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The map label for this gene is mdmC [H]

Identifier: 154248218

GI number: 154248218

Start: 4765469

End: 4766134

Strand: Direct

Name: mdmC [H]

Synonym: Xaut_4298

Alternate gene names: 154248218

Gene position: 4765469-4766134 (Clockwise)

Preceding gene: 154248217

Following gene: 154248222

Centisome position: 89.76

GC content: 68.02

Gene sequence:

>666_bases
ATGAGCGCGACCCTCTGGGCCGAGATGGACGACTATATCGTCGAGCGCCTGCTGCCGGCGGACCCCGTGCTGGACGAGGC
GCTCGCGGCCTCCGCCAAGGCCGGGCTGCCGGCCATCTCCGTGTCGGCAGCGCAGGGGCAGATGCTGCATCTCTTCGCCC
GCATGATCGGGGCGAGGCGCATCCTGGAGATCGGCACCCTGGGCGGCTACAGCGCCATCTTCCTCGCCCGCGCCTTGCCG
GCGGATGGCAAACTGGTGACGCTGGAATTCGAGCCGCGCCATGCCGAAGTGGCGCGCGCAAACCTCGCCCGTGCCGGCCT
TTCCGACAAGGTTGACCTGCGCGTGGGCCGGGCCATCGACACCCTGCCCAAGCTGGAAGCGGAAGGGCAGGGGCCGTTCG
ACCTCATCTTCATCGACGCCGACAAGCCCAGCAATCCGGACTATCTCCATTGGGCGCTGAGGCTGTCGCGTCCGGGCACG
GTCATCATCTGCGACAATGTGGTGCGCAGCGGCAAGGTGCTGGATTCCGAAAGCAGTGACGCCAACGTCATCGGCGTGCG
ACGCTTGTTCGACCTCGCGGGCGCCGACCCGCGCCTGTCCTCCACCGCGGTCCAGACCGTGGGCGCCAAGGGCTATGACG
GCTTCGCGCTGCTGCTGGTGGAGTAA

Upstream 100 bases:

>100_bases
AGTGGGTTTCGCTCAGGAGCCGCGCGGGCTTTACCAAAGGCCCGTGAGCCAAGCTCAAGGGCCTTTGGTATTACTCCCCG
GAATGCACGGAGACGGAACC

Downstream 100 bases:

>100_bases
ACCCAGAAAAAGGGCGCCGGAAGACTCGGTCCCGGCGCCTCGTCCTCAGGACCAGCTGCCGAGATAGGCCAGCGTGGCGA
TGATCAGGATGATCGCGACG

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MSATLWAEMDDYIVERLLPADPVLDEALAASAKAGLPAISVSAAQGQMLHLFARMIGARRILEIGTLGGYSAIFLARALP
ADGKLVTLEFEPRHAEVARANLARAGLSDKVDLRVGRAIDTLPKLEAEGQGPFDLIFIDADKPSNPDYLHWALRLSRPGT
VIICDNVVRSGKVLDSESSDANVIGVRRLFDLAGADPRLSSTAVQTVGAKGYDGFALLLVE

Sequences:

>Translated_221_residues
MSATLWAEMDDYIVERLLPADPVLDEALAASAKAGLPAISVSAAQGQMLHLFARMIGARRILEIGTLGGYSAIFLARALP
ADGKLVTLEFEPRHAEVARANLARAGLSDKVDLRVGRAIDTLPKLEAEGQGPFDLIFIDADKPSNPDYLHWALRLSRPGT
VIICDNVVRSGKVLDSESSDANVIGVRRLFDLAGADPRLSSTAVQTVGAKGYDGFALLLVE
>Mature_220_residues
SATLWAEMDDYIVERLLPADPVLDEALAASAKAGLPAISVSAAQGQMLHLFARMIGARRILEIGTLGGYSAIFLARALPA
DGKLVTLEFEPRHAEVARANLARAGLSDKVDLRVGRAIDTLPKLEAEGQGPFDLIFIDADKPSNPDYLHWALRLSRPGTV
IICDNVVRSGKVLDSESSDANVIGVRRLFDLAGADPRLSSTAVQTVGAKGYDGFALLLVE

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=160, Percent_Identity=38.75, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI6466450, Length=181, Percent_Identity=30.939226519337, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI205830453, Length=181, Percent_Identity=30.939226519337, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI205830451, Length=181, Percent_Identity=30.939226519337, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI4502969, Length=181, Percent_Identity=30.939226519337, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25148771, Length=183, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17565612, Length=156, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI72001127, Length=160, Percent_Identity=32.5, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI72001028, Length=156, Percent_Identity=32.0512820512821, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23605; Mature: 23474

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATLWAEMDDYIVERLLPADPVLDEALAASAKAGLPAISVSAAQGQMLHLFARMIGARR
CCCEEECHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHH
ILEIGTLGGYSAIFLARALPADGKLVTLEFEPRHAEVARANLARAGLSDKVDLRVGRAID
HEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCHHH
TLPKLEAEGQGPFDLIFIDADKPSNPDYLHWALRLSRPGTVIICDNVVRSGKVLDSESSD
HCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCEECCCCCC
ANVIGVRRLFDLAGADPRLSSTAVQTVGAKGYDGFALLLVE
CCEEHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SATLWAEMDDYIVERLLPADPVLDEALAASAKAGLPAISVSAAQGQMLHLFARMIGARR
CCEEECHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHH
ILEIGTLGGYSAIFLARALPADGKLVTLEFEPRHAEVARANLARAGLSDKVDLRVGRAID
HEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCHHH
TLPKLEAEGQGPFDLIFIDADKPSNPDYLHWALRLSRPGTVIICDNVVRSGKVLDSESSD
HCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCEECCCCCC
ANVIGVRRLFDLAGADPRLSSTAVQTVGAKGYDGFALLLVE
CCEEHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]