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The map label for this gene is 154245649

Identifier: 154245649

GI number: 154245649

Start: 1920602

End: 1921567

Strand: Reverse

Name: 154245649

Synonym: Xaut_1705

Alternate gene names: NA

Gene position: 1921567-1920602 (Counterclockwise)

Preceding gene: 154245659

Following gene: 154245647

Centisome position: 36.19

GC content: 68.94

Gene sequence:

>966_bases
ATGCGGACTTCGCCGTCGCCGGAAAGTCGGTGGCGACGATCCAGGCCGAGCGCGCCGCGCGGACCGGCTGAGGCCATGCG
GAAACCTGATGCTCCCGCCTCCCATCGCATCCAGGCCGGCGGGCTGGATGTCCACTATCTGCGGGCCGGGCGGGGGCGGC
CCCTCGTCCTGCTGCACGGCTGGCCGGAATTCAGCGGGGTGTGGGAGCCGCTGATGGCGCGGCTCGCGCCCGATTTCGAC
GTCATTGCCCCGGACCTGCGCGGCTTCGGAGATACCCAGAAGCCCGATGCCGGCCCCAGCGAAAAGGTGAGCGCGGACCT
GCTCGCCGCCGACCTTATCGCCCTTCTCGACGGGCTCGGGCTTGAGGGGCCGGTGGGCCTCGTCTCCCACGATGTGGGCG
CCGTGGTGGGCCAGTCCCTGGGGCGTAGCCATCCGGAGCGGTTCCGCGGCCTGTTCTTCTTCAACTGCCCCTATCCGGGC
ATCGGCCGGCGCTGGGCGGAGCCCGACCATATCCGCGAGATCTGGTACCACAGCTTCCATTGCCTGCCGTGGGCGGCGGC
CATGGTGGGGTCATCGCGCGAGGCCTGCCGGCAGTATTTCTCACACTTCCTACGCCACTGGTCCGCCGATCCCCACACGT
TCGACGACGTGCTGGAGCGCTGGGTGGACAACTTCATGAAGCCGGGCAATCTGCAGGGCGGCTTCAACTGGTATTTGAGC
ATGCGCGCGGGCCGCCTCGCCCTCATGAAGGGGGAGGCCCCGCCGGTGGCGCCCATCACCGTGCCCACGCGGGTGTTCTG
GGGCGACCGCGATCCCGTGCTCAGGTCGGAATGGATGGACCGGCTGCCGGAGTATTTCCTCGATCTTGAGGCCTCGGTGG
CTGAGGGCCTCGGTCATTTCGTCCATTACGAGGACCCGGACCGGGCCGCCGCCGAAGTGCGGGCCTTCTTCCACCGCGTG
GGTTGA

Upstream 100 bases:

>100_bases
GCCCAGAAGGACGACATGTACCGGGAGGTGACCAACGCCCTGTGCCGCACGCTGGAATGCCGGCCCGATCAGGTGCGCAT
CATGGTGCAGGATTTCGCCA

Downstream 100 bases:

>100_bases
AGCCTGCGCGGCGCCTGAGCGGGGCTGTCTGGTCCATCACGCCGGAGCCGGTTCGAACCGTTGGCGCAACTCGGTTTTCA
GTACCTTGCCCATGGGGTTC

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: SEH; Cytosolic epoxide hydrolase; cEH; Epoxide hydratase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MRTSPSPESRWRRSRPSAPRGPAEAMRKPDAPASHRIQAGGLDVHYLRAGRGRPLVLLHGWPEFSGVWEPLMARLAPDFD
VIAPDLRGFGDTQKPDAGPSEKVSADLLAADLIALLDGLGLEGPVGLVSHDVGAVVGQSLGRSHPERFRGLFFFNCPYPG
IGRRWAEPDHIREIWYHSFHCLPWAAAMVGSSREACRQYFSHFLRHWSADPHTFDDVLERWVDNFMKPGNLQGGFNWYLS
MRAGRLALMKGEAPPVAPITVPTRVFWGDRDPVLRSEWMDRLPEYFLDLEASVAEGLGHFVHYEDPDRAAAEVRAFFHRV
G

Sequences:

>Translated_321_residues
MRTSPSPESRWRRSRPSAPRGPAEAMRKPDAPASHRIQAGGLDVHYLRAGRGRPLVLLHGWPEFSGVWEPLMARLAPDFD
VIAPDLRGFGDTQKPDAGPSEKVSADLLAADLIALLDGLGLEGPVGLVSHDVGAVVGQSLGRSHPERFRGLFFFNCPYPG
IGRRWAEPDHIREIWYHSFHCLPWAAAMVGSSREACRQYFSHFLRHWSADPHTFDDVLERWVDNFMKPGNLQGGFNWYLS
MRAGRLALMKGEAPPVAPITVPTRVFWGDRDPVLRSEWMDRLPEYFLDLEASVAEGLGHFVHYEDPDRAAAEVRAFFHRV
G
>Mature_321_residues
MRTSPSPESRWRRSRPSAPRGPAEAMRKPDAPASHRIQAGGLDVHYLRAGRGRPLVLLHGWPEFSGVWEPLMARLAPDFD
VIAPDLRGFGDTQKPDAGPSEKVSADLLAADLIALLDGLGLEGPVGLVSHDVGAVVGQSLGRSHPERFRGLFFFNCPYPG
IGRRWAEPDHIREIWYHSFHCLPWAAAMVGSSREACRQYFSHFLRHWSADPHTFDDVLERWVDNFMKPGNLQGGFNWYLS
MRAGRLALMKGEAPPVAPITVPTRVFWGDRDPVLRSEWMDRLPEYFLDLEASVAEGLGHFVHYEDPDRAAAEVRAFFHRV
G

Specific function: Involved in catabolic degradation of epoxides. Shows highest activity towards C6 and C7 carbocyclic epoxides. Also active towards linear 1,2-epoxyalkanes [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI218777837, Length=328, Percent_Identity=26.5243902439024, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI218777840, Length=293, Percent_Identity=27.3037542662116, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI13376164, Length=293, Percent_Identity=27.3037542662116, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17554012, Length=309, Percent_Identity=24.5954692556634, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324392, Length=120, Percent_Identity=39.1666666666667, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639
- InterPro:   IPR010497 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF06441 EHN [H]

EC number: =3.3.2.10 [H]

Molecular weight: Translated: 36047; Mature: 36047

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTSPSPESRWRRSRPSAPRGPAEAMRKPDAPASHRIQAGGLDVHYLRAGRGRPLVLLHG
CCCCCCHHHHHHHCCCCCCCCHHHHHCCCCCCHHCEEECCCCEEEEEECCCCCEEEEEEC
WPEFSGVWEPLMARLAPDFDVIAPDLRGFGDTQKPDAGPSEKVSADLLAADLIALLDGLG
CCCHHHHHHHHHHHHCCCCHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
LEGPVGLVSHDVGAVVGQSLGRSHPERFRGLFFFNCPYPGIGRRWAEPDHIREIWYHSFH
CCCCCHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
CLPWAAAMVGSSREACRQYFSHFLRHWSADPHTFDDVLERWVDNFMKPGNLQGGFNWYLS
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEE
MRAGRLALMKGEAPPVAPITVPTRVFWGDRDPVLRSEWMDRLPEYFLDLEASVAEGLGHF
ECCCEEEEEECCCCCCCCEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VHYEDPDRAAAEVRAFFHRVG
CCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRTSPSPESRWRRSRPSAPRGPAEAMRKPDAPASHRIQAGGLDVHYLRAGRGRPLVLLHG
CCCCCCHHHHHHHCCCCCCCCHHHHHCCCCCCHHCEEECCCCEEEEEECCCCCEEEEEEC
WPEFSGVWEPLMARLAPDFDVIAPDLRGFGDTQKPDAGPSEKVSADLLAADLIALLDGLG
CCCHHHHHHHHHHHHCCCCHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
LEGPVGLVSHDVGAVVGQSLGRSHPERFRGLFFFNCPYPGIGRRWAEPDHIREIWYHSFH
CCCCCHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
CLPWAAAMVGSSREACRQYFSHFLRHWSADPHTFDDVLERWVDNFMKPGNLQGGFNWYLS
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEE
MRAGRLALMKGEAPPVAPITVPTRVFWGDRDPVLRSEWMDRLPEYFLDLEASVAEGLGHF
ECCCEEEEEECCCCCCCCEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VHYEDPDRAAAEVRAFFHRVG
CCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9578475 [H]