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The map label for this gene is trpC

Identifier: 154686514

GI number: 154686514

Start: 2180641

End: 2181393

Strand: Reverse

Name: trpC

Synonym: RBAM_020820

Alternate gene names: 154686514

Gene position: 2181393-2180641 (Counterclockwise)

Preceding gene: 154686515

Following gene: 154686513

Centisome position: 55.67

GC content: 48.07

Gene sequence:

>753_bases
ATGCTTGATCAAATCATTCAGCAGAAAAAAGAAGAAATCAAATCCATCGTGCTGCCGGAAACCTGTCAAATTGAACGGAG
ATCCTTTAAAAAAGCGCTCCAGAACCCGAACCGTTTTATCGGGCTGATTGCCGAAGTGAAAAAAGCTTCGCCGTCTAAAG
GATTGATTAAAGAGCATTTTGTTCCGGAAACGATTGCGGCGGATTATGAAGCGGCTAAAGCCGACGCCCTTTCAGTTCTC
ACGGATACCCGTTTTTTTCAGGGGAGAAATCAATTTCTGACAGATGTTAAACAAACCGTGTCTCTTCCCGTGCTGAGAAA
AGATTTTATTATTGATTCCCTTCAGGTGGAGGAATCGTTCAGGATCGGCGCCGATGCCATTTTGCTGATCGGGGAAGCGC
TGGAACCTTCAGAGCTTCATGAGCTTTATCTGGAAGCCCGCGAGAAGGGCATGGACGTTCTCGTTGAAGTCCATGATGAA
ACTGTGCTTGAACGGATTTTACAAGTGTTTCAGCCGGACATTCTCGGCATAAACAACCGGGACTTAAAAACGTTCCGTAC
TTCTGTTTCGCAAACGGAAAAAATAGCGCAGCTTGTACCGGACGGCTGTCTGCTGGTCAGCGAAAGCGGCATCGGTTCTT
TGGCTGACCTGCAATTCGTCAACAAGCACGGGGCGCAGGCTGTATTGGTCGGAGAATCCTTAATGAGAGAGGATTCGCAG
CAAAAGGCGATCCGCGGACTGTTCGGGGAGTGA

Upstream 100 bases:

>100_bases
AACGATCTGAAAGAAGGAACGAAAACCGCCTTAGAAGCGATTCAAAACGGAGATGCCAAAAGGCAGCTCGAACGTCTGAA
ACAGAAAGAGGAAGAAATGT

Downstream 100 bases:

>100_bases
CGATATGAAAAAGCCTGAGGTAAAGTACTGCGGAATACGATCGAAGCGTGATTACGAACTTGCGGCAGCTTCAGGAGCGG
ATTATCTGGGATTTATTTTT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MLDQIIQQKKEEIKSIVLPETCQIERRSFKKALQNPNRFIGLIAEVKKASPSKGLIKEHFVPETIAADYEAAKADALSVL
TDTRFFQGRNQFLTDVKQTVSLPVLRKDFIIDSLQVEESFRIGADAILLIGEALEPSELHELYLEAREKGMDVLVEVHDE
TVLERILQVFQPDILGINNRDLKTFRTSVSQTEKIAQLVPDGCLLVSESGIGSLADLQFVNKHGAQAVLVGESLMREDSQ
QKAIRGLFGE

Sequences:

>Translated_250_residues
MLDQIIQQKKEEIKSIVLPETCQIERRSFKKALQNPNRFIGLIAEVKKASPSKGLIKEHFVPETIAADYEAAKADALSVL
TDTRFFQGRNQFLTDVKQTVSLPVLRKDFIIDSLQVEESFRIGADAILLIGEALEPSELHELYLEAREKGMDVLVEVHDE
TVLERILQVFQPDILGINNRDLKTFRTSVSQTEKIAQLVPDGCLLVSESGIGSLADLQFVNKHGAQAVLVGESLMREDSQ
QKAIRGLFGE
>Mature_250_residues
MLDQIIQQKKEEIKSIVLPETCQIERRSFKKALQNPNRFIGLIAEVKKASPSKGLIKEHFVPETIAADYEAAKADALSVL
TDTRFFQGRNQFLTDVKQTVSLPVLRKDFIIDSLQVEESFRIGADAILLIGEALEPSELHELYLEAREKGMDVLVEVHDE
TVLERILQVFQPDILGINNRDLKTFRTSVSQTEKIAQLVPDGCLLVSESGIGSLADLQFVNKHGAQAVLVGESLMREDSQ
QKAIRGLFGE

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=245, Percent_Identity=37.9591836734694, Blast_Score=132, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322638, Length=227, Percent_Identity=36.1233480176211, Blast_Score=126, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_BACA2 (A7Z618)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001421675.1
- ProteinModelPortal:   A7Z618
- SMR:   A7Z618
- STRING:   A7Z618
- EnsemblBacteria:   EBBACT00000005012
- GeneID:   5462028
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_020820
- eggNOG:   COG0134
- GeneTree:   EBGT00050000001798
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- ProtClustDB:   PRK00278
- BioCyc:   BAMY326423:RBAM_020820-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27958; Mature: 27958

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDQIIQQKKEEIKSIVLPETCQIERRSFKKALQNPNRFIGLIAEVKKASPSKGLIKEHF
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHC
VPETIAADYEAAKADALSVLTDTRFFQGRNQFLTDVKQTVSLPVLRKDFIIDSLQVEESF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
RIGADAILLIGEALEPSELHELYLEAREKGMDVLVEVHDETVLERILQVFQPDILGINNR
HCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCC
DLKTFRTSVSQTEKIAQLVPDGCLLVSESGIGSLADLQFVNKHGAQAVLVGESLMREDSQ
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECHHHHHCCHH
QKAIRGLFGE
HHHHHHHCCC
>Mature Secondary Structure
MLDQIIQQKKEEIKSIVLPETCQIERRSFKKALQNPNRFIGLIAEVKKASPSKGLIKEHF
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHC
VPETIAADYEAAKADALSVLTDTRFFQGRNQFLTDVKQTVSLPVLRKDFIIDSLQVEESF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
RIGADAILLIGEALEPSELHELYLEAREKGMDVLVEVHDETVLERILQVFQPDILGINNR
HCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCC
DLKTFRTSVSQTEKIAQLVPDGCLLVSESGIGSLADLQFVNKHGAQAVLVGESLMREDSQ
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECHHHHHCCHH
QKAIRGLFGE
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA