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The map label for this gene is fumC

Identifier: 154245611

GI number: 154245611

Start: 1885406

End: 1886794

Strand: Direct

Name: fumC

Synonym: Xaut_1667

Alternate gene names: 154245611

Gene position: 1885406-1886794 (Clockwise)

Preceding gene: 154245610

Following gene: 154245612

Centisome position: 35.51

GC content: 66.67

Gene sequence:

>1389_bases
ATGAGCACCCGCATCGAGACCGACACGTTCGGTCCCATCGAAGTTCAATCCGACCGTTATTGGGGTGCGCAGGCGCAGCG
CTCGCTGGGGAACTTCAAGATCGGCTGGGAAAAGCAGCCGCTCCCGGTGGTGCGCGCCCTCGGCATCGTCAAGCGTGCTG
CCGCGGAAGTAAACCGCGACCTCGGCCGCCTCGATCCCAAGATCGCCGACGCCATTGTCGCCGCCGCCCAGGAAGTCATC
GACGGCAAGCTCGATGAACACTTCCCGCTGGTGGTCTGGCAGACCGGCTCGGGCACCCAGTCCAACATGAACGCCAACGA
GGTGATCTCGAACCGGGCCATCGAGCTGCTCGGCGGGGAGAAGGGCTCCAAGAAGCCCGTGCATCCCAACGATCACGTCA
ACATGAGCCAGTCGTCCAACGACACCTACCCCACCGCCATGCACATCGCCTGCGCGGAGGAGATCGTCCACCGCCTGCTG
CCGGCGCTGCGCCACCTGCATGCGGCGCTGAAGGCCAAGTCCGAGGCCTGGGCCGGCATCATCAAGATCGGCCGCACCCA
CACCCAGGACGCCACGCCGCTGACGCTGGGCCAGGAATTCTCCGGCTACGCCCAGCAGGTGGAGAACGGCATCGCCCGCC
TGGAACTGACCCTGCCGGGCCTCCAGCAGCTGGCCCAGGGCGGCACCGCGGTGGGCACCGGCCTCAACGCCCCCGTCGGC
TTCGCCGAGCAGGTCGCGGCGAAGATCGCCGCCATCACCGGCATCGCCTTCACCTCGGCGCCCAACAAGTTCGAGGCGCT
CGCCGCCCATGACGCCATGGTGTTCTCCCACGGTGCCATCAACACGCTGGCGGCCTCCCTGTTCAAGATCGCCAACGACA
TCCGCCTGCTCGGCTCGGGTCCGCGCTCGGGCCTTGGCGAGCTGTCGCTGCCGGAGAACGAGCCCGGCTCGTCCATCATG
CCGGGCAAGGTGAACCCCACCCAGTGCGAGGCGCTGACCCAGGTCTGCGTGCAGATCTTCGGCAACAACGCCGCGCTCAC
CTTCGCCGGCAGCCAGGGCCACTTCGAGTTGAACGTGTACAACCCGGTGATGGCCTACAATTTCCTCCAGTCGGTGCGGC
TGATGGCGGACGCGGCGGTGAGTTTCACCGACAATTGCGTCGTCGGCATCGAGGCCCGCGAGGACAACATCAAGTCGGCG
CTGGAGCGCTCGCTCATGCTGGTCACCGCGCTGGCTCCGAAGATCGGCTACGACAACGCCGCCAAGATCGCCAAGACCGC
GCACAAGAATGGCACCACCCTGCGCGAGGAGGCCGTTGGCGGCGGCTATGTGACCAACGAGGAGTTCGACGCCGTCGTGC
GTCCCGAGAACATGATCTCGCCCGGCTGA

Upstream 100 bases:

>100_bases
ACCGCCTTGGAATTATTTTAGCCTACATGTCTAACTCCCCCGAACGCCTCCAGCCGTGCTATGAGCCCGCCGCCCGCGAG
ACCATGGAAAGGCTAAGGCG

Downstream 100 bases:

>100_bases
TCGTCACCGGCATCGCTCATCGGCGCGGCGGCATCCCCGGCGGGGTGCCGCCGCGCGCGTTTTCAGCCATGCTGCAGATT
GCCGGACACGCGCCGCCGCT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSTRIETDTFGPIEVQSDRYWGAQAQRSLGNFKIGWEKQPLPVVRALGIVKRAAAEVNRDLGRLDPKIADAIVAAAQEVI
DGKLDEHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGEKGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAEEIVHRLL
PALRHLHAALKAKSEAWAGIIKIGRTHTQDATPLTLGQEFSGYAQQVENGIARLELTLPGLQQLAQGGTAVGTGLNAPVG
FAEQVAAKIAAITGIAFTSAPNKFEALAAHDAMVFSHGAINTLAASLFKIANDIRLLGSGPRSGLGELSLPENEPGSSIM
PGKVNPTQCEALTQVCVQIFGNNAALTFAGSQGHFELNVYNPVMAYNFLQSVRLMADAAVSFTDNCVVGIEAREDNIKSA
LERSLMLVTALAPKIGYDNAAKIAKTAHKNGTTLREEAVGGGYVTNEEFDAVVRPENMISPG

Sequences:

>Translated_462_residues
MSTRIETDTFGPIEVQSDRYWGAQAQRSLGNFKIGWEKQPLPVVRALGIVKRAAAEVNRDLGRLDPKIADAIVAAAQEVI
DGKLDEHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGEKGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAEEIVHRLL
PALRHLHAALKAKSEAWAGIIKIGRTHTQDATPLTLGQEFSGYAQQVENGIARLELTLPGLQQLAQGGTAVGTGLNAPVG
FAEQVAAKIAAITGIAFTSAPNKFEALAAHDAMVFSHGAINTLAASLFKIANDIRLLGSGPRSGLGELSLPENEPGSSIM
PGKVNPTQCEALTQVCVQIFGNNAALTFAGSQGHFELNVYNPVMAYNFLQSVRLMADAAVSFTDNCVVGIEAREDNIKSA
LERSLMLVTALAPKIGYDNAAKIAKTAHKNGTTLREEAVGGGYVTNEEFDAVVRPENMISPG
>Mature_461_residues
STRIETDTFGPIEVQSDRYWGAQAQRSLGNFKIGWEKQPLPVVRALGIVKRAAAEVNRDLGRLDPKIADAIVAAAQEVID
GKLDEHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGEKGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAEEIVHRLLP
ALRHLHAALKAKSEAWAGIIKIGRTHTQDATPLTLGQEFSGYAQQVENGIARLELTLPGLQQLAQGGTAVGTGLNAPVGF
AEQVAAKIAAITGIAFTSAPNKFEALAAHDAMVFSHGAINTLAASLFKIANDIRLLGSGPRSGLGELSLPENEPGSSIMP
GKVNPTQCEALTQVCVQIFGNNAALTFAGSQGHFELNVYNPVMAYNFLQSVRLMADAAVSFTDNCVVGIEAREDNIKSAL
ERSLMLVTALAPKIGYDNAAKIAKTAHKNGTTLREEAVGGGYVTNEEFDAVVRPENMISPG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=68.1818181818182, Blast_Score=626, Evalue=1e-179,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=48.4848484848485, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=57.6419213973799, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI87082375, Length=463, Percent_Identity=38.4449244060475, Blast_Score=330, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=69.1304347826087, Blast_Score=648, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=68.1957186544342, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=66.4502164502164, Blast_Score=609, Evalue=1e-175,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=65.29284164859, Blast_Score=617, Evalue=1e-177,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=65.29284164859, Blast_Score=616, Evalue=1e-177,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=61.9047619047619, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=61.0752688172043, Blast_Score=583, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=52.9157667386609, Blast_Score=501, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49187; Mature: 49056

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRIETDTFGPIEVQSDRYWGAQAQRSLGNFKIGWEKQPLPVVRALGIVKRAAAEVNRD
CCCCCCCCCCCCEEECCCCCCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LGRLDPKIADAIVAAAQEVIDGKLDEHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGE
HHHCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHEECCC
KGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAEEIVHRLLPALRHLHAALKAKSEAWAGI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKIGRTHTQDATPLTLGQEFSGYAQQVENGIARLELTLPGLQQLAQGGTAVGTGLNAPVG
HHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECHHHHHHHCCCCEECCCCCCCCC
FAEQVAAKIAAITGIAFTSAPNKFEALAAHDAMVFSHGAINTLAASLFKIANDIRLLGSG
HHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCC
PRSGLGELSLPENEPGSSIMPGKVNPTQCEALTQVCVQIFGNNAALTFAGSQGHFELNVY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEC
NPVMAYNFLQSVRLMADAAVSFTDNCVVGIEAREDNIKSALERSLMLVTALAPKIGYDNA
CHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCH
AKIAKTAHKNGTTLREEAVGGGYVTNEEFDAVVRPENMISPG
HHHHHHHCCCCCCHHHHCCCCCCEECCCCCEEECCCCCCCCC
>Mature Secondary Structure 
STRIETDTFGPIEVQSDRYWGAQAQRSLGNFKIGWEKQPLPVVRALGIVKRAAAEVNRD
CCCCCCCCCCCEEECCCCCCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LGRLDPKIADAIVAAAQEVIDGKLDEHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGE
HHHCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHEECCC
KGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAEEIVHRLLPALRHLHAALKAKSEAWAGI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKIGRTHTQDATPLTLGQEFSGYAQQVENGIARLELTLPGLQQLAQGGTAVGTGLNAPVG
HHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECHHHHHHHCCCCEECCCCCCCCC
FAEQVAAKIAAITGIAFTSAPNKFEALAAHDAMVFSHGAINTLAASLFKIANDIRLLGSG
HHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCC
PRSGLGELSLPENEPGSSIMPGKVNPTQCEALTQVCVQIFGNNAALTFAGSQGHFELNVY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEC
NPVMAYNFLQSVRLMADAAVSFTDNCVVGIEAREDNIKSALERSLMLVTALAPKIGYDNA
CHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCH
AKIAKTAHKNGTTLREEAVGGGYVTNEEFDAVVRPENMISPG
HHHHHHHCCCCCCHHHHCCCCCCEECCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]