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The map label for this gene is dctA1 [H]

Identifier: 154248662

GI number: 154248662

Start: 5265001

End: 5266362

Strand: Direct

Name: dctA1 [H]

Synonym: Xaut_4744

Alternate gene names: 154248662

Gene position: 5265001-5266362 (Clockwise)

Preceding gene: 154248661

Following gene: 154248664

Centisome position: 99.17

GC content: 64.68

Gene sequence:

>1362_bases
ATGGCCTTTGCCACAGCGAAACCTGTCACCCGGAAGCCATTCTACAAGATACTCTACGTCCAGGTCCTGTTCGCCATCGC
CGTCGGCATCGCGCTGGGCCATTTCTGGCCCACACTCGCGATCCAGATGAAGCCGCTGGGCGACGGCTTCATCAAGCTGA
TCAAGATGCTGATCGCGCTGGTGATCTTCTGCACCGTGGTCTCCGGCATCGCCGGCATGGAAAGCATGAAGAAGATCGGG
CGCATCGGCGGCAAGTCTTTGCTGTATTTCGAGGTGGTGTCCACCCTCGCGCTGGCCATCGGCATGATCGTCGGCAACGT
GCTGCGCCCCGGCGCCGGCTTCAACGTGGATCCGGCCACCCTCGATGCAAAAGCTGTCATGAGCTATGCCGGCAAGGCGC
AGGAACAGACCATTGTCGAGTTTCTGCTGAACATCATCCCCAATACCGTGGTCGATGCCTTCGCCAAGGGCGATATCCTC
TCGGTGGTGATGATCTCCGTTCTGTTCGGCTGCGTGCTGTCGCGGCTCGGCGAGAAGGGCCGGCTGGTCAAGGAGATGAT
CGACGGCACCAGCGGCCTCGTGTTCGGCGCCATCAACGTGGTCATGAAGCTGGCGCCCGCCGGCGCTTTCGGGGCCATGG
CCTTCACCATCGGGCGCTACGGCATCGCATCGCTTGGCCCGCTGCTCCAGCTCATCCTCGCCTTCTACCTCACCTCCCTC
ATCTTCGTGCTGGTGGTGCTCGGGGCGATCGCGCGGGCAGCCGGCTTCAGCATCATCAGGTTTCTCGCCTACATCAAGGA
AGAGATCCTGATCGTGCTCGGCACCAGTTCCTCGGATTCCGCCCTGCCCTCGCTGATGGCAAAGCTGGAGCGGCTCGGCT
GCTCCAGGCCGGTGGTCGGCCTCGTGGTGCCCACGGGCTATGTCTTCAACACCGACGGCACCAGCATCTACATGACCATG
GCGGCCCTGTTCGTGGCCCAGGCCACCAATACCGACCTGACGCTGACCCAGCAGCTGTCGATCTTCGCGGTGGCCATGCT
CACCTCGAAGGGGGCGAGCGGGGTCACCGGCGCCTCCTTCATCGCCTTGGTGGGGACGCTGTCCGTGGTGCCCACCATCC
CGGTGGCGGGCATGGCGCTGATCCTGGGCATCGACCGCTTCATGAGCGAGGCGCGGGCGCTGGTGAATATGATCGGCAAC
GGCGTCGCCACCGTGGTGATGGCCCGCTGGGAAGGCGAGCTCGACCATGCGCGGCTCACTGCCGTGCTGCGCGGTGAAGC
GGTGCAGGACGAGCTGTCGCTTGGGCATGAGGCGGGGGAGCCCGAGCCCCTGCGGCCGGCGGTGGCCCAGCCCGCCGCCT
GA

Upstream 100 bases:

>100_bases
CAGAAAGCGGCCCCGCAAGTCGCTCTCACAGGAAACCGTCCGACACACAGCCTGATCGCGCCAATCCGCCCGGTCGAGGC
CTTTTCCCAGGGAGGATCCA

Downstream 100 bases:

>100_bases
GCCAAGACCGGACGGCTCATCCAACGCAAAGAGGCGCCCACAGGCGCCTCTTTTTCGTAATGGCACGCCAAACCCGTGCT
CGCGCCGAAAGCCCCTATCC

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MAFATAKPVTRKPFYKILYVQVLFAIAVGIALGHFWPTLAIQMKPLGDGFIKLIKMLIALVIFCTVVSGIAGMESMKKIG
RIGGKSLLYFEVVSTLALAIGMIVGNVLRPGAGFNVDPATLDAKAVMSYAGKAQEQTIVEFLLNIIPNTVVDAFAKGDIL
SVVMISVLFGCVLSRLGEKGRLVKEMIDGTSGLVFGAINVVMKLAPAGAFGAMAFTIGRYGIASLGPLLQLILAFYLTSL
IFVLVVLGAIARAAGFSIIRFLAYIKEEILIVLGTSSSDSALPSLMAKLERLGCSRPVVGLVVPTGYVFNTDGTSIYMTM
AALFVAQATNTDLTLTQQLSIFAVAMLTSKGASGVTGASFIALVGTLSVVPTIPVAGMALILGIDRFMSEARALVNMIGN
GVATVVMARWEGELDHARLTAVLRGEAVQDELSLGHEAGEPEPLRPAVAQPAA

Sequences:

>Translated_453_residues
MAFATAKPVTRKPFYKILYVQVLFAIAVGIALGHFWPTLAIQMKPLGDGFIKLIKMLIALVIFCTVVSGIAGMESMKKIG
RIGGKSLLYFEVVSTLALAIGMIVGNVLRPGAGFNVDPATLDAKAVMSYAGKAQEQTIVEFLLNIIPNTVVDAFAKGDIL
SVVMISVLFGCVLSRLGEKGRLVKEMIDGTSGLVFGAINVVMKLAPAGAFGAMAFTIGRYGIASLGPLLQLILAFYLTSL
IFVLVVLGAIARAAGFSIIRFLAYIKEEILIVLGTSSSDSALPSLMAKLERLGCSRPVVGLVVPTGYVFNTDGTSIYMTM
AALFVAQATNTDLTLTQQLSIFAVAMLTSKGASGVTGASFIALVGTLSVVPTIPVAGMALILGIDRFMSEARALVNMIGN
GVATVVMARWEGELDHARLTAVLRGEAVQDELSLGHEAGEPEPLRPAVAQPAA
>Mature_452_residues
AFATAKPVTRKPFYKILYVQVLFAIAVGIALGHFWPTLAIQMKPLGDGFIKLIKMLIALVIFCTVVSGIAGMESMKKIGR
IGGKSLLYFEVVSTLALAIGMIVGNVLRPGAGFNVDPATLDAKAVMSYAGKAQEQTIVEFLLNIIPNTVVDAFAKGDILS
VVMISVLFGCVLSRLGEKGRLVKEMIDGTSGLVFGAINVVMKLAPAGAFGAMAFTIGRYGIASLGPLLQLILAFYLTSLI
FVLVVLGAIARAAGFSIIRFLAYIKEEILIVLGTSSSDSALPSLMAKLERLGCSRPVVGLVVPTGYVFNTDGTSIYMTMA
ALFVAQATNTDLTLTQQLSIFAVAMLTSKGASGVTGASFIALVGTLSVVPTIPVAGMALILGIDRFMSEARALVNMIGNG
VATVVMARWEGELDHARLTAVLRGEAVQDELSLGHEAGEPEPLRPAVAQPAA

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=334, Percent_Identity=27.8443113772455, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI169790839, Length=410, Percent_Identity=24.1463414634146, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI66773030, Length=409, Percent_Identity=23.7163814180929, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI194239697, Length=488, Percent_Identity=23.9754098360656, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI40254478, Length=429, Percent_Identity=22.6107226107226, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI21314632, Length=426, Percent_Identity=24.1784037558685, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI5032093, Length=429, Percent_Identity=23.5431235431235, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI223468564, Length=298, Percent_Identity=27.1812080536913, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI223468566, Length=295, Percent_Identity=27.1186440677966, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI301601644, Length=190, Percent_Identity=26.8421052631579, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI262359914, Length=349, Percent_Identity=23.4957020057307, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789947, Length=417, Percent_Identity=62.1103117505995, Blast_Score=539, Evalue=1e-154,
Organism=Escherichia coli, GI1790514, Length=417, Percent_Identity=37.8896882494005, Blast_Score=284, Evalue=9e-78,
Organism=Escherichia coli, GI1788024, Length=413, Percent_Identity=22.0338983050847, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789473, Length=324, Percent_Identity=24.3827160493827, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=396, Percent_Identity=24.2424242424242, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71983106, Length=445, Percent_Identity=24.4943820224719, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=445, Percent_Identity=24.4943820224719, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71996953, Length=451, Percent_Identity=23.9467849223947, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI193206505, Length=463, Percent_Identity=24.1900647948164, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI193206654, Length=455, Percent_Identity=22.8571428571429, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17541374, Length=435, Percent_Identity=22.5287356321839, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583025, Length=436, Percent_Identity=24.3119266055046, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17137668, Length=436, Percent_Identity=24.3119266055046, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24583023, Length=436, Percent_Identity=24.3119266055046, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281360483, Length=430, Percent_Identity=22.7906976744186, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17137666, Length=430, Percent_Identity=22.7906976744186, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281360481, Length=430, Percent_Identity=22.7906976744186, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47591; Mature: 47460

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AFATAKPVTRKPFYKILYVQVLFAIAVGIALGHFWPTLAIQMKPLGDGFIKLIKMLIAL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHH
VIFCTVVSGIAGMESMKKIGRIGGKSLLYFEVVSTLALAIGMIVGNVLRPGAGFNVDPAT
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
LDAKAVMSYAGKAQEQTIVEFLLNIIPNTVVDAFAKGDILSVVMISVLFGCVLSRLGEKG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCH
RLVKEMIDGTSGLVFGAINVVMKLAPAGAFGAMAFTIGRYGIASLGPLLQLILAFYLTSL
HHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFVLVVLGAIARAAGFSIIRFLAYIKEEILIVLGTSSSDSALPSLMAKLERLGCSRPVVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEE
LVVPTGYVFNTDGTSIYMTMAALFVAQATNTDLTLTQQLSIFAVAMLTSKGASGVTGASF
EEECCCEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHH
IALVGTLSVVPTIPVAGMALILGIDRFMSEARALVNMIGNGVATVVMARWEGELDHARLT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHH
AVLRGEAVQDELSLGHEAGEPEPLRPAVAQPAA
HHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA