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The map label for this gene is nuoD [H]

Identifier: 154248549

GI number: 154248549

Start: 5117641

End: 5118849

Strand: Reverse

Name: nuoD [H]

Synonym: Xaut_4630

Alternate gene names: 154248549

Gene position: 5118849-5117641 (Counterclockwise)

Preceding gene: 154248550

Following gene: 154248548

Centisome position: 96.42

GC content: 65.43

Gene sequence:

>1209_bases
ATGGTTGACATCGCCGACGAGATGAAGCCGGCCGACAAGGTCCGTAACTTCCAGATCAATTTCGGCCCGCAGCACCCTGC
TGCGCATGGCGTGCTGCGCCTCGTGCTGGAACTGGACGGCGAGGTGGTCGAGCGGGTGGACCCGCATATCGGCCTCCTGC
ACCGCGGCACCGAGAAGCTGATCGAGGCCAAGACCTATCTGCAGGCTGTGCCCTATTTCGACCGGCTCGACTATTGCGCG
CCCATGAACCAGGAGCACGCCTTCTGCCTCGCGGCGGAAAAGCTCCTGGGCATCGAGGTGCCCAAGCGCGGCCAGCTCAT
CCGCGTGCTGTATTCCGAGATCGGGCGCCTGCTCTCCCACCTCCTCAACGTCACCACGTTCGCCATGGACGTGGGCGCGC
TGACCCCGCCGCTGTGGGGCTTCGAGGAGCGTGAGAAGCTCATGATCTTCTATGAGCGCGCCTCGGGCAGCCGCATGCAC
GCGGCCTATTTCCGTCCCGGCGGCGTGCACCAGGACCTGCCGCGCGCGCTGGTGGAGGATATTGGCGCCTTCTGCGACCC
GTTCCTGAAGCTGCTGGACGATCTCGACGGCCTCGTCACCGAGAACCGCATCTTCAAGCAGCGCACCGTGGACATCGGCG
TGGTGTCGCTGGAGGACGCGCTGGCCTGGGGCTTCTCGGGCGTGATGGTGCGCGGCTCCGGCGCGGCCTGGGACCTGCGC
CGCGCCCAGCCCTATGAGTGCTATTCCGAGCTGGACTTCGACATCCCCATCGGCAAGCACGGCGACTGCTACGACCGCTA
CGTGGTGCGCATGGAAGAGATGCGCCAGTCCACCAAGATCATGAAGCAGTGCGTGGAACGCCTGCTGAAGGAGGCCGGCC
CGGTCTCCACCACGGACAACAAGATCGTGCCGCCCAAGCGGGGCGAGATGAAGCGCTCCATGGAAGCGCTCATCCACCAC
TTCAAGCTCTACACCGAGGGCTTCCACGTCCCGGCCGGCGACGTGTACGCCGCGGTTGAGGCGCCCAAAGGCGAATTCGG
CGTCTATCTGGTCTCGGACGGCACCAACAAGCCTTACCGCTGCAAGATCCGCGCTCCGGGCTTCGCCCACCTTCAGGCGA
TGGATTTCCTGTGTCGTGGTCACATGCTCGCCGACGTGTCGGCGGTGCTGGGCTCGCTCGACATCGTGTTCGGGGAGGTG
GACCGCTGA

Upstream 100 bases:

>100_bases
TCCTCTCCCCGTGGGAGGGCGTGGAATACGTCCTTCCCGGTGACGAGAAGGCCTCGGGCCAGCCGCCCGTTCCCCCCAAG
GCCGGCTGAGGGAGCGCCTT

Downstream 100 bases:

>100_bases
TGGCCCGCCTCGCCCTGTCTTTCCGCCGGGTTTCTCGCCGCCGGGTTTCCTGTCGCCGCGTTTCTTGCCGCCCGATGCCG
GCGCACGCTTCGTGCGCCGC

Product: NADH dehydrogenase I subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MVDIADEMKPADKVRNFQINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEAKTYLQAVPYFDRLDYCA
PMNQEHAFCLAAEKLLGIEVPKRGQLIRVLYSEIGRLLSHLLNVTTFAMDVGALTPPLWGFEEREKLMIFYERASGSRMH
AAYFRPGGVHQDLPRALVEDIGAFCDPFLKLLDDLDGLVTENRIFKQRTVDIGVVSLEDALAWGFSGVMVRGSGAAWDLR
RAQPYECYSELDFDIPIGKHGDCYDRYVVRMEEMRQSTKIMKQCVERLLKEAGPVSTTDNKIVPPKRGEMKRSMEALIHH
FKLYTEGFHVPAGDVYAAVEAPKGEFGVYLVSDGTNKPYRCKIRAPGFAHLQAMDFLCRGHMLADVSAVLGSLDIVFGEV
DR

Sequences:

