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The map label for this gene is gmk

Identifier: 154247065

GI number: 154247065

Start: 3479034

End: 3479729

Strand: Direct

Name: gmk

Synonym: Xaut_3136

Alternate gene names: 154247065

Gene position: 3479034-3479729 (Clockwise)

Preceding gene: 154247064

Following gene: 154247066

Centisome position: 65.53

GC content: 67.24

Gene sequence:

>696_bases
ATGCCGCAATCCGCCTCTTCCTCCGTGTCGTCGCACTTCGCGCTGCCGGGCTGGAAGCCGGGCGCGGGTATCCTCGCGCG
GCGCGGGCTGATGCTGGTGCTGTCCTCGCCATCGGGCGCAGGCAAGACCACCCTGTCGCGCAAGCTGCTGGCGAGCGACG
ATCGAATCACCATGTCCGTGTCCGTCACCACGCGGCCGCCCCGGCCGGGCGAGGTGGAGGGCAAGGACTATTATTTCGTG
GACGTGCCCACCTTCCACCGCATGCGGGACGAGGGCGAACTGCTGGAGCACGCGGTGGTGTTCGACAATCTCTACGGCAC
GCCGCGCCCCGCCGTGGAACTGGCCCTATCCGCCGGCCGGGACGTGCTGTTCGACATCGACTGGCAGGGCACCCAGCAGT
TGGGCGAGACCGCCCAGCAGGACCTGGTGAAAGTCTTCCTGTTGCCGCCCACCGCCGCGGACCTTGAGCAGCGCCTGCGC
TCCCGCGCTCAGGATTCGGAAGAGGTGGTGCACCAGCGCATGGCCAAGGCCTCCGACGAGATCAGCCACTATACCGAATA
CGACTACATCATCATCAACCACGAGGTGGACGACAGCCTCGTCAAGCTCACCGCCATCCTGCAGGCGGAACGGCTGAAGC
GCCGGCGCCTGACCGGCCTGTCGAGCTTCGTGAAGGGCCTGCGCGACGCCCTGTGA

Upstream 100 bases:

>100_bases
AGTCCAATTCCGTGGCGCTGACGCAGATCGGGCTTGACCTGAAGCTGCTGGTGGACCAGTTCCGCGAGCAGATCCAGAAC
CTCGAGTGAAGCCCGAACCC

Downstream 100 bases:

>100_bases
GGCGTTCCATCGCGAGATGCCCGCCTGTCCGCGACAGGCCGTCGCGCCTGCGCCAATTCCCGCACACATTTGAGCAACGA
ACGCCCCGTGCCCGGCAGCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MPQSASSSVSSHFALPGWKPGAGILARRGLMLVLSSPSGAGKTTLSRKLLASDDRITMSVSVTTRPPRPGEVEGKDYYFV
DVPTFHRMRDEGELLEHAVVFDNLYGTPRPAVELALSAGRDVLFDIDWQGTQQLGETAQQDLVKVFLLPPTAADLEQRLR
SRAQDSEEVVHQRMAKASDEISHYTEYDYIIINHEVDDSLVKLTAILQAERLKRRRLTGLSSFVKGLRDAL

Sequences:

>Translated_231_residues
MPQSASSSVSSHFALPGWKPGAGILARRGLMLVLSSPSGAGKTTLSRKLLASDDRITMSVSVTTRPPRPGEVEGKDYYFV
DVPTFHRMRDEGELLEHAVVFDNLYGTPRPAVELALSAGRDVLFDIDWQGTQQLGETAQQDLVKVFLLPPTAADLEQRLR
SRAQDSEEVVHQRMAKASDEISHYTEYDYIIINHEVDDSLVKLTAILQAERLKRRRLTGLSSFVKGLRDAL
>Mature_230_residues
PQSASSSVSSHFALPGWKPGAGILARRGLMLVLSSPSGAGKTTLSRKLLASDDRITMSVSVTTRPPRPGEVEGKDYYFVD
VPTFHRMRDEGELLEHAVVFDNLYGTPRPAVELALSAGRDVLFDIDWQGTQQLGETAQQDLVKVFLLPPTAADLEQRLRS
RAQDSEEVVHQRMAKASDEISHYTEYDYIIINHEVDDSLVKLTAILQAERLKRRRLTGLSSFVKGLRDAL

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=194, Percent_Identity=40.2061855670103, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI4504221, Length=194, Percent_Identity=40.2061855670103, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI226874831, Length=194, Percent_Identity=40.2061855670103, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI262118259, Length=173, Percent_Identity=29.4797687861272, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI262118255, Length=173, Percent_Identity=29.4797687861272, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4505237, Length=173, Percent_Identity=29.4797687861272, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI262118263, Length=173, Percent_Identity=29.4797687861272, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI38570142, Length=192, Percent_Identity=25.5208333333333, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=191, Percent_Identity=48.1675392670157, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17508835, Length=198, Percent_Identity=31.3131313131313, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI193203132, Length=182, Percent_Identity=32.4175824175824, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71984092, Length=183, Percent_Identity=27.3224043715847, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=36.9565217391304, Blast_Score=125, Evalue=7e-30,
Organism=Drosophila melanogaster, GI21356141, Length=194, Percent_Identity=34.5360824742268, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25646; Mature: 25515

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQSASSSVSSHFALPGWKPGAGILARRGLMLVLSSPSGAGKTTLSRKLLASDDRITMSV
CCCCCCCHHHHCCCCCCCCCCCHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEE
SVTTRPPRPGEVEGKDYYFVDVPTFHRMRDEGELLEHAVVFDNLYGTPRPAVELALSAGR
EEEECCCCCCCCCCCEEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
DVLFDIDWQGTQQLGETAQQDLVKVFLLPPTAADLEQRLRSRAQDSEEVVHQRMAKASDE
EEEEEECCCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ISHYTEYDYIIINHEVDDSLVKLTAILQAERLKRRRLTGLSSFVKGLRDAL
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PQSASSSVSSHFALPGWKPGAGILARRGLMLVLSSPSGAGKTTLSRKLLASDDRITMSV
CCCCCCHHHHCCCCCCCCCCCHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEE
SVTTRPPRPGEVEGKDYYFVDVPTFHRMRDEGELLEHAVVFDNLYGTPRPAVELALSAGR
EEEECCCCCCCCCCCEEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
DVLFDIDWQGTQQLGETAQQDLVKVFLLPPTAADLEQRLRSRAQDSEEVVHQRMAKASDE
EEEEEECCCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ISHYTEYDYIIINHEVDDSLVKLTAILQAERLKRRRLTGLSSFVKGLRDAL
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA