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The map label for this gene is bdhA [H]

Identifier: 154247961

GI number: 154247961

Start: 4468702

End: 4469772

Strand: Reverse

Name: bdhA [H]

Synonym: Xaut_4040

Alternate gene names: 154247961

Gene position: 4469772-4468702 (Counterclockwise)

Preceding gene: 154247962

Following gene: 154247960

Centisome position: 84.19

GC content: 67.13

Gene sequence:

>1071_bases
ATGAAGGCCGCCCGCTTCCACGCCCGGCGCGACGTGCGCGTCGAGGACATCCCGACCCCGACCGACCAGCCGGCCCCCCG
CCAAGTCCTTGTGAAAAATAGGTTTTGCGGCATCTGCGGCACGGACCTGCATGAATATGCCGCCGGTCCCATCTTCATCC
CCACCCAGCCCCACCCCTACACCGGCGCCAAGGCCCCCCAGATCCTCGGCCATGAGTACGGCGGAACCGTTGTGGCTGTT
GGATCTTCGGTCACCAACGTGGCCGTCGGCGATCGCGTCTCGGTGCAGCCCATGGTGTCCCCGAGGGATGATTATTTCGG
CCAGCGCGGCCTCTATCAACTGAGCGAGAGCCTCGCCATCATCGGCCTCGCCTGGCCGTGGGGCGGCATGGCGGAATACT
CGCTTGTCAATGATTACAACGTGTTCCGGGTGCCAGACAGCGTCAGCGACGCGCAGGCCGCCCTTATCGAGCCCACCGCA
GTCACCGTCTATGCGGCCGAGCGGGGCGGCGTGAAGCCCGGCGACAGCGTCCTCGTCACCGGCGCCGGCCCCATCGGACA
GTTGCAGGTGCTGGCGGCGCGGGCGGCCGGGGCGACCCGGATTTTCCTAAGCGATACCAACGACAACCGCCTCGCCATGG
CCCGGCAGATCCTGCCCGACGTCATCACCCTCAACCCCCGCTCGGACAAGGTGCCGGAGGCCATTCGCGACCAGACCGAA
GGCGGCGTCGGCGTGGACGTGGCGCTGGAATGCGTGGGTGCCGAGGCGGCGCTTGGCACCTGCATCGAGGCGGTGCGCCG
GCAGGGGGTGGTGGTGCAGGTCGGGCTTCACGTGGGCAAGCCCGCCGTGGACGGATTCACCGTCACCTTCAAGGACATCG
ATGTGCGCGGCTCGTGGTGCTACACGACTCTCATGTGGCCGCGCGTCGCCGCTCTCATCGGCAGCGGCATCCTGCCGGCG
GAAAAGGTTGTGACCCGCCGCATCCGCCTCGACGAGGTGGTGGAAAACGGCTTCGAGGCCCTGCTCAGCCCCGCCGGAAC
GGAACTGAAAATCCTCATCGATCTTCAGTGA

Upstream 100 bases:

>100_bases
GTGGCCATCGAGATGGGCGGCGGCCCTGCCGCCGTCTACGCCGGCAAGGCCTTGGCCGCCTACGACGCGCTAACCAACGA
TAAATGAAGGAGAAACGCCC

Downstream 100 bases:

>100_bases
CACCAACGGCCCACGAACCGCAGGGATGGGCCATGGGTGCCAGCCCGCGCGGCGCCTGAGCCCAACCCTCTCGGTGACGG
TCGCAGACCGGCATCGTCGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKAARFHARRDVRVEDIPTPTDQPAPRQVLVKNRFCGICGTDLHEYAAGPIFIPTQPHPYTGAKAPQILGHEYGGTVVAV
GSSVTNVAVGDRVSVQPMVSPRDDYFGQRGLYQLSESLAIIGLAWPWGGMAEYSLVNDYNVFRVPDSVSDAQAALIEPTA
VTVYAAERGGVKPGDSVLVTGAGPIGQLQVLAARAAGATRIFLSDTNDNRLAMARQILPDVITLNPRSDKVPEAIRDQTE
GGVGVDVALECVGAEAALGTCIEAVRRQGVVVQVGLHVGKPAVDGFTVTFKDIDVRGSWCYTTLMWPRVAALIGSGILPA
EKVVTRRIRLDEVVENGFEALLSPAGTELKILIDLQ

Sequences:

>Translated_356_residues
MKAARFHARRDVRVEDIPTPTDQPAPRQVLVKNRFCGICGTDLHEYAAGPIFIPTQPHPYTGAKAPQILGHEYGGTVVAV
GSSVTNVAVGDRVSVQPMVSPRDDYFGQRGLYQLSESLAIIGLAWPWGGMAEYSLVNDYNVFRVPDSVSDAQAALIEPTA
VTVYAAERGGVKPGDSVLVTGAGPIGQLQVLAARAAGATRIFLSDTNDNRLAMARQILPDVITLNPRSDKVPEAIRDQTE
GGVGVDVALECVGAEAALGTCIEAVRRQGVVVQVGLHVGKPAVDGFTVTFKDIDVRGSWCYTTLMWPRVAALIGSGILPA
EKVVTRRIRLDEVVENGFEALLSPAGTELKILIDLQ
>Mature_356_residues
MKAARFHARRDVRVEDIPTPTDQPAPRQVLVKNRFCGICGTDLHEYAAGPIFIPTQPHPYTGAKAPQILGHEYGGTVVAV
GSSVTNVAVGDRVSVQPMVSPRDDYFGQRGLYQLSESLAIIGLAWPWGGMAEYSLVNDYNVFRVPDSVSDAQAALIEPTA
VTVYAAERGGVKPGDSVLVTGAGPIGQLQVLAARAAGATRIFLSDTNDNRLAMARQILPDVITLNPRSDKVPEAIRDQTE
GGVGVDVALECVGAEAALGTCIEAVRRQGVVVQVGLHVGKPAVDGFTVTFKDIDVRGSWCYTTLMWPRVAALIGSGILPA
EKVVTRRIRLDEVVENGFEALLSPAGTELKILIDLQ

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=351, Percent_Identity=34.7578347578348, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1790045, Length=346, Percent_Identity=30.635838150289, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788073, Length=312, Percent_Identity=29.4871794871795, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1786825, Length=387, Percent_Identity=30.4909560723514, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI226510992, Length=323, Percent_Identity=28.7925696594427, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1790718, Length=290, Percent_Identity=30.3448275862069, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1787863, Length=322, Percent_Identity=28.2608695652174, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI87082125, Length=364, Percent_Identity=28.8461538461538, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788075, Length=377, Percent_Identity=25.7294429708223, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788407, Length=285, Percent_Identity=28.0701754385965, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081918, Length=274, Percent_Identity=30.6569343065693, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=336, Percent_Identity=32.7380952380952, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17562878, Length=341, Percent_Identity=33.1378299120235, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71988145, Length=330, Percent_Identity=28.7878787878788, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562584, Length=279, Percent_Identity=26.8817204301075, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=326, Percent_Identity=26.0736196319018, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=374, Percent_Identity=31.283422459893, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319257, Length=378, Percent_Identity=30.6878306878307, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322619, Length=349, Percent_Identity=29.2263610315186, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319955, Length=349, Percent_Identity=29.2263610315186, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323099, Length=348, Percent_Identity=29.0229885057471, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323729, Length=306, Percent_Identity=27.1241830065359, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17737897, Length=360, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17137530, Length=357, Percent_Identity=31.9327731092437, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 38004; Mature: 38004

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAARFHARRDVRVEDIPTPTDQPAPRQVLVKNRFCGICGTDLHEYAAGPIFIPTQPHPY
CCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHCCCCEEECCCCCCC
TGAKAPQILGHEYGGTVVAVGSSVTNVAVGDRVSVQPMVSPRDDYFGQRGLYQLSESLAI
CCCCCCHHHCCCCCCEEEEECCCEEEEEECCCEEECCCCCCCHHHCCCCHHHHHCCCEEE
IGLAWPWGGMAEYSLVNDYNVFRVPDSVSDAQAALIEPTAVTVYAAERGGVKPGDSVLVT
EEEECCCCCCEEEEEECCCEEEECCCCCCCCHHEEECCCEEEEEEECCCCCCCCCCEEEE
GAGPIGQLQVLAARAAGATRIFLSDTNDNRLAMARQILPDVITLNPRSDKVPEAIRDQTE
CCCCCCHHHEEEECCCCCEEEEEECCCCCHHHHHHHHCCCEEEECCCCCCCCHHHHHHCC
GGVGVDVALECVGAEAALGTCIEAVRRQGVVVQVGLHVGKPAVDGFTVTFKDIDVRGSWC
CCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCEEEEEEEEECCCCEE
YTTLMWPRVAALIGSGILPAEKVVTRRIRLDEVVENGFEALLSPAGTELKILIDLQ
EEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC
>Mature Secondary Structure
MKAARFHARRDVRVEDIPTPTDQPAPRQVLVKNRFCGICGTDLHEYAAGPIFIPTQPHPY
CCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHCCCCEEECCCCCCC
TGAKAPQILGHEYGGTVVAVGSSVTNVAVGDRVSVQPMVSPRDDYFGQRGLYQLSESLAI
CCCCCCHHHCCCCCCEEEEECCCEEEEEECCCEEECCCCCCCHHHCCCCHHHHHCCCEEE
IGLAWPWGGMAEYSLVNDYNVFRVPDSVSDAQAALIEPTAVTVYAAERGGVKPGDSVLVT
EEEECCCCCCEEEEEECCCEEEECCCCCCCCHHEEECCCEEEEEEECCCCCCCCCCEEEE
GAGPIGQLQVLAARAAGATRIFLSDTNDNRLAMARQILPDVITLNPRSDKVPEAIRDQTE
CCCCCCHHHEEEECCCCCEEEEEECCCCCHHHHHHHHCCCEEEECCCCCCCCHHHHHHCC
GGVGVDVALECVGAEAALGTCIEAVRRQGVVVQVGLHVGKPAVDGFTVTFKDIDVRGSWC
CCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCEEEEEEEEECCCCEE
YTTLMWPRVAALIGSGILPAEKVVTRRIRLDEVVENGFEALLSPAGTELKILIDLQ
EEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]