>Translated_402_residues
MVDIADEMKPADKVRNFQINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEAKTYLQAVPYFDRLDYCA
PMNQEHAFCLAAEKLLGIEVPKRGQLIRVLYSEIGRLLSHLLNVTTFAMDVGALTPPLWGFEEREKLMIFYERASGSRMH
AAYFRPGGVHQDLPRALVEDIGAFCDPFLKLLDDLDGLVTENRIFKQRTVDIGVVSLEDALAWGFSGVMVRGSGAAWDLR
RAQPYECYSELDFDIPIGKHGDCYDRYVVRMEEMRQSTKIMKQCVERLLKEAGPVSTTDNKIVPPKRGEMKRSMEALIHH
FKLYTEGFHVPAGDVYAAVEAPKGEFGVYLVSDGTNKPYRCKIRAPGFAHLQAMDFLCRGHMLADVSAVLGSLDIVFGEV
DR
>Mature_402_residues
MVDIADEMKPADKVRNFQINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEAKTYLQAVPYFDRLDYCA
PMNQEHAFCLAAEKLLGIEVPKRGQLIRVLYSEIGRLLSHLLNVTTFAMDVGALTPPLWGFEEREKLMIFYERASGSRMH
AAYFRPGGVHQDLPRALVEDIGAFCDPFLKLLDDLDGLVTENRIFKQRTVDIGVVSLEDALAWGFSGVMVRGSGAAWDLR
RAQPYECYSELDFDIPIGKHGDCYDRYVVRMEEMRQSTKIMKQCVERLLKEAGPVSTTDNKIVPPKRGEMKRSMEALIHH
FKLYTEGFHVPAGDVYAAVEAPKGEFGVYLVSDGTNKPYRCKIRAPGFAHLQAMDFLCRGHMLADVSAVLGSLDIVFGEV
DR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=389, Percent_Identity=64.7814910025707, Blast_Score=531, Evalue=1e-151,
Organism=Homo sapiens, GI260898743, Length=383, Percent_Identity=63.9686684073107, Blast_Score=517, Evalue=1e-147,
Organism=Escherichia coli, GI145693162, Length=385, Percent_Identity=40.2597402597403, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI1789076, Length=389, Percent_Identity=26.4781491002571, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788832, Length=393, Percent_Identity=27.735368956743, Blast_Score=108, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17555284, Length=394, Percent_Identity=60.9137055837564, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17568379, Length=390, Percent_Identity=60.7692307692308, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24638644, Length=398, Percent_Identity=62.5628140703518, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI221459469, Length=397, Percent_Identity=55.919395465995, Blast_Score=478, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 45212; Mature: 45212

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00535 COMPLEX1_49K ; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDIADEMKPADKVRNFQINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKL
CCCCHHHCCCHHHHCEEEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCHHHH
IEAKTYLQAVPYFDRLDYCAPMNQEHAFCLAAEKLLGIEVPKRGQLIRVLYSEIGRLLSH
HHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LLNVTTFAMDVGALTPPLWGFEEREKLMIFYERASGSRMHAAYFRPGGVHQDLPRALVED
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHH
IGAFCDPFLKLLDDLDGLVTENRIFKQRTVDIGVVSLEDALAWGFSGVMVRGSGAAWDLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHCCCCEEEECCCCCEECC
RAQPYECYSELDFDIPIGKHGDCYDRYVVRMEEMRQSTKIMKQCVERLLKEAGPVSTTDN
CCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KIVPPKRGEMKRSMEALIHHFKLYTEGFHVPAGDVYAAVEAPKGEFGVYLVSDGTNKPYR
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEE
CKIRAPGFAHLQAMDFLCRGHMLADVSAVLGSLDIVFGEVDR
EEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECCCC
>Mature Secondary Structure
MVDIADEMKPADKVRNFQINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKL
CCCCHHHCCCHHHHCEEEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCHHHH
IEAKTYLQAVPYFDRLDYCAPMNQEHAFCLAAEKLLGIEVPKRGQLIRVLYSEIGRLLSH
HHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LLNVTTFAMDVGALTPPLWGFEEREKLMIFYERASGSRMHAAYFRPGGVHQDLPRALVED
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHH
IGAFCDPFLKLLDDLDGLVTENRIFKQRTVDIGVVSLEDALAWGFSGVMVRGSGAAWDLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHCCCCEEEECCCCCEECC
RAQPYECYSELDFDIPIGKHGDCYDRYVVRMEEMRQSTKIMKQCVERLLKEAGPVSTTDN
CCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KIVPPKRGEMKRSMEALIHHFKLYTEGFHVPAGDVYAAVEAPKGEFGVYLVSDGTNKPYR
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEE
CKIRAPGFAHLQAMDFLCRGHMLADVSAVLGSLDIVFGEVDR
EEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA