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The map label for this gene is nadC [H]

Identifier: 154686921

GI number: 154686921

Start: 2611573

End: 2612421

Strand: Reverse

Name: nadC [H]

Synonym: RBAM_024910

Alternate gene names: 154686921

Gene position: 2612421-2611573 (Counterclockwise)

Preceding gene: 154686922

Following gene: 154686920

Centisome position: 66.67

GC content: 50.06

Gene sequence:

>849_bases
ATGGACATTCTGCAGCTGAAACAAATGCTGACTCATTTTTTTCAGGAAGATATCGGAACGGGTGATGTCACGTCACAAGC
GATTTTTTCTGATCAGCAATGTAAAGCGCGAATCATCACAAAAACAGACGGCGTGTTTGCCGGAGAAGCCGTTATCCGTG
AAGGATGGAAGCTTTTACACGATGACATCCGCATCCGCTCCCTGAAAAAAGACGGAGAACGGATGAAAAAAGGAGACGTG
CTCGCTGAAATAGAAGGCCAGGCGGCGGCTCTTCTTACGGGGGAGCGGGTCATTCTGAATCTCATACAAAGAATGTCAGG
CATTGCGACAATGACGGATGAGGCCAAAAGGCGTCTTGATGATCCGTCCATCAAGCTTTGTGATACGAGAAAAACGACAC
CCGGGCTCAGAATGCTGGAAAAATACGCCGTTCGGGTCGGAGGCGGCTTTAATCATCGCTTCGGCTTATATGACGGCATC
ATGATAAAAGATAATCATATTGCCGCCTGCGGATCGATAAGGGCGGCCATGGAGCGGGCAAGAAAAACGGCGGGGCAGAT
GCTTGCGGTGGAAGTCGAAATCGAATCCGAACAGCAGCTGCTCGAGGCAATAGAAGCGGGTGCAGACGTTATTATGTTTG
ACAACTGTCCGCCTGAGTCCGTCCGGCGTTTTGCAGGTATGACACCGGGCCATATCAAAACGGAAGCATCCGGAGGCATA
ACGCTCGACACGTTGCCCGCTTATAAAGGAACGGGGGTCCAATATATTTCACTCGGATTTCTGACTCATTCAGTAAAAAG
CGCCGACATCAGCATGGATGTTGAGGCAGCGGAACAGGGGGATTTTTAA

Upstream 100 bases:

>100_bases
GCGCTGATTTTCCCGGGACGGAGAAAGAGTGGCACGGAAAACAAATCATTCATTCAACATCTGGAACAGCTATCAGAAAA
AACGAAAGGATTGGGGAACT

Downstream 100 bases:

>100_bases
GATGTCTATTTTTGACGTGCTAACTGCATCAGCCGAAATGATGCCGAGCCATTATAAAGACATGAGCACTGGAGAAATGG
AAAAGCGGGTCGCCGCCATT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MDILQLKQMLTHFFQEDIGTGDVTSQAIFSDQQCKARIITKTDGVFAGEAVIREGWKLLHDDIRIRSLKKDGERMKKGDV
LAEIEGQAAALLTGERVILNLIQRMSGIATMTDEAKRRLDDPSIKLCDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGI
MIKDNHIAACGSIRAAMERARKTAGQMLAVEVEIESEQQLLEAIEAGADVIMFDNCPPESVRRFAGMTPGHIKTEASGGI
TLDTLPAYKGTGVQYISLGFLTHSVKSADISMDVEAAEQGDF

Sequences:

>Translated_282_residues
MDILQLKQMLTHFFQEDIGTGDVTSQAIFSDQQCKARIITKTDGVFAGEAVIREGWKLLHDDIRIRSLKKDGERMKKGDV
LAEIEGQAAALLTGERVILNLIQRMSGIATMTDEAKRRLDDPSIKLCDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGI
MIKDNHIAACGSIRAAMERARKTAGQMLAVEVEIESEQQLLEAIEAGADVIMFDNCPPESVRRFAGMTPGHIKTEASGGI
TLDTLPAYKGTGVQYISLGFLTHSVKSADISMDVEAAEQGDF
>Mature_282_residues
MDILQLKQMLTHFFQEDIGTGDVTSQAIFSDQQCKARIITKTDGVFAGEAVIREGWKLLHDDIRIRSLKKDGERMKKGDV
LAEIEGQAAALLTGERVILNLIQRMSGIATMTDEAKRRLDDPSIKLCDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGI
MIKDNHIAACGSIRAAMERARKTAGQMLAVEVEIESEQQLLEAIEAGADVIMFDNCPPESVRRFAGMTPGHIKTEASGGI
TLDTLPAYKGTGVQYISLGFLTHSVKSADISMDVEAAEQGDF

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=249, Percent_Identity=37.3493975903614, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1786299, Length=265, Percent_Identity=41.1320754716981, Blast_Score=171, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6321162, Length=258, Percent_Identity=37.5968992248062, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30951; Mature: 30951

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILQLKQMLTHFFQEDIGTGDVTSQAIFSDQQCKARIITKTDGVFAGEAVIREGWKLLH
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
DDIRIRSLKKDGERMKKGDVLAEIEGQAAALLTGERVILNLIQRMSGIATMTDEAKRRLD
HHHHHHHHHHHHHHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHCC
DPSIKLCDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGIMIKDNHIAACGSIRAAMERA
CCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEHHHHHHHHHHHH
RKTAGQMLAVEVEIESEQQLLEAIEAGADVIMFDNCPPESVRRFAGMTPGHIKTEASGGI
HHHHCCEEEEEEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCCCEEECCCCCE
TLDTLPAYKGTGVQYISLGFLTHSVKSADISMDVEAAEQGDF
EEECCCCCCCCCEEEEEEEHHHHHHCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MDILQLKQMLTHFFQEDIGTGDVTSQAIFSDQQCKARIITKTDGVFAGEAVIREGWKLLH
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
DDIRIRSLKKDGERMKKGDVLAEIEGQAAALLTGERVILNLIQRMSGIATMTDEAKRRLD
HHHHHHHHHHHHHHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHCC
DPSIKLCDTRKTTPGLRMLEKYAVRVGGGFNHRFGLYDGIMIKDNHIAACGSIRAAMERA
CCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEHHHHHHHHHHHH
RKTAGQMLAVEVEIESEQQLLEAIEAGADVIMFDNCPPESVRRFAGMTPGHIKTEASGGI
HHHHCCEEEEEEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCCCEEECCCCCE
TLDTLPAYKGTGVQYISLGFLTHSVKSADISMDVEAAEQGDF
EEECCCCCCCCCEEEEEEEHHHHHHCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]