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The map label for this gene is aslA [H]

Identifier: 154246874

GI number: 154246874

Start: 3263331

End: 3265001

Strand: Direct

Name: aslA [H]

Synonym: Xaut_2939

Alternate gene names: 154246874

Gene position: 3263331-3265001 (Clockwise)

Preceding gene: 154246873

Following gene: 154246875

Centisome position: 61.47

GC content: 64.63

Gene sequence:

>1671_bases
ATGAGAACAGCAATCTCGACCACGCTGGCCGCCGCGGTGGCGGCAACGCTCATCGTTTGGGGCCCCGCAGCCCAGGCCCA
AGGCACCGCGCCTGCCGCAGCCCAGGCCAAGAAGCCGAACATCCTGCTGATCGTCTCCGACGATACCGGCTGGGGCGACC
TCGGCGCCTTTCTCGGCGGCGCGCGCCGCGGCATGCCGACGCCCAACATGGACGAACTGGCGGCCGAGGGCATGGTGTTC
ACCAACTTCTACGGCCAGCCGAGCTGCACGCCCGGCCGGGCCGCGATCCAGACCGGGCGCATCCCCAACCGCTCCGGCAT
GACCACCGTGGCCTTCCAGGGCCAGGGCGGCGGCCTGCCGAAGGCCGAATGGACACTGGCCTCCGTGCTCAAGCAGGGCG
GCTATAAGACCTATTTCACCGGGAAATGGCATCTCGGCGAGGCGGACTATGCGCTGCCCAACGCCCAGGGCTATGACGTG
ATGAAGTACGCCTTCCTCTACCACCTGAACGCCTACACCTATCCGGATCCCAAATGGTTCCCCGGCATGAGCCCCGATTT
GCGGCACATGTTCGATACCGTCACGAAGGGCGCGCTATCCGGCAACGCCGGCGGCCCGGTGAAGGAAGACTTCAAGGTCA
ACGGCGAGTATGTGGACACGCCCGACAAGGGCGTGGTCGGCATTCCCTTCCTTGACGCCTACGTCGAGAAGGCCGCGGTC
GAGTTTCTGGAGGAGGCCGCCAAGGCGCCCAACACGCCGTTCTTCATCAATGTCAACTTCATGAAGAACCACCAGCCGAA
CCTGCCGGCGCCCGAATTCGTGGGCAAGTCCCTTTCCAAGTCCAAGTATGCGGATTCGGTGGTGGAGCTGGACGCGCGGA
TCGGCAACGTGCTGAAGAAGCTCGACCAGCTCGGCCTCGCCGACAACACGCTGGTGGTCTACACCGTGGATAACGGCGCC
TGGCAGGACGTCTATCCCGATGCCGGCTACACCCCGTTCCGCGGCACCAAGGGCACCGTGCGCGAAGGCGGCAACCTCGT
CCCGTCCATGGCCCGCTGGCCGGGCAAGATCAAGGCCGCGACCAAGAGCGACGACATCATGGGCGGCCTGGACCTGATGG
CCACCTTCGCCTCCGTCGCCGGCGTGAAGCTGCCGGAGAAGGACCGCGAGGGACAGCCCATCATCTTCGACAGCTACGAC
ATGACTCCGGTCTGGCTCGGCAAGGGTGCGGATCTGCGGCACGAGTGGTTCTACTTCACCGAGAACGAGCTCACCCCCGG
GGCCGTGCGGGTCGACAACTTCAAATATGTCTTCAACCTGCGCGGCGATAACGGCGCCTATACGGGCGGCCTCGCAGTGG
ACACGAACCAGGGCTGGAAGGGGCCGGAGAAGTACGTGGCGACCGTGCCGCAGGTGTTCGACCTGCCGGCCGATCCGCAG
GAGCGCTACGACATCTTCATGACCACCTTCACCGAGAGCACCTGGGCGGCGATCCCGTTCAACGTGGCGGTCGAGAAGCT
CATGAAGACCTATGTGCAATATCCGCCCCGCAAGGCCCAGAGCGAGGCCTATTCTGGCCCGATCACCCTGTCCCAGTATG
AGCGCTTCAAGTTCGTGCAGGATGCGCTGAAGGAACAAGGTTTCAAGCTGCCCCTGCCCACCGGCAACTGA

Upstream 100 bases:

>100_bases
GGACGGTCGTGGACATGAAGTCCGACTGGAAGACGATCTTCCCGCCGGCGAAGTGAACGCCTCACCGCAGCTTACGTCTC
CAACTGCACTGGAAACGACA

Downstream 100 bases:

>100_bases
GGCGGGCGAGGCGGGGCATCCTCCAGAGCTGCCCCGCCCCTCGCGACCGCCGCTGAACCTGCCCGACCAGGGTGTCTGTT
CCGGCAGGTTCCGCTACACG

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MRTAISTTLAAAVAATLIVWGPAAQAQGTAPAAAQAKKPNILLIVSDDTGWGDLGAFLGGARRGMPTPNMDELAAEGMVF
TNFYGQPSCTPGRAAIQTGRIPNRSGMTTVAFQGQGGGLPKAEWTLASVLKQGGYKTYFTGKWHLGEADYALPNAQGYDV
MKYAFLYHLNAYTYPDPKWFPGMSPDLRHMFDTVTKGALSGNAGGPVKEDFKVNGEYVDTPDKGVVGIPFLDAYVEKAAV
EFLEEAAKAPNTPFFINVNFMKNHQPNLPAPEFVGKSLSKSKYADSVVELDARIGNVLKKLDQLGLADNTLVVYTVDNGA
WQDVYPDAGYTPFRGTKGTVREGGNLVPSMARWPGKIKAATKSDDIMGGLDLMATFASVAGVKLPEKDREGQPIIFDSYD
MTPVWLGKGADLRHEWFYFTENELTPGAVRVDNFKYVFNLRGDNGAYTGGLAVDTNQGWKGPEKYVATVPQVFDLPADPQ
ERYDIFMTTFTESTWAAIPFNVAVEKLMKTYVQYPPRKAQSEAYSGPITLSQYERFKFVQDALKEQGFKLPLPTGN

Sequences:

>Translated_556_residues
MRTAISTTLAAAVAATLIVWGPAAQAQGTAPAAAQAKKPNILLIVSDDTGWGDLGAFLGGARRGMPTPNMDELAAEGMVF
TNFYGQPSCTPGRAAIQTGRIPNRSGMTTVAFQGQGGGLPKAEWTLASVLKQGGYKTYFTGKWHLGEADYALPNAQGYDV
MKYAFLYHLNAYTYPDPKWFPGMSPDLRHMFDTVTKGALSGNAGGPVKEDFKVNGEYVDTPDKGVVGIPFLDAYVEKAAV
EFLEEAAKAPNTPFFINVNFMKNHQPNLPAPEFVGKSLSKSKYADSVVELDARIGNVLKKLDQLGLADNTLVVYTVDNGA
WQDVYPDAGYTPFRGTKGTVREGGNLVPSMARWPGKIKAATKSDDIMGGLDLMATFASVAGVKLPEKDREGQPIIFDSYD
MTPVWLGKGADLRHEWFYFTENELTPGAVRVDNFKYVFNLRGDNGAYTGGLAVDTNQGWKGPEKYVATVPQVFDLPADPQ
ERYDIFMTTFTESTWAAIPFNVAVEKLMKTYVQYPPRKAQSEAYSGPITLSQYERFKFVQDALKEQGFKLPLPTGN
>Mature_556_residues
MRTAISTTLAAAVAATLIVWGPAAQAQGTAPAAAQAKKPNILLIVSDDTGWGDLGAFLGGARRGMPTPNMDELAAEGMVF
TNFYGQPSCTPGRAAIQTGRIPNRSGMTTVAFQGQGGGLPKAEWTLASVLKQGGYKTYFTGKWHLGEADYALPNAQGYDV
MKYAFLYHLNAYTYPDPKWFPGMSPDLRHMFDTVTKGALSGNAGGPVKEDFKVNGEYVDTPDKGVVGIPFLDAYVEKAAV
EFLEEAAKAPNTPFFINVNFMKNHQPNLPAPEFVGKSLSKSKYADSVVELDARIGNVLKKLDQLGLADNTLVVYTVDNGA
WQDVYPDAGYTPFRGTKGTVREGGNLVPSMARWPGKIKAATKSDDIMGGLDLMATFASVAGVKLPEKDREGQPIIFDSYD
MTPVWLGKGADLRHEWFYFTENELTPGAVRVDNFKYVFNLRGDNGAYTGGLAVDTNQGWKGPEKYVATVPQVFDLPADPQ
ERYDIFMTTFTESTWAAIPFNVAVEKLMKTYVQYPPRKAQSEAYSGPITLSQYERFKFVQDALKEQGFKLPLPTGN

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=499, Percent_Identity=30.8617234468938, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI146229331, Length=465, Percent_Identity=32.4731182795699, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI146229329, Length=465, Percent_Identity=32.4731182795699, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI6005990, Length=465, Percent_Identity=32.4731182795699, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI146229324, Length=465, Percent_Identity=32.4731182795699, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI45430057, Length=473, Percent_Identity=30.4439746300211, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI157266309, Length=534, Percent_Identity=28.4644194756554, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI31742482, Length=510, Percent_Identity=29.4117647058824, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI71852584, Length=516, Percent_Identity=28.8759689922481, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI146229327, Length=380, Percent_Identity=28.9473684210526, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI38569405, Length=359, Percent_Identity=29.2479108635098, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI38569407, Length=359, Percent_Identity=29.2479108635098, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI59797060, Length=478, Percent_Identity=26.7782426778243, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI109389362, Length=433, Percent_Identity=25.8660508083141, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI71852586, Length=313, Percent_Identity=32.2683706070287, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI53831991, Length=270, Percent_Identity=30, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI58743319, Length=138, Percent_Identity=41.304347826087, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1790233, Length=493, Percent_Identity=32.657200811359, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87081924, Length=387, Percent_Identity=28.1653746770026, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790112, Length=405, Percent_Identity=23.9506172839506, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533416, Length=468, Percent_Identity=25, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI115533418, Length=459, Percent_Identity=24.400871459695, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17559078, Length=117, Percent_Identity=41.8803418803419, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281366397, Length=398, Percent_Identity=28.1407035175879, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281366395, Length=398, Percent_Identity=28.1407035175879, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24666163, Length=398, Percent_Identity=28.1407035175879, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281363223, Length=450, Percent_Identity=26.2222222222222, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24666109, Length=423, Percent_Identity=26.9503546099291, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24666175, Length=366, Percent_Identity=28.1420765027322, Blast_Score=108, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 60625; Mature: 60625

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTAISTTLAAAVAATLIVWGPAAQAQGTAPAAAQAKKPNILLIVSDDTGWGDLGAFLGG
CCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHCCCCCEEEEEECCCCCHHHHHHHCC
ARRGMPTPNMDELAAEGMVFTNFYGQPSCTPGRAAIQTGRIPNRSGMTTVAFQGQGGGLP
HHCCCCCCCHHHHHHCCEEEEECCCCCCCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCC
KAEWTLASVLKQGGYKTYFTGKWHLGEADYALPNAQGYDVMKYAFLYHLNAYTYPDPKWF
CHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCCCC
PGMSPDLRHMFDTVTKGALSGNAGGPVKEDFKVNGEYVDTPDKGVVGIPFLDAYVEKAAV
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCEECCCCCCEEECHHHHHHHHHHHH
EFLEEAAKAPNTPFFINVNFMKNHQPNLPAPEFVGKSLSKSKYADSVVELDARIGNVLKK
HHHHHHHCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDQLGLADNTLVVYTVDNGAWQDVYPDAGYTPFRGTKGTVREGGNLVPSMARWPGKIKAA
HHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEEC
TKSDDIMGGLDLMATFASVAGVKLPEKDREGQPIIFDSYDMTPVWLGKGADLRHEWFYFT
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCEEEEEEE
ENELTPGAVRVDNFKYVFNLRGDNGAYTGGLAVDTNQGWKGPEKYVATVPQVFDLPADPQ
CCCCCCCEEEECCEEEEEEEECCCCCEECCEEEECCCCCCCHHHHHHHCHHHHCCCCCCH
ERYDIFMTTFTESTWAAIPFNVAVEKLMKTYVQYPPRKAQSEAYSGPITLSQYERFKFVQ
HHEEEEEEEECCCCCEECCHHHHHHHHHHHHHHCCCCHHCCHHCCCCEEHHHHHHHHHHH
DALKEQGFKLPLPTGN
HHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRTAISTTLAAAVAATLIVWGPAAQAQGTAPAAAQAKKPNILLIVSDDTGWGDLGAFLGG
CCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHCCCCCEEEEEECCCCCHHHHHHHCC
ARRGMPTPNMDELAAEGMVFTNFYGQPSCTPGRAAIQTGRIPNRSGMTTVAFQGQGGGLP
HHCCCCCCCHHHHHHCCEEEEECCCCCCCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCC
KAEWTLASVLKQGGYKTYFTGKWHLGEADYALPNAQGYDVMKYAFLYHLNAYTYPDPKWF
CHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCCCC
PGMSPDLRHMFDTVTKGALSGNAGGPVKEDFKVNGEYVDTPDKGVVGIPFLDAYVEKAAV
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCEECCCCCCEEECHHHHHHHHHHHH
EFLEEAAKAPNTPFFINVNFMKNHQPNLPAPEFVGKSLSKSKYADSVVELDARIGNVLKK
HHHHHHHCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDQLGLADNTLVVYTVDNGAWQDVYPDAGYTPFRGTKGTVREGGNLVPSMARWPGKIKAA
HHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEEC
TKSDDIMGGLDLMATFASVAGVKLPEKDREGQPIIFDSYDMTPVWLGKGADLRHEWFYFT
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCEEEEEEE
ENELTPGAVRVDNFKYVFNLRGDNGAYTGGLAVDTNQGWKGPEKYVATVPQVFDLPADPQ
CCCCCCCEEEECCEEEEEEEECCCCCEECCEEEECCCCCCCHHHHHHHCHHHHCCCCCCH
ERYDIFMTTFTESTWAAIPFNVAVEKLMKTYVQYPPRKAQSEAYSGPITLSQYERFKFVQ
HHEEEEEEEECCCCCEECCHHHHHHHHHHHHHHCCCCHHCCHHCCCCEEHHHHHHHHHHH
DALKEQGFKLPLPTGN
HHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]