Click here to switch to the map view.

The map label for this gene is adh [H]

Identifier: 154686177

GI number: 154686177

Start: 1810556

End: 1811572

Strand: Reverse

Name: adh [H]

Synonym: RBAM_017440

Alternate gene names: 154686177

Gene position: 1811572-1810556 (Counterclockwise)

Preceding gene: 154686184

Following gene: 154686175

Centisome position: 46.23

GC content: 42.97

Gene sequence:

>1017_bases
TTGAAAGCAGTAGTAGCAACAAAAGACAAAAGTATAGCGATCGTACAAAAAGAATTACGTCCTTTGCGACATGGTGAAGC
CAAAGTTAAGATGGAATACTGTGGTGTATGTCATACTGACTTGCATGTTAAAAATGCTGATTTCGGGGATGTTACTGGCG
TCACTTTAGGTCATGAGGGAATAGGCATTGTAACTGAGATTGGTGAAGGTGTAACAAGTCTGAATAAGGGCGACCGCGTC
TCTATTGCCTGGATGTTTGAAAGCTGCGGCTGCTGTGAATATTGCTTAACTGGCCGTGAAACCTTGTGCCGGGATGTAAA
AAATGCCGGCTATACAGTTGACGGCGCAATGGCTGAAGAAGCAATCGTAGCGGTTGATTATGCAATAAAGGTGCCGGAAA
ATTTAGACCCTGCAGCAGCAAGCAGCATTACTTGTGCAGGTGTAACAACTTATAAATCCGTTAAAGTCAGTGAAATTAAG
CCAGGTCAATGGATCGGTGTATTTGGAGTTGGCGGTTTAGGCAACTTGGCTGTTCAATATGCAAAAAATGTCTTTAACGC
TAAAGTAATTGCTTTCGACATTAGCGATGAAAAATTGAATTTTGCTAAGAGCTTAGGCGCTGATGCGGTTGTAAACAGTT
TAAACGAAGACCCCGTCGCTAAGGCAAAAGAAGTGACTAACGATTTAGGGCTTGATGCTGTGGTCATCACAGCTGTCTCT
AAAACCCCTTTCAATCAAGCGATTGATGTTGTAAAAGCAGGAGCTCGCGTAGTCGCTGTCGGTTTACCGGTGGACAAAAT
GGATTTAGATATTCCCCGTCTCGTGTTAGATGGCATTCAGGTAGTAGGTTCATTAGTAGGTACCAGAGAAGACCTGAAGG
AAGCTTTTCAATTTGCTGCAGACGGTAAAGTTGTACCTAAAGTGACAAAACGCCCGATCGAAGATGTGAATGATATTTTT
GAAGAAATGGAGCAAGGTAAAGTGACCGGCCGCATGGTTATCGATTTTACTTCCTAA

Upstream 100 bases:

>100_bases
CTTGTCCGCAAAAAATGTAAGGGTTTTCAAAAGGAGAGCAGTGTGCTAAATTGTAAGATAAGTAAAAATTTTCTGCTAAT
ATTCGAAAGGGGTGCATGAT

Downstream 100 bases:

>100_bases
TCATTAAGGCTGCCGGGAATGATACGGCAGCCTTTGATCTCGATTCTTGCTCGGCGCCCTACCCAGACTGAATGAGACTT
TGTCATTTTGTTCAGAAAAG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKAVVATKDKSIAIVQKELRPLRHGEAKVKMEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGIVTEIGEGVTSLNKGDRV
SIAWMFESCGCCEYCLTGRETLCRDVKNAGYTVDGAMAEEAIVAVDYAIKVPENLDPAAASSITCAGVTTYKSVKVSEIK
PGQWIGVFGVGGLGNLAVQYAKNVFNAKVIAFDISDEKLNFAKSLGADAVVNSLNEDPVAKAKEVTNDLGLDAVVITAVS
KTPFNQAIDVVKAGARVVAVGLPVDKMDLDIPRLVLDGIQVVGSLVGTREDLKEAFQFAADGKVVPKVTKRPIEDVNDIF
EEMEQGKVTGRMVIDFTS

Sequences:

>Translated_338_residues
MKAVVATKDKSIAIVQKELRPLRHGEAKVKMEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGIVTEIGEGVTSLNKGDRV
SIAWMFESCGCCEYCLTGRETLCRDVKNAGYTVDGAMAEEAIVAVDYAIKVPENLDPAAASSITCAGVTTYKSVKVSEIK
PGQWIGVFGVGGLGNLAVQYAKNVFNAKVIAFDISDEKLNFAKSLGADAVVNSLNEDPVAKAKEVTNDLGLDAVVITAVS
KTPFNQAIDVVKAGARVVAVGLPVDKMDLDIPRLVLDGIQVVGSLVGTREDLKEAFQFAADGKVVPKVTKRPIEDVNDIF
EEMEQGKVTGRMVIDFTS
>Mature_338_residues
MKAVVATKDKSIAIVQKELRPLRHGEAKVKMEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGIVTEIGEGVTSLNKGDRV
SIAWMFESCGCCEYCLTGRETLCRDVKNAGYTVDGAMAEEAIVAVDYAIKVPENLDPAAASSITCAGVTTYKSVKVSEIK
PGQWIGVFGVGGLGNLAVQYAKNVFNAKVIAFDISDEKLNFAKSLGADAVVNSLNEDPVAKAKEVTNDLGLDAVVITAVS
KTPFNQAIDVVKAGARVVAVGLPVDKMDLDIPRLVLDGIQVVGSLVGTREDLKEAFQFAADGKVVPKVTKRPIEDVNDIF
EEMEQGKVTGRMVIDFTS

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=368, Percent_Identity=28.5326086956522, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=28.5326086956522, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4501929, Length=359, Percent_Identity=28.4122562674095, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI71565154, Length=254, Percent_Identity=29.5275590551181, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI71743840, Length=364, Percent_Identity=26.3736263736264, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI262073058, Length=364, Percent_Identity=26.3736263736264, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI71565152, Length=370, Percent_Identity=25.4054054054054, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI156523966, Length=363, Percent_Identity=24.5179063360882, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=24.5179063360882, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI156627571, Length=310, Percent_Identity=24.5161290322581, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI194239674, Length=320, Percent_Identity=22.8125, Blast_Score=65, Evalue=1e-10,
Organism=Homo sapiens, GI13236495, Length=320, Percent_Identity=22.8125, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI87081918, Length=336, Percent_Identity=68.4523809523809, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1786518, Length=334, Percent_Identity=29.6407185628743, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87082401, Length=325, Percent_Identity=31.0769230769231, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1788073, Length=260, Percent_Identity=29.6153846153846, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790045, Length=346, Percent_Identity=25.7225433526012, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787863, Length=271, Percent_Identity=30.6273062730627, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=28.4153005464481, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788075, Length=302, Percent_Identity=26.8211920529801, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788407, Length=266, Percent_Identity=28.9473684210526, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI226510992, Length=306, Percent_Identity=24.1830065359477, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790718, Length=336, Percent_Identity=25.5952380952381, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87082125, Length=324, Percent_Identity=25.6172839506173, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786825, Length=234, Percent_Identity=26.4957264957265, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790485, Length=331, Percent_Identity=24.773413897281, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=316, Percent_Identity=37.6582278481013, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17562584, Length=321, Percent_Identity=39.2523364485981, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17562582, Length=316, Percent_Identity=36.3924050632911, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17562876, Length=251, Percent_Identity=30.2788844621514, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=192, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI25146526, Length=235, Percent_Identity=29.3617021276596, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=237, Percent_Identity=29.1139240506329, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=203, Percent_Identity=28.0788177339901, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=314, Percent_Identity=35.6687898089172, Blast_Score=192, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6324486, Length=314, Percent_Identity=35.031847133758, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6319621, Length=314, Percent_Identity=33.7579617834395, Blast_Score=182, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6323729, Length=315, Percent_Identity=33.968253968254, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319949, Length=337, Percent_Identity=27.893175074184, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323980, Length=328, Percent_Identity=26.219512195122, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=343, Percent_Identity=27.4052478134111, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=315, Percent_Identity=26.984126984127, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323099, Length=314, Percent_Identity=26.4331210191083, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=315, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=237, Percent_Identity=25.7383966244726, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737895, Length=235, Percent_Identity=29.3617021276596, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17737897, Length=197, Percent_Identity=26.3959390862944, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17137530, Length=197, Percent_Identity=26.3959390862944, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35997; Mature: 35997

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVATKDKSIAIVQKELRPLRHGEAKVKMEYCGVCHTDLHVKNADFGDVTGVTLGHEG
CCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCEECCEEECCCCCCCCCEEEECCCC
IGIVTEIGEGVTSLNKGDRVSIAWMFESCGCCEYCLTGRETLCRDVKNAGYTVDGAMAEE
CCHHHHHCCCHHHCCCCCEEEEEEEECCCCHHHHHHCCHHHHHHHHHHCCEEECCHHHHC
AIVAVDYAIKVPENLDPAAASSITCAGVTTYKSVKVSEIKPGQWIGVFGVGGLGNLAVQY
EEEEEEEEEECCCCCCCHHHCCEEEEEEEEECCEEEEECCCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAFDISDEKLNFAKSLGADAVVNSLNEDPVAKAKEVTNDLGLDAVVITAVS
HHHHHCCEEEEEECCCCHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEEC
KTPFNQAIDVVKAGARVVAVGLPVDKMDLDIPRLVLDGIQVVGSLVGTREDLKEAFQFAA
CCCHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
DGKVVPKVTKRPIEDVNDIFEEMEQGKVTGRMVIDFTS
CCCCCCHHHHCCHHHHHHHHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure
MKAVVATKDKSIAIVQKELRPLRHGEAKVKMEYCGVCHTDLHVKNADFGDVTGVTLGHEG
CCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCEECCEEECCCCCCCCCEEEECCCC
IGIVTEIGEGVTSLNKGDRVSIAWMFESCGCCEYCLTGRETLCRDVKNAGYTVDGAMAEE
CCHHHHHCCCHHHCCCCCEEEEEEEECCCCHHHHHHCCHHHHHHHHHHCCEEECCHHHHC
AIVAVDYAIKVPENLDPAAASSITCAGVTTYKSVKVSEIKPGQWIGVFGVGGLGNLAVQY
EEEEEEEEEECCCCCCCHHHCCEEEEEEEEECCEEEEECCCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAFDISDEKLNFAKSLGADAVVNSLNEDPVAKAKEVTNDLGLDAVVITAVS
HHHHHCCEEEEEECCCCHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEEC
KTPFNQAIDVVKAGARVVAVGLPVDKMDLDIPRLVLDGIQVVGSLVGTREDLKEAFQFAA
CCCHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
DGKVVPKVTKRPIEDVNDIFEEMEQGKVTGRMVIDFTS
CCCCCCHHHHCCHHHHHHHHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA