Click here to switch to the map view.

The map label for this gene is sdhA

Identifier: 154245908

GI number: 154245908

Start: 2222048

End: 2223883

Strand: Reverse

Name: sdhA

Synonym: Xaut_1965

Alternate gene names: 154245908

Gene position: 2223883-2222048 (Counterclockwise)

Preceding gene: 154245909

Following gene: 154245907

Centisome position: 41.89

GC content: 68.3

Gene sequence:

>1836_bases
ATGGCCGACACCGCAACCAACGGGGCCGCCGCGCCCGGCATCAACGGCGCTGCCTACCCCATCGAGGACCACACCTACGA
CGTGCTCGTGGTGGGCGCTGGCGGCGCCGGCCTGCGCGCCGTGGTCGGCTGCTCGGAAGCCGGCCTGCGCACCGCCTGCA
TCACCAAGGTGTTCCCCACCCGCTCCCACACGGTGGCGGCCCAGGGCGGCGTCGCCGCCTCCCTCGCCAACATGGGCGAG
GACAAGTGGGAATGGCACATGTACGACACCGTGAAGGGGTCGGACTGGCTGGGTGATCAGGACGCCATCGAATACATGGT
GCGCAACGCGCCCGCAGCGGTCTACGAGCTGGAGCACTGGGGCGTGCCCTTCTCCCGCACCGAGGACGGCAAGATCTACC
AGCGCCCGTTCGGCGGCATGACCACCCATTACGGCAAGGGCACCGCCCAGCGCACCTGCGCCGCGGCGGACCGCACCGGT
CACGCCATGCTGCACACGCTCTATGGGGCGGCGCTGAAGCACCACGCCGAATTCTTCGTCGAATACTTCGCCATCGACCT
CATCATGGATGAGGACGGCCGCTGCCGGGGCGTCATCGCCATCAAGCTCGACGACGGCACCATCCATCGCTTCCGCGCCC
ATCTCGTGGTGCTCGCCACCGGCGGCTACGGCCGCGCCTATTTCTCCGCCACCTCGGCCCATACCTGCACCGGCGACGGC
GGCGGCATGGTGCTGCGCGCCGGCCTGCCGCTGCAGGACATGGAATTCGTGCAGTTCCATCCCACCGGCATCTACGGCTC
GGGCTGCCTCATCACCGAGGGCGCCCGCGGCGAAGGCGGCTACCTCACCAATTCCGCGGGCGAGCGCTTCATGGAGCGCT
ATGCCCCGTCGGCCAAGGACCTTGCCTCGCGCGACGTGGTCTCCCGCTCCATGACCATGGAGATCCGCGAGGGCCGCGGC
GTCGGCAAGAACAAGGACCACATCTTCCTGCACCTCGACCATCTCGACCCCGCCATCCTCCACGAGCGCCTGCCCGGCAT
CTCGGAGAGCGCGAAGATCTTCGCCGGCGTGGACCTGACCCGCGAGCCGATCCCGGTGATCCCGACCGTGCACTACAACA
TGGGCGGCATCCCCACGAACTATTACGGCGAGGTGCTGGACAAGCGCTCCGGCGATCCCGACACGGTGGTGCCCGGCCTC
ATGGCCATCGGCGAAGCCGCCTGCGTCTCGGTGCACGGCGCCAACCGCCTCGGCTCCAACTCGCTCATCGACCTCGTGGT
GTTCGGCCGCGCGGCCGGCCTGCGCGCCGCCGAGCTGGTGAAGCCCGGCGAGAAGCACCGCGAGCTGCCGGCCGGCAGCG
CAGACCTCGCGCTCTCCCGTCTGGATGCGGCCCGTTATGCTTCCGGTGGCACCCCCACCGCCGAGCTGCGGCTCGCCATG
CAGAAGGTGATGCAGAGCAACTGCGCCGTCTTCCGCACCGGCGAGGTGCTTGAGGAAGGCTGCAAGCTGATCCACGACGT
CTACAAGGGCGCAAGCGACATCGGCGTCACCGACCGGTCGCTGGTGTGGAACTCGGACCTCATCGAGACGCTGGAGTTCG
AGAACCTCATCGCCCAGGCCATCGTCACCATGGAGGGCGCGAGCGCCCGCAAGGAAAGCCGTGGCGGCCACGCCCGCGAG
GACTTCCCGGATCGCGACGACGTGAACTGGATGAAGCACACCCTCGCCTACTTCGACACCGCAACCGGCAACGTGCGTCT
CGATGACCGGCCGGTGCACACCTACACGCTGTCCAACGACATCCAGTACATCGAGCCCAAGAAGCGCGTGTACTGA

Upstream 100 bases:

>100_bases
GCACTCAAGGTGATGCTCATCGTGGCCAACACCTTCTTCAGCATCGCCATTGCCCTCGCCGGCGCCTTCGCCGTGCTCAA
GATCAGCCTGGGAGGCTGAC

Downstream 100 bases:

>100_bases
TCGTGTCATCGCGACCGCGCGCGGCACGGGCTGGAATGCCCACCGCGCGCGGCCATGGCCAGAAATCCTGCGGGCGGTTA
CCGCTCCAGCGTTCCAGGAC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MADTATNGAAAPGINGAAYPIEDHTYDVLVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSHTVAAQGGVAASLANMGE
DKWEWHMYDTVKGSDWLGDQDAIEYMVRNAPAAVYELEHWGVPFSRTEDGKIYQRPFGGMTTHYGKGTAQRTCAAADRTG
HAMLHTLYGAALKHHAEFFVEYFAIDLIMDEDGRCRGVIAIKLDDGTIHRFRAHLVVLATGGYGRAYFSATSAHTCTGDG
GGMVLRAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLTNSAGERFMERYAPSAKDLASRDVVSRSMTMEIREGRG
VGKNKDHIFLHLDHLDPAILHERLPGISESAKIFAGVDLTREPIPVIPTVHYNMGGIPTNYYGEVLDKRSGDPDTVVPGL
MAIGEAACVSVHGANRLGSNSLIDLVVFGRAAGLRAAELVKPGEKHRELPAGSADLALSRLDAARYASGGTPTAELRLAM
QKVMQSNCAVFRTGEVLEEGCKLIHDVYKGASDIGVTDRSLVWNSDLIETLEFENLIAQAIVTMEGASARKESRGGHARE
DFPDRDDVNWMKHTLAYFDTATGNVRLDDRPVHTYTLSNDIQYIEPKKRVY

Sequences:

>Translated_611_residues
MADTATNGAAAPGINGAAYPIEDHTYDVLVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSHTVAAQGGVAASLANMGE
DKWEWHMYDTVKGSDWLGDQDAIEYMVRNAPAAVYELEHWGVPFSRTEDGKIYQRPFGGMTTHYGKGTAQRTCAAADRTG
HAMLHTLYGAALKHHAEFFVEYFAIDLIMDEDGRCRGVIAIKLDDGTIHRFRAHLVVLATGGYGRAYFSATSAHTCTGDG
GGMVLRAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLTNSAGERFMERYAPSAKDLASRDVVSRSMTMEIREGRG
VGKNKDHIFLHLDHLDPAILHERLPGISESAKIFAGVDLTREPIPVIPTVHYNMGGIPTNYYGEVLDKRSGDPDTVVPGL
MAIGEAACVSVHGANRLGSNSLIDLVVFGRAAGLRAAELVKPGEKHRELPAGSADLALSRLDAARYASGGTPTAELRLAM
QKVMQSNCAVFRTGEVLEEGCKLIHDVYKGASDIGVTDRSLVWNSDLIETLEFENLIAQAIVTMEGASARKESRGGHARE
DFPDRDDVNWMKHTLAYFDTATGNVRLDDRPVHTYTLSNDIQYIEPKKRVY
>Mature_610_residues
ADTATNGAAAPGINGAAYPIEDHTYDVLVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSHTVAAQGGVAASLANMGED
KWEWHMYDTVKGSDWLGDQDAIEYMVRNAPAAVYELEHWGVPFSRTEDGKIYQRPFGGMTTHYGKGTAQRTCAAADRTGH
AMLHTLYGAALKHHAEFFVEYFAIDLIMDEDGRCRGVIAIKLDDGTIHRFRAHLVVLATGGYGRAYFSATSAHTCTGDGG
GMVLRAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLTNSAGERFMERYAPSAKDLASRDVVSRSMTMEIREGRGV
GKNKDHIFLHLDHLDPAILHERLPGISESAKIFAGVDLTREPIPVIPTVHYNMGGIPTNYYGEVLDKRSGDPDTVVPGLM
AIGEAACVSVHGANRLGSNSLIDLVVFGRAAGLRAAELVKPGEKHRELPAGSADLALSRLDAARYASGGTPTAELRLAMQ
KVMQSNCAVFRTGEVLEEGCKLIHDVYKGASDIGVTDRSLVWNSDLIETLEFENLIAQAIVTMEGASARKESRGGHARED
FPDRDDVNWMKHTLAYFDTATGNVRLDDRPVHTYTLSNDIQYIEPKKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=614, Percent_Identity=62.5407166123778, Blast_Score=750, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=551, Percent_Identity=54.4464609800363, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI1790597, Length=578, Percent_Identity=42.7335640138408, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1788928, Length=563, Percent_Identity=30.9058614564831, Blast_Score=204, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17550100, Length=627, Percent_Identity=60.4465709728868, Blast_Score=735, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=613, Percent_Identity=59.3800978792822, Blast_Score=704, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=611, Percent_Identity=63.6661211129296, Blast_Score=780, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=599, Percent_Identity=64.2737896494157, Blast_Score=766, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=621, Percent_Identity=62.1578099838969, Blast_Score=763, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=621, Percent_Identity=62.1578099838969, Blast_Score=763, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=621, Percent_Identity=62.1578099838969, Blast_Score=763, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=613, Percent_Identity=54.6492659053834, Blast_Score=657, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66081; Mature: 65950

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTATNGAAAPGINGAAYPIEDHTYDVLVVGAGGAGLRAVVGCSEAGLRTACITKVFPT
CCCCCCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHCCC
RSHTVAAQGGVAASLANMGEDKWEWHMYDTVKGSDWLGDQDAIEYMVRNAPAAVYELEHW
CCCEEEECCCHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEHHHC
GVPFSRTEDGKIYQRPFGGMTTHYGKGTAQRTCAAADRTGHAMLHTLYGAALKHHAEFFV
CCCCCCCCCCCEEECCCCCCCEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EYFAIDLIMDEDGRCRGVIAIKLDDGTIHRFRAHLVVLATGGYGRAYFSATSAHTCTGDG
HHHEEEEEECCCCCEEEEEEEEECCCCEEEEEEEEEEEEECCCCEEEEECCCCCEEECCC
GGMVLRAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLTNSAGERFMERYAPSAKD
CCEEEECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECHHHHHHHHHHCCCHHH
LASRDVVSRSMTMEIREGRGVGKNKDHIFLHLDHLDPAILHERLPGISESAKIFAGVDLT
HHHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCC
REPIPVIPTVHYNMGGIPTNYYGEVLDKRSGDPDTVVPGLMAIGEAACVSVHGANRLGSN
CCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCC
SLIDLVVFGRAAGLRAAELVKPGEKHRELPAGSADLALSRLDAARYASGGTPTAELRLAM
CEEEEEEECCCCCCCHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
QKVMQSNCAVFRTGEVLEEGCKLIHDVYKGASDIGVTDRSLVWNSDLIETLEFENLIAQA
HHHHHCCCCEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHH
IVTMEGASARKESRGGHAREDFPDRDDVNWMKHTLAYFDTATGNVRLDDRPVHTYTLSND
HHHCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCC
IQYIEPKKRVY
CEEECCHHCCC
>Mature Secondary Structure 
ADTATNGAAAPGINGAAYPIEDHTYDVLVVGAGGAGLRAVVGCSEAGLRTACITKVFPT
CCCCCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHCCC
RSHTVAAQGGVAASLANMGEDKWEWHMYDTVKGSDWLGDQDAIEYMVRNAPAAVYELEHW
CCCEEEECCCHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEHHHC
GVPFSRTEDGKIYQRPFGGMTTHYGKGTAQRTCAAADRTGHAMLHTLYGAALKHHAEFFV
CCCCCCCCCCCEEECCCCCCCEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EYFAIDLIMDEDGRCRGVIAIKLDDGTIHRFRAHLVVLATGGYGRAYFSATSAHTCTGDG
HHHEEEEEECCCCCEEEEEEEEECCCCEEEEEEEEEEEEECCCCEEEEECCCCCEEECCC
GGMVLRAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLTNSAGERFMERYAPSAKD
CCEEEECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECHHHHHHHHHHCCCHHH
LASRDVVSRSMTMEIREGRGVGKNKDHIFLHLDHLDPAILHERLPGISESAKIFAGVDLT
HHHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCC
REPIPVIPTVHYNMGGIPTNYYGEVLDKRSGDPDTVVPGLMAIGEAACVSVHGANRLGSN
CCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCC
SLIDLVVFGRAAGLRAAELVKPGEKHRELPAGSADLALSRLDAARYASGGTPTAELRLAM
CEEEEEEECCCCCCCHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
QKVMQSNCAVFRTGEVLEEGCKLIHDVYKGASDIGVTDRSLVWNSDLIETLEFENLIAQA
HHHHHCCCCEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHH
IVTMEGASARKESRGGHAREDFPDRDDVNWMKHTLAYFDTATGNVRLDDRPVHTYTLSND
HHHCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCC
IQYIEPKKRVY
CEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA