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The map label for this gene is tpx [H]

Identifier: 154687070

GI number: 154687070

Start: 2770433

End: 2770936

Strand: Reverse

Name: tpx [H]

Synonym: RBAM_026420

Alternate gene names: 154687070

Gene position: 2770936-2770433 (Counterclockwise)

Preceding gene: 154687071

Following gene: 154687069

Centisome position: 70.71

GC content: 46.43

Gene sequence:

>504_bases
ATGGCTGAAATTACATTTAAAGGCGGAGCCGTGACGCTGATCGGACAAGAAGTGAAACCGGGTGACCAAGCTCCTGACTT
CACGGTTCTGACAAACGGATTAGAAGAGAAGACATTAGCAGATATGAAAGGGAAAGTAACGATCATATCCGTTATTCCTT
CCATTGACACAGGCGTATGTGACGCGCAGACACGCCGCTTCAACGAAGAAGCCGCAAAACTCGGTGATGTGAACGTTTAT
ACAATCAGCGCCGACCTTCCGTTTGCACAAGCGCGCTGGTGCGGAGCGAACGGAATTGATAAAGTTGAAACATTATCGGA
TCATAAAGAGATGTCATTTGGTGAAGCATTCGGTGTTCACATCAAAGAACTTCGTCTTTTGGCGCGTTCCGTATTCGTCC
TTGATCAGGACGGAAAAGTCGTTTACGCGGAATACGTAAGCGAAGCGACAAACCACCCGAATTATGAAAAGCCTATCGAA
GCTGCAAAAGCGTTAATCAAGTAA

Upstream 100 bases:

>100_bases
CCGCCCGCAGTTAACTTTTTTTACGATGCGGCATAACCTTTGCAGTTTGCATAAAACTCGACTATGATAGAGCTATACAT
AGATAAAGGGAGGAATCAGA

Downstream 100 bases:

>100_bases
AGAGAGAAAAAGAGCTCCGGGTGCTGCCGCGGAGCTCTTTTCATGGCAAGGAGGAAACAGCATGCAACACGACCATGTCG
GTCAGATTTATGAACTTTTA

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: Superoxide-inducible protein 8; SOI8 [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MAEITFKGGAVTLIGQEVKPGDQAPDFTVLTNGLEEKTLADMKGKVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVY
TISADLPFAQARWCGANGIDKVETLSDHKEMSFGEAFGVHIKELRLLARSVFVLDQDGKVVYAEYVSEATNHPNYEKPIE
AAKALIK

Sequences:

>Translated_167_residues
MAEITFKGGAVTLIGQEVKPGDQAPDFTVLTNGLEEKTLADMKGKVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVY
TISADLPFAQARWCGANGIDKVETLSDHKEMSFGEAFGVHIKELRLLARSVFVLDQDGKVVYAEYVSEATNHPNYEKPIE
AAKALIK
>Mature_166_residues
AEITFKGGAVTLIGQEVKPGDQAPDFTVLTNGLEEKTLADMKGKVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYT
ISADLPFAQARWCGANGIDKVETLSDHKEMSFGEAFGVHIKELRLLARSVFVLDQDGKVVYAEYVSEATNHPNYEKPIEA
AKALIK

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=164, Percent_Identity=40.2439024390244, Blast_Score=129, Evalue=8e-32,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 18160; Mature: 18029

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEITFKGGAVTLIGQEVKPGDQAPDFTVLTNGLEEKTLADMKGKVTIISVIPSIDTGVC
CCEEEECCCEEEEEECCCCCCCCCCCEEEEECCCCHHHHHHCCCCEEEEEEECCCCCCCC
DAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKVETLSDHKEMSFGEAFGVH
CHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHH
IKELRLLARSVFVLDQDGKVVYAEYVSEATNHPNYEKPIEAAKALIK
HHHHHHHHHHHEEECCCCCEEHHHHHHHHHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
AEITFKGGAVTLIGQEVKPGDQAPDFTVLTNGLEEKTLADMKGKVTIISVIPSIDTGVC
CEEEECCCEEEEEECCCCCCCCCCCEEEEECCCCHHHHHHCCCCEEEEEEECCCCCCCC
DAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKVETLSDHKEMSFGEAFGVH
CHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHH
IKELRLLARSVFVLDQDGKVVYAEYVSEATNHPNYEKPIEAAKALIK
HHHHHHHHHHHEEECCCCCEEHHHHHHHHHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 9298659 [H]