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The map label for this gene is trpE [H]

Identifier: 154248298

GI number: 154248298

Start: 4853425

End: 4854936

Strand: Reverse

Name: trpE [H]

Synonym: Xaut_4378

Alternate gene names: 154248298

Gene position: 4854936-4853425 (Counterclockwise)

Preceding gene: 154248299

Following gene: 154248297

Centisome position: 91.45

GC content: 68.52

Gene sequence:

>1512_bases
GTGAACGCACCCACCGATTTCGACCTCTTCACCTCGCGCTACCTGAAGGGCGAGGCGCAGGTGGTTTCCACCACCCTGGT
GGCCGACCTGGAAACCCCGGTCTCGGCCTTCCTGAAGCTCGCCGGGGACACCCCCAACGCCTTCCTCCTCGAATCGGTGG
AAGGCGGGCAGACCCGCGGTCGCTATTCCATGATCGGGCTCGCGCCCGACCTTATCTTCCGCGCGTCCGGCGATACGGCG
GAGATCAACCGCACCCCGGCGGCGGACAAGGACGCCTTCGTCCCCTGCTCCGAGCCGCCGCTGAAGGCGCTGCGGACCCT
GCTCGCCGAATCGGCCATCGACCTGCCGGCCGGTGCCCCGCCCATGGCGGCGGGCGTATTCGGCTATCTCGGCTACGACA
TGGTACGGCAGATGGAGAAGCTGGCCCCCGCCAAGCCGGACCCCATCGGCGTGCCCGAGGCGCTGCTCATCCGCCCCACC
CTCATGGTGGTGTTCGACGCGGTGAAGGACGAGCTGACCGCCGTCACCCCGGTGCGCCCGAAGGAGGGTGTCTCCCCCCG
CGCGGCCTATGAGGCGGCGCTGGAGCGGCTCGACCAGGTGGTGGCGGGGCTGGAGCGAGCTATCGCCCATCCGGCGCCTG
AGCCCTTCCACGGCGAGGTTCTGCCGGTCTCCAACACCAGTGCGGACGAGTTCTGCGCCATGGTGGACAAGGCAAAGGAC
TATATCCGCGCCGGCGACATCTTCCAGGTGGTGCTGTCCCAGCGCTTCGAGAGCCCGTTCACCCTGCCGCCCTTCGCCCT
CTACCGGGCTCTGCGGCGCGTGAACCCGGCGCCGTTCCTGGTCTATCTCAACTTCGACGGCTTCTCCGTGGTGTGCTCCT
CGCCCGAGATCCTGGTGCGGCTGCGCGGCGGGCAGGTGACCATCCGTCCCATCGCCGGCACCCGCAAGCGCGGCGCCAGC
CATGTGGAGGATGACGCGCTGGCCGCCGAGCTTCTGGCCGATCCCAAGGAGCGCGCCGAGCATCTCATGCTGCTGGACCT
CGGCCGAAACGATGCCGGGCGAGTGTCGCAGATCGGCACGGTGAAGGTGACCGACAGCTTCTTCATCGAGCGCTACAGTC
AGGTGATGCACATCGTCTCCAACGTGGAGGGCACGCTGGACCCGCGCTTCGACGCGGTGGATGCGCTGGCCGCCGGCTTT
CCCGCCGGCACCGTCTCCGGCTCGCCCAAGGTGCGGGCGATGGAGATCATCGACGAGCTGGAGAAGGACAAGCGCGGCAT
CTATGCCGGCGCCATCGGCTATTTCGGCGCCAATGGCGAGATGGACACCTGCATCGTCCTGCGCACCGCCGTGGTGAAGG
ATGGCCGCATGTATGTGCAGGCCGGCGCCGGCATCGTCTACGACAGCGTGCCCGAGAGCGAGCAGCAGGAATGCGTGAAC
AAGGCCAAGGCCCTGTTCCGCGCCGGGGAAGAGGCGGTGCGCTTCGCCGCCCGCGCCGGCAAGGGGCAGTGA

Upstream 100 bases:

>100_bases
ATCTTTCCGCCATCCAGAAGGAGATCGGCGTGAAGATCAACGACAAGCTCTTCGCCCAGGCCACGGGCGCTGGCGCGACC
AACTGAAGGTGGGCCACAGC

Downstream 100 bases:

>100_bases
AGGCGATGGGTGCGCGCCACGCCGATGCACCGCTGGTTCGGATCAGGCACGCGGGCATGGCCGGCGTCGTGGCGGCCCGA
TGGCGTGGGTCGCCCCGCAC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MNAPTDFDLFTSRYLKGEAQVVSTTLVADLETPVSAFLKLAGDTPNAFLLESVEGGQTRGRYSMIGLAPDLIFRASGDTA
EINRTPAADKDAFVPCSEPPLKALRTLLAESAIDLPAGAPPMAAGVFGYLGYDMVRQMEKLAPAKPDPIGVPEALLIRPT
LMVVFDAVKDELTAVTPVRPKEGVSPRAAYEAALERLDQVVAGLERAIAHPAPEPFHGEVLPVSNTSADEFCAMVDKAKD
YIRAGDIFQVVLSQRFESPFTLPPFALYRALRRVNPAPFLVYLNFDGFSVVCSSPEILVRLRGGQVTIRPIAGTRKRGAS
HVEDDALAAELLADPKERAEHLMLLDLGRNDAGRVSQIGTVKVTDSFFIERYSQVMHIVSNVEGTLDPRFDAVDALAAGF
PAGTVSGSPKVRAMEIIDELEKDKRGIYAGAIGYFGANGEMDTCIVLRTAVVKDGRMYVQAGAGIVYDSVPESEQQECVN
KAKALFRAGEEAVRFAARAGKGQ

Sequences:

>Translated_503_residues
MNAPTDFDLFTSRYLKGEAQVVSTTLVADLETPVSAFLKLAGDTPNAFLLESVEGGQTRGRYSMIGLAPDLIFRASGDTA
EINRTPAADKDAFVPCSEPPLKALRTLLAESAIDLPAGAPPMAAGVFGYLGYDMVRQMEKLAPAKPDPIGVPEALLIRPT
LMVVFDAVKDELTAVTPVRPKEGVSPRAAYEAALERLDQVVAGLERAIAHPAPEPFHGEVLPVSNTSADEFCAMVDKAKD
YIRAGDIFQVVLSQRFESPFTLPPFALYRALRRVNPAPFLVYLNFDGFSVVCSSPEILVRLRGGQVTIRPIAGTRKRGAS
HVEDDALAAELLADPKERAEHLMLLDLGRNDAGRVSQIGTVKVTDSFFIERYSQVMHIVSNVEGTLDPRFDAVDALAAGF
PAGTVSGSPKVRAMEIIDELEKDKRGIYAGAIGYFGANGEMDTCIVLRTAVVKDGRMYVQAGAGIVYDSVPESEQQECVN
KAKALFRAGEEAVRFAARAGKGQ
>Mature_503_residues
MNAPTDFDLFTSRYLKGEAQVVSTTLVADLETPVSAFLKLAGDTPNAFLLESVEGGQTRGRYSMIGLAPDLIFRASGDTA
EINRTPAADKDAFVPCSEPPLKALRTLLAESAIDLPAGAPPMAAGVFGYLGYDMVRQMEKLAPAKPDPIGVPEALLIRPT
LMVVFDAVKDELTAVTPVRPKEGVSPRAAYEAALERLDQVVAGLERAIAHPAPEPFHGEVLPVSNTSADEFCAMVDKAKD
YIRAGDIFQVVLSQRFESPFTLPPFALYRALRRVNPAPFLVYLNFDGFSVVCSSPEILVRLRGGQVTIRPIAGTRKRGAS
HVEDDALAAELLADPKERAEHLMLLDLGRNDAGRVSQIGTVKVTDSFFIERYSQVMHIVSNVEGTLDPRFDAVDALAAGF
PAGTVSGSPKVRAMEIIDELEKDKRGIYAGAIGYFGANGEMDTCIVLRTAVVKDGRMYVQAGAGIVYDSVPESEQQECVN
KAKALFRAGEEAVRFAARAGKGQ

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=504, Percent_Identity=35.3174603174603, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788114, Length=448, Percent_Identity=30.3571428571429, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI87082077, Length=260, Percent_Identity=29.6153846153846, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786809, Length=204, Percent_Identity=26.9607843137255, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=463, Percent_Identity=40.1727861771058, Blast_Score=292, Evalue=7e-80,
Organism=Saccharomyces cerevisiae, GI6324361, Length=398, Percent_Identity=24.6231155778894, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54163; Mature: 54163

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPTDFDLFTSRYLKGEAQVVSTTLVADLETPVSAFLKLAGDTPNAFLLESVEGGQTRG
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
RYSMIGLAPDLIFRASGDTAEINRTPAADKDAFVPCSEPPLKALRTLLAESAIDLPAGAP
CEEEEECCHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PMAAGVFGYLGYDMVRQMEKLAPAKPDPIGVPEALLIRPTLMVVFDAVKDELTAVTPVRP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
KEGVSPRAAYEAALERLDQVVAGLERAIAHPAPEPFHGEVLPVSNTSADEFCAMVDKAKD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHH
YIRAGDIFQVVLSQRFESPFTLPPFALYRALRRVNPAPFLVYLNFDGFSVVCSSPEILVR
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCEEEEE
LRGGQVTIRPIAGTRKRGASHVEDDALAAELLADPKERAEHLMLLDLGRNDAGRVSQIGT
ECCCEEEEEECCCCHHCCCCCCCHHHHHHHHHCCHHHHHCEEEEEECCCCCCCCHHCCCE
VKVTDSFFIERYSQVMHIVSNVEGTLDPRFDAVDALAAGFPAGTVSGSPKVRAMEIIDEL
EEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
EKDKRGIYAGAIGYFGANGEMDTCIVLRTAVVKDGRMYVQAGAGIVYDSVPESEQQECVN
HHHCCCEEEEHHEEECCCCCCCHHHEEHHHHHCCCCEEEEECCCEEECCCCCHHHHHHHH
KAKALFRAGEEAVRFAARAGKGQ
HHHHHHHCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MNAPTDFDLFTSRYLKGEAQVVSTTLVADLETPVSAFLKLAGDTPNAFLLESVEGGQTRG
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
RYSMIGLAPDLIFRASGDTAEINRTPAADKDAFVPCSEPPLKALRTLLAESAIDLPAGAP
CEEEEECCHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PMAAGVFGYLGYDMVRQMEKLAPAKPDPIGVPEALLIRPTLMVVFDAVKDELTAVTPVRP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
KEGVSPRAAYEAALERLDQVVAGLERAIAHPAPEPFHGEVLPVSNTSADEFCAMVDKAKD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHH
YIRAGDIFQVVLSQRFESPFTLPPFALYRALRRVNPAPFLVYLNFDGFSVVCSSPEILVR
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCEEEEE
LRGGQVTIRPIAGTRKRGASHVEDDALAAELLADPKERAEHLMLLDLGRNDAGRVSQIGT
ECCCEEEEEECCCCHHCCCCCCCHHHHHHHHHCCHHHHHCEEEEEECCCCCCCCHHCCCE
VKVTDSFFIERYSQVMHIVSNVEGTLDPRFDAVDALAAGFPAGTVSGSPKVRAMEIIDEL
EEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
EKDKRGIYAGAIGYFGANGEMDTCIVLRTAVVKDGRMYVQAGAGIVYDSVPESEQQECVN
HHHCCCEEEEHHEEECCCCCCCHHHEEHHHHHCCCCEEEEECCCEEECCCCCHHHHHHHH
KAKALFRAGEEAVRFAARAGKGQ
HHHHHHHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA