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The map label for this gene is phoQ [H]

Identifier: 154247106

GI number: 154247106

Start: 3522209

End: 3523636

Strand: Direct

Name: phoQ [H]

Synonym: Xaut_3177

Alternate gene names: 154247106

Gene position: 3522209-3523636 (Clockwise)

Preceding gene: 154247105

Following gene: 154247107

Centisome position: 66.34

GC content: 70.59

Gene sequence:

>1428_bases
ATGGAAACAGCGTCGCGGCCTTCCGAATACGCCCCCGGCTCACTCGCCTTCCGGCTGGTGCTGTCGGCCATGGGCATCAC
CTTGGTGGTGCTGCTGGTGGTGGGATTCGTGCTGTCCTCGCTCTACCGCACCGCCGCCGAGCGCGCCTTCGACCGGCGGC
TCGACGTGTATCTCAAGACCATCGTGGCCGAGGTCGCCAACGCCACCGACGATGCGCTCCCCGAGCCGGTGGCCCTCGGC
GATCCCCTGTTCGCCTTTCCCAATTCCGGCTGGTACTGGCAGATCACCCTCGTTTCCAATGGCGAGCCCCGGCGGCGCAG
CTCGCGCTCGCTGGTGCAGGGCACGCTGCCGCTGCTCGCCGCCCAGGGCATCACCGGCCGGCCCGGCCTCATGCGCCAGG
GCTATGTGAAGGGCCCGCGCGGGGAAGCGCTGCGCCTTGCCGAGCGCGACGTGGATCTCGGCGCCAACGAGCGCTACGTG
GTGTCGGTGGCGGCGGTGGCCTCCGAGCTGGACGAGGAGATTTCCGCCTTCAACCTGGCGCTGGCCGGCACGCTGGTGGT
GCTCGCCTGCGCCTTCCTGCTGGTGGTGATGGTGCAGGTGCGGTTCGGCCTCATGCCGCTGACGCGCATCTCCAAGGTGC
TCGCCGACGTGCGCTCCGGCAAGGCGGAGCGGCTGGACGGCCCCTATCCGGACGAGATCGTGCCGCTGGTGCGGGAGGTC
AACGCCCTCATCGATGCCAACAAGGAGATCGTGGAGCGTGCCCGCACCCATGTGGGCAACCTGGCCCACGCCCTCAAGAC
GCCGCTCTCGGTGCTGATGAACGAGGCCGGCACCAGGGACGATCCCCTCGCCGTCCGGGTGCGCGACCAGGCCGGGGTCA
TGCGCGACCAGGTGGCCCACCACCTGGAGCGCGCGCGCATGGCGGCCCGCGTCTCCATGGTGGCGAGCGTGTGCGAGGTG
ACCCCGGTCATCACCGCGCTGGCCCGCACCATGGAGAAGATCCACCGCACCAAGGACCTCGCCATCGAGGTCCACATCCG
CGACGACGTTCACTTCCGCGGCGAGCAGCAGGACCTGGAGGAGATGGTGGGCAACCTCGTGGACAATGCCTGCAAGTGGG
CCTCGTCCCGGGTCGAGCTGGAGGTCTGCGTCGGCCAGCCCAAGTCCCCCGGCGACCGGGTGTTCTTCCACGTCATCATC
GACGACGACGGGCCGGGGCTCGACCCGGCGCGTCGGGTCGACGTGGGCCGGCGCGGGCGGCGGCTCGACGAATCGAAGCC
GGGTTCCGGGCTCGGCCTGTCCATCGTGCACGAACTGGCGCTGCTCTACGGCGGCCGCTTCGAGCTGAGTTCCGCGCCCA
TCGGTGGCCTGCGCACTGAACTGGTGCTGCCGGCCGCCGCGCCGCCACCGCCGGCCGCCGCCTCGTGA

Upstream 100 bases:

>100_bases
GCCTGCGCAAGAAGCTCGACTGCGACGTGATCCAGACCGTGCGCGGCCTCGGCTATCTGCTGGCCGCGCCGGAGGGGCAG
CGCTAAGGCGCGCAACGATC

Downstream 100 bases:

>100_bases
AGGGTGCTGCCGCGCTACAGCTGCCCCGCTGCGCTCCAGTGACGCGCCCGTGGCGGCCGTGTCGCGAAGGCTGTTTTCAG
GCGGCCCGCGACCGCTTAAG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
METASRPSEYAPGSLAFRLVLSAMGITLVVLLVVGFVLSSLYRTAAERAFDRRLDVYLKTIVAEVANATDDALPEPVALG
DPLFAFPNSGWYWQITLVSNGEPRRRSSRSLVQGTLPLLAAQGITGRPGLMRQGYVKGPRGEALRLAERDVDLGANERYV
VSVAAVASELDEEISAFNLALAGTLVVLACAFLLVVMVQVRFGLMPLTRISKVLADVRSGKAERLDGPYPDEIVPLVREV
NALIDANKEIVERARTHVGNLAHALKTPLSVLMNEAGTRDDPLAVRVRDQAGVMRDQVAHHLERARMAARVSMVASVCEV
TPVITALARTMEKIHRTKDLAIEVHIRDDVHFRGEQQDLEEMVGNLVDNACKWASSRVELEVCVGQPKSPGDRVFFHVII
DDDGPGLDPARRVDVGRRGRRLDESKPGSGLGLSIVHELALLYGGRFELSSAPIGGLRTELVLPAAAPPPPAAAS

