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The map label for this gene is aroE

Identifier: 154686508

GI number: 154686508

Start: 2174451

End: 2175737

Strand: Reverse

Name: aroE

Synonym: RBAM_020760

Alternate gene names: 154686508

Gene position: 2175737-2174451 (Counterclockwise)

Preceding gene: 154686509

Following gene: 154686507

Centisome position: 55.52

GC content: 52.06

Gene sequence:

>1287_bases
TTGAAAAGAGAAAAAGTGACGTCTTTAAACGGTGAAATTCATATTCCGGGGGATAAATCCATCTCCCACCGTTCTGTTAT
GTTCGGAGCGCTTGCGGAAGGAACCACAACGGTAAAAAACTTTTTGCCCGGAGCCGATTGTCTGAGCACCATTGCCTGCT
TCAGAAAAATGGGTGTCTCCATTGAACAAAACGGAAGTGATGTAACGATATACGGGAAGGGCATTGACGCACTTTGTGAG
CCTGACAGCCTTCTTGATGTCGGAAATTCCGGCACGACCATCCGTCTGATGCTCGGCATTTTAGCCGGACGCCCATTTCA
CAGTACGGTAGCGGGCGACGAAAGTATTGCAAAGCGCCCGATGAAGAGGGTGACGGAGCCTTTAAAACAGATGGGAGCCG
CGATTGACGGAAGAGCGGACGGAGGATTTACGCCTTTATCCGTAAGAGGCGGACAATTGAAAGGCATTGATTACGTCTCC
CCTGTTGCAAGCGCGCAGATCAAATCCGCCGTGCTGCTTGCCGGATTGCAGGCTGAAGGGACGACGACCGTCACTGAGCC
TCATAAATCAAGAGACCATACGGAACGGATGCTGAACGCTTTTGGCGCCGAGCTTGCGGAAACGGAGACGAGCGCTTCCG
TAACGGGCGGTCAGAAGCTCCGGGGAGCTGATATTTTCGTGCCCGGCGATATTTCTTCAGCGGCCTTTTTCCTCGCGGCA
GGCGCTGTCGTTCCCGGAAGCCGGATTGTGCTGAAAAACGTCGGCCTGAACCCGACACGCACGGGAATGATTGATGTCTT
AAAGCAAATGGGGGCTTCACTTGAAGTGATTCCTTCAGAAGCGGACAGCGCAGAGCCTTACGGAGACCTGGTTATTGAAA
CCTCAGCTCTGAAAGCGGCAGAAATCGGCGGAGAAATCATTCCCCGTTTAATTGACGAGATCCCGATTATCGCCCTTTTG
GCAACGCAGGCTGAAGGCACAACTGTCATTAAAGACGCTGCGGAGCTGAAGGTGAAGGAAACGAACCGGATCGACACCGT
CGTATCAGAGCTCCGGAAAATCGGCGCAGACATTGAACCGACTGAAGACGGCATGAAAATACACGGCAAAAAAACGCTTG
CGGGCGGAGCCGATGTGTCAAGCCACGGTGACCACCGCATCGGCATGATGCTTGGTGTCGCTTCATGCCTGACAGAAGAG
CCGATTGACATCCGTGATACTGAGGCAATCCATGTCTCATATCCGACATTTTTTGAGCATTTAGATCAATTAGCCAAAAA
AGCCTGA

Upstream 100 bases:

>100_bases
GAATCAGTTTCCAGACTGATGATGACCGGAAGCGTGCGGAAACCTGCATTCAATCCCGCGCCAAATATGACACATTTTAC
GCTGACTGAGGTGGAAAACA

Downstream 100 bases:

>100_bases
AGAGATTCTTCGGGCTTTTTTCTTCATGTGTCATAAAACTTTGGGCTTTGACATAGCTTGTCTTAAACAGAAAATAACAG
AAAGGGGGAATGCGTTTTCG

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKREKVTSLNGEIHIPGDKSISHRSVMFGALAEGTTTVKNFLPGADCLSTIACFRKMGVSIEQNGSDVTIYGKGIDALCE
PDSLLDVGNSGTTIRLMLGILAGRPFHSTVAGDESIAKRPMKRVTEPLKQMGAAIDGRADGGFTPLSVRGGQLKGIDYVS
PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLNAFGAELAETETSASVTGGQKLRGADIFVPGDISSAAFFLAA
GAVVPGSRIVLKNVGLNPTRTGMIDVLKQMGASLEVIPSEADSAEPYGDLVIETSALKAAEIGGEIIPRLIDEIPIIALL
ATQAEGTTVIKDAAELKVKETNRIDTVVSELRKIGADIEPTEDGMKIHGKKTLAGGADVSSHGDHRIGMMLGVASCLTEE
PIDIRDTEAIHVSYPTFFEHLDQLAKKA

Sequences:

