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The map label for this gene is pdhA [H]

Identifier: 154245517

GI number: 154245517

Start: 1781206

End: 1783392

Strand: Direct

Name: pdhA [H]

Synonym: Xaut_1571

Alternate gene names: 154245517

Gene position: 1781206-1783392 (Clockwise)

Preceding gene: 154245516

Following gene: 154245518

Centisome position: 33.55

GC content: 69.14

Gene sequence:

>2187_bases
ATGGCGACCCATATCGACCTGAAACCCGCCGCCCCCTGGCGTGAGCTGACCACCTCCCGCGACGACTGGAATGCGGCCGA
TCCGGCCCTGCTCGGGACCATGCTCACCTCCATGGCGCTGATCCGCGCATTCGAGGAGAAGGTGCTGGAGCTGGCCGGGC
AGGGGCTGGTGCACGGCCCGGCGCATTCGGCCATCGGGCAGGAAGGCGGCGCCACCGGATCCGCCGTGATGATGCGCACT
TCCGACCAGGTGAACGGATCCCACCGGGCCCACCACCAGTTCCTCGCCAAGTCGCTGGCCTATGTGGCGCCGGACGGCCT
GTCCCCCACCGCCGCCATCAGTGGCGACGTGCGCGACCTGTCCAAGAAGACCATGGCGGAAATCCTCGGCCTCGCTCAGG
GCTTCTGCAAGGGGCGCGGCGGCTCCATGCACTTGCGCTGGGGCGAGGCGGGCAATCTCGGCACCAACGCCATCGTCGGC
GGCGGCGTGCCGCTGGCGGCGGGGGCGGCCTTCGCCCACAAGCGCGCCGGCACGGGCGATGCAGTCTTCACCTATTTCGG
CGACGGCGCCACCAATATCGGGTCGGTGCTGGAGACCATGAACCTCGCGGCGGCCTGGAAGCTGCCCTTGTGCTTCTTCA
TCGAGAACAACCGCTACGCGGTCTCCACCCATGTGGAGGAGGCCACCGCGGAGACCCGCCTCTCCGCCCGCGGGCTGGGC
TTTGCCATCCCCTCCTGGAAGGTGGACGGCATGGACCCGCTGGCGGTGGCGCTGGCCAGCGCCGAGGCGCTGGAGGTGAT
GCGCTCGGGCGGCGGCCCCACCGTCATCGAGGCCGATGTCTACCGCTTCTTCCACCAGAACGGCCCCTTGCCCGGCAGCG
CCTTCGGCTATCGCACCCGCGAGGAAGAGCAGGAGTGGCGCCGGCGCGATCCCATCGATCTCCTGGCCCGTGAGATGGCT
TTGCGCCAGCTCATCGGCGACGAGGAGGTCGCCGCCCTGCGCGCCCGTGCCAAGGCGCTCATGGAGGATGTGGCCGGCGA
GTTGGTGGAGCAGGTGGACGGCAAGCGCCGCATCATCCCGGCTTTGTGGCCCTCGCCCGATTTCCGCGACTTTGGCGTGC
GCGGCGACCTGTCCGAACTCGACGGCGTGCGCACCGAGGAACTGGAGACCTTCACCGGCGGCATCGACCCGCAGGCCCGC
TTCGTGGACGTGGTAGCGGACGTGATGCACCGGCGCATGAGTGAGGACGGCCGCATCGTGGTGATGGGCGAGGACGTGCA
TCGCCTCAAGGGCGGCACCAATGGCGCCACGCGCGGCCTCAAGGAGGCTTTCGGCGACCGCGTGCTCGGCACCCCCATCA
GCGAGAACGCCTTTGCGGGCCTCGCCGGCGGCATCGCCATGGACGGGCGCTATGTGCCGGTGATCGAGTTCATGTATCCG
GACTTCATGTGGGTGGCCGCCGACCAGGTGTTCAACCAGATCGGCAAGGCGCGGCACATGTTCGGCGGCGACATGGCGGT
GCCGCTGGTGCTGCGCACCAAGGTGGCCATGGGCACGGGCTATGGCTCGCAGCATTCCATGGACCCGGCCGGAATCTTCG
CCACCGCCGTGGGCTGGCGCATCGTCGCCCCCTCCACGCCGTTCGATTATGTGGGCCTCATGAACAGCGCGCTGGCCTGC
CAGGACCCCGTGCTCGTGCTGGAGCATGTGGACCTCTACAACGCCAAGGGCCCGGCGCCGCTGGATGACCTCGACTATTT
CATTCCCCTCGGCAAGGCCAAGGTGGTGCGGCCCGGCTCGGCCCTGACCATCCTCACCTATCTGTCCATGGTGAAGCCGA
CCCTGGAGGAGGTGGAGCGCCTGGGCGTGGACGCGGAGGTCATCGACCTGCGCAGCCTCGACCGCGCCGGCCTCGACTGG
GAGACCATCGAGACCTCCATCGCCAAGACCGGCAACGTGCTGGTGGTGGAGCAGGGCTCGGTGGGCACCTCCTACGGCGG
GTTCCTTGCCGCCGAGATCCAGTCGCGCTGCTTCGATGCGCTCGACCAGCCGGTGCAGCGCGTCCATGGCGGGGAGGCCT
CGCCTTCCATCTCCAAGGTGCTGGAAGCCGCCGCCTGCGCCGGTCCCAAGGACATCGAGGCCGGCATCCGTCGCGTCATG
GCCGAGCAGGGCCTCGCCCTCGCCTGA

Upstream 100 bases:

>100_bases
ATCCGGGCGGCTGAGCCGTGGCGCGCCCCTCGATGTCCCGTTCTTTCGCGCGGGGGAAGTTCGCACCCCCGACGTTTCCA
GCGTTTTCGGAGCTGCCGTG

Downstream 100 bases:

>100_bases
TCAGGAGCCCCACATGCCCAAGGAAATCCTGATGCCCGCCCTCTCTGCCGGAATGGAGGAGGGTCACCTCGTCCGCTGGC
TGAAGAAGGAAGGCGAGGCG

Product: dehydrogenase E1 component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 728; Mature: 727

Protein sequence:

>728_residues
MATHIDLKPAAPWRELTTSRDDWNAADPALLGTMLTSMALIRAFEEKVLELAGQGLVHGPAHSAIGQEGGATGSAVMMRT
SDQVNGSHRAHHQFLAKSLAYVAPDGLSPTAAISGDVRDLSKKTMAEILGLAQGFCKGRGGSMHLRWGEAGNLGTNAIVG
GGVPLAAGAAFAHKRAGTGDAVFTYFGDGATNIGSVLETMNLAAAWKLPLCFFIENNRYAVSTHVEEATAETRLSARGLG
FAIPSWKVDGMDPLAVALASAEALEVMRSGGGPTVIEADVYRFFHQNGPLPGSAFGYRTREEEQEWRRRDPIDLLAREMA
LRQLIGDEEVAALRARAKALMEDVAGELVEQVDGKRRIIPALWPSPDFRDFGVRGDLSELDGVRTEELETFTGGIDPQAR
FVDVVADVMHRRMSEDGRIVVMGEDVHRLKGGTNGATRGLKEAFGDRVLGTPISENAFAGLAGGIAMDGRYVPVIEFMYP
DFMWVAADQVFNQIGKARHMFGGDMAVPLVLRTKVAMGTGYGSQHSMDPAGIFATAVGWRIVAPSTPFDYVGLMNSALAC
QDPVLVLEHVDLYNAKGPAPLDDLDYFIPLGKAKVVRPGSALTILTYLSMVKPTLEEVERLGVDAEVIDLRSLDRAGLDW
ETIETSIAKTGNVLVVEQGSVGTSYGGFLAAEIQSRCFDALDQPVQRVHGGEASPSISKVLEAAACAGPKDIEAGIRRVM
AEQGLALA

Sequences:

>Translated_728_residues
MATHIDLKPAAPWRELTTSRDDWNAADPALLGTMLTSMALIRAFEEKVLELAGQGLVHGPAHSAIGQEGGATGSAVMMRT
SDQVNGSHRAHHQFLAKSLAYVAPDGLSPTAAISGDVRDLSKKTMAEILGLAQGFCKGRGGSMHLRWGEAGNLGTNAIVG
GGVPLAAGAAFAHKRAGTGDAVFTYFGDGATNIGSVLETMNLAAAWKLPLCFFIENNRYAVSTHVEEATAETRLSARGLG
FAIPSWKVDGMDPLAVALASAEALEVMRSGGGPTVIEADVYRFFHQNGPLPGSAFGYRTREEEQEWRRRDPIDLLAREMA
LRQLIGDEEVAALRARAKALMEDVAGELVEQVDGKRRIIPALWPSPDFRDFGVRGDLSELDGVRTEELETFTGGIDPQAR
FVDVVADVMHRRMSEDGRIVVMGEDVHRLKGGTNGATRGLKEAFGDRVLGTPISENAFAGLAGGIAMDGRYVPVIEFMYP
DFMWVAADQVFNQIGKARHMFGGDMAVPLVLRTKVAMGTGYGSQHSMDPAGIFATAVGWRIVAPSTPFDYVGLMNSALAC
QDPVLVLEHVDLYNAKGPAPLDDLDYFIPLGKAKVVRPGSALTILTYLSMVKPTLEEVERLGVDAEVIDLRSLDRAGLDW
ETIETSIAKTGNVLVVEQGSVGTSYGGFLAAEIQSRCFDALDQPVQRVHGGEASPSISKVLEAAACAGPKDIEAGIRRVM
AEQGLALA
>Mature_727_residues
ATHIDLKPAAPWRELTTSRDDWNAADPALLGTMLTSMALIRAFEEKVLELAGQGLVHGPAHSAIGQEGGATGSAVMMRTS
DQVNGSHRAHHQFLAKSLAYVAPDGLSPTAAISGDVRDLSKKTMAEILGLAQGFCKGRGGSMHLRWGEAGNLGTNAIVGG
GVPLAAGAAFAHKRAGTGDAVFTYFGDGATNIGSVLETMNLAAAWKLPLCFFIENNRYAVSTHVEEATAETRLSARGLGF
AIPSWKVDGMDPLAVALASAEALEVMRSGGGPTVIEADVYRFFHQNGPLPGSAFGYRTREEEQEWRRRDPIDLLAREMAL
RQLIGDEEVAALRARAKALMEDVAGELVEQVDGKRRIIPALWPSPDFRDFGVRGDLSELDGVRTEELETFTGGIDPQARF
VDVVADVMHRRMSEDGRIVVMGEDVHRLKGGTNGATRGLKEAFGDRVLGTPISENAFAGLAGGIAMDGRYVPVIEFMYPD
FMWVAADQVFNQIGKARHMFGGDMAVPLVLRTKVAMGTGYGSQHSMDPAGIFATAVGWRIVAPSTPFDYVGLMNSALACQ
DPVLVLEHVDLYNAKGPAPLDDLDYFIPLGKAKVVRPGSALTILTYLSMVKPTLEEVERLGVDAEVIDLRSLDRAGLDWE
TIETSIAKTGNVLVVEQGSVGTSYGGFLAAEIQSRCFDALDQPVQRVHGGEASPSISKVLEAAACAGPKDIEAGIRRVMA
EQGLALA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=355, Percent_Identity=33.2394366197183, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI4885543, Length=309, Percent_Identity=38.1877022653722, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4505685, Length=310, Percent_Identity=38.7096774193548, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI291084742, Length=310, Percent_Identity=38.7096774193548, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI291084744, Length=317, Percent_Identity=37.8548895899054, Blast_Score=151, Evalue=3e-36,
Organism=Homo sapiens, GI291084858, Length=355, Percent_Identity=31.5492957746479, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4557353, Length=328, Percent_Identity=30.7926829268293, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI34101272, Length=328, Percent_Identity=30.7926829268293, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI291084757, Length=310, Percent_Identity=33.8709677419355, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI11386135, Length=331, Percent_Identity=29.9093655589124, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI258645172, Length=331, Percent_Identity=29.9093655589124, Blast_Score=94, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17538422, Length=325, Percent_Identity=35.0769230769231, Blast_Score=172, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17536047, Length=297, Percent_Identity=34.3434343434343, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32564172, Length=297, Percent_Identity=34.3434343434343, Blast_Score=140, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17506935, Length=317, Percent_Identity=31.2302839116719, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI86563357, Length=307, Percent_Identity=28.6644951140065, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=307, Percent_Identity=28.6644951140065, Blast_Score=101, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321026, Length=316, Percent_Identity=35.126582278481, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319698, Length=321, Percent_Identity=32.7102803738318, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21358145, Length=325, Percent_Identity=34.4615384615385, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24650940, Length=325, Percent_Identity=34.4615384615385, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24639740, Length=310, Percent_Identity=35.4838709677419, Blast_Score=158, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24639744, Length=310, Percent_Identity=35.4838709677419, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI28571106, Length=310, Percent_Identity=35.4838709677419, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24639746, Length=308, Percent_Identity=35.3896103896104, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24639748, Length=315, Percent_Identity=34.2857142857143, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI160714832, Length=309, Percent_Identity=31.7152103559871, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI160714828, Length=309, Percent_Identity=31.7152103559871, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21355903, Length=323, Percent_Identity=27.5541795665635, Blast_Score=87, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 77782; Mature: 77651

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHIDLKPAAPWRELTTSRDDWNAADPALLGTMLTSMALIRAFEEKVLELAGQGLVHGP
CCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AHSAIGQEGGATGSAVMMRTSDQVNGSHRAHHQFLAKSLAYVAPDGLSPTAAISGDVRDL
CHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHH
SKKTMAEILGLAQGFCKGRGGSMHLRWGEAGNLGTNAIVGGGVPLAAGAAFAHKRAGTGD
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHCCCCCC
AVFTYFGDGATNIGSVLETMNLAAAWKLPLCFFIENNRYAVSTHVEEATAETRLSARGLG
EEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECHHHHHHHHHHHHCCCC
FAIPSWKVDGMDPLAVALASAEALEVMRSGGGPTVIEADVYRFFHQNGPLPGSAFGYRTR
EECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCC
EEEQEWRRRDPIDLLAREMALRQLIGDEEVAALRARAKALMEDVAGELVEQVDGKRRIIP
HHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
ALWPSPDFRDFGVRGDLSELDGVRTEELETFTGGIDPQARFVDVVADVMHRRMSEDGRIV
CCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEE
VMGEDVHRLKGGTNGATRGLKEAFGDRVLGTPISENAFAGLAGGIAMDGRYVPVIEFMYP
EECCHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCEEECCEEEEEEHHHCC
DFMWVAADQVFNQIGKARHMFGGDMAVPLVLRTKVAMGTGYGSQHSMDPAGIFATAVGWR
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCE
IVAPSTPFDYVGLMNSALACQDPVLVLEHVDLYNAKGPAPLDDLDYFIPLGKAKVVRPGS
EECCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCHHHEECCCCEEECCCC
ALTILTYLSMVKPTLEEVERLGVDAEVIDLRSLDRAGLDWETIETSIAKTGNVLVVEQGS
HHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCC
VGTSYGGFLAAEIQSRCFDALDQPVQRVHGGEASPSISKVLEAAACAGPKDIEAGIRRVM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
AEQGLALA
HHCCCCCC
>Mature Secondary Structure 
ATHIDLKPAAPWRELTTSRDDWNAADPALLGTMLTSMALIRAFEEKVLELAGQGLVHGP
CCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AHSAIGQEGGATGSAVMMRTSDQVNGSHRAHHQFLAKSLAYVAPDGLSPTAAISGDVRDL
CHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHH
SKKTMAEILGLAQGFCKGRGGSMHLRWGEAGNLGTNAIVGGGVPLAAGAAFAHKRAGTGD
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHCCCCCC
AVFTYFGDGATNIGSVLETMNLAAAWKLPLCFFIENNRYAVSTHVEEATAETRLSARGLG
EEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECHHHHHHHHHHHHCCCC
FAIPSWKVDGMDPLAVALASAEALEVMRSGGGPTVIEADVYRFFHQNGPLPGSAFGYRTR
EECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCC
EEEQEWRRRDPIDLLAREMALRQLIGDEEVAALRARAKALMEDVAGELVEQVDGKRRIIP
HHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
ALWPSPDFRDFGVRGDLSELDGVRTEELETFTGGIDPQARFVDVVADVMHRRMSEDGRIV
CCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEE
VMGEDVHRLKGGTNGATRGLKEAFGDRVLGTPISENAFAGLAGGIAMDGRYVPVIEFMYP
EECCHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCEEECCEEEEEEHHHCC
DFMWVAADQVFNQIGKARHMFGGDMAVPLVLRTKVAMGTGYGSQHSMDPAGIFATAVGWR
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCE
IVAPSTPFDYVGLMNSALACQDPVLVLEHVDLYNAKGPAPLDDLDYFIPLGKAKVVRPGS
EECCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCHHHEECCCCEEECCCC
ALTILTYLSMVKPTLEEVERLGVDAEVIDLRSLDRAGLDWETIETSIAKTGNVLVVEQGS
HHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCC
VGTSYGGFLAAEIQSRCFDALDQPVQRVHGGEASPSISKVLEAAACAGPKDIEAGIRRVM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
AEQGLALA
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]