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The map label for this gene is manP [H]

Identifier: 154686850

GI number: 154686850

Start: 2536355

End: 2538313

Strand: Reverse

Name: manP [H]

Synonym: RBAM_024200

Alternate gene names: 154686850

Gene position: 2538313-2536355 (Counterclockwise)

Preceding gene: 154686851

Following gene: 154686849

Centisome position: 64.78

GC content: 48.65

Gene sequence:

>1959_bases
ATGAAACTGTTAGCGATTACATCATGTCCGAACGGCATTGCCCATACGTATATGGCTGCTGAAAATTTACAAAAAGCAGC
CGGCAGATTAGGCGTTGAGATCAAAGTGGAAACCCAGGGGGGAATCGGGGTGGAAAATAGGCTGACCGAAGAGGAAATCC
GGGAAGCAGACGCAATCATTATCGCGGCGGACCGTTCGGTGAACAAAGACCGATTCGCGGGAAAAAAGCTGCTGGCCGTC
GGGGTTCAGGAAGGCATCCGCAAACCGGAAGAATTAATTCAAAAAGCGCTTAGCAGTGAAGTGCCGGTCTATCAATCTGC
TTCAAAAGCTGAATCCGCAAGTCAGCAGGGCAAAAAACAAAACCCGATTTACCGTCATTTAATGAACGGCGTTTCTTTTA
TGGTTCCTTTCATTGTCGTCGGCGGATTATTGATAGCGGTTGCATTGACGCTTGGAGGAGAAAAAACACCAAAGGGCTTA
GTCATTCCGGACGAGTCTTTTTGGAAGACGATTGAACAGATCGGCAGTGCTTCTTTTTCATTCATGATCCCGATTTTAGC
CGGGTATATCGCGTTCAGCATCGCTGATAAGCCGGGGCTTGTCCCCGGAATGATCGGCGGATATATTGCGGCATCCGGCA
GCTTTTACGACAGTGCAAGCGGCGCAGGATTTCTTGGAGGAATCATTGCGGGATTTTTGGCGGGATATGCGGCGCTTGGA
ATCAAAAAATGTAAAGTTCCTAAAGCAATACAGCCGATTATGCCGATCATTATTATTCCGGTGTTTGCCTCACTGATCGT
CGGTTTGGCGTTTGTCTTTCTGATCGGCGCCCCCGTCGCTCATATTTTCGCATCATTAACGGTTTGGCTTGCGGGAATGA
AAGGTTCGAGTTCAATTCTTCTGGCATTGATTTTAGGAGCGATGATCTCCTTTGATATGGGAGGACCCGTAAACAAGGTG
GCCTTTCTTTTCGGATCGGCAATGATCGGAGAAGGAAATTATGAAATCATGGGCCCGATTGCCGTTTCCATTTGTATACC
GCCGATAGGGCTTGGGATTGCAACGTTTTTAGGAAAAAGAAAATTCGCCGCCGCAGAAAAAGAAATGGGAAAAGCATCAT
TTACGATGGGCCTTTTCGGTATCACGGAAGGAGCCATTCCATTTGCGGCCCAAGACCCCCTTCGTGTGATCCCGAGTATT
ATGGCGGGTTCTATGACCGGATCGGTGATAGCGATGATCGGCCATGTGGGGGACAGAGTGGCACACGGCGGCCCCATCGT
TGCTGTACTTGGAGCAGTAGATCATGTACTGATGTTTTTTATCGCTGTAACAGCAGGCTCTCTTGTCACCGCTCTGTTGG
TTAATGTACTGAAGAAAGATATGGCGAAATCCCCCGCGCCCGGCGAGGTGCTGCCGTCTGACGCACCAAATGAAGCTGCA
GCGGCAAAAGAAACAAAGGAACCATCTCAGGCTGACAGCCGAAAAGCCGGGATGACCGAAATCAAAAAACTGACTGACAT
TATCAGTACGGACTTGATTGAACCGCATTTATCCGGCGAAACGAGGGATGACATTATCGATGAAATGATCGCGAAAATGT
CCCGTAAAGGTATGCTGCTGTCTGACAGCGGATTTAAGCAGGCCATTTTGAGCCGGGAACAGCAGGGAACCACGGCGATA
GGTATGAATATCGCCATTCCGCACGGAAAGTCTGAAGCCGTCAAAACGCCGGGTGTCGCATTCGGAATAAGACGTTCGGG
TGTTGACTGGAACAGCCTTGATGGTTCTGATGCAAAACTGATTTTTATGATTGCCGTACCGAAGGAAAGCGGCGGAAATC
AGCATCTGAAAATATTGCAGATGTTATCCCGAAAACTGATGGATGACAGCTATCGGGAAAGGCTGCTCTCCGTTCAGACA
AAAGAAGAGGCGTATGAGCTTCTGGAAGAAATCGAATAA

Upstream 100 bases:

>100_bases
ATTTCCGGAACTTATGGTAAAAAAACGTGCTTATCACAGGCTGATTTCAGTATAAAGTTGAGACAAGATCTTGAAATTCA
GACTGCAAAGGAGGATTTAT

Downstream 100 bases:

>100_bases
AGCGGGGGATGATCATGTCTACTGAACCAATATTTTTCAATCCGGTTTTCAAAGAAAGAATTTGGGGAGGCGCTGCCCTG
CGTGATTTTCACTATAATAT

Product: ManP

Products: NA

Alternate protein names: EIIBCA-Man; EII-Man; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific EIIB component; Mannose permease IIC component; PTS system mannose-specific EIIC component; Mannose-specific phosphotransferase enzyme IIA component; PTS system mannose-specific EIIA component [H]

Number of amino acids: Translated: 652; Mature: 652

Protein sequence:

>652_residues
MKLLAITSCPNGIAHTYMAAENLQKAAGRLGVEIKVETQGGIGVENRLTEEEIREADAIIIAADRSVNKDRFAGKKLLAV
GVQEGIRKPEELIQKALSSEVPVYQSASKAESASQQGKKQNPIYRHLMNGVSFMVPFIVVGGLLIAVALTLGGEKTPKGL
VIPDESFWKTIEQIGSASFSFMIPILAGYIAFSIADKPGLVPGMIGGYIAASGSFYDSASGAGFLGGIIAGFLAGYAALG
IKKCKVPKAIQPIMPIIIIPVFASLIVGLAFVFLIGAPVAHIFASLTVWLAGMKGSSSILLALILGAMISFDMGGPVNKV
AFLFGSAMIGEGNYEIMGPIAVSICIPPIGLGIATFLGKRKFAAAEKEMGKASFTMGLFGITEGAIPFAAQDPLRVIPSI
MAGSMTGSVIAMIGHVGDRVAHGGPIVAVLGAVDHVLMFFIAVTAGSLVTALLVNVLKKDMAKSPAPGEVLPSDAPNEAA
AAKETKEPSQADSRKAGMTEIKKLTDIISTDLIEPHLSGETRDDIIDEMIAKMSRKGMLLSDSGFKQAILSREQQGTTAI
GMNIAIPHGKSEAVKTPGVAFGIRRSGVDWNSLDGSDAKLIFMIAVPKESGGNQHLKILQMLSRKLMDDSYRERLLSVQT
KEEAYELLEEIE

Sequences:

>Translated_652_residues
MKLLAITSCPNGIAHTYMAAENLQKAAGRLGVEIKVETQGGIGVENRLTEEEIREADAIIIAADRSVNKDRFAGKKLLAV
GVQEGIRKPEELIQKALSSEVPVYQSASKAESASQQGKKQNPIYRHLMNGVSFMVPFIVVGGLLIAVALTLGGEKTPKGL
VIPDESFWKTIEQIGSASFSFMIPILAGYIAFSIADKPGLVPGMIGGYIAASGSFYDSASGAGFLGGIIAGFLAGYAALG
IKKCKVPKAIQPIMPIIIIPVFASLIVGLAFVFLIGAPVAHIFASLTVWLAGMKGSSSILLALILGAMISFDMGGPVNKV
AFLFGSAMIGEGNYEIMGPIAVSICIPPIGLGIATFLGKRKFAAAEKEMGKASFTMGLFGITEGAIPFAAQDPLRVIPSI
MAGSMTGSVIAMIGHVGDRVAHGGPIVAVLGAVDHVLMFFIAVTAGSLVTALLVNVLKKDMAKSPAPGEVLPSDAPNEAA
AAKETKEPSQADSRKAGMTEIKKLTDIISTDLIEPHLSGETRDDIIDEMIAKMSRKGMLLSDSGFKQAILSREQQGTTAI
GMNIAIPHGKSEAVKTPGVAFGIRRSGVDWNSLDGSDAKLIFMIAVPKESGGNQHLKILQMLSRKLMDDSYRERLLSVQT
KEEAYELLEEIE
>Mature_652_residues
MKLLAITSCPNGIAHTYMAAENLQKAAGRLGVEIKVETQGGIGVENRLTEEEIREADAIIIAADRSVNKDRFAGKKLLAV
GVQEGIRKPEELIQKALSSEVPVYQSASKAESASQQGKKQNPIYRHLMNGVSFMVPFIVVGGLLIAVALTLGGEKTPKGL
VIPDESFWKTIEQIGSASFSFMIPILAGYIAFSIADKPGLVPGMIGGYIAASGSFYDSASGAGFLGGIIAGFLAGYAALG
IKKCKVPKAIQPIMPIIIIPVFASLIVGLAFVFLIGAPVAHIFASLTVWLAGMKGSSSILLALILGAMISFDMGGPVNKV
AFLFGSAMIGEGNYEIMGPIAVSICIPPIGLGIATFLGKRKFAAAEKEMGKASFTMGLFGITEGAIPFAAQDPLRVIPSI
MAGSMTGSVIAMIGHVGDRVAHGGPIVAVLGAVDHVLMFFIAVTAGSLVTALLVNVLKKDMAKSPAPGEVLPSDAPNEAA
AAKETKEPSQADSRKAGMTEIKKLTDIISTDLIEPHLSGETRDDIIDEMIAKMSRKGMLLSDSGFKQAILSREQQGTTAI
GMNIAIPHGKSEAVKTPGVAFGIRRSGVDWNSLDGSDAKLIFMIAVPKESGGNQHLKILQMLSRKLMDDSYRERLLSVQT
KEEAYELLEEIE

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=465, Percent_Identity=44.3010752688172, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI87082348, Length=471, Percent_Identity=35.8811040339703, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1786951, Length=419, Percent_Identity=40.0954653937947, Blast_Score=268, Evalue=1e-72,
Organism=Escherichia coli, GI1790386, Length=341, Percent_Identity=44.8680351906158, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1788729, Length=419, Percent_Identity=27.9236276849642, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1790387, Length=95, Percent_Identity=45.2631578947368, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1788730, Length=88, Percent_Identity=42.0454545454545, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1790390, Length=101, Percent_Identity=36.6336633663366, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789597, Length=127, Percent_Identity=32.2834645669291, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI2367327, Length=135, Percent_Identity=27.4074074074074, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 68740; Mature: 68740

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLAITSCPNGIAHTYMAAENLQKAAGRLGVEIKVETQGGIGVENRLTEEEIREADAII
CCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHCCCHHHHHCCCEEE
IAADRSVNKDRFAGKKLLAVGVQEGIRKPEELIQKALSSEVPVYQSASKAESASQQGKKQ
EEECCCCCHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHCHHHHHHHHHCCCCC
NPIYRHLMNGVSFMVPFIVVGGLLIAVALTLGGEKTPKGLVIPDESFWKTIEQIGSASFS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHCCCCHH
FMIPILAGYIAFSIADKPGLVPGMIGGYIAASGSFYDSASGAGFLGGIIAGFLAGYAALG
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
IKKCKVPKAIQPIMPIIIIPVFASLIVGLAFVFLIGAPVAHIFASLTVWLAGMKGSSSIL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHH
LALILGAMISFDMGGPVNKVAFLFGSAMIGEGNYEIMGPIAVSICIPPIGLGIATFLGKR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEECCEEEEEECCCHHHHHHHHHHHH
KFAAAEKEMGKASFTMGLFGITEGAIPFAAQDPLRVIPSIMAGSMTGSVIAMIGHVGDRV
HHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AHGGPIVAVLGAVDHVLMFFIAVTAGSLVTALLVNVLKKDMAKSPAPGEVLPSDAPNEAA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
AAKETKEPSQADSRKAGMTEIKKLTDIISTDLIEPHLSGETRDDIIDEMIAKMSRKGMLL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEE
SDSGFKQAILSREQQGTTAIGMNIAIPHGKSEAVKTPGVAFGIRRSGVDWNSLDGSDAKL
CCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCEE
IFMIAVPKESGGNQHLKILQMLSRKLMDDSYRERLLSVQTKEEAYELLEEIE
EEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLLAITSCPNGIAHTYMAAENLQKAAGRLGVEIKVETQGGIGVENRLTEEEIREADAII
CCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHCCCHHHHHCCCEEE
IAADRSVNKDRFAGKKLLAVGVQEGIRKPEELIQKALSSEVPVYQSASKAESASQQGKKQ
EEECCCCCHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHCHHHHHHHHHCCCCC
NPIYRHLMNGVSFMVPFIVVGGLLIAVALTLGGEKTPKGLVIPDESFWKTIEQIGSASFS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHCCCCHH
FMIPILAGYIAFSIADKPGLVPGMIGGYIAASGSFYDSASGAGFLGGIIAGFLAGYAALG
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
IKKCKVPKAIQPIMPIIIIPVFASLIVGLAFVFLIGAPVAHIFASLTVWLAGMKGSSSIL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHH
LALILGAMISFDMGGPVNKVAFLFGSAMIGEGNYEIMGPIAVSICIPPIGLGIATFLGKR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEECCEEEEEECCCHHHHHHHHHHHH
KFAAAEKEMGKASFTMGLFGITEGAIPFAAQDPLRVIPSIMAGSMTGSVIAMIGHVGDRV
HHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AHGGPIVAVLGAVDHVLMFFIAVTAGSLVTALLVNVLKKDMAKSPAPGEVLPSDAPNEAA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
AAKETKEPSQADSRKAGMTEIKKLTDIISTDLIEPHLSGETRDDIIDEMIAKMSRKGMLL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEE
SDSGFKQAILSREQQGTTAIGMNIAIPHGKSEAVKTPGVAFGIRRSGVDWNSLDGSDAKL
CCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCEE
IFMIAVPKESGGNQHLKILQMLSRKLMDDSYRERLLSVQTKEEAYELLEEIE
EEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]