Sequences:

>Translated_475_residues
METASRPSEYAPGSLAFRLVLSAMGITLVVLLVVGFVLSSLYRTAAERAFDRRLDVYLKTIVAEVANATDDALPEPVALG
DPLFAFPNSGWYWQITLVSNGEPRRRSSRSLVQGTLPLLAAQGITGRPGLMRQGYVKGPRGEALRLAERDVDLGANERYV
VSVAAVASELDEEISAFNLALAGTLVVLACAFLLVVMVQVRFGLMPLTRISKVLADVRSGKAERLDGPYPDEIVPLVREV
NALIDANKEIVERARTHVGNLAHALKTPLSVLMNEAGTRDDPLAVRVRDQAGVMRDQVAHHLERARMAARVSMVASVCEV
TPVITALARTMEKIHRTKDLAIEVHIRDDVHFRGEQQDLEEMVGNLVDNACKWASSRVELEVCVGQPKSPGDRVFFHVII
DDDGPGLDPARRVDVGRRGRRLDESKPGSGLGLSIVHELALLYGGRFELSSAPIGGLRTELVLPAAAPPPPAAAS
>Mature_475_residues
METASRPSEYAPGSLAFRLVLSAMGITLVVLLVVGFVLSSLYRTAAERAFDRRLDVYLKTIVAEVANATDDALPEPVALG
DPLFAFPNSGWYWQITLVSNGEPRRRSSRSLVQGTLPLLAAQGITGRPGLMRQGYVKGPRGEALRLAERDVDLGANERYV
VSVAAVASELDEEISAFNLALAGTLVVLACAFLLVVMVQVRFGLMPLTRISKVLADVRSGKAERLDGPYPDEIVPLVREV
NALIDANKEIVERARTHVGNLAHALKTPLSVLMNEAGTRDDPLAVRVRDQAGVMRDQVAHHLERARMAARVSMVASVCEV
TPVITALARTMEKIHRTKDLAIEVHIRDDVHFRGEQQDLEEMVGNLVDNACKWASSRVELEVCVGQPKSPGDRVFFHVII
DDDGPGLDPARRVDVGRRGRRLDESKPGSGLGLSIVHELALLYGGRFELSSAPIGGLRTELVLPAAAPPPPAAAS

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=300, Percent_Identity=27.3333333333333, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1787894, Length=248, Percent_Identity=27.4193548387097, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789403, Length=300, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51450; Mature: 51450

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METASRPSEYAPGSLAFRLVLSAMGITLVVLLVVGFVLSSLYRTAAERAFDRRLDVYLKT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVAEVANATDDALPEPVALGDPLFAFPNSGWYWQITLVSNGEPRRRSSRSLVQGTLPLLA
HHHHHHCCCHHCCCCCCCCCCCCEECCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
AQGITGRPGLMRQGYVKGPRGEALRLAERDVDLGANERYVVSVAAVASELDEEISAFNLA
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
LAGTLVVLACAFLLVVMVQVRFGLMPLTRISKVLADVRSGKAERLDGPYPDEIVPLVREV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHH
NALIDANKEIVERARTHVGNLAHALKTPLSVLMNEAGTRDDPLAVRVRDQAGVMRDQVAH
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHH
HLERARMAARVSMVASVCEVTPVITALARTMEKIHRTKDLAIEVHIRDDVHFRGEQQDLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHH
EMVGNLVDNACKWASSRVELEVCVGQPKSPGDRVFFHVIIDDDGPGLDPARRVDVGRRGR
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCCCCHHHHCCCCCCCC
RLDESKPGSGLGLSIVHELALLYGGRFELSSAPIGGLRTELVLPAAAPPPPAAAS
CCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCHHEEECCCCCCCCCCCC
>Mature Secondary Structure
METASRPSEYAPGSLAFRLVLSAMGITLVVLLVVGFVLSSLYRTAAERAFDRRLDVYLKT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVAEVANATDDALPEPVALGDPLFAFPNSGWYWQITLVSNGEPRRRSSRSLVQGTLPLLA
HHHHHHCCCHHCCCCCCCCCCCCEECCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
AQGITGRPGLMRQGYVKGPRGEALRLAERDVDLGANERYVVSVAAVASELDEEISAFNLA
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
LAGTLVVLACAFLLVVMVQVRFGLMPLTRISKVLADVRSGKAERLDGPYPDEIVPLVREV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHH
NALIDANKEIVERARTHVGNLAHALKTPLSVLMNEAGTRDDPLAVRVRDQAGVMRDQVAH
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHH
HLERARMAARVSMVASVCEVTPVITALARTMEKIHRTKDLAIEVHIRDDVHFRGEQQDLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHH
EMVGNLVDNACKWASSRVELEVCVGQPKSPGDRVFFHVIIDDDGPGLDPARRVDVGRRGR
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCCCCHHHHCCCCCCCC
RLDESKPGSGLGLSIVHELALLYGGRFELSSAPIGGLRTELVLPAAAPPPPAAAS
CCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCHHEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA