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The map label for this gene is trpC [H]

Identifier: 154248222

GI number: 154248222

Start: 4768064

End: 4768915

Strand: Direct

Name: trpC [H]

Synonym: Xaut_4302

Alternate gene names: 154248222

Gene position: 4768064-4768915 (Clockwise)

Preceding gene: 154248218

Following gene: 154248223

Centisome position: 89.81

GC content: 69.48

Gene sequence:

>852_bases
TTGCCCCGTTGGAGACGGACGTTTTTCATGATTTTGCCAGACGCCAGCCCGCTCAAGCCCTTCATCCTCCAGCGCCGCGA
CCAGCTCGCGAAGGCCAAGGTCCGCCGCTCCCTCGGCCAGATCCAGGGCAAGGTGGGCGACATGCCCATGACTCGCGGCT
TCCAGGGCGCCCTTGCCGCCTCCTTCAAGGCCAATGGCGCGCCGGGCATCATCGCCGAGCTGAAGGGCGGCTCGCCGTTC
GACCCCTCCTTCCGCACCATGGTGCCCTACAAAGCGCTGGCCGAGGATTTCGATGCGGTGGGCGCGGCGGCGCTTTCGGT
GGCGGTGGAGCGGCAGGCGTTCCGCGGCTCCTATTCGGACCTCGCCACGGTGCGCGACGCGGTGGACATCCCGCTTCTGG
CGCAGGACATCATCTTCGATCTCTACCAGATCCTTGAGGCGCGCCTCGCCGGCGCCGACGCGGTGGTGCTCTCCGCTGCC
CTGCTCGGCCCGCAGCTGGCCGAATTCCGCGAGCGGGCGGCCTCCGTCGCCATGGATGCGCTGGTGCAGGTCCACACCCC
GCAGGAGGTGGAAGCCGCGCTGGCCGCCGGGGCGGATTTCGTCTGCGCCACCAACCGCAATATCCACACCTTCGAGCTGG
TTCCGGGCACCTGCGAGACGCTGATCCCGCTCATTCCAGCGGCCAAGGCGCTGGTGGTGGCGGAAGGCGGCCTTGGCACC
GCCGCCGACCGCGAGCGGCTCGGTGCCGCCGGGGCCAAGGCCCTGCTCATCGGCACCGCGATGATGAAGGACGCCGACCC
CGCCGGCGTGCTGGAACAGGTGCTCGGCATCGAGACCGAAGCCGCTGACTGA

Upstream 100 bases:

>100_bases
CCCGAGGGAAGAGGAAACCATGCCGCGCCCCAACCGCGACGGTGGCGAAGCGCGGCAAAATCTGGGAAGTTCAAGGGGCA
TTTTTCGCGCCGGGGCGTCT

Downstream 100 bases:

>100_bases
TCTGGCCCGCTTCCTGCTTGTCCCACACGAGCGCAGCCGCACCGGGCGACGACGGTGTGGCGCGCGACCGTTCGTCTTTG
GCGCAAATGCACCGCAGATC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPRWRRTFFMILPDASPLKPFILQRRDQLAKAKVRRSLGQIQGKVGDMPMTRGFQGALAASFKANGAPGIIAELKGGSPF
DPSFRTMVPYKALAEDFDAVGAAALSVAVERQAFRGSYSDLATVRDAVDIPLLAQDIIFDLYQILEARLAGADAVVLSAA
LLGPQLAEFRERAASVAMDALVQVHTPQEVEAALAAGADFVCATNRNIHTFELVPGTCETLIPLIPAAKALVVAEGGLGT
AADRERLGAAGAKALLIGTAMMKDADPAGVLEQVLGIETEAAD

Sequences:

>Translated_283_residues
MPRWRRTFFMILPDASPLKPFILQRRDQLAKAKVRRSLGQIQGKVGDMPMTRGFQGALAASFKANGAPGIIAELKGGSPF
DPSFRTMVPYKALAEDFDAVGAAALSVAVERQAFRGSYSDLATVRDAVDIPLLAQDIIFDLYQILEARLAGADAVVLSAA
LLGPQLAEFRERAASVAMDALVQVHTPQEVEAALAAGADFVCATNRNIHTFELVPGTCETLIPLIPAAKALVVAEGGLGT
AADRERLGAAGAKALLIGTAMMKDADPAGVLEQVLGIETEAAD
>Mature_282_residues
PRWRRTFFMILPDASPLKPFILQRRDQLAKAKVRRSLGQIQGKVGDMPMTRGFQGALAASFKANGAPGIIAELKGGSPFD
PSFRTMVPYKALAEDFDAVGAAALSVAVERQAFRGSYSDLATVRDAVDIPLLAQDIIFDLYQILEARLAGADAVVLSAAL
LGPQLAEFRERAASVAMDALVQVHTPQEVEAALAAGADFVCATNRNIHTFELVPGTCETLIPLIPAAKALVVAEGGLGTA
ADRERLGAAGAKALLIGTAMMKDADPAGVLEQVLGIETEAAD

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=254, Percent_Identity=31.1023622047244, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322638, Length=240, Percent_Identity=33.75, Blast_Score=115, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29840; Mature: 29709

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRWRRTFFMILPDASPLKPFILQRRDQLAKAKVRRSLGQIQGKVGDMPMTRGFQGALAA
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
SFKANGAPGIIAELKGGSPFDPSFRTMVPYKALAEDFDAVGAAALSVAVERQAFRGSYSD
HCCCCCCCCEEEEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LATVRDAVDIPLLAQDIIFDLYQILEARLAGADAVVLSAALLGPQLAEFRERAASVAMDA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LVQVHTPQEVEAALAAGADFVCATNRNIHTFELVPGTCETLIPLIPAAKALVVAEGGLGT
HHHCCCCHHHHHHHHCCCCEEEECCCCEEEEEECCCCHHHHHHHHCCCCEEEEECCCCCC
AADRERLGAAGAKALLIGTAMMKDADPAGVLEQVLGIETEAAD
CHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PRWRRTFFMILPDASPLKPFILQRRDQLAKAKVRRSLGQIQGKVGDMPMTRGFQGALAA
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
SFKANGAPGIIAELKGGSPFDPSFRTMVPYKALAEDFDAVGAAALSVAVERQAFRGSYSD
HCCCCCCCCEEEEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LATVRDAVDIPLLAQDIIFDLYQILEARLAGADAVVLSAALLGPQLAEFRERAASVAMDA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LVQVHTPQEVEAALAAGADFVCATNRNIHTFELVPGTCETLIPLIPAAKALVVAEGGLGT
HHHCCCCHHHHHHHHCCCCEEEECCCCEEEEEECCCCHHHHHHHHCCCCEEEEECCCCCC
AADRERLGAAGAKALLIGTAMMKDADPAGVLEQVLGIETEAAD
CHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA