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The map label for this gene is hisN [H]

Identifier: 154246757

GI number: 154246757

Start: 3139954

End: 3140736

Strand: Direct

Name: hisN [H]

Synonym: Xaut_2818

Alternate gene names: 154246757

Gene position: 3139954-3140736 (Clockwise)

Preceding gene: 154246756

Following gene: 154246760

Centisome position: 59.14

GC content: 68.58

Gene sequence:

>783_bases
ATGACCGCCGTCGATTTCGACGCATTCGTCCACAAGCTCGCGACCGTTTCCGGCGAGGCCATCCTGCCCTTCTTCCGCAC
CGCCCTCGGCGTCGAGGACAAAGGCGCCGGCCGGGGCTTTGATCCGGTCACCGAGGCGGACCGCGCCGCCGAGCAGGCCA
TGCGTAGGCTCATCCGCGACACCTTCCCGGCCCATGGCATCATCGGCGAGGAATTCGACAACGTGGCCGGCGATGCGCCT
TATGTCTGGGCGCTGGATCCCATCGACGGCACCAAGTCCTTCATCGCCGGCCTGCCGGCGTGGGGAACGCTCATCGGCCT
GCTGAAGGACGGCGATCCGGTCTATGGCATGATGCACCAGCCCTTCATCGGCGAGCGTTTCTTCGGCGATGGCGGCGTGG
CGCGCTACCGGGGCCCGGCGGGCGAGCGCATCCTGTCGGCGCGCGATTGCGGGCGGCTCGAAGATGCCATCCTCTTCACC
ACCAGCCCGCGCCTGATGAACACCGCCGACCGGGCCGCCTTCGAGACCGTGGAGGAGCGCGCGCGCCTCTCCCGGTACGG
TGGCGATTGCTATGCCTATTGCATGGTGGCGGCGGGGCTGGTGGATCTCGTCGTCGAGACCGAGCTGAAGGACCATGACA
TCATCGCCCTGGTCCCTATCATCGAGGGGGCGGGGGGCATCGTCACCAGCTGGGAAGGCGGCTCGCCGGTGCACGGCGGG
CGCGTGGTGGCGGCGGGCAGCCGCAAGGTTCACGAGGAGGCGTTGCGCCTGCTCACTGCGTGA

Upstream 100 bases:

>100_bases
TGTGGCCCCGCGCTTTTTGGCGCCGACCGCCGCGATCCCGGCGCCGTTCGCCGGCGCCGGGTGCGGGGCTCGCCCATCGC
TTTCATTCTGCGGAGCCGTC

Downstream 100 bases:

>100_bases
AATCTGGAGGCGTTGCGCCTCCTCACGGCCTGAGGGCGTGGCCGCTCACAGGATCGGCGTTCCGGGGATGAAGGCATCGA
ACGCGGCCCAGAACTGGGCG

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTAVDFDAFVHKLATVSGEAILPFFRTALGVEDKGAGRGFDPVTEADRAAEQAMRRLIRDTFPAHGIIGEEFDNVAGDAP
YVWALDPIDGTKSFIAGLPAWGTLIGLLKDGDPVYGMMHQPFIGERFFGDGGVARYRGPAGERILSARDCGRLEDAILFT
TSPRLMNTADRAAFETVEERARLSRYGGDCYAYCMVAAGLVDLVVETELKDHDIIALVPIIEGAGGIVTSWEGGSPVHGG
RVVAAGSRKVHEEALRLLTA

Sequences:

>Translated_260_residues
MTAVDFDAFVHKLATVSGEAILPFFRTALGVEDKGAGRGFDPVTEADRAAEQAMRRLIRDTFPAHGIIGEEFDNVAGDAP
YVWALDPIDGTKSFIAGLPAWGTLIGLLKDGDPVYGMMHQPFIGERFFGDGGVARYRGPAGERILSARDCGRLEDAILFT
TSPRLMNTADRAAFETVEERARLSRYGGDCYAYCMVAAGLVDLVVETELKDHDIIALVPIIEGAGGIVTSWEGGSPVHGG
RVVAAGSRKVHEEALRLLTA
>Mature_259_residues
TAVDFDAFVHKLATVSGEAILPFFRTALGVEDKGAGRGFDPVTEADRAAEQAMRRLIRDTFPAHGIIGEEFDNVAGDAPY
VWALDPIDGTKSFIAGLPAWGTLIGLLKDGDPVYGMMHQPFIGERFFGDGGVARYRGPAGERILSARDCGRLEDAILFTT
SPRLMNTADRAAFETVEERARLSRYGGDCYAYCMVAAGLVDLVVETELKDHDIIALVPIIEGAGGIVTSWEGGSPVHGGR
VVAAGSRKVHEEALRLLTA

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788882, Length=246, Percent_Identity=30.8943089430894, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI193202572, Length=235, Percent_Identity=28.936170212766, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193202570, Length=235, Percent_Identity=28.5106382978723, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24664918, Length=263, Percent_Identity=27.3764258555133, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357957, Length=263, Percent_Identity=29.277566539924, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21357329, Length=229, Percent_Identity=27.9475982532751, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27897; Mature: 27766

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVDFDAFVHKLATVSGEAILPFFRTALGVEDKGAGRGFDPVTEADRAAEQAMRRLIRD
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TFPAHGIIGEEFDNVAGDAPYVWALDPIDGTKSFIAGLPAWGTLIGLLKDGDPVYGMMHQ
CCCCCCCCCHHHHHCCCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCC
PFIGERFFGDGGVARYRGPAGERILSARDCGRLEDAILFTTSPRLMNTADRAAFETVEER
CCCCCEEECCCCCEECCCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
ARLSRYGGDCYAYCMVAAGLVDLVVETELKDHDIIALVPIIEGAGGIVTSWEGGSPVHGG
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCCCCCCC
RVVAAGSRKVHEEALRLLTA
EEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure 
TAVDFDAFVHKLATVSGEAILPFFRTALGVEDKGAGRGFDPVTEADRAAEQAMRRLIRD
CCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TFPAHGIIGEEFDNVAGDAPYVWALDPIDGTKSFIAGLPAWGTLIGLLKDGDPVYGMMHQ
CCCCCCCCCHHHHHCCCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCC
PFIGERFFGDGGVARYRGPAGERILSARDCGRLEDAILFTTSPRLMNTADRAAFETVEER
CCCCCEEECCCCCEECCCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
ARLSRYGGDCYAYCMVAAGLVDLVVETELKDHDIIALVPIIEGAGGIVTSWEGGSPVHGG
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCCCCCCC
RVVAAGSRKVHEEALRLLTA
EEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]