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The map label for this gene is hbd [H]

Identifier: 154248210

GI number: 154248210

Start: 4757855

End: 4758892

Strand: Reverse

Name: hbd [H]

Synonym: Xaut_4290

Alternate gene names: 154248210

Gene position: 4758892-4757855 (Counterclockwise)

Preceding gene: 154248211

Following gene: 154248208

Centisome position: 89.64

GC content: 69.75

Gene sequence:

>1038_bases
ATGTCCCAACCGAACCACCCCATCCGCCGCGTCGCCGTCATCGGAGCCGGGACCATCGGCGCGAGCTGGGCTGCGCTGTT
CCTCGCGCGCGGGCTCGACGTGGTGGTGAGCGACCCCGCGCCGGGCGCGGCCGAGGCCACCCAGAGCCTCATCTCGGCCG
CCTGGCCGATTCTGATGGAACTGGGCGGCGAAGGCGCGATCGACCCCACCAGCTGGCGCTTCGAGCCGGACCCGGTAAAG
GCGGTGGCGGGCGTCGACTTCGTGCAGGAGAACGCGCCCGAGCGCTACGAGTTGAAGCAGAAGCTGTTTCCCGCCATCGA
CGCGGTGCTGCCGCCGGAGGTGGTGATCGCCTCGTCTTCCTCAGGCCTGCTGGTGAGCCGCATCGCCGAGGGCTGCCGGC
ATCCCGAGCGCTGCATCATCGGCCACCCCTTCAATCCCCCGCACCTCATTCCGCTGGTGGAGGTGGTGGGCGGCGAGAAG
GCAAGCCGCGCCGCCATCGAAACCGCCATGGATTTCTACCGGGCCATGGGCAAGCACCCCATCGAGATCCACAAGGAGGT
CGCCGGCCATGTGGCCAACCGCCTGCAGGCGGCGCTGTGGCGCGAGGCCATCCATCTGGTGGAGCAGGGCGTGGTTTCGG
TGGCGGACGTGGATGCGGCGGTCTCGGAAGGCCCCGGCCTGCGCTGGGCGCTCATGGGCCAGCACATGACCTTCCACCTC
GGCGGCGGCGCGGGCGGCCTCGCCCATTTCATGCACCACCTTTTGCCGGCGGTGGAAACCTGGTGGGACGATCTCGGCAC
GCCGAAAGTGACGCCGGAGCTTCAGGCGAAGCTGGTGGAAGGGGTGACGGAGGAAGCCGGCGGCCGGTCCATCGCCGAAC
TGGCGCAGCGGCGCGACACCCTGCTGACACAGATCGTGGCGCTGAAGCGCGCCCATGATGCGGTGGAGGAGAAGCAGGAC
CTGAGCGAGCGGCTCGACGAGGCGCTGGAGGAGAGCTTCCCGGCCAGCGACCCGGTGGCGGTGCACAAGGCGGACTGA

Upstream 100 bases:

>100_bases
GCCGGCCGAACAGGGCAGTCATACCGTCGCAGCTCTGCCGGTAGAGAATTCCTCCTGCTAGAAGACCGGGAATCCCCCCG
AGCCTCAGGCAGGAGTTGCC

Downstream 100 bases:

>100_bases
GGGCAACCGCCCTCACCCCAAGCGGGTGAGGGCGGCTGTCGCTTGAGACTCAGGCCAGCGCCTTCAGCGCGGCCTTGCCG
GCGTAGCGGGCACTGTCGCC

Product: NAD-binding 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSQPNHPIRRVAVIGAGTIGASWAALFLARGLDVVVSDPAPGAAEATQSLISAAWPILMELGGEGAIDPTSWRFEPDPVK
AVAGVDFVQENAPERYELKQKLFPAIDAVLPPEVVIASSSSGLLVSRIAEGCRHPERCIIGHPFNPPHLIPLVEVVGGEK
ASRAAIETAMDFYRAMGKHPIEIHKEVAGHVANRLQAALWREAIHLVEQGVVSVADVDAAVSEGPGLRWALMGQHMTFHL
GGGAGGLAHFMHHLLPAVETWWDDLGTPKVTPELQAKLVEGVTEEAGGRSIAELAQRRDTLLTQIVALKRAHDAVEEKQD
LSERLDEALEESFPASDPVAVHKAD

Sequences:

