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The map label for this gene is acoC [H]

Identifier: 154247964

GI number: 154247964

Start: 4471027

End: 4472145

Strand: Reverse

Name: acoC [H]

Synonym: Xaut_4043

Alternate gene names: 154247964

Gene position: 4472145-4471027 (Counterclockwise)

Preceding gene: 154247965

Following gene: 154247963

Centisome position: 84.24

GC content: 68.63

Gene sequence:

>1119_bases
ATGCTGGACACCCGCATCAAGCCCATCGTCATGCCCAAGTGGGGCCTGTCCATGTCGGAGGGCAAGGTCACGGGCTGGCT
CAAGCCGCCCGGCACCAAGATCTCCGTGGGCGATGAAATCCTCGAGGTGGAGACCGACAAGATCGCCGGCGTGGTGGAGG
CGGGCGATGCCGGTATCCTGCGCCGCGCCATCGGCGCCCGCGACACCGTCTATCCGGTCAAGGCCCTGATCGGCGTGATC
GCCGATGAAGAGGTGAGCGACGACGAGATCGACGCCTTCGTCGCCACCTATGCCGCCCCCGCCGAGGAGGACGAGACGGC
GGAGGAGAGCGCGCCGAAATACGAGTTCGCCGACACCCCCTTCGGCCGCCTGCGCTATGCCAGGCGCGGCGATGGCGCCC
GCACGGTGGTGCTCATCCACGGCTTCGGCGGCGATCTCGACAACTGGCTGTTCAACATCGACGCTTTGGCCGGCTCCGCC
ACCGTCTATGCCCTCGACCTGCCGGGCCATGGCCAGTCGGACAAGGCCATCGGCGAGGCGAGCCTCGGCTGGCTGTCCGG
CGCCGTGCTCGCCTTCATGGACCAGACCGGGATCGAGAAGGCCCATCTGGTCGGCCATTCCATGGGCGGGGCGGTGGCCA
TGCGCACCGCGCTGGACCAGCCGGGGCGGGTGGCCTCCCTCGGCCTCATCGGCTCGGCCGGGCTCGGGGCCGAGATCAAC
AGCGGCTACACGGACGGCTTCGTCGCCGGATCGTCCCGCCGCGACATGAAGCCGGTGCTGGAACAGCTGTTCCACGATCC
CGGCACGGTCACCCGCCAGCTGGTGGAAGACATCCTGAAGTACAAGCGCCTCGACGGGGTGGATGACGCCTTGCGCGCGC
TCGCCGCCAACCTGTTCCCGGCCAGCCGCCAGAGCGAGATCCTGGCCGAAAAGCTGAAGGCGGCGGATGTGCCGGTGCTC
GTCATCTTCGGCGCCAGCGACAAGGTGATCCCGCCCGCCCATGCCGGGGCTCTCGGGGACCGCGCCCGGGCCGAGGTGCT
CAGCGAGGCCGGACACATGGTGCAGATGGAAAAGGCCAACAAGGTCAATGAGCTGCTGCTCGAGCACATCGGCCGCTGA

Upstream 100 bases:

>100_bases
CGGCCATGACGATACCCGTGAAACAGAGCAATCGAGAGCCGTTGCGACGGACCGTAACCCGCCTCGATCCGTCTCACCAA
ACCCCTTTTGAGGAACCCCA

Downstream 100 bases:

>100_bases
CCGCTCGTCCACCGCCGCCGCAGCCCGGAAATGGCCGCCCGAGAGGGCGGTCAACGGCGGCGTGTGGCCAATCAAAATCC
AGGAGGAACCATGCCCAGTC

Product: branched-chain alpha-keto acid dehydrogenase subunit E2

Products: NA

Alternate protein names: Acetoin dehydrogenase E2 component; Dihydrolipoamide acetyltransferase component of acetoin cleaving system; Fast-migrating protein; FMP [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MLDTRIKPIVMPKWGLSMSEGKVTGWLKPPGTKISVGDEILEVETDKIAGVVEAGDAGILRRAIGARDTVYPVKALIGVI
ADEEVSDDEIDAFVATYAAPAEEDETAEESAPKYEFADTPFGRLRYARRGDGARTVVLIHGFGGDLDNWLFNIDALAGSA
TVYALDLPGHGQSDKAIGEASLGWLSGAVLAFMDQTGIEKAHLVGHSMGGAVAMRTALDQPGRVASLGLIGSAGLGAEIN
SGYTDGFVAGSSRRDMKPVLEQLFHDPGTVTRQLVEDILKYKRLDGVDDALRALAANLFPASRQSEILAEKLKAADVPVL
VIFGASDKVIPPAHAGALGDRARAEVLSEAGHMVQMEKANKVNELLLEHIGR

Sequences:

>Translated_372_residues
MLDTRIKPIVMPKWGLSMSEGKVTGWLKPPGTKISVGDEILEVETDKIAGVVEAGDAGILRRAIGARDTVYPVKALIGVI
ADEEVSDDEIDAFVATYAAPAEEDETAEESAPKYEFADTPFGRLRYARRGDGARTVVLIHGFGGDLDNWLFNIDALAGSA
TVYALDLPGHGQSDKAIGEASLGWLSGAVLAFMDQTGIEKAHLVGHSMGGAVAMRTALDQPGRVASLGLIGSAGLGAEIN
SGYTDGFVAGSSRRDMKPVLEQLFHDPGTVTRQLVEDILKYKRLDGVDDALRALAANLFPASRQSEILAEKLKAADVPVL
VIFGASDKVIPPAHAGALGDRARAEVLSEAGHMVQMEKANKVNELLLEHIGR
>Mature_372_residues
MLDTRIKPIVMPKWGLSMSEGKVTGWLKPPGTKISVGDEILEVETDKIAGVVEAGDAGILRRAIGARDTVYPVKALIGVI
ADEEVSDDEIDAFVATYAAPAEEDETAEESAPKYEFADTPFGRLRYARRGDGARTVVLIHGFGGDLDNWLFNIDALAGSA
TVYALDLPGHGQSDKAIGEASLGWLSGAVLAFMDQTGIEKAHLVGHSMGGAVAMRTALDQPGRVASLGLIGSAGLGAEIN
SGYTDGFVAGSSRRDMKPVLEQLFHDPGTVTRQLVEDILKYKRLDGVDDALRALAANLFPASRQSEILAEKLKAADVPVL
VIFGASDKVIPPAHAGALGDRARAEVLSEAGHMVQMEKANKVNELLLEHIGR

Specific function: Dihydrolipoamide acetyltransferase involved in acetoin catabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI189027141, Length=272, Percent_Identity=25.3676470588235, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87081721, Length=272, Percent_Identity=29.0441176470588, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32566936, Length=262, Percent_Identity=27.0992366412214, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17558492, Length=262, Percent_Identity=27.0992366412214, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000073
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF00364 Biotin_lipoyl [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 39446; Mature: 39446

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTRIKPIVMPKWGLSMSEGKVTGWLKPPGTKISVGDEILEVETDKIAGVVEAGDAGIL
CCCCCCCEEEECCCCCCCCCCCEEEEECCCCCEEECCCHHEEEEHHHHHEEEECCCHHHH
RRAIGARDTVYPVKALIGVIADEEVSDDEIDAFVATYAAPAEEDETAEESAPKYEFADTP
HHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCC
FGRLRYARRGDGARTVVLIHGFGGDLDNWLFNIDALAGSATVYALDLPGHGQSDKAIGEA
HHHHHHHHCCCCCEEEEEEECCCCCHHHHHEEHHHCCCCEEEEEEECCCCCCCCCCCCCH
SLGWLSGAVLAFMDQTGIEKAHLVGHSMGGAVAMRTALDQPGRVASLGLIGSAGLGAEIN
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
SGYTDGFVAGSSRRDMKPVLEQLFHDPGTVTRQLVEDILKYKRLDGVDDALRALAANLFP
CCCCCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
ASRQSEILAEKLKAADVPVLVIFGASDKVIPPAHAGALGDRARAEVLSEAGHMVQMEKAN
CCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEHHHH
KVNELLLEHIGR
HHHHHHHHHHCC
>Mature Secondary Structure
MLDTRIKPIVMPKWGLSMSEGKVTGWLKPPGTKISVGDEILEVETDKIAGVVEAGDAGIL
CCCCCCCEEEECCCCCCCCCCCEEEEECCCCCEEECCCHHEEEEHHHHHEEEECCCHHHH
RRAIGARDTVYPVKALIGVIADEEVSDDEIDAFVATYAAPAEEDETAEESAPKYEFADTP
HHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCC
FGRLRYARRGDGARTVVLIHGFGGDLDNWLFNIDALAGSATVYALDLPGHGQSDKAIGEA
HHHHHHHHCCCCCEEEEEEECCCCCHHHHHEEHHHCCCCEEEEEEECCCCCCCCCCCCCH
SLGWLSGAVLAFMDQTGIEKAHLVGHSMGGAVAMRTALDQPGRVASLGLIGSAGLGAEIN
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
SGYTDGFVAGSSRRDMKPVLEQLFHDPGTVTRQLVEDILKYKRLDGVDDALRALAANLFP
CCCCCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
ASRQSEILAEKLKAADVPVLVIFGASDKVIPPAHAGALGDRARAEVLSEAGHMVQMEKAN
CCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEHHHH
KVNELLLEHIGR
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2061286 [H]