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The map label for this gene is msrA

Identifier: 154686418

GI number: 154686418

Start: 2095601

End: 2096134

Strand: Reverse

Name: msrA

Synonym: RBAM_019860

Alternate gene names: 154686418

Gene position: 2096134-2095601 (Counterclockwise)

Preceding gene: 154686420

Following gene: 154686417

Centisome position: 53.49

GC content: 46.63

Gene sequence:

>534_bases
ATGTCAGAAAAAAAAGAAATCGCCACATTTGCAGGCGGCTGTTTTTGGTGCATGGTGAAGCCGTTTGACGAACAGCCCGG
GATTGAAAAGGTGGTGTCCGGCTATACAGGAGGTCATACTGAGAATCCGACTTACGAAGAAGTGTGCAGTGAAACGACCG
GACACAGAGAAGCCGTTCAAATCACATTTCAACCTGACATTTATCCGTATGAAAAGCTTGTCGAGCTGTTTTGGCAGCAG
ATCGACCCGACTGATGCAGGCGGCCAGTTTGCAGACCGCGGAAGTTCATATCGGGCGGCGATATATTACCATAATGATGA
ACAAAAACAAATCGCTGAAGCCTCAAAAAAACAGCTTGAAGAAAGCGGCATATTTAAAAAGCCGATCGTGACAGACATCT
TGAAGGCTGAGCCTTTTTATGAAGCGGAAGGCTATCATCAGCACTTTTATAAGAAAAATCCTGATCACTACGGGCGCTAC
CGTGTAGGTTCCGGACGTCAAGGCTTTCTGGATGAGCATTGGAGGGACAGATAA

Upstream 100 bases:

>100_bases
TGGCATTCGTTTAGCTTCCCCTGAAAGCAGAATTATTTTTATTCTGTTTATACATGCTATAATATAATAATACCACGTAT
GAACAAAGGAGGGCACCCGT

Downstream 100 bases:

>100_bases
GATGGCTTTTAATAAAGAAGAAAAAATCAAATCATTAAACCGCATGCAATATGAAGTCACACAAAATAACGGAACGGAGC
CGCCGTTTCAAAATGAATTC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPTYEEVCSETTGHREAVQITFQPDIYPYEKLVELFWQQ
IDPTDAGGQFADRGSSYRAAIYYHNDEQKQIAEASKKQLEESGIFKKPIVTDILKAEPFYEAEGYHQHFYKKNPDHYGRY
RVGSGRQGFLDEHWRDR

Sequences:

>Translated_177_residues
MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPTYEEVCSETTGHREAVQITFQPDIYPYEKLVELFWQQ
IDPTDAGGQFADRGSSYRAAIYYHNDEQKQIAEASKKQLEESGIFKKPIVTDILKAEPFYEAEGYHQHFYKKNPDHYGRY
RVGSGRQGFLDEHWRDR
>Mature_176_residues
SEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPTYEEVCSETTGHREAVQITFQPDIYPYEKLVELFWQQI
DPTDAGGQFADRGSSYRAAIYYHNDEQKQIAEASKKQLEESGIFKKPIVTDILKAEPFYEAEGYHQHFYKKNPDHYGRYR
VGSGRQGFLDEHWRDR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=42.7672955974843, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=42.7672955974843, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI208609993, Length=111, Percent_Identity=42.3423423423423, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1790665, Length=157, Percent_Identity=43.312101910828, Blast_Score=134, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=33.7931034482759, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320881, Length=164, Percent_Identity=29.8780487804878, Blast_Score=75, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664627, Length=147, Percent_Identity=34.0136054421769, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24664631, Length=147, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=33.0935251798561, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_BACA2 (A7Z5S2)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001421579.1
- ProteinModelPortal:   A7Z5S2
- SMR:   A7Z5S2
- STRING:   A7Z5S2
- EnsemblBacteria:   EBBACT00000007105
- GeneID:   5460039
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_019860
- eggNOG:   COG0225
- GeneTree:   EBGT00050000000580
- HOGENOM:   HBG748152
- OMA:   SIFPYEK
- ProtClustDB:   PRK14054
- BioCyc:   BAMY326423:RBAM_019860-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 20476; Mature: 20345

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: ACT_SITE 14-14

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPTYEEVCSETTGHREAVQ
CCCHHHHHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEE
ITFQPDIYPYEKLVELFWQQIDPTDAGGQFADRGSSYRAAIYYHNDEQKQIAEASKKQLE
EEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCEEEEEEEECCHHHHHHHHHHHHHH
ESGIFKKPIVTDILKAEPFYEAEGYHQHFYKKNPDHYGRYRVGSGRQGFLDEHWRDR
HCCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCEECCCCCCCCCCHHCCCC
>Mature Secondary Structure 
SEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPTYEEVCSETTGHREAVQ
CCHHHHHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEE
ITFQPDIYPYEKLVELFWQQIDPTDAGGQFADRGSSYRAAIYYHNDEQKQIAEASKKQLE
EEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCEEEEEEEECCHHHHHHHHHHHHHH
ESGIFKKPIVTDILKAEPFYEAEGYHQHFYKKNPDHYGRYRVGSGRQGFLDEHWRDR
HCCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCEECCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA