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The map label for this gene is fabI1 [H]

Identifier: 154248064

GI number: 154248064

Start: 4584074

End: 4584901

Strand: Reverse

Name: fabI1 [H]

Synonym: Xaut_4143

Alternate gene names: 154248064

Gene position: 4584901-4584074 (Counterclockwise)

Preceding gene: 154248065

Following gene: 154248063

Centisome position: 86.36

GC content: 64.73

Gene sequence:

>828_bases
ATGGCGACGGACGGTTTCGCGAGCGGTCTCCTGAAGGGCAAGCGCGGGCTGATTCTCGGTGTCGCCAATAATCGATCCAT
CGCCTACGGCATCGCCAAGTCCGCCCGTGCCCACGGCGCCGAGCTCGCCCTCACCTATCAGGGCGAAGCGTTGAAGAAGC
GGGTGGAGCCGCTGGCGGCCGAGCTGGGCGGCCATCTGGTCGGCCATTGTGACGTGACCGAGCCGGAGACCCTGGACGCC
GTCTTCGCCGAGACCGAGCGGCTCTTCGGCACGCTGGATTTCGTGGTCCACTGCATCGCCTTCTCCAACAAGGACGAGCT
GGACGGCCGCTATGTGGACACCTCGGCTGACAATTTCACCAAGACAATGTTCATCTCCTGCTACTCCTTCACCGCCGTGG
CCCAGCGGGCGGAGAAGCTGATGACCAACGGCGGCTCCCTGCTGACCCTCACCTATTACGGTGCGGAAAAGTGGATGCCG
CACTACAACGTCATGGGCGTTGCCAAGGCGGCGCTGGAGGCGAGCGTGCGCTACCTGGCCGCCGACCTCGGCCCCAAGGC
GATCCGCGTCAACGCCATCTCCGCCGGCCCGATCAAGACGCTCGCGGCCTCGGGAATCGGTGATTTCCGATATATCCTCA
AGTGGAACGAGCTGAATTCCCCGCTGCGCCGCACCGTCACCACCGACGAGGTGGGCGACACCGGCGTCTATCTCGTGTCC
GATTTGTCGCGCGGTGTGACCGGCGAAGTGCACCATGTGGACGCCGGATATCATATCGTCGGCATGAAGCACCCGGACGC
GCCCGACCTCGCCCTCGTCCGCGAGTGA

Upstream 100 bases:

>100_bases
AACGGTGGATGGCCCCATGCCATAGGAAGCGCGCCCCATGGAGTGTGCCTTTGCCCGCGCCATGGGGCATCAATGGCTTG
AAGCATGTGGAGTTGGGTCA

Downstream 100 bases:

>100_bases
GATCGCAAACCCGCGCACCCGCGCGCCATCAGGAGAACCCCATGCCGGCGATCGTCCTTCGCGCCGCCCTGTCCGCCCTG
GCGGTTTCGGCCGGCCTTGT

Product: enoyl-acyl carrier protein reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MATDGFASGLLKGKRGLILGVANNRSIAYGIAKSARAHGAELALTYQGEALKKRVEPLAAELGGHLVGHCDVTEPETLDA
VFAETERLFGTLDFVVHCIAFSNKDELDGRYVDTSADNFTKTMFISCYSFTAVAQRAEKLMTNGGSLLTLTYYGAEKWMP
HYNVMGVAKAALEASVRYLAADLGPKAIRVNAISAGPIKTLAASGIGDFRYILKWNELNSPLRRTVTTDEVGDTGVYLVS
DLSRGVTGEVHHVDAGYHIVGMKHPDAPDLALVRE

Sequences:

>Translated_275_residues
MATDGFASGLLKGKRGLILGVANNRSIAYGIAKSARAHGAELALTYQGEALKKRVEPLAAELGGHLVGHCDVTEPETLDA
VFAETERLFGTLDFVVHCIAFSNKDELDGRYVDTSADNFTKTMFISCYSFTAVAQRAEKLMTNGGSLLTLTYYGAEKWMP
HYNVMGVAKAALEASVRYLAADLGPKAIRVNAISAGPIKTLAASGIGDFRYILKWNELNSPLRRTVTTDEVGDTGVYLVS
DLSRGVTGEVHHVDAGYHIVGMKHPDAPDLALVRE
>Mature_274_residues
ATDGFASGLLKGKRGLILGVANNRSIAYGIAKSARAHGAELALTYQGEALKKRVEPLAAELGGHLVGHCDVTEPETLDAV
FAETERLFGTLDFVVHCIAFSNKDELDGRYVDTSADNFTKTMFISCYSFTAVAQRAEKLMTNGGSLLTLTYYGAEKWMPH
YNVMGVAKAALEASVRYLAADLGPKAIRVNAISAGPIKTLAASGIGDFRYILKWNELNSPLRRTVTTDEVGDTGVYLVSD
LSRGVTGEVHHVDAGYHIVGMKHPDAPDLALVRE

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=263, Percent_Identity=27.7566539923954, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787545, Length=257, Percent_Identity=51.7509727626459, Blast_Score=264, Evalue=6e-72,
Organism=Escherichia coli, GI1789378, Length=256, Percent_Identity=28.125, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=28.2868525896414, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082100, Length=263, Percent_Identity=27.3764258555133, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 29594; Mature: 29463

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDGFASGLLKGKRGLILGVANNRSIAYGIAKSARAHGAELALTYQGEALKKRVEPLAA
CCCCHHHHHHHCCCCEEEEEEECCCEEEEEHHHHHCCCCCEEEEEECCHHHHHHHHHHHH
ELGGHLVGHCDVTEPETLDAVFAETERLFGTLDFVVHCIAFSNKDELDGRYVDTSADNFT
HHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHH
KTMFISCYSFTAVAQRAEKLMTNGGSLLTLTYYGAEKWMPHYNVMGVAKAALEASVRYLA
EEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHCCCCCCHHHHHHHHHHHHHHHHH
ADLGPKAIRVNAISAGPIKTLAASGIGDFRYILKWNELNSPLRRTVTTDEVGDTGVYLVS
HCCCCCEEEEEEECCCCHHHHHHCCCCCEEEEEEECCCCCHHHHCCCCCCCCCCCEEEEE
DLSRGVTGEVHHVDAGYHIVGMKHPDAPDLALVRE
HHCCCCCCCEEEECCCEEEEEECCCCCCCEEEECC
>Mature Secondary Structure 
ATDGFASGLLKGKRGLILGVANNRSIAYGIAKSARAHGAELALTYQGEALKKRVEPLAA
CCCHHHHHHHCCCCEEEEEEECCCEEEEEHHHHHCCCCCEEEEEECCHHHHHHHHHHHH
ELGGHLVGHCDVTEPETLDAVFAETERLFGTLDFVVHCIAFSNKDELDGRYVDTSADNFT
HHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHH
KTMFISCYSFTAVAQRAEKLMTNGGSLLTLTYYGAEKWMPHYNVMGVAKAALEASVRYLA
EEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHCCCCCCHHHHHHHHHHHHHHHHH
ADLGPKAIRVNAISAGPIKTLAASGIGDFRYILKWNELNSPLRRTVTTDEVGDTGVYLVS
HCCCCCEEEEEEECCCCHHHHHHCCCCCEEEEEEECCCCCHHHHCCCCCCCCCCCEEEEE
DLSRGVTGEVHHVDAGYHIVGMKHPDAPDLALVRE
HHCCCCCCCEEEECCCEEEEEECCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]