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The map label for this gene is phoP [H]

Identifier: 154247105

GI number: 154247105

Start: 3521523

End: 3522194

Strand: Direct

Name: phoP [H]

Synonym: Xaut_3176

Alternate gene names: 154247105

Gene position: 3521523-3522194 (Clockwise)

Preceding gene: 154247104

Following gene: 154247106

Centisome position: 66.33

GC content: 68.15

Gene sequence:

>672_bases
GTGCGTCTTTTGGTGGTCGAGGACGATCCCGAGCTGAACCGACAGCTGGTCGAGGCCCTGTCCGACGCGGGCTATGCGGT
GGATCGCGCCTATGACGGCGAGGAGGGGCAGTATCTGGGCGAGACCGAGCCCTACGACGCCATCGTCCTCGACATCGGCC
TGCCCAAGCTCGACGGCATCTCGGTGCTGGAGAGCTGGCGCCGCGCCGGCAAGGTCACGCCGGTGCTGATCCTCACCGCC
CGCGATCGCTGGAGCGACAAGGTGCAGGGCTTCGATGCCGGCGCCGACGACTATGTGGCCAAGCCGTTCCACATGGAGGA
GGTTCTGGCCCGCCTGCGCGCCCTGCTGCGCCGCGCCTCCGGCCACGCTTCCAGCGAGATGACCTGCGGGCCGGTGCGGC
TCGACACCCGCTCCGGCCGGGTCACGGTGGAGGGCACTGCGGTCAAGCTCACCTCCCATGAATACCGGCTGCTGAGCTAT
CTCATGCACCATGCCGGGCGCGTGGTGTCGCGCGGGGAGCTGGTGGAGCACCTCTACGACCAGGATTTCGATCGCGATTC
CAACACCATCGAGGTGTTCGTCGGGCGCCTGCGCAAGAAGCTCGACTGCGACGTGATCCAGACCGTGCGCGGCCTCGGCT
ATCTGCTGGCCGCGCCGGAGGGGCAGCGCTAA

Upstream 100 bases:

>100_bases
AGCCGGGCGGCGCGGAATGAAAACGTTATCCCTCCAAAAGGGGGATGCCGGCCGGCTGGCGCGTGATCTAAGAGGTGGAA
GCCGAAGCCGGAGGAAACCT

Downstream 100 bases:

>100_bases
GGCGCGCAACGATCATGGAAACAGCGTCGCGGCCTTCCGAATACGCCCCCGGCTCACTCGCCTTCCGGCTGGTGCTGTCG
GCCATGGGCATCACCTTGGT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRLLVVEDDPELNRQLVEALSDAGYAVDRAYDGEEGQYLGETEPYDAIVLDIGLPKLDGISVLESWRRAGKVTPVLILTA
RDRWSDKVQGFDAGADDYVAKPFHMEEVLARLRALLRRASGHASSEMTCGPVRLDTRSGRVTVEGTAVKLTSHEYRLLSY
LMHHAGRVVSRGELVEHLYDQDFDRDSNTIEVFVGRLRKKLDCDVIQTVRGLGYLLAAPEGQR

Sequences:

>Translated_223_residues
MRLLVVEDDPELNRQLVEALSDAGYAVDRAYDGEEGQYLGETEPYDAIVLDIGLPKLDGISVLESWRRAGKVTPVLILTA
RDRWSDKVQGFDAGADDYVAKPFHMEEVLARLRALLRRASGHASSEMTCGPVRLDTRSGRVTVEGTAVKLTSHEYRLLSY
LMHHAGRVVSRGELVEHLYDQDFDRDSNTIEVFVGRLRKKLDCDVIQTVRGLGYLLAAPEGQR
>Mature_223_residues
MRLLVVEDDPELNRQLVEALSDAGYAVDRAYDGEEGQYLGETEPYDAIVLDIGLPKLDGISVLESWRRAGKVTPVLILTA
RDRWSDKVQGFDAGADDYVAKPFHMEEVLARLRALLRRASGHASSEMTCGPVRLDTRSGRVTVEGTAVKLTSHEYRLLSY
LMHHAGRVVSRGELVEHLYDQDFDRDSNTIEVFVGRLRKKLDCDVIQTVRGLGYLLAAPEGQR

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=45.2488687782805, Blast_Score=186, Evalue=7e-49,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=42.7312775330396, Blast_Score=182, Evalue=1e-47,
Organism=Escherichia coli, GI1789402, Length=217, Percent_Identity=45.1612903225806, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=39.9103139013453, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=43.1818181818182, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=34.3891402714932, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=35.3982300884956, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=36.3636363636364, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=32.4786324786325, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=34.2465753424658, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=33.9130434782609, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=30.3571428571429, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=28.6343612334802, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=27.1551724137931, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=169, Percent_Identity=27.2189349112426, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24957; Mature: 24957

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVVEDDPELNRQLVEALSDAGYAVDRAYDGEEGQYLGETEPYDAIVLDIGLPKLDGI
CEEEEECCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
SVLESWRRAGKVTPVLILTARDRWSDKVQGFDAGADDYVAKPFHMEEVLARLRALLRRAS
HHHHHHHHCCCCCEEEEEEECCCCHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHC
GHASSEMTCGPVRLDTRSGRVTVEGTAVKLTSHEYRLLSYLMHHAGRVVSRGELVEHLYD
CCCCCCCCCCCEEEECCCCEEEEECEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKLDCDVIQTVRGLGYLLAAPEGQR
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCEEEEECCCCCC
>Mature Secondary Structure
MRLLVVEDDPELNRQLVEALSDAGYAVDRAYDGEEGQYLGETEPYDAIVLDIGLPKLDGI
CEEEEECCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
SVLESWRRAGKVTPVLILTARDRWSDKVQGFDAGADDYVAKPFHMEEVLARLRALLRRAS
HHHHHHHHCCCCCEEEEEEECCCCHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHC
GHASSEMTCGPVRLDTRSGRVTVEGTAVKLTSHEYRLLSYLMHHAGRVVSRGELVEHLYD
CCCCCCCCCCCEEEECCCCEEEEECEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKLDCDVIQTVRGLGYLLAAPEGQR
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA