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The map label for this gene is fadA [H]

Identifier: 154248363

GI number: 154248363

Start: 4930502

End: 4931650

Strand: Direct

Name: fadA [H]

Synonym: Xaut_4443

Alternate gene names: 154248363

Gene position: 4930502-4931650 (Clockwise)

Preceding gene: 154248362

Following gene: 154248364

Centisome position: 92.87

GC content: 67.45

Gene sequence:

>1149_bases
ATGCAAAACGTTGTGATTGCGGGGTACGCCCGCTCGCCCTTCGCCCTTGCCAAGAAGGGTGAACTGGCGCGCGTGCGCCC
GGATGACCTCGCCGCACAGGTGGTGGCGGAGCTGGTGGCCCGCACCGGCGTCAAGGTCGAGGACATCGAGGACCTCATCG
TCGGCTGCGCTTTTCCCGAGGCGGAGCAGGGCTTTAACATCGCGCGCCTGATCGGCATGATCGCCGGCCTACCCGACAGC
GTCGCCGGCGCAACGGTAAACCGCTTCTGCGGCTCGTCCATGCAGTCGGTGCACATGGCGGCCGGTCAGATCCAACTGGG
CGCCGGCGAAGTCTTCATCTGCGCCGGCATCGAGAGCATGAGCCGCGTGCCCATGACCGGCTTCAATCCCATGCCCAATC
CGGCGCTCTACGCCAAGCTCCCGCAGGCCTACATGGGCATGGGCGAGACGGCGGAAAATGTCGCCGCCAAGTGGCAGATC
ACCCGCGCCGACCAGGATGCTTTCGCCTTGAAAAGCCATGCGAAAGCAACGGCGGCCGAGGCCGCCGGCAAGTTCGCCGA
CGAGATCGTTTCCATCCGCATAAACGGCAAGGACTCGGGCAAGACCGCCACCCAGGACGGCTGCATCCGCCGCGATGCCA
CGGCCGAGCAGCTGGCCGGCCTCAAGCCCGCTTTTGACGAGCATGGCACCGTCACCGCCGGCACCTCCTCCCCCCTCACC
GATGGCGCGTCTGCCGTGCTGGTGTGCTCGGAGGACTATGCGCTGAAGCATGGCCTGGAGCCCCTCGCCCGCCTGAAAGG
CGTTGCGGTTGCTGGCTGCGCGCCGGAGATCATGGGCATCGGCCCGGTGGCGGCGACCAAGAAGGCGCTGACCCGCTCCG
GCATCGACATCTCGCAGATCGACGTGGTGGAGCTGAACGAGGCCTTCGCCTCCCAGGCCCTTGCCTGCCAACGCGAACTC
GGCGTCCGCGACGAGACCCTCAACATCGACGGCGGCGCCATCGCGCTCGGCCATCCGCTGGGGGCTACCGGGGCGCGCAT
CGTCGGCAAAGCCGCGTCGTTGCTGAAGCGGGAAGGCGGCAAATATGCCCTCGCCACCCAGTGCATCGGCGGCGGACAGG
GCATCGCCACCGTCCTCGAACGCGTCTGA

Upstream 100 bases:

>100_bases
CAAAATAAAGAATGAGATCGTTTTATTGATTTGATTGCACAGCAATCTGGTCAAAACGGGATCAGACGCGGACCAACAAG
ATATATAGGCAGGAGAGCCC

Downstream 100 bases:

>100_bases
GGGGGCGCGTCATGACCAGCGAAACCGATATCAAGAGCTTCGCCGACATCGGCGGGTTCGACATCAAGAAGGTGGCGGTC
ATCGGCGCCGGCGTCATGGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MQNVVIAGYARSPFALAKKGELARVRPDDLAAQVVAELVARTGVKVEDIEDLIVGCAFPEAEQGFNIARLIGMIAGLPDS
VAGATVNRFCGSSMQSVHMAAGQIQLGAGEVFICAGIESMSRVPMTGFNPMPNPALYAKLPQAYMGMGETAENVAAKWQI
TRADQDAFALKSHAKATAAEAAGKFADEIVSIRINGKDSGKTATQDGCIRRDATAEQLAGLKPAFDEHGTVTAGTSSPLT
DGASAVLVCSEDYALKHGLEPLARLKGVAVAGCAPEIMGIGPVAATKKALTRSGIDISQIDVVELNEAFASQALACQREL
GVRDETLNIDGGAIALGHPLGATGARIVGKAASLLKREGGKYALATQCIGGGQGIATVLERV

Sequences:

>Translated_382_residues
MQNVVIAGYARSPFALAKKGELARVRPDDLAAQVVAELVARTGVKVEDIEDLIVGCAFPEAEQGFNIARLIGMIAGLPDS
VAGATVNRFCGSSMQSVHMAAGQIQLGAGEVFICAGIESMSRVPMTGFNPMPNPALYAKLPQAYMGMGETAENVAAKWQI
TRADQDAFALKSHAKATAAEAAGKFADEIVSIRINGKDSGKTATQDGCIRRDATAEQLAGLKPAFDEHGTVTAGTSSPLT
DGASAVLVCSEDYALKHGLEPLARLKGVAVAGCAPEIMGIGPVAATKKALTRSGIDISQIDVVELNEAFASQALACQREL
GVRDETLNIDGGAIALGHPLGATGARIVGKAASLLKREGGKYALATQCIGGGQGIATVLERV
>Mature_382_residues
MQNVVIAGYARSPFALAKKGELARVRPDDLAAQVVAELVARTGVKVEDIEDLIVGCAFPEAEQGFNIARLIGMIAGLPDS
VAGATVNRFCGSSMQSVHMAAGQIQLGAGEVFICAGIESMSRVPMTGFNPMPNPALYAKLPQAYMGMGETAENVAAKWQI
TRADQDAFALKSHAKATAAEAAGKFADEIVSIRINGKDSGKTATQDGCIRRDATAEQLAGLKPAFDEHGTVTAGTSSPLT
DGASAVLVCSEDYALKHGLEPLARLKGVAVAGCAPEIMGIGPVAATKKALTRSGIDISQIDVVELNEAFASQALACQREL
GVRDETLNIDGGAIALGHPLGATGARIVGKAASLLKREGGKYALATQCIGGGQGIATVLERV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=38.7755102040816, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=38.1074168797954, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI4501853, Length=385, Percent_Identity=38.4415584415584, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=33.9578454332553, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=32.0610687022901, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI194353979, Length=379, Percent_Identity=29.5514511873351, Blast_Score=138, Evalue=8e-33,
Organism=Escherichia coli, GI48994986, Length=390, Percent_Identity=46.6666666666667, Blast_Score=308, Evalue=5e-85,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=43.7810945273632, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=39.9491094147583, Blast_Score=258, Evalue=3e-70,
Organism=Escherichia coli, GI1788554, Length=395, Percent_Identity=40.7594936708861, Blast_Score=251, Evalue=4e-68,
Organism=Escherichia coli, GI1788683, Length=428, Percent_Identity=33.8785046728972, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=40.4092071611253, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=35.3689567430025, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=33.411214953271, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI25147385, Length=394, Percent_Identity=31.7258883248731, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=386, Percent_Identity=27.720207253886, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6325229, Length=420, Percent_Identity=35, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322031, Length=387, Percent_Identity=35.6589147286822, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=37.1501272264631, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI17648125, Length=376, Percent_Identity=38.031914893617, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=33.3333333333333, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=30.6791569086651, Blast_Score=180, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 39386; Mature: 39386

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNVVIAGYARSPFALAKKGELARVRPDDLAAQVVAELVARTGVKVEDIEDLIVGCAFPE
CCCEEEEECCCCCCHHHCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
AEQGFNIARLIGMIAGLPDSVAGATVNRFCGSSMQSVHMAAGQIQLGAGEVFICAGIESM
HHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCEEEECCCCEEEEECCHHH
SRVPMTGFNPMPNPALYAKLPQAYMGMGETAENVAAKWQITRADQDAFALKSHAKATAAE
HCCCCCCCCCCCCCHHHHHCCHHHHCCCCCHHHHHHEEEEEECCCHHHHHHHHHHHHHHH
AAGKFADEIVSIRINGKDSGKTATQDGCIRRDATAEQLAGLKPAFDEHGTVTAGTSSPLT
HHHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEEECCCCCCC
DGASAVLVCSEDYALKHGLEPLARLKGVAVAGCAPEIMGIGPVAATKKALTRSGIDISQI
CCCCEEEEECCCHHHHHCCCHHHHHCCCEEECCCHHHHCCCCHHHHHHHHHHCCCCCHHE
DVVELNEAFASQALACQRELGVRDETLNIDGGAIALGHPLGATGARIVGKAASLLKREGG
EHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCC
KYALATQCIGGGQGIATVLERV
CEEEEEECCCCCCHHHHHHHCC
>Mature Secondary Structure
MQNVVIAGYARSPFALAKKGELARVRPDDLAAQVVAELVARTGVKVEDIEDLIVGCAFPE
CCCEEEEECCCCCCHHHCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
AEQGFNIARLIGMIAGLPDSVAGATVNRFCGSSMQSVHMAAGQIQLGAGEVFICAGIESM
HHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCEEEECCCCEEEEECCHHH
SRVPMTGFNPMPNPALYAKLPQAYMGMGETAENVAAKWQITRADQDAFALKSHAKATAAE
HCCCCCCCCCCCCCHHHHHCCHHHHCCCCCHHHHHHEEEEEECCCHHHHHHHHHHHHHHH
AAGKFADEIVSIRINGKDSGKTATQDGCIRRDATAEQLAGLKPAFDEHGTVTAGTSSPLT
HHHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEEECCCCCCC
DGASAVLVCSEDYALKHGLEPLARLKGVAVAGCAPEIMGIGPVAATKKALTRSGIDISQI
CCCCEEEEECCCHHHHHCCCHHHHHCCCEEECCCHHHHCCCCHHHHHHHHHHCCCCCHHE
DVVELNEAFASQALACQRELGVRDETLNIDGGAIALGHPLGATGARIVGKAASLLKREGG
EHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCC
KYALATQCIGGGQGIATVLERV
CEEEEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]