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The map label for this gene is clpP

Identifier: 154247518

GI number: 154247518

Start: 4015363

End: 4015998

Strand: Direct

Name: clpP

Synonym: Xaut_3591

Alternate gene names: 154247518

Gene position: 4015363-4015998 (Clockwise)

Preceding gene: 154247517

Following gene: 154247519

Centisome position: 75.63

GC content: 61.01

Gene sequence:

>636_bases
ATGCGTGATCCTGTCGATACTTATATGAATTATCTCATTCCCATGGTGGTCGAGCAGACCAACCGCGGGGAGCGGTCCTA
CGACATCTTTTCCCGCCTCCTGAAGGAGCGCATCATCTTCCTGACCGGCCCGGTCGAGGACGGCATGTCCACCCTCGCGG
TGGCGCAGCTGCTGTTCCTGGAAGCGGACAATCCGAAGAAGGAAATCTCGATGTACATCAACTCCCCCGGGGGAGTGGTG
ACATCGGGCCTCGCCATCTACGACACCATGCAGTTCATCAAGCCTGCGGTGTCCACGCTCTGCATCGGCCAGGCCGCCTC
CATGGGCTCGCTGCTGCTGACCGCCGGCGAGAAGGATATGCGCTTCGCCCTGCCCAACGCCCGAATCATGGTGCACCAGC
CGTCGGGCGGCTTCCAGGGTCAGGTCACGGACATCATGCTGCACGCCCAGGAGATCCTGAACCTGAAGCGCCGGCTGAAT
GAAATCTATGTGAAGCACACTGGCCGCTCGATGGACAAGATCGAGGACGCGCTGGAGCGCGACAACTTCATGACCGCAAA
GGCCGCACTGGACTTCGGTCTCATCGATGCCGTGATCGATCAGCGCCCCACCGACGACACCTCCAAGGCGGCGTGA

Upstream 100 bases:

>100_bases
GAGAAGGCGGCCTGAGGGCCAAAGTCCGCCTTCGTCCTGCGACGATATTGCGCGGCACGCCCCCCGGGGCGTGCCATCGC
CCGCGCCCCGAGGACTGACG

Downstream 100 bases:

>100_bases
TCGGGAGCCGCGCGACGGGGGTTCTCGTATTGCCCCCCTTGCGTGCGGTGCAAGATCGCGCTTGCATGTCGTTAAGCCGG
CATCGGATGCCGCGTATCCG

Product: endopeptidase Clp

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MRDPVDTYMNYLIPMVVEQTNRGERSYDIFSRLLKERIIFLTGPVEDGMSTLAVAQLLFLEADNPKKEISMYINSPGGVV
TSGLAIYDTMQFIKPAVSTLCIGQAASMGSLLLTAGEKDMRFALPNARIMVHQPSGGFQGQVTDIMLHAQEILNLKRRLN
EIYVKHTGRSMDKIEDALERDNFMTAKAALDFGLIDAVIDQRPTDDTSKAA

Sequences:

>Translated_211_residues
MRDPVDTYMNYLIPMVVEQTNRGERSYDIFSRLLKERIIFLTGPVEDGMSTLAVAQLLFLEADNPKKEISMYINSPGGVV
TSGLAIYDTMQFIKPAVSTLCIGQAASMGSLLLTAGEKDMRFALPNARIMVHQPSGGFQGQVTDIMLHAQEILNLKRRLN
EIYVKHTGRSMDKIEDALERDNFMTAKAALDFGLIDAVIDQRPTDDTSKAA
>Mature_211_residues
MRDPVDTYMNYLIPMVVEQTNRGERSYDIFSRLLKERIIFLTGPVEDGMSTLAVAQLLFLEADNPKKEISMYINSPGGVV
TSGLAIYDTMQFIKPAVSTLCIGQAASMGSLLLTAGEKDMRFALPNARIMVHQPSGGFQGQVTDIMLHAQEILNLKRRLN
EIYVKHTGRSMDKIEDALERDNFMTAKAALDFGLIDAVIDQRPTDDTSKAA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=194, Percent_Identity=59.7938144329897, Blast_Score=255, Evalue=2e-68,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=64.3979057591623, Blast_Score=278, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=62.9032258064516, Blast_Score=247, Evalue=3e-66,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=62.5, Blast_Score=263, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_XANP2 (A7ILC6)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001418476.1
- ProteinModelPortal:   A7ILC6
- SMR:   A7ILC6
- STRING:   A7ILC6
- MEROPS:   S14.001
- GeneID:   5421767
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_3591
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- ProtClustDB:   CLSK2516786
- BioCyc:   XAUT78245:XAUT_3591-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23435; Mature: 23435

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 107-107 ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPVDTYMNYLIPMVVEQTNRGERSYDIFSRLLKERIIFLTGPVEDGMSTLAVAQLLFL
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHH
EADNPKKEISMYINSPGGVVTSGLAIYDTMQFIKPAVSTLCIGQAASMGSLLLTAGEKDM
CCCCCHHEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCHHCCCCEEEECCCCCC
RFALPNARIMVHQPSGGFQGQVTDIMLHAQEILNLKRRLNEIYVKHTGRSMDKIEDALER
EEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DNFMTAKAALDFGLIDAVIDQRPTDDTSKAA
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRDPVDTYMNYLIPMVVEQTNRGERSYDIFSRLLKERIIFLTGPVEDGMSTLAVAQLLFL
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHH
EADNPKKEISMYINSPGGVVTSGLAIYDTMQFIKPAVSTLCIGQAASMGSLLLTAGEKDM
CCCCCHHEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCHHCCCCEEEECCCCCC
RFALPNARIMVHQPSGGFQGQVTDIMLHAQEILNLKRRLNEIYVKHTGRSMDKIEDALER
EEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DNFMTAKAALDFGLIDAVIDQRPTDDTSKAA
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA