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The map label for this gene is aroE [H]

Identifier: 154686826

GI number: 154686826

Start: 2514104

End: 2514946

Strand: Reverse

Name: aroE [H]

Synonym: RBAM_023960

Alternate gene names: 154686826

Gene position: 2514946-2514104 (Counterclockwise)

Preceding gene: 154686827

Following gene: 154686825

Centisome position: 64.18

GC content: 47.57

Gene sequence:

>843_bases
ATGAAACAATTGTACGGAGTAATCGGAAATCCGATCGGGCATTCAATGTCACCCGATATTCATAACGCGGCTTTGCAAGA
TAAGAACATCAACGGGCAGTATTTTGCGTTTCAGGTGGAACCTCATCATCTCAAGGACGCCGTTAACGGAATCAAGGCGC
TTGGCATCTGCGGAGTGAACGTCACAGTCCCGCATAAAGTCGCGATCATGGAGCATCTGGATGAAATACATGAAAGCGCG
AAAGTACTCGGGGCCGTAAATACCGTCAAAAGAGAGGGAGACAGGCTCATCGGGTATAATACTGACGGAGATGGGTTTTA
TAAATCCTTAGTCAAAGTATTGGACAAACCGATATCAGAGCTCTCCATCCTCATGATTGGGGCGGGAGGAGCGGCAAGAG
CGATTTTTACGACGATCGTCCGCAGAGAGCCGAAACAATTTGACGTTTGCAACCGCACGCCGGAAAAAGCAGAAAGTCTG
ATTGCGGCTGCTCCCTCTTTTCAGCAGAAACGCGCCCTTACTTTAAAAGAAGCTGAAAATCAGCTTGAACAATATGACGT
CATTATTCATACAACATCTGTCGGCATGTATCCGAAAACGGATGCCGTGCCGCTCTCATTGGAACGGGCCAAAACGGGCG
CCATCGTTTGTGATATCGTATACAACCCGATTCAAACGGCGTTCTTAAAAGAAGCTGAAAAAAGAGGTTTAACAACCCTT
GACGGTGTCGGCATGTTTGTGGAACAGGCCGCACTGTCTTTCAAGCTGTGGACGGAACAAGAGCCTGACAGCGGCTTAAT
GAGAGCGATTGTTGTAGGAAAACTAGGAGGAACACAATGTTAA

Upstream 100 bases:

>100_bases
ACGGTGCAGCAAGCAGATAAAAAAATAACGGCATACGCTCCGAAAGGCGTACACGTATTTGTCCGCCGTTCATTAATATA
GAGAGAAGGGGAGAGGGAGC

Downstream 100 bases:

>100_bases
CAGGAAAACAAAAACGGTTTTTGCGTTCAAAAGCGCATCATTTAACGCCTATTTTTCAAGTGGGAAAAGGCGGAGTCAAC
GAAAACATGGTGAAACAGAT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKQLYGVIGNPIGHSMSPDIHNAALQDKNINGQYFAFQVEPHHLKDAVNGIKALGICGVNVTVPHKVAIMEHLDEIHESA
KVLGAVNTVKREGDRLIGYNTDGDGFYKSLVKVLDKPISELSILMIGAGGAARAIFTTIVRREPKQFDVCNRTPEKAESL
IAAAPSFQQKRALTLKEAENQLEQYDVIIHTTSVGMYPKTDAVPLSLERAKTGAIVCDIVYNPIQTAFLKEAEKRGLTTL
DGVGMFVEQAALSFKLWTEQEPDSGLMRAIVVGKLGGTQC

Sequences:

>Translated_280_residues
MKQLYGVIGNPIGHSMSPDIHNAALQDKNINGQYFAFQVEPHHLKDAVNGIKALGICGVNVTVPHKVAIMEHLDEIHESA
KVLGAVNTVKREGDRLIGYNTDGDGFYKSLVKVLDKPISELSILMIGAGGAARAIFTTIVRREPKQFDVCNRTPEKAESL
IAAAPSFQQKRALTLKEAENQLEQYDVIIHTTSVGMYPKTDAVPLSLERAKTGAIVCDIVYNPIQTAFLKEAEKRGLTTL
DGVGMFVEQAALSFKLWTEQEPDSGLMRAIVVGKLGGTQC
>Mature_280_residues
MKQLYGVIGNPIGHSMSPDIHNAALQDKNINGQYFAFQVEPHHLKDAVNGIKALGICGVNVTVPHKVAIMEHLDEIHESA
KVLGAVNTVKREGDRLIGYNTDGDGFYKSLVKVLDKPISELSILMIGAGGAARAIFTTIVRREPKQFDVCNRTPEKAESL
IAAAPSFQQKRALTLKEAENQLEQYDVIIHTTSVGMYPKTDAVPLSLERAKTGAIVCDIVYNPIQTAFLKEAEKRGLTTL
DGVGMFVEQAALSFKLWTEQEPDSGLMRAIVVGKLGGTQC

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=268, Percent_Identity=32.089552238806, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1789675, Length=264, Percent_Identity=37.1212121212121, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320332, Length=270, Percent_Identity=30.7407407407407, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 30499; Mature: 30499

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLYGVIGNPIGHSMSPDIHNAALQDKNINGQYFAFQVEPHHLKDAVNGIKALGICGVN
CCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHEEECCE
VTVPHKVAIMEHLDEIHESAKVLGAVNTVKREGDRLIGYNTDGDGFYKSLVKVLDKPISE
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCHHH
LSILMIGAGGAARAIFTTIVRREPKQFDVCNRTPEKAESLIAAAPSFQQKRALTLKEAEN
EEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
QLEQYDVIIHTTSVGMYPKTDAVPLSLERAKTGAIVCDIVYNPIQTAFLKEAEKRGLTTL
HHHHEEEEEEEECCCCCCCCCCCCEEHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCH
DGVGMFVEQAALSFKLWTEQEPDSGLMRAIVVGKLGGTQC
HHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKQLYGVIGNPIGHSMSPDIHNAALQDKNINGQYFAFQVEPHHLKDAVNGIKALGICGVN
CCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHEEECCE
VTVPHKVAIMEHLDEIHESAKVLGAVNTVKREGDRLIGYNTDGDGFYKSLVKVLDKPISE
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCHHH
LSILMIGAGGAARAIFTTIVRREPKQFDVCNRTPEKAESLIAAAPSFQQKRALTLKEAEN
EEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
QLEQYDVIIHTTSVGMYPKTDAVPLSLERAKTGAIVCDIVYNPIQTAFLKEAEKRGLTTL
HHHHEEEEEEEECCCCCCCCCCCCEEHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCH
DGVGMFVEQAALSFKLWTEQEPDSGLMRAIVVGKLGGTQC
HHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]