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The map label for this gene is lolC [H]

Identifier: 154248382

GI number: 154248382

Start: 4952011

End: 4953354

Strand: Reverse

Name: lolC [H]

Synonym: Xaut_4462

Alternate gene names: 154248382

Gene position: 4953354-4952011 (Counterclockwise)

Preceding gene: 154248383

Following gene: 154248381

Centisome position: 93.3

GC content: 66.29

Gene sequence:

>1344_bases
ATGAGCGTCACCGGGTCCACGGCGGCAAGGGGCGGGACCAAGGGCGCCAAAGGCGGCCCGAAGGCCGGCAAAGGCGACGG
TGAGGCCACCGGCACGCGCCCCTTCTCGGCATTCGAGTGGATGCTGTCGCTGCGGTATCTGAGGGCCCGGCGCAAGGAAG
GCTTCATCTCGGTCATCGCCGGCTTCTCCTTCCTCGGCATCATGCTGGGGGTGGCGACCCTCATCATCGTGATGGCGGTG
ATGAACGGGTTCCGGCAGGAACTGCTCGGCAAGATCCTCGGCCTCAACGGCCATGTGCTGGTGCAGCCGCTGGAAAGCCC
GCTCACCGATTACGCGGCGGTGGCGGACCGCATCGCCAAGCTCAACGGCATCCGCCTCGCGGTGCCGCTGGTGGAGGGGC
AGGCGCTGGCGTCCTCGCCGTTCGGTGCCTCGGGCGTGCTGGTGCGGGGCCTTGCGGAAAAGGACCTGCGGGAGCTGCCC
TCGGTGGCCCACAATATCCGCCAGGGCACGCTGGAGAATTTCGACCAGGGCCAGGGCATCGCCATCGGCAAGCGCCTCGC
CGACCAGCTCTCCCTGCACGCGGGCGACAACCTCACCTTGGTGGCGCCGCGCGGGGCGGTGACGCCCATGGGCACCTCGC
CGCGCATCAAGGTTTACAAGGTGGCGGCGGTGTTCGAGGTGGGCATGTCGGAATACGATAGCGCCTTCGTCTTCATGCCG
CTGGCCGAGGCGCAGGCCTATTTCAACCGCAACGCCGACGTGAACGCCATCGAGGTCTACCTCAACAATCCCGACGACGT
GGGTGAACTGCGCGGCGCCATCCAGAGCGCGGCGGAGCGGCCCGTGTATCTGGTGGACTGGCGGGTGCGCAACGCAACCT
TCTTCAACGCGCTGCAGGTGGAGCGGAACGTCATGTTCCTCATCCTCACCCTCATCGTTCTGGTGGCGGCGCTGAACATC
GTGTCCGGTCTCATCATGCTCGTGAAGGACAAGGGCCACGACATCGCCATCCTGCGCACCATGGGGGCGACGCAGGGCGC
CATCATGCGGGTGTTCTTCATCACTGGCGCCGCCATCGGCGTGGTGGGCACCCTCTCCGGGCTGCTCCTGGGCGTGATCG
TCTGCCTCAACATCGAGAGCATCCGCCAGTTCATCTCCTGGCTCACCGCCACCGAGCTGTTCTCGCCGGAGCTGTACTAT
CTGAGCCGCCTGCCGGCTGAGATGAATTTCGGCGAGACCACATCCGTGGTGGTGATGGCCATGGTGCTGTCCTTCCTCGC
CACCCTGTATCCGTCCTGGCGGGCCGCCCGGCTCGATCCGGTGGAAGCCCTGAGATACGAGTGA

Upstream 100 bases:

>100_bases
GGCCGAAGGGCCTGGCCGACGGCAAGGTGGAACTGAAGCGCCGCGTGGATGGCTCCCGTGAGCTGATCGCGCCCGGCGAC
ATCCTGGAGAGGCTGAAGGC

Downstream 100 bases:

>100_bases
TGGATCAGCGCGCAAATCCCAATGGACGGCCCGAGGGACAACCGGGCCGGCAGGGCGGACGCCCGCCGCTGGCGCTGGCG
CTCACCGGCGTGGTGCGGCG

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSVTGSTAARGGTKGAKGGPKAGKGDGEATGTRPFSAFEWMLSLRYLRARRKEGFISVIAGFSFLGIMLGVATLIIVMAV
MNGFRQELLGKILGLNGHVLVQPLESPLTDYAAVADRIAKLNGIRLAVPLVEGQALASSPFGASGVLVRGLAEKDLRELP
SVAHNIRQGTLENFDQGQGIAIGKRLADQLSLHAGDNLTLVAPRGAVTPMGTSPRIKVYKVAAVFEVGMSEYDSAFVFMP
LAEAQAYFNRNADVNAIEVYLNNPDDVGELRGAIQSAAERPVYLVDWRVRNATFFNALQVERNVMFLILTLIVLVAALNI
VSGLIMLVKDKGHDIAILRTMGATQGAIMRVFFITGAAIGVVGTLSGLLLGVIVCLNIESIRQFISWLTATELFSPELYY
LSRLPAEMNFGETTSVVVMAMVLSFLATLYPSWRAARLDPVEALRYE

Sequences:

>Translated_447_residues
MSVTGSTAARGGTKGAKGGPKAGKGDGEATGTRPFSAFEWMLSLRYLRARRKEGFISVIAGFSFLGIMLGVATLIIVMAV
MNGFRQELLGKILGLNGHVLVQPLESPLTDYAAVADRIAKLNGIRLAVPLVEGQALASSPFGASGVLVRGLAEKDLRELP
SVAHNIRQGTLENFDQGQGIAIGKRLADQLSLHAGDNLTLVAPRGAVTPMGTSPRIKVYKVAAVFEVGMSEYDSAFVFMP
LAEAQAYFNRNADVNAIEVYLNNPDDVGELRGAIQSAAERPVYLVDWRVRNATFFNALQVERNVMFLILTLIVLVAALNI
VSGLIMLVKDKGHDIAILRTMGATQGAIMRVFFITGAAIGVVGTLSGLLLGVIVCLNIESIRQFISWLTATELFSPELYY
LSRLPAEMNFGETTSVVVMAMVLSFLATLYPSWRAARLDPVEALRYE
>Mature_446_residues
SVTGSTAARGGTKGAKGGPKAGKGDGEATGTRPFSAFEWMLSLRYLRARRKEGFISVIAGFSFLGIMLGVATLIIVMAVM
NGFRQELLGKILGLNGHVLVQPLESPLTDYAAVADRIAKLNGIRLAVPLVEGQALASSPFGASGVLVRGLAEKDLRELPS
VAHNIRQGTLENFDQGQGIAIGKRLADQLSLHAGDNLTLVAPRGAVTPMGTSPRIKVYKVAAVFEVGMSEYDSAFVFMPL
AEAQAYFNRNADVNAIEVYLNNPDDVGELRGAIQSAAERPVYLVDWRVRNATFFNALQVERNVMFLILTLIVLVAALNIV
SGLIMLVKDKGHDIAILRTMGATQGAIMRVFFITGAAIGVVGTLSGLLLGVIVCLNIESIRQFISWLTATELFSPELYYL
SRLPAEMNFGETTSVVVMAMVLSFLATLYPSWRAARLDPVEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=405, Percent_Identity=31.8518518518519, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1787360, Length=417, Percent_Identity=30.4556354916067, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 48126; Mature: 47995

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTGSTAARGGTKGAKGGPKAGKGDGEATGTRPFSAFEWMLSLRYLRARRKEGFISVIA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
GFSFLGIMLGVATLIIVMAVMNGFRQELLGKILGLNGHVLVQPLESPLTDYAAVADRIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHCCHHHHHHHHHHHHH
LNGIRLAVPLVEGQALASSPFGASGVLVRGLAEKDLRELPSVAHNIRQGTLENFDQGQGI
HCCCEEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AIGKRLADQLSLHAGDNLTLVAPRGAVTPMGTSPRIKVYKVAAVFEVGMSEYDSAFVFMP
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCEEEEEE
LAEAQAYFNRNADVNAIEVYLNNPDDVGELRGAIQSAAERPVYLVDWRVRNATFFNALQV
HHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHH
ERNVMFLILTLIVLVAALNIVSGLIMLVKDKGHDIAILRTMGATQGAIMRVFFITGAAIG
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
VVGTLSGLLLGVIVCLNIESIRQFISWLTATELFSPELYYLSRLPAEMNFGETTSVVVMA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHH
MVLSFLATLYPSWRAARLDPVEALRYE
HHHHHHHHHCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure 
SVTGSTAARGGTKGAKGGPKAGKGDGEATGTRPFSAFEWMLSLRYLRARRKEGFISVIA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
GFSFLGIMLGVATLIIVMAVMNGFRQELLGKILGLNGHVLVQPLESPLTDYAAVADRIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHCCHHHHHHHHHHHHH
LNGIRLAVPLVEGQALASSPFGASGVLVRGLAEKDLRELPSVAHNIRQGTLENFDQGQGI
HCCCEEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AIGKRLADQLSLHAGDNLTLVAPRGAVTPMGTSPRIKVYKVAAVFEVGMSEYDSAFVFMP
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCEEEEEE
LAEAQAYFNRNADVNAIEVYLNNPDDVGELRGAIQSAAERPVYLVDWRVRNATFFNALQV
HHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHH
ERNVMFLILTLIVLVAALNIVSGLIMLVKDKGHDIAILRTMGATQGAIMRVFFITGAAIG
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
VVGTLSGLLLGVIVCLNIESIRQFISWLTATELFSPELYYLSRLPAEMNFGETTSVVVMA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHH
MVLSFLATLYPSWRAARLDPVEALRYE
HHHHHHHHHCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]