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The map label for this gene is csd [H]

Identifier: 154248386

GI number: 154248386

Start: 4956282

End: 4957541

Strand: Reverse

Name: csd [H]

Synonym: Xaut_4466

Alternate gene names: 154248386

Gene position: 4957541-4956282 (Counterclockwise)

Preceding gene: 154248387

Following gene: 154248385

Centisome position: 93.38

GC content: 64.6

Gene sequence:

>1260_bases
ATGAACACCGCGTCTTCCACCCTCCACCCGGCTGTCCGCAACGGCAGCTTCGACGTGGAGGCCGTGCGCGCCGACTTTCC
GGCGCTGTCGCTGGAGGTGAACGGCCATCCGCTCACCTATCTGGACAATGCCGCCTCCGCGCAGAAGCCGCGGCAGGTGA
TCCAGCGCATGGTCACCGCCTACGAGCGGGAATATTCCAACGTCCACCGTGGCCTGCATTATCTCGCCAATGCCGCCACC
GAGGCCTTCGAGCAGGCCCGCGAGAGCGTGCGCGGCTTCATCAACGCCGCGTCCGTGGACGAGATCATCTTCACCCGCTC
GGGCACGGGGGCCATCAATACGGTGGCCAGCTCCCTCGGCCAGTCCATCGAGGCGGGCGACGAGATCGTGCTCTCCATCA
TGGAGCACCATTCCAACATCGTGCCGTGGAACTTCCTGCGCGAGCGCAAGGGCGCGGTGATCAGGTGGGCGCCGGTCACC
GAGGACGGCTCGTTCGACTTCGAGGCGTTCAAGGGCCTGCTCACCGAGCGCACGAAGATCGTCGCCATCACCCAGATGTC
CAACGTGCTCGGCACCGTGACGCCCATCAAGGAGATCGTGGCGGCGGCGCATGCGGTGGGGGCCAAGGTGCTGGTGGATG
CCTGCCAGTCCATCGTCCACATGCCCGTGGACGTGCGCGACCTCGATGTGGATTTCCTCGCCGTCACCGGCCACAAGCTC
TATGCGCCCACCGGCATCGGCGTGCTCTACGGCAAGCTTGACCTGCTGGCGCAGATGCCGCCCTATGAAGGTGGCGGCGA
GATGATCCGCGAGGTCACGGAAGATTATGTGACCTATGGCGTGCCGCCCCACAGATTTGAAGCTGGAACTCCTCCAATTG
TTCAGGCCATCGGGCTCGGCGCGGCGGTGGAATATGTCAACTCCATCGGCCGCGAGCGCATCGCCGCCCACGAGCATGAG
CTGTCCGTCTATGCGCACGAACGCTTGGGAGCGCTCAATTCCCTGCGCATCATCGGCACCGCGCCGGGCAAGGGCGGCAT
CATTTCCTTCGAGATGAAGGGCGCCCATCCCCACGATGTGGCCACCATCATCGACCGCTACGGTGTTGCAGTGCGAGCCG
GCACCCATTGCGCCCAGCCGCTTTTGGCCCGATATGGGACAACAGCGACGTGCCGCGCATCCTTTGCCCTTTACAACACG
CGCGCCGACGTGGACCGTCTGGTGGACGCTCTCGTCAAGGCGCAGGATTTGTTCGCATGA

Upstream 100 bases:

>100_bases
GGAGAAACGGGCGGCCTGAAGGGCCTCTCCCGTTGTGTTCTCTCCCTCTCCCGCCTGCGGGAGAGGGCTTAGCTCGCGAT
TTCACGAGGACAGGATTGCC

Downstream 100 bases:

>100_bases
CCGAGACGAAGACCACCGAGCAGGCGAATGCGCCGCAGATCAAGTCCTCCATCGCCGAGGCTGAGCTGGAGCGCCTGACC
GACAGCATCGTCAGCGCGCT

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MNTASSTLHPAVRNGSFDVEAVRADFPALSLEVNGHPLTYLDNAASAQKPRQVIQRMVTAYEREYSNVHRGLHYLANAAT
EAFEQARESVRGFINAASVDEIIFTRSGTGAINTVASSLGQSIEAGDEIVLSIMEHHSNIVPWNFLRERKGAVIRWAPVT
EDGSFDFEAFKGLLTERTKIVAITQMSNVLGTVTPIKEIVAAAHAVGAKVLVDACQSIVHMPVDVRDLDVDFLAVTGHKL
YAPTGIGVLYGKLDLLAQMPPYEGGGEMIREVTEDYVTYGVPPHRFEAGTPPIVQAIGLGAAVEYVNSIGRERIAAHEHE
LSVYAHERLGALNSLRIIGTAPGKGGIISFEMKGAHPHDVATIIDRYGVAVRAGTHCAQPLLARYGTTATCRASFALYNT
RADVDRLVDALVKAQDLFA

Sequences:

>Translated_419_residues
MNTASSTLHPAVRNGSFDVEAVRADFPALSLEVNGHPLTYLDNAASAQKPRQVIQRMVTAYEREYSNVHRGLHYLANAAT
EAFEQARESVRGFINAASVDEIIFTRSGTGAINTVASSLGQSIEAGDEIVLSIMEHHSNIVPWNFLRERKGAVIRWAPVT
EDGSFDFEAFKGLLTERTKIVAITQMSNVLGTVTPIKEIVAAAHAVGAKVLVDACQSIVHMPVDVRDLDVDFLAVTGHKL
YAPTGIGVLYGKLDLLAQMPPYEGGGEMIREVTEDYVTYGVPPHRFEAGTPPIVQAIGLGAAVEYVNSIGRERIAAHEHE
LSVYAHERLGALNSLRIIGTAPGKGGIISFEMKGAHPHDVATIIDRYGVAVRAGTHCAQPLLARYGTTATCRASFALYNT
RADVDRLVDALVKAQDLFA
>Mature_419_residues
MNTASSTLHPAVRNGSFDVEAVRADFPALSLEVNGHPLTYLDNAASAQKPRQVIQRMVTAYEREYSNVHRGLHYLANAAT
EAFEQARESVRGFINAASVDEIIFTRSGTGAINTVASSLGQSIEAGDEIVLSIMEHHSNIVPWNFLRERKGAVIRWAPVT
EDGSFDFEAFKGLLTERTKIVAITQMSNVLGTVTPIKEIVAAAHAVGAKVLVDACQSIVHMPVDVRDLDVDFLAVTGHKL
YAPTGIGVLYGKLDLLAQMPPYEGGGEMIREVTEDYVTYGVPPHRFEAGTPPIVQAIGLGAAVEYVNSIGRERIAAHEHE
LSVYAHERLGALNSLRIIGTAPGKGGIISFEMKGAHPHDVATIIDRYGVAVRAGTHCAQPLLARYGTTATCRASFALYNT
RADVDRLVDALVKAQDLFA

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=294, Percent_Identity=24.8299319727891, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI156713448, Length=424, Percent_Identity=26.1792452830189, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1787970, Length=404, Percent_Identity=50.2475247524753, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=40.4466501240695, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI48994898, Length=291, Percent_Identity=27.4914089347079, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=233, Percent_Identity=29.1845493562232, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI193211090, Length=405, Percent_Identity=25.4320987654321, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319831, Length=227, Percent_Identity=26.431718061674, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI20129463, Length=295, Percent_Identity=27.4576271186441, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45267; Mature: 45267

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTASSTLHPAVRNGSFDVEAVRADFPALSLEVNGHPLTYLDNAASAQKPRQVIQRMVTA
CCCCCCHHCHHHCCCCCCEEEHCCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHH
YEREYSNVHRGLHYLANAATEAFEQARESVRGFINAASVDEIIFTRSGTGAINTVASSLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHC
QSIEAGDEIVLSIMEHHSNIVPWNFLRERKGAVIRWAPVTEDGSFDFEAFKGLLTERTKI
CHHCCHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCEE
VAITQMSNVLGTVTPIKEIVAAAHAVGAKVLVDACQSIVHMPVDVRDLDVDFLAVTGHKL
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCEEEEEECCCEE
YAPTGIGVLYGKLDLLAQMPPYEGGGEMIREVTEDYVTYGVPPHRFEAGTPPIVQAIGLG
ECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
AAVEYVNSIGRERIAAHEHELSVYAHERLGALNSLRIIGTAPGKGGIISFEMKGAHPHDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCHHH
ATIIDRYGVAVRAGTHCAQPLLARYGTTATCRASFALYNTRADVDRLVDALVKAQDLFA
HHHHHHCCCEEECCCHHHHHHHHHCCCCHHHHHHHEEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTASSTLHPAVRNGSFDVEAVRADFPALSLEVNGHPLTYLDNAASAQKPRQVIQRMVTA
CCCCCCHHCHHHCCCCCCEEEHCCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHH
YEREYSNVHRGLHYLANAATEAFEQARESVRGFINAASVDEIIFTRSGTGAINTVASSLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHC
QSIEAGDEIVLSIMEHHSNIVPWNFLRERKGAVIRWAPVTEDGSFDFEAFKGLLTERTKI
CHHCCHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCEE
VAITQMSNVLGTVTPIKEIVAAAHAVGAKVLVDACQSIVHMPVDVRDLDVDFLAVTGHKL
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCEEEEEECCCEE
YAPTGIGVLYGKLDLLAQMPPYEGGGEMIREVTEDYVTYGVPPHRFEAGTPPIVQAIGLG
ECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
AAVEYVNSIGRERIAAHEHELSVYAHERLGALNSLRIIGTAPGKGGIISFEMKGAHPHDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCHHH
ATIIDRYGVAVRAGTHCAQPLLARYGTTATCRASFALYNTRADVDRLVDALVKAQDLFA
HHHHHHCCCEEECCCHHHHHHHHHCCCCHHHHHHHEEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]