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The map label for this gene is dapL [H]

Identifier: 154245786

GI number: 154245786

Start: 2072062

End: 2073312

Strand: Reverse

Name: dapL [H]

Synonym: Xaut_1842

Alternate gene names: 154245786

Gene position: 2073312-2072062 (Counterclockwise)

Preceding gene: 154245787

Following gene: 154245785

Centisome position: 39.05

GC content: 72.66

Gene sequence:

>1251_bases
ATGATCGCCGCGAGAAAAGACCGCTCCGCCGTGCCAGCTTCCCCCGTCGCGCCTCCCGAGGACCGCCGCTCGCCCTTCAT
CCGCCTCGCCGACCTGTTGGCGGGGATCGATCCCGGCCGCCAGCCCCTGAGCGCGGCCGTGGGCGAGCCGCAGCATGCCA
TGCCGGATTTCGTCGGCCCGGTGCTGGCGCAGGCGCTGCCCGGCTTCGGCCGCTATCCGCGCGCCGAGGGCACCCCCACC
TTCCGCGCCGCCGCCGCCCGCTGGCTGGCGCAGCGCTATGCTCTCGCCCGCCCCATCGATGCCGACCGCGAGGTGCTGGC
GCTCAACGGCTCACGCGAGGGCCTGTTCTCCGCCGCCATCGTGGCGCGGCGGCTGACCGATCCGAAGAAGGGCGCCAAGG
GCCGCCCCGCCATGCTGCTGCCCAACCCCTTCTATGCTGCGTACGCTGCCGGCGCCGAGGCGGCGGGCTGCGAGGCGGTG
GTGGTGCCCACCTCCCGCGAGAGCGGCTGGCTGCCCGATCTCGACGCCCTCGACCCCGCGCTGCTGGAACGCACGGTGGC
GCTCTACATCGCCTCCCCCGCCAATCCGCAGGGCTCCATCGCCTCCGCCGCCTATCTCGGGCGAGCGCTGGAGCTGGCCC
GCCGGCACGGGGCCTTCCTGTTCTCGGACGAGTGCTATTCGGAAATCTACCTCGGCGCGGAAAAGCCTGCCGGCATTCTG
GAGGTGGCCGGGGGCGACTTCAGCCGAGCGGTGGCGTTCAACTCGCTGTCCAAGCGCTCGTCTTTGCCCGGCCTGCGCTG
CGGCTTCTGCGCCGGCGACCCGGCCTTCCTGAAGGATTTCCTCGCCTTCCGCTGGGTGGCGGCGCCGCAGGTGCCCGAGC
CGTTGCAGGCGGTGGCGGTGGCGGCGCTGGAGGACGAGGCCCATGTGACCATCTCCCGCGACCTCTATCGCGCCAAGTTC
GACCTCGCTGACCGCATGCTGGAGGGTCGCCTCGGCTACGAGCGGCCTGGCGGCGGCTTCTTCCTGTGGCTCGACGTGTC
GCACCTGGCCTCCGACACCCTGTCGGGCGGCGAGGCGGCGGCGGTGAAGCTGTGGCGCGAGCAGGGCCTGCGCACGGTGC
CCGGCGGCTATCTCGCCCGCCGCGACCTCACCGGCGCCAACCCCGCCGCAAACTTCCTGCGCGTCGCTTTGGTCCAGGAT
CTTCCCACCTGCGAGGAGGTGCTGACCCGCCTCGTCGCCGCCCTCACCTGA

Upstream 100 bases:

>100_bases
AGGCCCGCGAGGTTCTCGCCAAGGTTTGATCCCGGTCACGCATCCCTGCGATCTGAGTTAGCCGCACCTTAACCGACGCG
GCCCCATTCTCGCGGCAACC

Downstream 100 bases:

>100_bases
AGGAGAGCCGCGCCGATGCCGAGGGCCAGAAGCCGTTCCTCCACCGCCGATGCCGTGCTGAACACGCGCATGCCGCCCGC
CGCCCCGCGCTTCGACCTCA

Product: class I and II aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MIAARKDRSAVPASPVAPPEDRRSPFIRLADLLAGIDPGRQPLSAAVGEPQHAMPDFVGPVLAQALPGFGRYPRAEGTPT
FRAAAARWLAQRYALARPIDADREVLALNGSREGLFSAAIVARRLTDPKKGAKGRPAMLLPNPFYAAYAAGAEAAGCEAV
VVPTSRESGWLPDLDALDPALLERTVALYIASPANPQGSIASAAYLGRALELARRHGAFLFSDECYSEIYLGAEKPAGIL
EVAGGDFSRAVAFNSLSKRSSLPGLRCGFCAGDPAFLKDFLAFRWVAAPQVPEPLQAVAVAALEDEAHVTISRDLYRAKF
DLADRMLEGRLGYERPGGGFFLWLDVSHLASDTLSGGEAAAVKLWREQGLRTVPGGYLARRDLTGANPAANFLRVALVQD
LPTCEEVLTRLVAALT

Sequences:

>Translated_416_residues
MIAARKDRSAVPASPVAPPEDRRSPFIRLADLLAGIDPGRQPLSAAVGEPQHAMPDFVGPVLAQALPGFGRYPRAEGTPT
FRAAAARWLAQRYALARPIDADREVLALNGSREGLFSAAIVARRLTDPKKGAKGRPAMLLPNPFYAAYAAGAEAAGCEAV
VVPTSRESGWLPDLDALDPALLERTVALYIASPANPQGSIASAAYLGRALELARRHGAFLFSDECYSEIYLGAEKPAGIL
EVAGGDFSRAVAFNSLSKRSSLPGLRCGFCAGDPAFLKDFLAFRWVAAPQVPEPLQAVAVAALEDEAHVTISRDLYRAKF
DLADRMLEGRLGYERPGGGFFLWLDVSHLASDTLSGGEAAAVKLWREQGLRTVPGGYLARRDLTGANPAANFLRVALVQD
LPTCEEVLTRLVAALT
>Mature_416_residues
MIAARKDRSAVPASPVAPPEDRRSPFIRLADLLAGIDPGRQPLSAAVGEPQHAMPDFVGPVLAQALPGFGRYPRAEGTPT
FRAAAARWLAQRYALARPIDADREVLALNGSREGLFSAAIVARRLTDPKKGAKGRPAMLLPNPFYAAYAAGAEAAGCEAV
VVPTSRESGWLPDLDALDPALLERTVALYIASPANPQGSIASAAYLGRALELARRHGAFLFSDECYSEIYLGAEKPAGIL
EVAGGDFSRAVAFNSLSKRSSLPGLRCGFCAGDPAFLKDFLAFRWVAAPQVPEPLQAVAVAALEDEAHVTISRDLYRAKF
DLADRMLEGRLGYERPGGGFFLWLDVSHLASDTLSGGEAAAVKLWREQGLRTVPGGYLARRDLTGANPAANFLRVALVQD
LPTCEEVLTRLVAALT

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=326, Percent_Identity=23.9263803680982, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI56713254, Length=326, Percent_Identity=23.9263803680982, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1788722, Length=312, Percent_Identity=25, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788627, Length=253, Percent_Identity=26.8774703557312, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788332, Length=243, Percent_Identity=27.1604938271605, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786816, Length=333, Percent_Identity=26.1261261261261, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 44341; Mature: 44341

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAARKDRSAVPASPVAPPEDRRSPFIRLADLLAGIDPGRQPLSAAVGEPQHAMPDFVGP
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCHHHHHH
VLAQALPGFGRYPRAEGTPTFRAAAARWLAQRYALARPIDADREVLALNGSREGLFSAAI
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHH
VARRLTDPKKGAKGRPAMLLPNPFYAAYAAGAEAAGCEAVVVPTSRESGWLPDLDALDPA
HHHHHCCCCCCCCCCCEEECCCCHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHCCHH
LLERTVALYIASPANPQGSIASAAYLGRALELARRHGAFLFSDECYSEIYLGAEKPAGIL
HHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHCCCCCCCCEE
EVAGGDFSRAVAFNSLSKRSSLPGLRCGFCAGDPAFLKDFLAFRWVAAPQVPEPLQAVAV
EECCCCHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
AALEDEAHVTISRDLYRAKFDLADRMLEGRLGYERPGGGFFLWLDVSHLASDTLSGGEAA
HHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHCCCCHHH
AVKLWREQGLRTVPGGYLARRDLTGANPAANFLRVALVQDLPTCEEVLTRLVAALT
HHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIAARKDRSAVPASPVAPPEDRRSPFIRLADLLAGIDPGRQPLSAAVGEPQHAMPDFVGP
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCHHHHHH
VLAQALPGFGRYPRAEGTPTFRAAAARWLAQRYALARPIDADREVLALNGSREGLFSAAI
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHH
VARRLTDPKKGAKGRPAMLLPNPFYAAYAAGAEAAGCEAVVVPTSRESGWLPDLDALDPA
HHHHHCCCCCCCCCCCEEECCCCHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHCCHH
LLERTVALYIASPANPQGSIASAAYLGRALELARRHGAFLFSDECYSEIYLGAEKPAGIL
HHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHCCCCCCCCEE
EVAGGDFSRAVAFNSLSKRSSLPGLRCGFCAGDPAFLKDFLAFRWVAAPQVPEPLQAVAV
EECCCCHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
AALEDEAHVTISRDLYRAKFDLADRMLEGRLGYERPGGGFFLWLDVSHLASDTLSGGEAA
HHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHCCCCHHH
AVKLWREQGLRTVPGGYLARRDLTGANPAANFLRVALVQDLPTCEEVLTRLVAALT
HHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA