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The map label for this gene is mazG [H]

Identifier: 154248311

GI number: 154248311

Start: 4867852

End: 4868688

Strand: Direct

Name: mazG [H]

Synonym: Xaut_4391

Alternate gene names: 154248311

Gene position: 4867852-4868688 (Clockwise)

Preceding gene: 154248309

Following gene: 154248322

Centisome position: 91.69

GC content: 70.61

Gene sequence:

>837_bases
ATGGACCCCTCCCGCGACATCGCGCGCCTCATCGAGATCATGGCCGCCTTGCGCACGCCCGGAACCGGTTGCCCGTGGGA
CCTGGAACAGAGCTTCGCCACCATCGCCCCCTACACGCTGGAGGAAGCCTACGAGGTGGCCGACGCCATCGCCCGCGCCG
ACATGGGCGACCTGAGGGAAGAACTGGGCGACCTGCTGTTGCAGGTGGTCTTCCACGCCCGGATGGCGGAGGAGGACGGC
GCCTTCGATTTCGGCGGCGTGGTCGAGGCCATCACCGCCAAGCTCATCCGCCGGCACCCCCATGTGTTCGGCACCGCGCG
GGATCTGTCGCCGGAGGCGGTGAAGGGCCTGTGGGCCGAGATCAAGGCGCAGGAAAAGCGGGAGCGGGCGCAGGCGCGGG
GGGCGGCGGGCCTGCCGGTGGAGGAGGCGCAGCAGGGCGCCCTGGCCGGCGTGCCTCTGCCCCTGCCCGCCCTCACCCGT
GCGCTGAAGCTTCAGGAAAAGGCGAGCCGCGTGGGGTTCGACTGGAACGATGCGCGCCAGGTGCTGGCCAAGATCCGCGA
GGAGACGCAGGAAGTCGCCGAGGCGCTGGAGGAAGGCGGCACCGCGGCCATCAAGGATGAGATGGGGGACTTGCTGTTCG
CCGTGGTGAACCTTGCCCGCCACGCCGGCGTGGACCCGGAGGACGCCTTGCGCGGCACCAACGACAAGTTCACCCGCCGC
TTCGGCCATGTGGAGCACCGGCTCGCGGCCGCCGGCCGCCGTCCGGAGCAGGCGAGCCTGGATGAGATGGAAGCCCTCTG
GCAGGAGGCGAAGCAGAAGGAGCGGGAAGGCGCGTGA

Upstream 100 bases:

>100_bases
CGGGCGCGATCTCGACCATGGTCTCTTCCTCTTCCTCGCTGGGCGGAGCATAGGACGGTCCAGCCTGCGGTAAAGATCGC
ACTCGAGCCTGGAGAACCTC

Downstream 100 bases:

>100_bases
GCGCGACGGCGTTCCAGCCCCTGCCCTGCCTCACTGAAACCGGCCGGCCAAAGGCGCGGCAGGCTGAGTTGCTCAGGTCG
GATGCACGCGCCGTGCGCCG

Product: MazG family protein

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MDPSRDIARLIEIMAALRTPGTGCPWDLEQSFATIAPYTLEEAYEVADAIARADMGDLREELGDLLLQVVFHARMAEEDG
AFDFGGVVEAITAKLIRRHPHVFGTARDLSPEAVKGLWAEIKAQEKRERAQARGAAGLPVEEAQQGALAGVPLPLPALTR
ALKLQEKASRVGFDWNDARQVLAKIREETQEVAEALEEGGTAAIKDEMGDLLFAVVNLARHAGVDPEDALRGTNDKFTRR
FGHVEHRLAAAGRRPEQASLDEMEALWQEAKQKEREGA

Sequences:

>Translated_278_residues
MDPSRDIARLIEIMAALRTPGTGCPWDLEQSFATIAPYTLEEAYEVADAIARADMGDLREELGDLLLQVVFHARMAEEDG
AFDFGGVVEAITAKLIRRHPHVFGTARDLSPEAVKGLWAEIKAQEKRERAQARGAAGLPVEEAQQGALAGVPLPLPALTR
ALKLQEKASRVGFDWNDARQVLAKIREETQEVAEALEEGGTAAIKDEMGDLLFAVVNLARHAGVDPEDALRGTNDKFTRR
FGHVEHRLAAAGRRPEQASLDEMEALWQEAKQKEREGA
>Mature_278_residues
MDPSRDIARLIEIMAALRTPGTGCPWDLEQSFATIAPYTLEEAYEVADAIARADMGDLREELGDLLLQVVFHARMAEEDG
AFDFGGVVEAITAKLIRRHPHVFGTARDLSPEAVKGLWAEIKAQEKRERAQARGAAGLPVEEAQQGALAGVPLPLPALTR
ALKLQEKASRVGFDWNDARQVLAKIREETQEVAEALEEGGTAAIKDEMGDLLFAVVNLARHAGVDPEDALRGTNDKFTRR
FGHVEHRLAAAGRRPEQASLDEMEALWQEAKQKEREGA

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=270, Percent_Identity=50.3703703703704, Blast_Score=248, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 30493; Mature: 30493

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPSRDIARLIEIMAALRTPGTGCPWDLEQSFATIAPYTLEEAYEVADAIARADMGDLRE
CCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHH
ELGDLLLQVVFHARMAEEDGAFDFGGVVEAITAKLIRRHPHVFGTARDLSPEAVKGLWAE
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHCCHHCCCHHHHHHHHHH
IKAQEKRERAQARGAAGLPVEEAQQGALAGVPLPLPALTRALKLQEKASRVGFDWNDARQ
HHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
VLAKIREETQEVAEALEEGGTAAIKDEMGDLLFAVVNLARHAGVDPEDALRGTNDKFTRR
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHH
FGHVEHRLAAAGRRPEQASLDEMEALWQEAKQKEREGA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDPSRDIARLIEIMAALRTPGTGCPWDLEQSFATIAPYTLEEAYEVADAIARADMGDLRE
CCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHH
ELGDLLLQVVFHARMAEEDGAFDFGGVVEAITAKLIRRHPHVFGTARDLSPEAVKGLWAE
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHCCHHCCCHHHHHHHHHH
IKAQEKRERAQARGAAGLPVEEAQQGALAGVPLPLPALTRALKLQEKASRVGFDWNDARQ
HHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
VLAKIREETQEVAEALEEGGTAAIKDEMGDLLFAVVNLARHAGVDPEDALRGTNDKFTRR
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHH
FGHVEHRLAAAGRRPEQASLDEMEALWQEAKQKEREGA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]