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The map label for this gene is hmgA [H]

Identifier: 154247261

GI number: 154247261

Start: 3707547

End: 3708914

Strand: Reverse

Name: hmgA [H]

Synonym: Xaut_3333

Alternate gene names: 154247261

Gene position: 3708914-3707547 (Counterclockwise)

Preceding gene: 154247263

Following gene: 154247260

Centisome position: 69.86

GC content: 66.89

Gene sequence:

>1368_bases
ATGAACAGTCTGCCCCACCCCCACCTTCAGGGCGCGCCGGTGCGCCACAGCGCGCTCGTGCCCGGCTACATGTCCGGCTT
CGGCAATTCGTTCGAGACCGAGGCGCTGGAAGGCACCTTGCCCATCGGCCGCAACTCGCCGCAGAAGATCAATTACGGGC
TCTATGCCGAGCAGCTCTCCGGCTCGCCCTTCACCGCGCCGCAGGCGGTGAACGAGCGCTCCTGGCTCTACCGCATCCGG
CCCACGGTGAAGCATTCCGGTCGCTACCGCCGCGTGGACAAGGGCCTGATCCGCACCGCGCCCATGGCCCGCGACGAGAG
CGAGTTGACGCTCGGCCAGTACCGCTGGAGCGCGCTCCCGCTACCGCAGGACAAGCGCACCTTCGTTTCGGGCCTTGCCA
CCCTGACCACGGCGGGGGACGCCGATGGCCAGAGCGGCATGGCGGCCCACATGGCCTTCGTCACGGCGTCCATGGAAAAC
GACTATTTCTTCAACGCGGACGGCGAATTGCTGGTGGTGGCGCAGCAGGGGGCGCTGCGCTTCCGCACCGAATTCGGCGT
CATCGACATCGCGCCCGGCGAGATCTGCGTGATCCCGCGCGGCGTGATCTTCAAGGTGGAGCTGATCGACGGGCCGGCCC
GCGCCTATGTCTGCGAGAATTACGGCGCCACCTTCACCCTGCCGGACCGTGGCCCCATCGGCGCCAATTGCCTTGCCAAC
CCGCGCGACTTCCTCACCCCCGTCGCCGCCTACGAGGACCGGGAGGAGCCCTCGCAGCTGTTCGTGAAGTGGGGCGGCGA
ATTGTTCGTCACCGACATCGGCCAGTCGCCCCTCGACGTGGTGGCCTGGCACGGCAATTACGCGCCGTACAAATATGACC
TGCGCACCTTCTCGCCCGTCGGCGCGCTGATGTTCGACCATCCGGACCCGTCCATCTTCACCGTGCTCACCTCGCCGTCG
GGCACGCCGGGCACGGCCAACATCGATTTCGTCATCTTCCCCGAGCGCTGGATGGTGGCGGAGAATACGTTCCGCCCGCC
GTGGTACCACCGTAACATCATGTCCGAATTCATGGGGCTCATCTTCGGCGTCTACGACGCCAAGCCCGAGGGCTTCGAGC
CCGGCGGCTTCTCCCTGCACAACCTCATGCTGCCCCACGGGCCGGACGAGCAGGCCTTCGAGCACGCCTCCACCGGCGAG
CTGAAGCCGGTGAAGCTGGAGAATACGCTGGCCTTCATGTTCGAGACCCGCGTGGCCCAGCGCGTCACCGCCTATGCCGC
CGGCGTGCCGCAGCTCCAGGCCGATTATGTGGACTGCTGGGCCGGCCTGAAGAAGCGCTTCGACCCTACCCGCAAGGATG
CGTGGTGA

Upstream 100 bases:

>100_bases
TTGAGCCGGTAGGGGAGGAAACGTTCGAGGTCGAGGGTGCTCATGGCTTGTTAGTTACATTTTCAACTGTCATGGTCGCA
ACCAAATTCGGGAGCTCGCC

Downstream 100 bases:

>100_bases
GGTGAGGGTCTTCCCCGTCTGACTTTGCCTCCGCGCCGGCGCCGCATCCCGGCGCCGGCCCTTCCTTGCCCCCTGCCCGG
ACCGCTCCCATGATCGACGC

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MNSLPHPHLQGAPVRHSALVPGYMSGFGNSFETEALEGTLPIGRNSPQKINYGLYAEQLSGSPFTAPQAVNERSWLYRIR
PTVKHSGRYRRVDKGLIRTAPMARDESELTLGQYRWSALPLPQDKRTFVSGLATLTTAGDADGQSGMAAHMAFVTASMEN
DYFFNADGELLVVAQQGALRFRTEFGVIDIAPGEICVIPRGVIFKVELIDGPARAYVCENYGATFTLPDRGPIGANCLAN
PRDFLTPVAAYEDREEPSQLFVKWGGELFVTDIGQSPLDVVAWHGNYAPYKYDLRTFSPVGALMFDHPDPSIFTVLTSPS
GTPGTANIDFVIFPERWMVAENTFRPPWYHRNIMSEFMGLIFGVYDAKPEGFEPGGFSLHNLMLPHGPDEQAFEHASTGE
LKPVKLENTLAFMFETRVAQRVTAYAAGVPQLQADYVDCWAGLKKRFDPTRKDAW

Sequences:

>Translated_455_residues
MNSLPHPHLQGAPVRHSALVPGYMSGFGNSFETEALEGTLPIGRNSPQKINYGLYAEQLSGSPFTAPQAVNERSWLYRIR
PTVKHSGRYRRVDKGLIRTAPMARDESELTLGQYRWSALPLPQDKRTFVSGLATLTTAGDADGQSGMAAHMAFVTASMEN
DYFFNADGELLVVAQQGALRFRTEFGVIDIAPGEICVIPRGVIFKVELIDGPARAYVCENYGATFTLPDRGPIGANCLAN
PRDFLTPVAAYEDREEPSQLFVKWGGELFVTDIGQSPLDVVAWHGNYAPYKYDLRTFSPVGALMFDHPDPSIFTVLTSPS
GTPGTANIDFVIFPERWMVAENTFRPPWYHRNIMSEFMGLIFGVYDAKPEGFEPGGFSLHNLMLPHGPDEQAFEHASTGE
LKPVKLENTLAFMFETRVAQRVTAYAAGVPQLQADYVDCWAGLKKRFDPTRKDAW
>Mature_455_residues
MNSLPHPHLQGAPVRHSALVPGYMSGFGNSFETEALEGTLPIGRNSPQKINYGLYAEQLSGSPFTAPQAVNERSWLYRIR
PTVKHSGRYRRVDKGLIRTAPMARDESELTLGQYRWSALPLPQDKRTFVSGLATLTTAGDADGQSGMAAHMAFVTASMEN
DYFFNADGELLVVAQQGALRFRTEFGVIDIAPGEICVIPRGVIFKVELIDGPARAYVCENYGATFTLPDRGPIGANCLAN
PRDFLTPVAAYEDREEPSQLFVKWGGELFVTDIGQSPLDVVAWHGNYAPYKYDLRTFSPVGALMFDHPDPSIFTVLTSPS
GTPGTANIDFVIFPERWMVAENTFRPPWYHRNIMSEFMGLIFGVYDAKPEGFEPGGFSLHNLMLPHGPDEQAFEHASTGE
LKPVKLENTLAFMFETRVAQRVTAYAAGVPQLQADYVDCWAGLKKRFDPTRKDAW

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=440, Percent_Identity=50.2272727272727, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17507969, Length=431, Percent_Identity=50.5800464037123, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24583650, Length=438, Percent_Identity=50.4566210045662, Blast_Score=406, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 50428; Mature: 50428

