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The map label for this gene is czcD [H]

Identifier: 154246795

GI number: 154246795

Start: 3183533

End: 3184459

Strand: Direct

Name: czcD [H]

Synonym: Xaut_2856

Alternate gene names: 154246795

Gene position: 3183533-3184459 (Clockwise)

Preceding gene: 154246794

Following gene: 154246796

Centisome position: 59.97

GC content: 65.37

Gene sequence:

>927_bases
ATGACAACCGAGCGGGACATCGGAGCCCTAAACCACGACCACATGTTCCTGGGCGAGGGCCACGACGACAACGCCCGGCG
CACGCTCTGGGTGGTCGCGCTGACGACCGTGATGATGGTCGGCGAGATCGTCGCCGGCTCCATCTTCAACTCGATGGCGC
TGCTCGCGGATGGTTTCCACATGGCGACGCACGCCGGTGCGCTCGCGATCGCGGCCGGCGCCTATGCTTTTGCCAAGCGC
AACGCCACCAACCGCCGCTTCAGCTTCGGCACTGGCAAGGTAGGAGATCTTGCCGGCTTCGCCTCAGCGCTGATCCTCGG
GGTCGTGGCTGTCGGAATCGCCTTCGAATCTGTAGGCCGCCTCCTAGAACCGCGCCCGGTGGCCTTCTCGCAAGCGACGG
TCGTGGCGGTGATCGGACTCGTGGTCAATATCGCCAGCGCGCTACTCCTCAGCGGCGGGCACCATCATGGCCACCAACAC
GATGACCATGGCGATCATCATCACGGACACGCGGCCCGCCATAACGACAACAATCTGCGATCTGCCTTCGTCCATGTCCT
GGCCGACGCGCTCACTTCGGTGCTGGCGATTGTTGCGCTGCTCGCCGGCAGCTACCTCGGCTGGATCTGGCTCGACCCGG
TGATGGGCATTGTGGGCGCGACCGTAATCGCGGTGTGGTCCTGGACTCTGATGCGGGATACCGCCGGCGTGCTGCTCGAC
ACGTCCGACACCCATTTGGAAACCGAGGTCCGCGAGCACGTCGAAGGCAAGGGTGACACGCGCATCACCGACCTCCACAT
CTGGCGCGTCGGGCCGGGGGCGCATGCGGCAATCGTCAGCGTGACCGGCTGTGTGGATGGAGACACAGTGCGCTCGCGGT
TGGCCCCGGTGCACGAGCTGGCGCACGTCACTGTCGAGACGCGCTAG

Upstream 100 bases:

>100_bases
AGCACGTCGCCCACCCGGACCTCAGCGATGCCGCGCGCGCGACGGGCGCCGAGGAACTGATCGCGGTCGTGCGCCGCTAC
ATCAAATAGGGACAGATGAG

Downstream 100 bases:

>100_bases
GCCGAGGGGGGCGGCGAGTTGTGGTTTCGCTTCTGGCGTCTAGTGGCCTTTAGAGGAAGAGGGCTGCGGCATTCGCCGTG
ACGGGTTTGAGGGTCGAGAG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTTERDIGALNHDHMFLGEGHDDNARRTLWVVALTTVMMVGEIVAGSIFNSMALLADGFHMATHAGALAIAAGAYAFAKR
NATNRRFSFGTGKVGDLAGFASALILGVVAVGIAFESVGRLLEPRPVAFSQATVVAVIGLVVNIASALLLSGGHHHGHQH
DDHGDHHHGHAARHNDNNLRSAFVHVLADALTSVLAIVALLAGSYLGWIWLDPVMGIVGATVIAVWSWTLMRDTAGVLLD
TSDTHLETEVREHVEGKGDTRITDLHIWRVGPGAHAAIVSVTGCVDGDTVRSRLAPVHELAHVTVETR

Sequences:

>Translated_308_residues
MTTERDIGALNHDHMFLGEGHDDNARRTLWVVALTTVMMVGEIVAGSIFNSMALLADGFHMATHAGALAIAAGAYAFAKR
NATNRRFSFGTGKVGDLAGFASALILGVVAVGIAFESVGRLLEPRPVAFSQATVVAVIGLVVNIASALLLSGGHHHGHQH
DDHGDHHHGHAARHNDNNLRSAFVHVLADALTSVLAIVALLAGSYLGWIWLDPVMGIVGATVIAVWSWTLMRDTAGVLLD
TSDTHLETEVREHVEGKGDTRITDLHIWRVGPGAHAAIVSVTGCVDGDTVRSRLAPVHELAHVTVETR
>Mature_307_residues
TTERDIGALNHDHMFLGEGHDDNARRTLWVVALTTVMMVGEIVAGSIFNSMALLADGFHMATHAGALAIAAGAYAFAKRN
ATNRRFSFGTGKVGDLAGFASALILGVVAVGIAFESVGRLLEPRPVAFSQATVVAVIGLVVNIASALLLSGGHHHGHQHD
DHGDHHHGHAARHNDNNLRSAFVHVLADALTSVLAIVALLAGSYLGWIWLDPVMGIVGATVIAVWSWTLMRDTAGVLLDT
SDTHLETEVREHVEGKGDTRITDLHIWRVGPGAHAAIVSVTGCVDGDTVRSRLAPVHELAHVTVETR

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=275, Percent_Identity=29.4545454545455, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI222080086, Length=317, Percent_Identity=23.9747634069401, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI40255009, Length=317, Percent_Identity=23.9747634069401, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI21359890, Length=266, Percent_Identity=26.6917293233083, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI52352805, Length=251, Percent_Identity=26.2948207171315, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786966, Length=301, Percent_Identity=31.5614617940199, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32564488, Length=256, Percent_Identity=28.90625, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193210990, Length=264, Percent_Identity=26.8939393939394, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17555794, Length=255, Percent_Identity=25.8823529411765, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17555796, Length=256, Percent_Identity=25.78125, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320411, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323899, Length=167, Percent_Identity=28.1437125748503, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24645863, Length=315, Percent_Identity=26.6666666666667, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24656728, Length=288, Percent_Identity=25.6944444444444, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24656724, Length=288, Percent_Identity=25.6944444444444, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24656720, Length=288, Percent_Identity=25.6944444444444, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24656715, Length=288, Percent_Identity=25.6944444444444, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357035, Length=288, Percent_Identity=25.6944444444444, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 32673; Mature: 32541

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTERDIGALNHDHMFLGEGHDDNARRTLWVVALTTVMMVGEIVAGSIFNSMALLADGFH
CCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
MATHAGALAIAAGAYAFAKRNATNRRFSFGTGKVGDLAGFASALILGVVAVGIAFESVGR
HHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLEPRPVAFSQATVVAVIGLVVNIASALLLSGGHHHGHQHDDHGDHHHGHAARHNDNNLR
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
SAFVHVLADALTSVLAIVALLAGSYLGWIWLDPVMGIVGATVIAVWSWTLMRDTAGVLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TSDTHLETEVREHVEGKGDTRITDLHIWRVGPGAHAAIVSVTGCVDGDTVRSRLAPVHEL
CCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHH
AHVTVETR
HHEEEECC
>Mature Secondary Structure 
TTERDIGALNHDHMFLGEGHDDNARRTLWVVALTTVMMVGEIVAGSIFNSMALLADGFH
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
MATHAGALAIAAGAYAFAKRNATNRRFSFGTGKVGDLAGFASALILGVVAVGIAFESVGR
HHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLEPRPVAFSQATVVAVIGLVVNIASALLLSGGHHHGHQHDDHGDHHHGHAARHNDNNLR
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
SAFVHVLADALTSVLAIVALLAGSYLGWIWLDPVMGIVGATVIAVWSWTLMRDTAGVLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TSDTHLETEVREHVEGKGDTRITDLHIWRVGPGAHAAIVSVTGCVDGDTVRSRLAPVHEL
CCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHH
AHVTVETR
HHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]