Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 154247062

GI number: 154247062

Start: 3475090

End: 3476352

Strand: Direct

Name: fabF [H]

Synonym: Xaut_3133

Alternate gene names: 154247062

Gene position: 3475090-3476352 (Clockwise)

Preceding gene: 154247061

Following gene: 154247063

Centisome position: 65.46

GC content: 67.38

Gene sequence:

>1263_bases
ATGAGACGTGTTGTCGTCACCGGCCTCGGCATGGTGACGCCGCTCGGCTGCGGCGTCGAGCCGACCTGGCGGCGGCTCAT
CGCCGGCGAGAGCGGCGTGAAGGCGGTCAGCCATTTCGAAGTGGCAGACCTCGCCTGCAAGATCGCCGCGAATGTTCCGC
GCGGTGATGGTTCCGACGGGACCTTCAATCCCGACCAGTGGATGGAGCCGAAAGAGCAGCGCAAGGTGGACGAGTTCATC
GTCTATGCCATGGCTGCCGCGACCCAGGCGCTGGATGACGCCGGCTGGCACCCATCCTCCTACGAGGACCAGATCAACAC
CGGCGTGCTCATCGGCTCCGGCATCGGCGGCATCGAAGGCATCGCCGAATCAGCCCTGCTGCTCAAGGAGCGCGGGCCGA
GACGCATCTCGCCCTTCTTCATTCCCGGCCGTCTCATCAATCTGGCCGGCGGCTACGTCTCCATCACCCACGGGCTGAAG
GGGCCGAACCACGCCGTGGTTACGGCCTGCTCCACCGGCGCCCATGCCATCGGCGATGCCGGGCGGCTCATCGCGCTGGG
GGATGCGGACGTGATGGTGGCCGGCGGCACCGAATCGACGGTCAACCGCCTGGCGTTGGCCGGCTTTGCCGCCTGCAAGG
CGCTCTGCACCGCTTTCAACGACGACCCCACCCGCGCCTCGCGCCCCTATGACAAGGACCGCGACGGCTTCGTGATGGGT
GAGGGCGCCGGCGTGGTGGTGCTTGAGGAGCTCGAGCATGCCAAGGCGCGCGGCGCGCGCATCTATGCGGAACTGGTGGG
CTACGGCCTGTCGGGCGACGCCTTCCACATCACCGCCCCCTCGCCGGACGGCGACGGCGCCTTCCGCTGCATGCAGGCGG
CTCTGAAGCGGGCGGGCCTGACGGCGGGCGACATCGACTACATCAACGCCCATGGCACCTCCACCATGGCTGACGAGATC
GAGCTGAAGGCGGTGGAACGGCTGCTCGGCAATGCCGCGGCGACCACCTCCATGTCGTCCACCAAGTCGTCCATCGGTCA
CCTGCTCGGGGCCGCCGGCGCGGTGGAGGCGATCTTCTCCGTCCTTGCCATCCGCGACCAGATCGCCCCGGCGACGCTCA
ATCTCGACAATCCGTCGGTGGAGACTCCCATCGATCTGGTTCCGCTCAAGGCGAAGCCGCGCAAGATCGATGCCGTGCTC
TCCAATTCCTTCGGGTTCGGCGGGACCAACGCATCCCTCATCTTCCAGCGCTTCGACGCCTGA

Upstream 100 bases:

>100_bases
CTGTTCATTCGACGGTCGCGCGGCGCTTGGCGCCCGCGGCCGTTGTCGCACCGGGTCGCGCGCAAGCCGCGCCAATGGCC
CGCCTGCCGGAGTTTTTCCC

Downstream 100 bases:

>100_bases
TGCTGCGCCGGCCGGGGCCTTGCCCCGACCGGTCCTTGCCCCGGTTGTCTCCTGCCTCAGCTTCGGGCTCGCCGCCGGAC
GCCGCCGCCCGGTCGAAGGG

Product: Beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MRRVVVTGLGMVTPLGCGVEPTWRRLIAGESGVKAVSHFEVADLACKIAANVPRGDGSDGTFNPDQWMEPKEQRKVDEFI
VYAMAAATQALDDAGWHPSSYEDQINTGVLIGSGIGGIEGIAESALLLKERGPRRISPFFIPGRLINLAGGYVSITHGLK
GPNHAVVTACSTGAHAIGDAGRLIALGDADVMVAGGTESTVNRLALAGFAACKALCTAFNDDPTRASRPYDKDRDGFVMG
EGAGVVVLEELEHAKARGARIYAELVGYGLSGDAFHITAPSPDGDGAFRCMQAALKRAGLTAGDIDYINAHGTSTMADEI
ELKAVERLLGNAAATTSMSSTKSSIGHLLGAAGAVEAIFSVLAIRDQIAPATLNLDNPSVETPIDLVPLKAKPRKIDAVL
SNSFGFGGTNASLIFQRFDA

Sequences:

>Translated_420_residues
MRRVVVTGLGMVTPLGCGVEPTWRRLIAGESGVKAVSHFEVADLACKIAANVPRGDGSDGTFNPDQWMEPKEQRKVDEFI
VYAMAAATQALDDAGWHPSSYEDQINTGVLIGSGIGGIEGIAESALLLKERGPRRISPFFIPGRLINLAGGYVSITHGLK
GPNHAVVTACSTGAHAIGDAGRLIALGDADVMVAGGTESTVNRLALAGFAACKALCTAFNDDPTRASRPYDKDRDGFVMG
EGAGVVVLEELEHAKARGARIYAELVGYGLSGDAFHITAPSPDGDGAFRCMQAALKRAGLTAGDIDYINAHGTSTMADEI
ELKAVERLLGNAAATTSMSSTKSSIGHLLGAAGAVEAIFSVLAIRDQIAPATLNLDNPSVETPIDLVPLKAKPRKIDAVL
SNSFGFGGTNASLIFQRFDA
>Mature_420_residues
MRRVVVTGLGMVTPLGCGVEPTWRRLIAGESGVKAVSHFEVADLACKIAANVPRGDGSDGTFNPDQWMEPKEQRKVDEFI
VYAMAAATQALDDAGWHPSSYEDQINTGVLIGSGIGGIEGIAESALLLKERGPRRISPFFIPGRLINLAGGYVSITHGLK
GPNHAVVTACSTGAHAIGDAGRLIALGDADVMVAGGTESTVNRLALAGFAACKALCTAFNDDPTRASRPYDKDRDGFVMG
EGAGVVVLEELEHAKARGARIYAELVGYGLSGDAFHITAPSPDGDGAFRCMQAALKRAGLTAGDIDYINAHGTSTMADEI
ELKAVERLLGNAAATTSMSSTKSSIGHLLGAAGAVEAIFSVLAIRDQIAPATLNLDNPSVETPIDLVPLKAKPRKIDAVL
SNSFGFGGTNASLIFQRFDA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=54.0865384615385, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI223972627, Length=193, Percent_Identity=47.6683937823834, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI41872631, Length=439, Percent_Identity=25.9681093394077, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1787337, Length=419, Percent_Identity=51.7899761336515, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1788663, Length=420, Percent_Identity=35.4761904761905, Blast_Score=242, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=39.8584905660377, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=44.7368421052632, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI212642053, Length=360, Percent_Identity=25.8333333333333, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=273, Percent_Identity=26.7399267399267, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=40.2684563758389, Blast_Score=298, Evalue=8e-82,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=46.3182897862233, Blast_Score=347, Evalue=7e-96,
Organism=Drosophila melanogaster, GI221330659, Length=358, Percent_Identity=24.3016759776536, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19920632, Length=358, Percent_Identity=24.3016759776536, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24581345, Length=356, Percent_Identity=25, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43789; Mature: 43789

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGMVTPLGCGVEPTWRRLIAGESGVKAVSHFEVADLACKIAANVPRGDGSDG
CCEEEEECCCHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
TFNPDQWMEPKEQRKVDEFIVYAMAAATQALDDAGWHPSSYEDQINTGVLIGSGIGGIEG
CCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCHHH
IAESALLLKERGPRRISPFFIPGRLINLAGGYVSITHGLKGPNHAVVTACSTGAHAIGDA
HHHHHHHHHHCCCCCCCCEECCCCCEECCCCEEEEECCCCCCCCEEEEEECCCCCCCCCC
GRLIALGDADVMVAGGTESTVNRLALAGFAACKALCTAFNDDPTRASRPYDKDRDGFVMG
CCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEE
EGAGVVVLEELEHAKARGARIYAELVGYGLSGDAFHITAPSPDGDGAFRCMQAALKRAGL
CCCCEEEEHHHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
TAGDIDYINAHGTSTMADEIELKAVERLLGNAAATTSMSSTKSSIGHLLGAAGAVEAIFS
CCCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
VLAIRDQIAPATLNLDNPSVETPIDLVPLKAKPRKIDAVLSNSFGFGGTNASLIFQRFDA
HHHHHHHCCCEEEECCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCCCHHEEEEECCC
>Mature Secondary Structure
MRRVVVTGLGMVTPLGCGVEPTWRRLIAGESGVKAVSHFEVADLACKIAANVPRGDGSDG
CCEEEEECCCHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
TFNPDQWMEPKEQRKVDEFIVYAMAAATQALDDAGWHPSSYEDQINTGVLIGSGIGGIEG
CCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCHHH
IAESALLLKERGPRRISPFFIPGRLINLAGGYVSITHGLKGPNHAVVTACSTGAHAIGDA
HHHHHHHHHHCCCCCCCCEECCCCCEECCCCEEEEECCCCCCCCEEEEEECCCCCCCCCC
GRLIALGDADVMVAGGTESTVNRLALAGFAACKALCTAFNDDPTRASRPYDKDRDGFVMG
CCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEE
EGAGVVVLEELEHAKARGARIYAELVGYGLSGDAFHITAPSPDGDGAFRCMQAALKRAGL
CCCCEEEEHHHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
TAGDIDYINAHGTSTMADEIELKAVERLLGNAAATTSMSSTKSSIGHLLGAAGAVEAIFS
CCCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
VLAIRDQIAPATLNLDNPSVETPIDLVPLKAKPRKIDAVLSNSFGFGGTNASLIFQRFDA
HHHHHHHCCCEEEECCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCCCCCHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]