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The map label for this gene is gor [H]

Identifier: 154246840

GI number: 154246840

Start: 3226638

End: 3227984

Strand: Direct

Name: gor [H]

Synonym: Xaut_2904

Alternate gene names: 154246840

Gene position: 3226638-3227984 (Clockwise)

Preceding gene: 154246839

Following gene: 154246846

Centisome position: 60.78

GC content: 63.77

Gene sequence:

>1347_bases
ATGGCGGAGCAATACGACCTCGTAGTCATAGGAACCGGCACGGCTGCCATGGTCGCTGCCATGCGCGTGCGCGCTGCCGG
CTGGAGTGTGGCGATCATCGACTACCGGCCTTTCGGCGGCACCTGCGCCCTACGCGGCTGCGACCCGAAAAAGATGCTTG
TCGGCGGTGCCTCGGCCCTCGACCACGCCCGGCGCATGCGGGGCAACGGCGTTGCCGGCGACGTCCATATCGACTGGCCC
GAACTGATTGCCTTCAAGCGCACCTTCACCGATCCAGTCCCTGAAAAACATGAACACCGCTACGATGAAAAGGGCATCCA
TACGTACCGCGGGCACGCGCGCTTCACGGGCCGGAACAGCCTGACGGTGGACGGCGAGAGCCTTGAAGCCCGCCACGTCC
TTATCGCTGCGGGTGCCGAGCCGATAAGGCTAGGGATTCCCGGTGAAGAGTACTTCGCCACCAACGAAGACTTCTTGGCC
ATGGAGCGACTGCCACGCCGGATCGTGCTGGTTGGCGGCGGGTATATTGCGTCGGAGTTCTCCCACATCGCTGCGCGTGC
GGGTGTGCAGGTGACGATTCTCCAGCGTGGCAAACGGATGCTTGGACACTTTGACCCGGACCTCGTGGGCTGGCTCATGG
ACAAGTTCCGGGAGATCCGGGTGGATGTGCGCTTGCGGACCACGGTAAGCGCGATCGAGAAGGACCATGCGGGCTTTGTC
GTCCGCGCTTCCTCAGAAGGCGGAGACGCGACCTTCGACGCCGACCTCGTTGTCCATTCGGCCGGCCGCGCGCCTGCGCT
CGACGCGCTTGATCTTGAGGCCGGCGGCGTCGCCGCGGAGAAGGGCCGGCTCAAGCTGAATGAGTACCTGCAGAGCGTCT
CTAACGCAGCCGTATATGCCGCCGGCGATGCGGCACAGGAGGGGCCGCCGCTGACTCCCGTCTCCAGCCACGACGCCAAG
ATGGTCGCCGCTAACCTCCTGGAGGGCAATCGGCATAGACCCGACTATCGCGGCGTGCCAAGCGTCGCCTTCACGATCCC
GCCGATCGCCGCCGTCGGGCTGAGCGAGGAACAAGCACGTCAGCAGGACCTGAAATTTCAGACGAAGTCCCAGAAGGCGT
CCGACTGGTTTACGGCCCGCCAGGCCGTAGAGAAGACCTATGGCTTCAAGGTGATGGTGGAGGACGATACGGGGCGCATC
ATCGGCGCTCATCTTGTCGGGCCGCACGCCGATGAAGTGATCAACCTGTTTGCCCTGGCGATCCGCCACGACCTGACGGC
CGACAATCTGAAGACGACAATGTTCGCGTATCCCACTGGCGCCTCGGATATCGGCTACATGCTCTGA

Upstream 100 bases:

>100_bases
TGACGAGCGCGACCCGGATAGGCACGCTGATGCCGCTTGCTCTCGCGGGAATCGGCGCCGCGTTCGGATGGGCGGCAGCA
GGCATAAGTAGGAGAGACGA

Downstream 100 bases:

>100_bases
ATGCTGGTATCAACGGCAAGCATGTCGCCGAGCGCCTTCAACTTGTTTGCAGCACCCCAAAGTCGTCGCAGGGAGATGGC
GTGCAGGATCGCATTTTAGG

Product: pyridine nucleotide-disulfide oxidoreductase dimerisation region

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MAEQYDLVVIGTGTAAMVAAMRVRAAGWSVAIIDYRPFGGTCALRGCDPKKMLVGGASALDHARRMRGNGVAGDVHIDWP
ELIAFKRTFTDPVPEKHEHRYDEKGIHTYRGHARFTGRNSLTVDGESLEARHVLIAAGAEPIRLGIPGEEYFATNEDFLA
MERLPRRIVLVGGGYIASEFSHIAARAGVQVTILQRGKRMLGHFDPDLVGWLMDKFREIRVDVRLRTTVSAIEKDHAGFV
VRASSEGGDATFDADLVVHSAGRAPALDALDLEAGGVAAEKGRLKLNEYLQSVSNAAVYAAGDAAQEGPPLTPVSSHDAK
MVAANLLEGNRHRPDYRGVPSVAFTIPPIAAVGLSEEQARQQDLKFQTKSQKASDWFTARQAVEKTYGFKVMVEDDTGRI
IGAHLVGPHADEVINLFALAIRHDLTADNLKTTMFAYPTGASDIGYML

Sequences:

>Translated_448_residues
MAEQYDLVVIGTGTAAMVAAMRVRAAGWSVAIIDYRPFGGTCALRGCDPKKMLVGGASALDHARRMRGNGVAGDVHIDWP
ELIAFKRTFTDPVPEKHEHRYDEKGIHTYRGHARFTGRNSLTVDGESLEARHVLIAAGAEPIRLGIPGEEYFATNEDFLA
MERLPRRIVLVGGGYIASEFSHIAARAGVQVTILQRGKRMLGHFDPDLVGWLMDKFREIRVDVRLRTTVSAIEKDHAGFV
VRASSEGGDATFDADLVVHSAGRAPALDALDLEAGGVAAEKGRLKLNEYLQSVSNAAVYAAGDAAQEGPPLTPVSSHDAK
MVAANLLEGNRHRPDYRGVPSVAFTIPPIAAVGLSEEQARQQDLKFQTKSQKASDWFTARQAVEKTYGFKVMVEDDTGRI
IGAHLVGPHADEVINLFALAIRHDLTADNLKTTMFAYPTGASDIGYML
>Mature_447_residues
AEQYDLVVIGTGTAAMVAAMRVRAAGWSVAIIDYRPFGGTCALRGCDPKKMLVGGASALDHARRMRGNGVAGDVHIDWPE
LIAFKRTFTDPVPEKHEHRYDEKGIHTYRGHARFTGRNSLTVDGESLEARHVLIAAGAEPIRLGIPGEEYFATNEDFLAM
ERLPRRIVLVGGGYIASEFSHIAARAGVQVTILQRGKRMLGHFDPDLVGWLMDKFREIRVDVRLRTTVSAIEKDHAGFVV
RASSEGGDATFDADLVVHSAGRAPALDALDLEAGGVAAEKGRLKLNEYLQSVSNAAVYAAGDAAQEGPPLTPVSSHDAKM
VAANLLEGNRHRPDYRGVPSVAFTIPPIAAVGLSEEQARQQDLKFQTKSQKASDWFTARQAVEKTYGFKVMVEDDTGRII
GAHLVGPHADEVINLFALAIRHDLTADNLKTTMFAYPTGASDIGYML

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=26.5217391304348, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI91199540, Length=457, Percent_Identity=25.601750547046, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI33519430, Length=424, Percent_Identity=26.6509433962264, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI33519428, Length=424, Percent_Identity=26.6509433962264, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI33519426, Length=424, Percent_Identity=26.6509433962264, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI148277065, Length=424, Percent_Identity=26.6509433962264, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI291045266, Length=423, Percent_Identity=27.4231678486998, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI148277071, Length=424, Percent_Identity=26.6509433962264, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI22035672, Length=471, Percent_Identity=26.1146496815287, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI291045268, Length=419, Percent_Identity=25.0596658711217, Blast_Score=100, Evalue=5e-21,
Organism=Escherichia coli, GI1789915, Length=457, Percent_Identity=30.4157549234136, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1786307, Length=457, Percent_Identity=26.4770240700219, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=29.010989010989, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI87082354, Length=469, Percent_Identity=24.9466950959488, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1789065, Length=253, Percent_Identity=28.4584980237154, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=28.8421052631579, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI32565766, Length=453, Percent_Identity=25.60706401766, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=457, Percent_Identity=28.0087527352298, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=457, Percent_Identity=28.0087527352298, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=24.375, Blast_Score=111, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6325166, Length=471, Percent_Identity=23.1422505307856, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=24.8936170212766, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=460, Percent_Identity=21.0869565217391, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24640549, Length=466, Percent_Identity=29.8283261802575, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24640553, Length=466, Percent_Identity=29.8283261802575, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24640551, Length=466, Percent_Identity=29.8283261802575, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21358499, Length=455, Percent_Identity=27.2527472527473, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI17737741, Length=468, Percent_Identity=26.7094017094017, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48611; Mature: 48480

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQYDLVVIGTGTAAMVAAMRVRAAGWSVAIIDYRPFGGTCALRGCDPKKMLVGGASAL
CCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEEEEECCCCEEEECCCCCHHEEECCHHHH
DHARRMRGNGVAGDVHIDWPELIAFKRTFTDPVPEKHEHRYDEKGIHTYRGHARFTGRNS
HHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCHHHCCCCCCCCEEECCCEEEECCCE
LTVDGESLEARHVLIAAGAEPIRLGIPGEEYFATNEDFLAMERLPRRIVLVGGGYIASEF
EEECCCCCCEEEEEEEECCCEEEECCCCHHHCCCCCCHHHHHHCCCEEEEEECCHHHHHH
SHIAARAGVQVTILQRGKRMLGHFDPDLVGWLMDKFREIRVDVRLRTTVSAIEKDHAGFV
HHHHHHCCCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEEEHHHHHHHCCCCCEE
VRASSEGGDATFDADLVVHSAGRAPALDALDLEAGGVAAEKGRLKLNEYLQSVSNAAVYA
EEECCCCCCCEEEEEEEEECCCCCCCCCEEECCCCCEECCCCCCHHHHHHHHHCCCEEEE
AGDAAQEGPPLTPVSSHDAKMVAANLLEGNRHRPDYRGVPSVAFTIPPIAAVGLSEEQAR
ECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEEECCCHHHHH
QQDLKFQTKSQKASDWFTARQAVEKTYGFKVMVEDDTGRIIGAHLVGPHADEVINLFALA
HHHCCEECCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHH
IRHDLTADNLKTTMFAYPTGASDIGYML
HHHCCCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
AEQYDLVVIGTGTAAMVAAMRVRAAGWSVAIIDYRPFGGTCALRGCDPKKMLVGGASAL
CCCEEEEEEECCHHHHHHHHHHHCCCCEEEEEEEECCCCEEEECCCCCHHEEECCHHHH
DHARRMRGNGVAGDVHIDWPELIAFKRTFTDPVPEKHEHRYDEKGIHTYRGHARFTGRNS
HHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCHHHCCCCCCCCEEECCCEEEECCCE
LTVDGESLEARHVLIAAGAEPIRLGIPGEEYFATNEDFLAMERLPRRIVLVGGGYIASEF
EEECCCCCCEEEEEEEECCCEEEECCCCHHHCCCCCCHHHHHHCCCEEEEEECCHHHHHH
SHIAARAGVQVTILQRGKRMLGHFDPDLVGWLMDKFREIRVDVRLRTTVSAIEKDHAGFV
HHHHHHCCCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEEEHHHHHHHCCCCCEE
VRASSEGGDATFDADLVVHSAGRAPALDALDLEAGGVAAEKGRLKLNEYLQSVSNAAVYA
EEECCCCCCCEEEEEEEEECCCCCCCCCEEECCCCCEECCCCCCHHHHHHHHHCCCEEEE
AGDAAQEGPPLTPVSSHDAKMVAANLLEGNRHRPDYRGVPSVAFTIPPIAAVGLSEEQAR
ECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEEECCCHHHHH
QQDLKFQTKSQKASDWFTARQAVEKTYGFKVMVEDDTGRIIGAHLVGPHADEVINLFALA
HHHCCEECCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHH
IRHDLTADNLKTTMFAYPTGASDIGYML
HHHCCCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1849605; 10984043 [H]