Click here to switch to the map view.

The map label for this gene is mmgA [H]

Identifier: 154686676

GI number: 154686676

Start: 2383228

End: 2384409

Strand: Reverse

Name: mmgA [H]

Synonym: RBAM_022450

Alternate gene names: 154686676

Gene position: 2384409-2383228 (Counterclockwise)

Preceding gene: 154686677

Following gene: 154686675

Centisome position: 60.85

GC content: 56.35

Gene sequence:

>1182_bases
GTGGGAAAAACGGTTATCGTCAGTGCGGCAAGAACGCCGTTCGGAAAATTTGGCGGCGCATTAAAAGAGGTAAAGGCAGC
CGAGCTTGGCGGCATTGCCATAAAAGAAGCAATCAAGCGCGCCGCTATCAGTGAAAGCGAAGCGGAAGGAGCGGTGATGG
GAATGGTCGTCCAGGCGGGTGCCGGGCAGATTCCGGCACGGCAGGCTGCAAGATATGCCGGGCTTCCGTGGTCCGTTCCG
GCTGAAACCATTAATAAGGTCTGTGCATCAGGGCTCAGGGCCGTTACCATCTGTGATCAAATGATCCGGGCGAAAGATGC
GGACGTGCTGATTGCAGGCGGAATGGAAAGCATGAGCAACATTCCGTACGCCATTCCGGCCGGCCGCTGGGGTGTGAGGA
TGGGGGACGGGGTGTTTCAGGATTTAATGGTTCATGACGGGCTGACCTGTGCGTTCGACCAGGTGCATATGGCTGTCCAC
GGAAGCACTGCGGCCAAAAAGTACGGCATTTCCCGGGATGAACAGGATCATTACGCTCTTTTGAGTCAGAAACGCGCGGC
TGAGGCGGCCGAGGCGGGCAAATTGCGTGAAGAAATTGTCCCCGTCACCTGGACCGGCAAAAAGGGCAAACAGCATACCG
TTGAAGCGGATGAGGGGCTGCGCCCTGATACGAGCCTTGAGCAGCTTGCAGCGCTCAAGCCAATTTTTACAGCCGACGGA
ACGGTTACAGCCGGAAACGCTCCCGGTGTAAATGACGGGGCAGGAGCATTTGTGCTGATGTCAGAGGAAAAAGCCGCGAA
GCAGCATGTCAGGCCGCTCGCAGCGATACTTGGCTTTGCGTCAGTCGGACTGGAAGCGTCCGAGCTGGCCAGCGCGCCGG
GAGAGGCCATCAGCCGGCTCTTGACAAAAACCGGACTGTCCGTTGACGATATTGATTTGTTTGAAGTAAATGAAGCATTT
GCGTCCGTCGTGCTGGTGAGTGAAAAAATAGCCGGGTTCAGCCGGGAAAAAGTGAATGTAAACGGAGGGGCAATCGCGTT
CGGCCACCCGATCGGCGCAAGCGGAGCGAGAATCATCATGAGTTTAATATACGAATTAAAGCGTCGCGGAGGGGGTTTAG
GCGTAGCGGCTATATGCAGCGGAGCGGCTCAAGGAGATGCCGTCCTGCTTGAGGTGTACTGA

Upstream 100 bases:

>100_bases
AAAGGCGGTGCACTCATAACTCGGTCAGCCGGTTCATATATTGTAACAGGGCGTTTTGTGTAAGCGTTATCTTTTATCTT
ATTGAAAGTGAGGCAAAATT

Downstream 100 bases:

>100_bases
TCAAAGGAGGGAGCGCCGGATGAAGATGAAAACAATCATGGTCGCAGGTGCGGGTCAGATGGGAGCAGGCATCGCGCAGA
CGGCTGCAGAAGCCGGGTTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MGKTVIVSAARTPFGKFGGALKEVKAAELGGIAIKEAIKRAAISESEAEGAVMGMVVQAGAGQIPARQAARYAGLPWSVP
AETINKVCASGLRAVTICDQMIRAKDADVLIAGGMESMSNIPYAIPAGRWGVRMGDGVFQDLMVHDGLTCAFDQVHMAVH
GSTAAKKYGISRDEQDHYALLSQKRAAEAAEAGKLREEIVPVTWTGKKGKQHTVEADEGLRPDTSLEQLAALKPIFTADG
TVTAGNAPGVNDGAGAFVLMSEEKAAKQHVRPLAAILGFASVGLEASELASAPGEAISRLLTKTGLSVDDIDLFEVNEAF
ASVVLVSEKIAGFSREKVNVNGGAIAFGHPIGASGARIIMSLIYELKRRGGGLGVAAICSGAAQGDAVLLEVY

Sequences:

