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The map label for this gene is ilvC

Identifier: 154686965

GI number: 154686965

Start: 2658225

End: 2659253

Strand: Reverse

Name: ilvC

Synonym: RBAM_025350

Alternate gene names: 154686965

Gene position: 2659253-2658225 (Counterclockwise)

Preceding gene: 154686966

Following gene: 154686964

Centisome position: 67.86

GC content: 46.65

Gene sequence:

>1029_bases
ATGGTAAAAGTATATTATAACGGTGATATCAAAGAGAACGTATTGGCAGGTAAAAAAGTAGCGATTATCGGTTACGGTTC
ACAAGGTCACGCACATGCGCTGAACTTAAAAGAAAGCGGAATTGATGTCATTGTCGGCGTCAGACAAGGAAAATCATTTA
CACAGGCCCAAGAAGACGGTCATCAAGTCTTTTCGGTAAGAGAAGCGGCTGCCCAGGCTGATATCATTATGGTTCTTCTT
CCGGATGAACAGCAGCAAAAAGTATATGAAGCTGAAATCAAAGATGAATTGACGGCGGGCAAGTCATTAGTATTCGCACA
CGGATTTAACGTCCATTTCCATCAGATCGTGCCTCCTGCCGATGTGGATGTATTCCTTGTCGCCCCTAAAGGACCGGGAC
ACCTTGTCAGAAGAACATATGAACAAGGCGCGGGCGTACCGGCATTGTTTGCCATCTACCAGGATGTATCAGGCGAAGCG
AAAGATACGGCTCTTGCTTATGCAAAAGGAATCGGCGGAGCGCGTGCGGGCGTTCTTGAAACAACATTTAAGGAAGAAAC
GGAAACGGATTTGTTCGGTGAGCAGGCTGTTCTGTGCGGAGGTTTAACGGCGCTTGTCAAAGCGGGTTTTGAAACGCTGA
CAGAAGCCGGCTACCAGCCTGAACTCGCATACTTCGAGTGTCTGCACGAACTGAAGCTGATCGTAGACTTGATGTATGAA
GAAGGATTGGCGGGCATGAGATACTCTATCTCTGATACGGCTCAATGGGGAGATTTTGTCTCAGGGCCGCGCGTAGTCGA
TGCGAAGGTAAAAGAATCGATGAAACAAGTATTAACGGATATTCAAAACGGTACATTCGCGAAAGAATGGATCGTGGAAA
ACCAAGTGAACCGTCCTCGTTTCAATGCGATCAATGCAAGTGAAAACGAGCATCAGATTGAAAAGGTCGGCAGACAGCTT
CGTGAAATGATGCCGTTTGTCAAACAAGGCAAAAAGAAGGAAGCGGTGGTCTCTGTTGCGCAAAATTAA

Upstream 100 bases:

>100_bases
GCGAGAACGGGCACAACGGCTTTTGCGAGGGGAACCCAGCAGAAGACGTCATCCAATAAAACAATTTCAATTGTATAACA
CAAAAAAGGGAGAGATTAAA

Downstream 100 bases:

>100_bases
TGTTTTCGACACGACCCTTCGTGACGGTGAACAATCCCCCGGGGTCAACCTCAATTCCCGGGAGAAACTGGCGATAGCCA
AGCAGCTTGAAAGACTCGGG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MVKVYYNGDIKENVLAGKKVAIIGYGSQGHAHALNLKESGIDVIVGVRQGKSFTQAQEDGHQVFSVREAAAQADIIMVLL
PDEQQQKVYEAEIKDELTAGKSLVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVSGEA
KDTALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLTALVKAGFETLTEAGYQPELAYFECLHELKLIVDLMYE
EGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKQVLTDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEKVGRQL
REMMPFVKQGKKKEAVVSVAQN

Sequences:

>Translated_342_residues
MVKVYYNGDIKENVLAGKKVAIIGYGSQGHAHALNLKESGIDVIVGVRQGKSFTQAQEDGHQVFSVREAAAQADIIMVLL
PDEQQQKVYEAEIKDELTAGKSLVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVSGEA
KDTALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLTALVKAGFETLTEAGYQPELAYFECLHELKLIVDLMYE
EGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKQVLTDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEKVGRQL
REMMPFVKQGKKKEAVVSVAQN
>Mature_342_residues
MVKVYYNGDIKENVLAGKKVAIIGYGSQGHAHALNLKESGIDVIVGVRQGKSFTQAQEDGHQVFSVREAAAQADIIMVLL
PDEQQQKVYEAEIKDELTAGKSLVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVSGEA
KDTALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLTALVKAGFETLTEAGYQPELAYFECLHELKLIVDLMYE
EGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKQVLTDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEKVGRQL
REMMPFVKQGKKKEAVVSVAQN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=287, Percent_Identity=34.8432055749129, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323387, Length=318, Percent_Identity=35.5345911949685, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_BACA2 (A7Z7B9)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001422126.1
- ProteinModelPortal:   A7Z7B9
- SMR:   A7Z7B9
- STRING:   A7Z7B9
- EnsemblBacteria:   EBBACT00000006771
- GeneID:   5462136
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_025350
- eggNOG:   COG0059
- GeneTree:   EBGT00050000000943
- HOGENOM:   HBG286525
- OMA:   KDELTAG
- ProtClustDB:   PRK05479
- BioCyc:   BAMY326423:RBAM_025350-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37473; Mature: 37473

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVYYNGDIKENVLAGKKVAIIGYGSQGHAHALNLKESGIDVIVGVRQGKSFTQAQEDG
CEEEEECCCCHHHHHCCCEEEEEEECCCCCEEEECCCCCCCEEEEEECCCCCHHHHHHHH
HQVFSVREAAAQADIIMVLLPDEQQQKVYEAEIKDELTAGKSLVFAHGFNVHFHQIVPPA
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCC
DVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVSGEAKDTALAYAKGIGGARAGVLE
CCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHH
TTFKEETETDLFGEQAVLCGGLTALVKAGFETLTEAGYQPELAYFECLHELKLIVDLMYE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKQVLTDIQNGTFAKEWIVENQVNRPR
CCCCCCEEECCCCHHHCHHCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
FNAINASENEHQIEKVGRQLREMMPFVKQGKKKEAVVSVAQN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCC
>Mature Secondary Structure
MVKVYYNGDIKENVLAGKKVAIIGYGSQGHAHALNLKESGIDVIVGVRQGKSFTQAQEDG
CEEEEECCCCHHHHHCCCEEEEEEECCCCCEEEECCCCCCCEEEEEECCCCCHHHHHHHH
HQVFSVREAAAQADIIMVLLPDEQQQKVYEAEIKDELTAGKSLVFAHGFNVHFHQIVPPA
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCC
DVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVSGEAKDTALAYAKGIGGARAGVLE
CCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHH
TTFKEETETDLFGEQAVLCGGLTALVKAGFETLTEAGYQPELAYFECLHELKLIVDLMYE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKQVLTDIQNGTFAKEWIVENQVNRPR
CCCCCCEEECCCCHHHCHHCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
FNAINASENEHQIEKVGRQLREMMPFVKQGKKKEAVVSVAQN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA