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The map label for this gene is merR1 [H]

Identifier: 154246836

GI number: 154246836

Start: 3222636

End: 3223058

Strand: Reverse

Name: merR1 [H]

Synonym: Xaut_2900

Alternate gene names: 154246836

Gene position: 3223058-3222636 (Counterclockwise)

Preceding gene: 154246841

Following gene: 154246835

Centisome position: 60.71

GC content: 67.38

Gene sequence:

>423_bases
ATGCGCGATCACGCCGTGGTGAAGGGCCTGCAACGGGCCGAGCTCGCCCAGCGGACGGGCTGCAACCTGGAGACCGTGCG
CTATTACGAGAAGGTCGGCCTTCTACCCGACCCGCCGCGCACAGCGAGCGGCTATCGCAGCTACGACACCTCGCATGAGC
GGCGCCTTCGGTTCGTGCTGCGGGCGCGCGAGCTCGGCTTCTCGCTCGACGAGATCCGCGAACTCTTGCGCCTCGTCGAC
GAGCGGGACCAGCCCTGCGCGGAAGCGCGGGTTGTGGCCGCCACGCACCTCGACGATGTGCGGGCGAAGATAGCCGACCT
AAGACGGATGGAGCGGGTGCTTAAGGACGTGGTCGCGCAATGCGCCGACGGCACGCTGCCGGAATGTCCGCTTATCGAGA
CGCTGTTCGCCGGACACAAGTAG

Upstream 100 bases:

>100_bases
TCGCGCGGTGTCCATGTCCGACCTCTCTATCCTTGCCGAAATACTATCTGTGCCGTACCATGCGGTCTGTAGTCACTACA
GGGTCAAGAGGGTTTTTGCG

Downstream 100 bases:

>100_bases
CCAGTCTGGAACAGGTGGCGAATTTTCTACGCCACAACTCACCTGCCTACGACGATGCCATCAGCAGTGATCGTAGTCTG
GAGTGCGAGGTCGTGCCGCC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MRDHAVVKGLQRAELAQRTGCNLETVRYYEKVGLLPDPPRTASGYRSYDTSHERRLRFVLRARELGFSLDEIRELLRLVD
ERDQPCAEARVVAATHLDDVRAKIADLRRMERVLKDVVAQCADGTLPECPLIETLFAGHK

Sequences:

>Translated_140_residues
MRDHAVVKGLQRAELAQRTGCNLETVRYYEKVGLLPDPPRTASGYRSYDTSHERRLRFVLRARELGFSLDEIRELLRLVD
ERDQPCAEARVVAATHLDDVRAKIADLRRMERVLKDVVAQCADGTLPECPLIETLFAGHK
>Mature_140_residues
MRDHAVVKGLQRAELAQRTGCNLETVRYYEKVGLLPDPPRTASGYRSYDTSHERRLRFVLRARELGFSLDEIRELLRLVD
ERDQPCAEARVVAATHLDDVRAKIADLRRMERVLKDVVAQCADGTLPECPLIETLFAGHK

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=130, Percent_Identity=37.6923076923077, Blast_Score=84, Evalue=5e-18,
Organism=Escherichia coli, GI1786695, Length=123, Percent_Identity=29.2682926829268, Blast_Score=70, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15986; Mature: 15986

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDHAVVKGLQRAELAQRTGCNLETVRYYEKVGLLPDPPRTASGYRSYDTSHERRLRFVL
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RARELGFSLDEIRELLRLVDERDQPCAEARVVAATHLDDVRAKIADLRRMERVLKDVVAQ
HHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CADGTLPECPLIETLFAGHK
HCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MRDHAVVKGLQRAELAQRTGCNLETVRYYEKVGLLPDPPRTASGYRSYDTSHERRLRFVL
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RARELGFSLDEIRELLRLVDERDQPCAEARVVAATHLDDVRAKIADLRRMERVLKDVVAQ
HHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CADGTLPECPLIETLFAGHK
HCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]