>Translated_393_residues
MGKTVIVSAARTPFGKFGGALKEVKAAELGGIAIKEAIKRAAISESEAEGAVMGMVVQAGAGQIPARQAARYAGLPWSVP
AETINKVCASGLRAVTICDQMIRAKDADVLIAGGMESMSNIPYAIPAGRWGVRMGDGVFQDLMVHDGLTCAFDQVHMAVH
GSTAAKKYGISRDEQDHYALLSQKRAAEAAEAGKLREEIVPVTWTGKKGKQHTVEADEGLRPDTSLEQLAALKPIFTADG
TVTAGNAPGVNDGAGAFVLMSEEKAAKQHVRPLAAILGFASVGLEASELASAPGEAISRLLTKTGLSVDDIDLFEVNEAF
ASVVLVSEKIAGFSREKVNVNGGAIAFGHPIGASGARIIMSLIYELKRRGGGLGVAAICSGAAQGDAVLLEVY
>Mature_392_residues
GKTVIVSAARTPFGKFGGALKEVKAAELGGIAIKEAIKRAAISESEAEGAVMGMVVQAGAGQIPARQAARYAGLPWSVPA
ETINKVCASGLRAVTICDQMIRAKDADVLIAGGMESMSNIPYAIPAGRWGVRMGDGVFQDLMVHDGLTCAFDQVHMAVHG
STAAKKYGISRDEQDHYALLSQKRAAEAAEAGKLREEIVPVTWTGKKGKQHTVEADEGLRPDTSLEQLAALKPIFTADGT
VTAGNAPGVNDGAGAFVLMSEEKAAKQHVRPLAAILGFASVGLEASELASAPGEAISRLLTKTGLSVDDIDLFEVNEAFA
SVVLVSEKIAGFSREKVNVNGGAIAFGHPIGASGARIIMSLIYELKRRGGGLGVAAICSGAAQGDAVLLEVY

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=44.987146529563, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=44.8979591836735, Blast_Score=313, Evalue=1e-85,
Organism=Homo sapiens, GI167614485, Length=387, Percent_Identity=43.6692506459948, Blast_Score=303, Evalue=1e-82,
Organism=Homo sapiens, GI4501853, Length=393, Percent_Identity=37.9134860050891, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=32.0754716981132, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=29.305912596401, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=46.0358056265985, Blast_Score=325, Evalue=2e-90,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=46.9387755102041, Blast_Score=318, Evalue=3e-88,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=41.6040100250627, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=35.929648241206, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788683, Length=424, Percent_Identity=32.311320754717, Blast_Score=171, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI25147385, Length=378, Percent_Identity=43.3862433862434, Blast_Score=287, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI133906874, Length=393, Percent_Identity=40.2035623409669, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=39.8477157360406, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=32.7102803738318, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17535917, Length=383, Percent_Identity=34.2036553524804, Blast_Score=187, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6325229, Length=392, Percent_Identity=40.5612244897959, Blast_Score=289, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6322031, Length=392, Percent_Identity=33.4183673469388, Blast_Score=189, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=45.2685421994885, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24640423, Length=397, Percent_Identity=42.3173803526448, Blast_Score=289, Evalue=3e-78,
Organism=Drosophila melanogaster, GI17648125, Length=388, Percent_Identity=36.340206185567, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=32.0754716981132, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40738; Mature: 40607

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKTVIVSAARTPFGKFGGALKEVKAAELGGIAIKEAIKRAAISESEAEGAVMGMVVQAG
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHEEEEEECC
AGQIPARQAARYAGLPWSVPAETINKVCASGLRAVTICDQMIRAKDADVLIAGGMESMSN
CCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCHHHHCC
IPYAIPAGRWGVRMGDGVFQDLMVHDGLTCAFDQVHMAVHGSTAAKKYGISRDEQDHYAL
CCEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHEECCCHHHHHCCCCCCCCHHHHH
LSQKRAAEAAEAGKLREEIVPVTWTGKKGKQHTVEADEGLRPDTSLEQLAALKPIFTADG
HHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCC
TVTAGNAPGVNDGAGAFVLMSEEKAAKQHVRPLAAILGFASVGLEASELASAPGEAISRL
EEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHH
LTKTGLSVDDIDLFEVNEAFASVVLVSEKIAGFSREKVNVNGGAIAFGHPIGASGARIIM
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCHHHHHHH
SLIYELKRRGGGLGVAAICSGAAQGDAVLLEVY
HHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure 
GKTVIVSAARTPFGKFGGALKEVKAAELGGIAIKEAIKRAAISESEAEGAVMGMVVQAG
CCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHEEEEEECC
AGQIPARQAARYAGLPWSVPAETINKVCASGLRAVTICDQMIRAKDADVLIAGGMESMSN
CCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCHHHHCC
IPYAIPAGRWGVRMGDGVFQDLMVHDGLTCAFDQVHMAVHGSTAAKKYGISRDEQDHYAL
CCEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHEECCCHHHHHCCCCCCCCHHHHH
LSQKRAAEAAEAGKLREEIVPVTWTGKKGKQHTVEADEGLRPDTSLEQLAALKPIFTADG
HHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCC
TVTAGNAPGVNDGAGAFVLMSEEKAAKQHVRPLAAILGFASVGLEASELASAPGEAISRL
EEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHH
LTKTGLSVDDIDLFEVNEAFASVVLVSEKIAGFSREKVNVNGGAIAFGHPIGASGARIIM
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCHHHHHHH
SLIYELKRRGGGLGVAAICSGAAQGDAVLLEVY
HHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]