTCG
GGTTGAGGGCGCTACACCCGGCCATACAGCCGGTCGCCGACAGGGCGGCCTTTATAGGCGGAGTGGACGGGGTGGCCGGC
GCGCTGAGCGAGAAGTTCTTAGGCTTGAAGCCCCAAGGAACTATGCCCCACGCATTAATTGTAATATTCGGGGACGAGGA
GAGCGCTTGGAAGGCCTTCGACGAGGCCTTGCCCGAGGAGGTACCAAGAATAGCCTTGGTTGACACCTTCTGTGACGAGA
GGGAGAGCGCGCTCAAGGCGGCAAGGGTGTTGAAAGAGAAGCTGAAGGGGGTGAGGCTCGACACGCCGAGCTCTAGGAGG
GGAAACATGAGGGCAATAGTGGAAGAGGTCAAGTGGACTTTGAGGCTACACGGCCTCGAGGTGCCCATAATAGTCAGCGG
AGGCCTCGACGAAGAGAAGGTAGAGGAGCTGAGGGACCTCGTAGACGCCTTCGGGGTCGGCACCAGCATAGCGTTCCCGC
CGAGCGTGGACGTGTCAGCGGACATAGTGGAGGTGCTCGAAGGGGACAAGTGGGTCCCGAGGTCGAAGAGGGGGAAGCTG
CCGGGCTTCAAGCAGCTCTTCCGGGACCGCTGCTTCAAAGACGAAGTCCTCCCCTGGGGCTCCGAGGGCAAAGGGACCCC
TCTCCTCACCAAGGTAATGGAGGGCGGCGAAGTGGTGACGAAGCTACCAAAGATAACTGAGATTAGGGATTACGTCTTGC
GTCAGCTCGAAGAGCTCAAGACTTGCAGAGCTTGA

Upstream 100 bases:

>100_bases
GCAGGCTGGTAAGGGGGACTTGGCAGAACGTCTTCTTGGTCGAACTCGACGGCCCTCGCCACTCTAGGAAGGTAATCGTT
ACTGTAATGGGTGAAGGGAA

Downstream 100 bases:

>100_bases
ACAAGTCGTCCCCCAAGTAGTGTAAGTTCTTAATTACTTTACCCCTTTCCATCTTTTCGGCCTCTTCCTTGTCATAGAGG
GCTAACCCGACGGCTATGGG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MRLYVASEEDILSGNATDIYFKRTVEVVKKSGKDKKVRMEFHAYSLPKGYEWGVFAGLEEALYVLRGRDVTVYSLPEGTL
FFRKEPIMVIEGKYSEFGELETALLGIIRHSTSIATKAARIKLAAGDKKVLFFGLRALHPAIQPVADRAAFIGGVDGVAG
ALSEKFLGLKPQGTMPHALIVIFGDEESAWKAFDEALPEEVPRIALVDTFCDERESALKAARVLKEKLKGVRLDTPSSRR
GNMRAIVEEVKWTLRLHGLEVPIIVSGGLDEEKVEELRDLVDAFGVGTSIAFPPSVDVSADIVEVLEGDKWVPRSKRGKL
PGFKQLFRDRCFKDEVLPWGSEGKGTPLLTKVMEGGEVVTKLPKITEIRDYVLRQLEELKTCRA

Sequences:

>Translated_384_residues
MRLYVASEEDILSGNATDIYFKRTVEVVKKSGKDKKVRMEFHAYSLPKGYEWGVFAGLEEALYVLRGRDVTVYSLPEGTL
FFRKEPIMVIEGKYSEFGELETALLGIIRHSTSIATKAARIKLAAGDKKVLFFGLRALHPAIQPVADRAAFIGGVDGVAG
ALSEKFLGLKPQGTMPHALIVIFGDEESAWKAFDEALPEEVPRIALVDTFCDERESALKAARVLKEKLKGVRLDTPSSRR
GNMRAIVEEVKWTLRLHGLEVPIIVSGGLDEEKVEELRDLVDAFGVGTSIAFPPSVDVSADIVEVLEGDKWVPRSKRGKL
PGFKQLFRDRCFKDEVLPWGSEGKGTPLLTKVMEGGEVVTKLPKITEIRDYVLRQLEELKTCRA
>Mature_384_residues
MRLYVASEEDILSGNATDIYFKRTVEVVKKSGKDKKVRMEFHAYSLPKGYEWGVFAGLEEALYVLRGRDVTVYSLPEGTL
FFRKEPIMVIEGKYSEFGELETALLGIIRHSTSIATKAARIKLAAGDKKVLFFGLRALHPAIQPVADRAAFIGGVDGVAG
ALSEKFLGLKPQGTMPHALIVIFGDEESAWKAFDEALPEEVPRIALVDTFCDERESALKAARVLKEKLKGVRLDTPSSRR
GNMRAIVEEVKWTLRLHGLEVPIIVSGGLDEEKVEELRDLVDAFGVGTSIAFPPSVDVSADIVEVLEGDKWVPRSKRGKL
PGFKQLFRDRCFKDEVLPWGSEGKGTPLLTKVMEGGEVVTKLPKITEIRDYVLRQLEELKTCRA

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=442, Percent_Identity=25.1131221719457, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71997952, Length=298, Percent_Identity=24.8322147651007, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71997947, Length=298, Percent_Identity=24.8322147651007, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71997955, Length=128, Percent_Identity=33.59375, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24581587, Length=411, Percent_Identity=26.0340632603406, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161076680, Length=147, Percent_Identity=38.0952380952381, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24581595, Length=147, Percent_Identity=38.0952380952381, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574709, Length=147, Percent_Identity=38.0952380952381, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24581593, Length=147, Percent_Identity=38.0952380952381, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24581591, Length=147, Percent_Identity=38.0952380952381, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 42649; Mature: 42649

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLYVASEEDILSGNATDIYFKRTVEVVKKSGKDKKVRMEFHAYSLPKGYEWGVFAGLEE
CEEEEECCCCCCCCCCCEEHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHH
ALYVLRGRDVTVYSLPEGTLFFRKEPIMVIEGKYSEFGELETALLGIIRHSTSIATKAAR
HHHHHCCCCEEEEECCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHE
IKLAAGDKKVLFFGLRALHPAIQPVADRAAFIGGVDGVAGALSEKFLGLKPQGTMPHALI
EEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEE
VIFGDEESAWKAFDEALPEEVPRIALVDTFCDERESALKAARVLKEKLKGVRLDTPSSRR
EEECCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GNMRAIVEEVKWTLRLHGLEVPIIVSGGLDEEKVEELRDLVDAFGVGTSIAFPPSVDVSA
CCHHHHHHHHHHHHEEECCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
DIVEVLEGDKWVPRSKRGKLPGFKQLFRDRCFKDEVLPWGSEGKGTPLLTKVMEGGEVVT
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCHHHH
KLPKITEIRDYVLRQLEELKTCRA
HCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLYVASEEDILSGNATDIYFKRTVEVVKKSGKDKKVRMEFHAYSLPKGYEWGVFAGLEE
CEEEEECCCCCCCCCCCEEHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHH
ALYVLRGRDVTVYSLPEGTLFFRKEPIMVIEGKYSEFGELETALLGIIRHSTSIATKAAR
HHHHHCCCCEEEEECCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHE
IKLAAGDKKVLFFGLRALHPAIQPVADRAAFIGGVDGVAGALSEKFLGLKPQGTMPHALI
EEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEE
VIFGDEESAWKAFDEALPEEVPRIALVDTFCDERESALKAARVLKEKLKGVRLDTPSSRR
EEECCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GNMRAIVEEVKWTLRLHGLEVPIIVSGGLDEEKVEELRDLVDAFGVGTSIAFPPSVDVSA
CCHHHHHHHHHHHHEEECCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
DIVEVLEGDKWVPRSKRGKLPGFKQLFRDRCFKDEVLPWGSEGKGTPLLTKVMEGGEVVT
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCHHHH
KLPKITEIRDYVLRQLEELKTCRA
HCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]