Click here to switch to the map view.

The map label for this gene is hemF [H]

Identifier: 154246889

GI number: 154246889

Start: 3279965

End: 3280912

Strand: Reverse

Name: hemF [H]

Synonym: Xaut_2954

Alternate gene names: 154246889

Gene position: 3280912-3279965 (Counterclockwise)

Preceding gene: 154246890

Following gene: 154246888

Centisome position: 61.8

GC content: 68.67

Gene sequence:

>948_bases
ATGTGCCCCTCGACCTCAGCGCCCGACGCGGCGTCCGCACCCGAAGCCGCCGGCGATGGGATCCTGGAGGAGCGACGCAG
CCGCGCCCGCTGCTGGTTCGAGGACCTGCAGGGCCGCATCATCGCCGCCTTCGAGGCGCTGGAGAATGAGGCGGACGCCG
CCCTCTATGCCGGCGCGCCCGGCCGATTCGCCCGCACCCCGTGGTCGCGCACCGACCATACGGGCGCGCCAGGCGGCGGC
GGCACCATGGCGCTCATGCGCGGACGCCTGTTCGAGAAGGTGGGGGTGCACACCTCCACCGTGTTCGGGGAGTTCGCACC
CGAATTCCGCAGCCAGATCCCCGGCGCGGCGGAGGATCCGCGCTTCTGGGCGTCGGGCATCTCCCTCATTGCCCACATGG
CCAACCCGCACGTGCCCGCGGTGCACATGAACACGCGCTTCGTGGTCACCACCAAGGCATGGTTCGGCGGCGGCGCCGAC
CTTACCCCCGTGCTCGACCGCCGCCGCACCCAGGACGACCCGGACACGGTAGCCTTCCACGCCGCCATGGCAGGTGCCTG
CACCGCCCACACGGTGGCCGACTACGCGCGCTACAAGACGTGGTGCGACGACTATTTCTTCCTGAAGCACAGGAACGAGA
TGCGCGGCATCGGCGGCATCTTCTACGATTATCTCGACAGCGCCTCCTCCGGCACCGGGACCTGGGACAACGATTTCGCC
TTTACCCGCGACGTGGGGCTCGCCTTCCTCGACATCTATCCGAAGCTGGTACGGGCCAACATGGGCCAGCCGTGGAGCGC
GGCGGACCGCGAGGAACAGCTGGTGCGGCGCGGGCGCTATGTGGAATTCAACCTGCTGTACGACCGGGGCACCATTTTCG
GCCTGAAGACCGGCGGCAACGTGGATTCGATCCTCTCCTCCATGCCGCCGGTGGTGAAGTGGCCGTGA

Upstream 100 bases:

>100_bases
CCGGCGCCTGCCGCCTTGCTTTCTTCCGCCGCGCCGAAGCGATAAAAGCCCGAACCAACAAGATCTGGTCCCAAGGCGAT
CAAGACAGGCGGAGCGCCCC

Downstream 100 bases:

>100_bases
TCGGCCCGTCATGAACGCCGGCTAAGGCTGCCCGGCGGCGTCGCGCATCGACGACAGCGGGAGACTGAAGCCATGGCGTT
CGCGCCCGGAGATATCGTTC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MCPSTSAPDAASAPEAAGDGILEERRSRARCWFEDLQGRIIAAFEALENEADAALYAGAPGRFARTPWSRTDHTGAPGGG
GTMALMRGRLFEKVGVHTSTVFGEFAPEFRSQIPGAAEDPRFWASGISLIAHMANPHVPAVHMNTRFVVTTKAWFGGGAD
LTPVLDRRRTQDDPDTVAFHAAMAGACTAHTVADYARYKTWCDDYFFLKHRNEMRGIGGIFYDYLDSASSGTGTWDNDFA
FTRDVGLAFLDIYPKLVRANMGQPWSAADREEQLVRRGRYVEFNLLYDRGTIFGLKTGGNVDSILSSMPPVVKWP

Sequences:

>Translated_315_residues
MCPSTSAPDAASAPEAAGDGILEERRSRARCWFEDLQGRIIAAFEALENEADAALYAGAPGRFARTPWSRTDHTGAPGGG
GTMALMRGRLFEKVGVHTSTVFGEFAPEFRSQIPGAAEDPRFWASGISLIAHMANPHVPAVHMNTRFVVTTKAWFGGGAD
LTPVLDRRRTQDDPDTVAFHAAMAGACTAHTVADYARYKTWCDDYFFLKHRNEMRGIGGIFYDYLDSASSGTGTWDNDFA
FTRDVGLAFLDIYPKLVRANMGQPWSAADREEQLVRRGRYVEFNLLYDRGTIFGLKTGGNVDSILSSMPPVVKWP
>Mature_315_residues
MCPSTSAPDAASAPEAAGDGILEERRSRARCWFEDLQGRIIAAFEALENEADAALYAGAPGRFARTPWSRTDHTGAPGGG
GTMALMRGRLFEKVGVHTSTVFGEFAPEFRSQIPGAAEDPRFWASGISLIAHMANPHVPAVHMNTRFVVTTKAWFGGGAD
LTPVLDRRRTQDDPDTVAFHAAMAGACTAHTVADYARYKTWCDDYFFLKHRNEMRGIGGIFYDYLDSASSGTGTWDNDFA
FTRDVGLAFLDIYPKLVRANMGQPWSAADREEQLVRRGRYVEFNLLYDRGTIFGLKTGGNVDSILSSMPPVVKWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=289, Percent_Identity=38.4083044982699, Blast_Score=182, Evalue=3e-46,
Organism=Escherichia coli, GI1788777, Length=278, Percent_Identity=41.3669064748201, Blast_Score=195, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6320249, Length=304, Percent_Identity=37.5, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17864388, Length=308, Percent_Identity=39.2857142857143, Blast_Score=196, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34586; Mature: 34586

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCPSTSAPDAASAPEAAGDGILEERRSRARCWFEDLQGRIIAAFEALENEADAALYAGAP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEECCC
GRFARTPWSRTDHTGAPGGGGTMALMRGRLFEKVGVHTSTVFGEFAPEFRSQIPGAAEDP
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
RFWASGISLIAHMANPHVPAVHMNTRFVVTTKAWFGGGADLTPVLDRRRTQDDPDTVAFH
HHHHHHHHHHHHHCCCCCCEEEECCEEEEEEEHCCCCCCCCCHHHHHHCCCCCCHHHHHH
AAMAGACTAHTVADYARYKTWCDDYFFLKHRNEMRGIGGIFYDYLDSASSGTGTWDNDFA
HHHHHHHHHHHHHHHHHHHHHHCCHHEEHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
FTRDVGLAFLDIYPKLVRANMGQPWSAADREEQLVRRGRYVEFNLLYDRGTIFGLKTGGN
EHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEEEEEECCEEEEEECCCC
VDSILSSMPPVVKWP
HHHHHHHCCCCCCCC
>Mature Secondary Structure
MCPSTSAPDAASAPEAAGDGILEERRSRARCWFEDLQGRIIAAFEALENEADAALYAGAP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEECCC
GRFARTPWSRTDHTGAPGGGGTMALMRGRLFEKVGVHTSTVFGEFAPEFRSQIPGAAEDP
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
RFWASGISLIAHMANPHVPAVHMNTRFVVTTKAWFGGGADLTPVLDRRRTQDDPDTVAFH
HHHHHHHHHHHHHCCCCCCEEEECCEEEEEEEHCCCCCCCCCHHHHHHCCCCCCHHHHHH
AAMAGACTAHTVADYARYKTWCDDYFFLKHRNEMRGIGGIFYDYLDSASSGTGTWDNDFA
HHHHHHHHHHHHHHHHHHHHHHCCHHEEHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
FTRDVGLAFLDIYPKLVRANMGQPWSAADREEQLVRRGRYVEFNLLYDRGTIFGLKTGGN
EHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEEEEEECCEEEEEECCCC
VDSILSSMPPVVKWP
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]