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLPHPHLQGAPVRHSALVPGYMSGFGNSFETEALEGTLPIGRNSPQKINYGLYAEQLS
CCCCCCCCCCCCCCCCCEECCHHHHHCCCCCCCHHCCCCCCCCCCCCCEEECCEEHHHCC
GSPFTAPQAVNERSWLYRIRPTVKHSGRYRRVDKGLIRTAPMARDESELTLGQYRWSALP
CCCCCCCCCCCCCCEEEEECCCHHCCCCEEHHHCCHHHCCCCCCCCCCCEEEEEEEECCC
LPQDKRTFVSGLATLTTAGDADGQSGMAAHMAFVTASMENDYFFNADGELLVVAQQGALR
CCCCHHHHHHHHHHEEECCCCCCCCCHHEEEEEEEEECCCCEEECCCCCEEEEECCCCEE
FRTEFGVIDIAPGEICVIPRGVIFKVELIDGPARAYVCENYGATFTLPDRGPIGANCLAN
EEEECCEEEECCCCEEEECCCEEEEEEEECCCCEEEEECCCCCEEECCCCCCCCCCCCCC
PRDFLTPVAAYEDREEPSQLFVKWGGELFVTDIGQSPLDVVAWHGNYAPYKYDLRTFSPV
CHHHHCHHHHHCCCCCCHHEEEEECCEEEEEECCCCCCEEEEECCCCCCEEEECEECCCC
GALMFDHPDPSIFTVLTSPSGTPGTANIDFVIFPERWMVAENTFRPPWYHRNIMSEFMGL
CEEEECCCCCCEEEEEECCCCCCCCCEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHH
IFGVYDAKPEGFEPGGFSLHNLMLPHGPDEQAFEHASTGELKPVKLENTLAFMFETRVAQ
HHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHHHCCCCCCCCEEEECCCEEHHHHHHHHH
RVTAYAAGVPQLQADYVDCWAGLKKRFDPTRKDAW
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNSLPHPHLQGAPVRHSALVPGYMSGFGNSFETEALEGTLPIGRNSPQKINYGLYAEQLS
CCCCCCCCCCCCCCCCCEECCHHHHHCCCCCCCHHCCCCCCCCCCCCCEEECCEEHHHCC
GSPFTAPQAVNERSWLYRIRPTVKHSGRYRRVDKGLIRTAPMARDESELTLGQYRWSALP
CCCCCCCCCCCCCCEEEEECCCHHCCCCEEHHHCCHHHCCCCCCCCCCCEEEEEEEECCC
LPQDKRTFVSGLATLTTAGDADGQSGMAAHMAFVTASMENDYFFNADGELLVVAQQGALR
CCCCHHHHHHHHHHEEECCCCCCCCCHHEEEEEEEEECCCCEEECCCCCEEEEECCCCEE
FRTEFGVIDIAPGEICVIPRGVIFKVELIDGPARAYVCENYGATFTLPDRGPIGANCLAN
EEEECCEEEECCCCEEEECCCEEEEEEEECCCCEEEEECCCCCEEECCCCCCCCCCCCCC
PRDFLTPVAAYEDREEPSQLFVKWGGELFVTDIGQSPLDVVAWHGNYAPYKYDLRTFSPV
CHHHHCHHHHHCCCCCCHHEEEEECCEEEEEECCCCCCEEEEECCCCCCEEEECEECCCC
GALMFDHPDPSIFTVLTSPSGTPGTANIDFVIFPERWMVAENTFRPPWYHRNIMSEFMGL
CEEEECCCCCCEEEEEECCCCCCCCCEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHH
IFGVYDAKPEGFEPGGFSLHNLMLPHGPDEQAFEHASTGELKPVKLENTLAFMFETRVAQ
HHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHHHCCCCCCCCEEEECCCEEHHHHHHHHH
RVTAYAAGVPQLQADYVDCWAGLKKRFDPTRKDAW
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA