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The map label for this gene is mutM [H]

Identifier: 154687040

GI number: 154687040

Start: 2735001

End: 2735837

Strand: Reverse

Name: mutM [H]

Synonym: RBAM_026120

Alternate gene names: 154687040

Gene position: 2735837-2735001 (Counterclockwise)

Preceding gene: 154687041

Following gene: 154687039

Centisome position: 69.82

GC content: 50.66

Gene sequence:

>837_bases
ATGATTGTGCCGGAATTACCAGAAGTTGAAACGGTCCGGCGCACTCTGACCGGTCTTGTGAAGGGGAAAACGATTGAATC
GGCGGATATCAGATGGCCGAATATCATCAAAAAACCCGCCGAGCCGGAGGAATTCGCGCGGCAGATTGCAGGAGAAACAA
TCCGATCCATCGGAAGAAGGGGAAAGTTTTTGCTTTTCCATCTGGATCATTATGTCATGGTGTCCCACCTGCGGATGGAG
GGGAAATACGGTCTTCATCAGGCCGATGAGCCTGACGATAAACATGTGCACGTCGTGTTTCACATGACGGACGGAACACA
GCTCCGCTACCGGGATGTCCGGAAATTCGGCACGATGCATTTGTTTGCGCCGGGAGAGGAACAGAATGCATTACCGCTTT
CACAGCTCGGGCCCGAACCCGATGATGAAGCATTTACCGCTGCTTATTTAAAAGAGCGGCTTGCAAAAACGAACCGCGCG
GTGAAAACAGCCCTGCTCGACCAAAAAGCGGTCGTCGGCCTCGGCAATATTTATGTCGATGAAGCTTTATTCCGGGCGCG
TATTCATCCTGAGACAAAAGCGAACAGTCTGTCAGACGGGCAGATAAAAACGCTTCATACAGAAATTAAAGACACCCTTC
AGGAAGCGATTGACGCGGGCGGGAGCACCGTCCGGTCTTATATCAATTCTCAAGGGGAGATCGGAATGTTTCAGCTCAAA
CATTACGTATACGGCAAAAAGGATGAACCGTGCAAAACGTGCGGCACGATGATTTCTAAAATCGTGGTCGGCGGAAGGGG
TACGCATTTTTGCGCCCGCTGCCAAAAAAAATCATGA

Upstream 100 bases:

>100_bases
AGTGATGGAGCATGCTTTGGCATTAGACGTGCCGCTGAAGGCGGATTATGCTTCAGGGCCGTCTTGGTACGATGCAAAAT
AAACAGAGAAAAAGGAAGTG

Downstream 100 bases:

>100_bases
ACTGAAGCGGTTCAAGCAGGCGGCAGCAGAATGACTTTTTTCTAACACAGTTGATGACCTTTCTCCATATATATATTGTG
ATTCACCCAATAGGCATATG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MIVPELPEVETVRRTLTGLVKGKTIESADIRWPNIIKKPAEPEEFARQIAGETIRSIGRRGKFLLFHLDHYVMVSHLRME
GKYGLHQADEPDDKHVHVVFHMTDGTQLRYRDVRKFGTMHLFAPGEEQNALPLSQLGPEPDDEAFTAAYLKERLAKTNRA
VKTALLDQKAVVGLGNIYVDEALFRARIHPETKANSLSDGQIKTLHTEIKDTLQEAIDAGGSTVRSYINSQGEIGMFQLK
HYVYGKKDEPCKTCGTMISKIVVGGRGTHFCARCQKKS

Sequences:

>Translated_278_residues
MIVPELPEVETVRRTLTGLVKGKTIESADIRWPNIIKKPAEPEEFARQIAGETIRSIGRRGKFLLFHLDHYVMVSHLRME
GKYGLHQADEPDDKHVHVVFHMTDGTQLRYRDVRKFGTMHLFAPGEEQNALPLSQLGPEPDDEAFTAAYLKERLAKTNRA
VKTALLDQKAVVGLGNIYVDEALFRARIHPETKANSLSDGQIKTLHTEIKDTLQEAIDAGGSTVRSYINSQGEIGMFQLK
HYVYGKKDEPCKTCGTMISKIVVGGRGTHFCARCQKKS
>Mature_278_residues
MIVPELPEVETVRRTLTGLVKGKTIESADIRWPNIIKKPAEPEEFARQIAGETIRSIGRRGKFLLFHLDHYVMVSHLRME
GKYGLHQADEPDDKHVHVVFHMTDGTQLRYRDVRKFGTMHLFAPGEEQNALPLSQLGPEPDDEAFTAAYLKERLAKTNRA
VKTALLDQKAVVGLGNIYVDEALFRARIHPETKANSLSDGQIKTLHTEIKDTLQEAIDAGGSTVRSYINSQGEIGMFQLK
HYVYGKKDEPCKTCGTMISKIVVGGRGTHFCARCQKKS

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=279, Percent_Identity=39.0681003584229, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1786932, Length=280, Percent_Identity=26.4285714285714, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31210; Mature: 31210

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVPELPEVETVRRTLTGLVKGKTIESADIRWPNIIKKPAEPEEFARQIAGETIRSIGRR
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCC
GKFLLFHLDHYVMVSHLRMEGKYGLHQADEPDDKHVHVVFHMTDGTQLRYRDVRKFGTMH
CCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCEE
LFAPGEEQNALPLSQLGPEPDDEAFTAAYLKERLAKTNRAVKTALLDQKAVVGLGNIYVD
EECCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHH
EALFRARIHPETKANSLSDGQIKTLHTEIKDTLQEAIDAGGSTVRSYINSQGEIGMFQLK
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHH
HYVYGKKDEPCKTCGTMISKIVVGGRGTHFCARCQKKS
HHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
>Mature Secondary Structure
MIVPELPEVETVRRTLTGLVKGKTIESADIRWPNIIKKPAEPEEFARQIAGETIRSIGRR
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCC
GKFLLFHLDHYVMVSHLRMEGKYGLHQADEPDDKHVHVVFHMTDGTQLRYRDVRKFGTMH
CCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCEE
LFAPGEEQNALPLSQLGPEPDDEAFTAAYLKERLAKTNRAVKTALLDQKAVVGLGNIYVD
EECCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHH
EALFRARIHPETKANSLSDGQIKTLHTEIKDTLQEAIDAGGSTVRSYINSQGEIGMFQLK
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHH
HYVYGKKDEPCKTCGTMISKIVVGGRGTHFCARCQKKS
HHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]