>Translated_345_residues
MSQPNHPIRRVAVIGAGTIGASWAALFLARGLDVVVSDPAPGAAEATQSLISAAWPILMELGGEGAIDPTSWRFEPDPVK
AVAGVDFVQENAPERYELKQKLFPAIDAVLPPEVVIASSSSGLLVSRIAEGCRHPERCIIGHPFNPPHLIPLVEVVGGEK
ASRAAIETAMDFYRAMGKHPIEIHKEVAGHVANRLQAALWREAIHLVEQGVVSVADVDAAVSEGPGLRWALMGQHMTFHL
GGGAGGLAHFMHHLLPAVETWWDDLGTPKVTPELQAKLVEGVTEEAGGRSIAELAQRRDTLLTQIVALKRAHDAVEEKQD
LSERLDEALEESFPASDPVAVHKAD
>Mature_344_residues
SQPNHPIRRVAVIGAGTIGASWAALFLARGLDVVVSDPAPGAAEATQSLISAAWPILMELGGEGAIDPTSWRFEPDPVKA
VAGVDFVQENAPERYELKQKLFPAIDAVLPPEVVIASSSSGLLVSRIAEGCRHPERCIIGHPFNPPHLIPLVEVVGGEKA
SRAAIETAMDFYRAMGKHPIEIHKEVAGHVANRLQAALWREAIHLVEQGVVSVADVDAAVSEGPGLRWALMGQHMTFHLG
GGAGGLAHFMHHLLPAVETWWDDLGTPKVTPELQAKLVEGVTEEAGGRSIAELAQRRDTLLTQIVALKRAHDAVEEKQDL
SERLDEALEESFPASDPVAVHKAD

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=310, Percent_Identity=31.9354838709677, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI296179429, Length=228, Percent_Identity=31.140350877193, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI296179427, Length=235, Percent_Identity=29.3617021276596, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI68989263, Length=210, Percent_Identity=27.1428571428571, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI261878539, Length=210, Percent_Identity=27.1428571428571, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI20127408, Length=218, Percent_Identity=25.2293577981651, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787661, Length=243, Percent_Identity=30.4526748971193, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788682, Length=136, Percent_Identity=32.3529411764706, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790281, Length=111, Percent_Identity=32.4324324324324, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=226, Percent_Identity=33.6283185840708, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193203623, Length=226, Percent_Identity=33.6283185840708, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17553560, Length=231, Percent_Identity=26.4069264069264, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17549919, Length=228, Percent_Identity=27.1929824561404, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17558304, Length=208, Percent_Identity=24.5192307692308, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45549573, Length=319, Percent_Identity=30.0940438871473, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI20129993, Length=317, Percent_Identity=31.5457413249211, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24583077, Length=219, Percent_Identity=25.5707762557078, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583079, Length=219, Percent_Identity=25.5707762557078, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921000, Length=217, Percent_Identity=25.3456221198157, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 36979; Mature: 36847

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPNHPIRRVAVIGAGTIGASWAALFLARGLDVVVSDPAPGAAEATQSLISAAWPILME
CCCCCCCHHEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
LGGEGAIDPTSWRFEPDPVKAVAGVDFVQENAPERYELKQKLFPAIDAVLPPEVVIASSS
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCC
SGLLVSRIAEGCRHPERCIIGHPFNPPHLIPLVEVVGGEKASRAAIETAMDFYRAMGKHP
CCHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
IEIHKEVAGHVANRLQAALWREAIHLVEQGVVSVADVDAAVSEGPGLRWALMGQHMTFHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEE
GGGAGGLAHFMHHLLPAVETWWDDLGTPKVTPELQAKLVEGVTEEAGGRSIAELAQRRDT
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LLTQIVALKRAHDAVEEKQDLSERLDEALEESFPASDPVAVHKAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
>Mature Secondary Structure 
SQPNHPIRRVAVIGAGTIGASWAALFLARGLDVVVSDPAPGAAEATQSLISAAWPILME
CCCCCCHHEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
LGGEGAIDPTSWRFEPDPVKAVAGVDFVQENAPERYELKQKLFPAIDAVLPPEVVIASSS
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCC
SGLLVSRIAEGCRHPERCIIGHPFNPPHLIPLVEVVGGEKASRAAIETAMDFYRAMGKHP
CCHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
IEIHKEVAGHVANRLQAALWREAIHLVEQGVVSVADVDAAVSEGPGLRWALMGQHMTFHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEE
GGGAGGLAHFMHHLLPAVETWWDDLGTPKVTPELQAKLVEGVTEEAGGRSIAELAQRRDT
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LLTQIVALKRAHDAVEEKQDLSERLDEALEESFPASDPVAVHKAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]