>Translated_428_residues
MKREKVTSLNGEIHIPGDKSISHRSVMFGALAEGTTTVKNFLPGADCLSTIACFRKMGVSIEQNGSDVTIYGKGIDALCE
PDSLLDVGNSGTTIRLMLGILAGRPFHSTVAGDESIAKRPMKRVTEPLKQMGAAIDGRADGGFTPLSVRGGQLKGIDYVS
PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLNAFGAELAETETSASVTGGQKLRGADIFVPGDISSAAFFLAA
GAVVPGSRIVLKNVGLNPTRTGMIDVLKQMGASLEVIPSEADSAEPYGDLVIETSALKAAEIGGEIIPRLIDEIPIIALL
ATQAEGTTVIKDAAELKVKETNRIDTVVSELRKIGADIEPTEDGMKIHGKKTLAGGADVSSHGDHRIGMMLGVASCLTEE
PIDIRDTEAIHVSYPTFFEHLDQLAKKA
>Mature_428_residues
MKREKVTSLNGEIHIPGDKSISHRSVMFGALAEGTTTVKNFLPGADCLSTIACFRKMGVSIEQNGSDVTIYGKGIDALCE
PDSLLDVGNSGTTIRLMLGILAGRPFHSTVAGDESIAKRPMKRVTEPLKQMGAAIDGRADGGFTPLSVRGGQLKGIDYVS
PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLNAFGAELAETETSASVTGGQKLRGADIFVPGDISSAAFFLAA
GAVVPGSRIVLKNVGLNPTRTGMIDVLKQMGASLEVIPSEADSAEPYGDLVIETSALKAAEIGGEIIPRLIDEIPIIALL
ATQAEGTTVIKDAAELKVKETNRIDTVVSELRKIGADIEPTEDGMKIHGKKTLAGGADVSSHGDHRIGMMLGVASCLTEE
PIDIRDTEAIHVSYPTFFEHLDQLAKKA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=440, Percent_Identity=28.6363636363636, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789580, Length=400, Percent_Identity=25.75, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320332, Length=456, Percent_Identity=25.219298245614, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_BACA2 (A7Z612)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001421669.1
- ProteinModelPortal:   A7Z612
- SMR:   A7Z612
- STRING:   A7Z612
- EnsemblBacteria:   EBBACT00000004766
- GeneID:   5460940
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_020760
- eggNOG:   COG0128
- GeneTree:   EBGT00050000001036
- HOGENOM:   HBG646626
- OMA:   LSRNHTE
- ProtClustDB:   PRK02427
- BioCyc:   BAMY326423:RBAM_020760-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 45049; Mature: 45049

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKREKVTSLNGEIHIPGDKSISHRSVMFGALAEGTTTVKNFLPGADCLSTIACFRKMGVS
CCCCCEECCCCEEECCCCCCCCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHCCC
IEQNGSDVTIYGKGIDALCEPDSLLDVGNSGTTIRLMLGILAGRPFHSTVAGDESIAKRP
EECCCCEEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHCCCCCCHHCCCCHHHHHHH
MKRVTEPLKQMGAAIDGRADGGFTPLSVRGGQLKGIDYVSPVASAQIKSAVLLAGLQAEG
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCHHCHHHHHHHHHHHHHCCCCCCC
TTTVTEPHKSRDHTERMLNAFGAELAETETSASVTGGQKLRGADIFVPGDISSAAFFLAA
CEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHH
GAVVPGSRIVLKNVGLNPTRTGMIDVLKQMGASLEVIPSEADSAEPYGDLVIETSALKAA
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEHHHHHHH
EIGGEIIPRLIDEIPIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKIGADIEP
HHCHHHHHHHHHHCCEEEEEEECCCCCEEEEHHHHEEEHHCHHHHHHHHHHHHHCCCCCC
TEDGMKIHGKKTLAGGADVSSHGDHRIGMMLGVASCLTEEPIDIRDTEAIHVSYPTFFEH
CCCCEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHH
LDQLAKKA
HHHHHHCC
>Mature Secondary Structure
MKREKVTSLNGEIHIPGDKSISHRSVMFGALAEGTTTVKNFLPGADCLSTIACFRKMGVS
CCCCCEECCCCEEECCCCCCCCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHCCC
IEQNGSDVTIYGKGIDALCEPDSLLDVGNSGTTIRLMLGILAGRPFHSTVAGDESIAKRP
EECCCCEEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHCCCCCCHHCCCCHHHHHHH
MKRVTEPLKQMGAAIDGRADGGFTPLSVRGGQLKGIDYVSPVASAQIKSAVLLAGLQAEG
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCHHCHHHHHHHHHHHHHCCCCCCC
TTTVTEPHKSRDHTERMLNAFGAELAETETSASVTGGQKLRGADIFVPGDISSAAFFLAA
CEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHH
GAVVPGSRIVLKNVGLNPTRTGMIDVLKQMGASLEVIPSEADSAEPYGDLVIETSALKAA
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEHHHHHHH
EIGGEIIPRLIDEIPIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKIGADIEP
HHCHHHHHHHHHHCCEEEEEEECCCCCEEEEHHHHEEEHHCHHHHHHHHHHHHHCCCCCC
TEDGMKIHGKKTLAGGADVSSHGDHRIGMMLGVASCLTEEPIDIRDTEAIHVSYPTFFEH
CCCCEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHH
LDQLAKKA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA