Click here to switch to the map view.

The map label for this gene is livM [H]

Identifier: 154245447

GI number: 154245447

Start: 1707900

End: 1708910

Strand: Reverse

Name: livM [H]

Synonym: Xaut_1500

Alternate gene names: 154245447

Gene position: 1708910-1707900 (Counterclockwise)

Preceding gene: 154245448

Following gene: 154245446

Centisome position: 32.19

GC content: 66.86

Gene sequence:

>1011_bases
ATGACCGACAGCACCCTCACCTCCCTCAAGCTGCGCGGCGATGCCTTCATCGCCAAGCGCCGGCGCCAACTCGTCGTCGC
GGCCGCGGTGTTCGCCGCCGTGGCCTGCCTGCCGCTGGGCATCCGGGACGTTTATCTCCAGAACGTCCTCATCCTCACCC
TGCTCTATGCGGCGGTGTCGCAGAGCTGGAACATCCTGGGCGGCTATTGCGGCCAGATCTCGCTGGGCCATGCCCTCTAC
TTCGGCATCGGCGCCTATGCGGCGTCCGTGCTCTACGTGAACTACGACATCGTGCCCTGGTTCGGCATGGTGGTGGGCGG
CCTGCTGTCGGCGGCGCTCGCGGTGGCCCTCGGCTTCATGACCTTCCGGCTGAAGGGCCATTACTTCGCAATCGCCACCC
TGGTGATCGCGGAAATCGGCCTGGTCCTGGTCCACAACTGGGACTTTGTCGGCGGCGCCCTGGGCATCCAGTGGCCGTTC
GGCACCGACAGCTTCTGGACCCTCCAGTTCGCCCGGGACAAGGTGCCCTATTTCTACATCGCCCTCGGGCTTTTGGTGGT
GGTGTGGCTCGTCACCTATCTCATCGAGAATTCCCGCTGGGGCTTCTGGTGGCGCGCGGTGAAGGACGATCCGGAGGCGG
CCGAGAGCCTGGGCGTGGAAGTGTTCCGCTCCAAGCTCGCGGCGGCGGCGGTGTCGGCCTTCTTCACCGCGGTGGGCGGC
GGCTTCTATGCGGCCTTCGTCTCCTACATCGACCCCGAAAGCGTGATGAGCTTCCGCTTCTCGCTGCTCTTCGCCCTGCC
GGCGGTGCTCGGCGGCATCGGCACCCTGTGGGGCGCCCCGCTCGGCGCGGCGATCCTCATCCCCCTCACCGAGATCACCC
GCTCCTATCTCGGCGGGTCGGGCTCCGGCCTCGACCTCATCATCTACGGCGCGCTGATCATGGTGGTGGCGCTGGCCAAG
CCCGAGGGCCTGCTCAGCCTCTTCACCCGCAAGTCGGGAGGCAAGGCATGA

Upstream 100 bases:

>100_bases
CCCTTATCCTGCCGCCGACCATGAAGGCAGTGGGCATCTACGCCCTCTATCTCGCCGTGGTGTTCTTCCGCCCGAGCGGC
CTGTTCGGAAAGCTGTGAAG

Downstream 100 bases:

>100_bases
CGTCCGATATCCTGCTCGAGACGCGCGGCGTCACCCAGCGCTTCGGCGGCCTGGTGGCCAACTCGGATGTCTCCATCTCC
ATCAAGCGCGGCGAGATCCT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTDSTLTSLKLRGDAFIAKRRRQLVVAAAVFAAVACLPLGIRDVYLQNVLILTLLYAAVSQSWNILGGYCGQISLGHALY
FGIGAYAASVLYVNYDIVPWFGMVVGGLLSAALAVALGFMTFRLKGHYFAIATLVIAEIGLVLVHNWDFVGGALGIQWPF
GTDSFWTLQFARDKVPYFYIALGLLVVVWLVTYLIENSRWGFWWRAVKDDPEAAESLGVEVFRSKLAAAAVSAFFTAVGG
GFYAAFVSYIDPESVMSFRFSLLFALPAVLGGIGTLWGAPLGAAILIPLTEITRSYLGGSGSGLDLIIYGALIMVVALAK
PEGLLSLFTRKSGGKA

Sequences:

>Translated_336_residues
MTDSTLTSLKLRGDAFIAKRRRQLVVAAAVFAAVACLPLGIRDVYLQNVLILTLLYAAVSQSWNILGGYCGQISLGHALY
FGIGAYAASVLYVNYDIVPWFGMVVGGLLSAALAVALGFMTFRLKGHYFAIATLVIAEIGLVLVHNWDFVGGALGIQWPF
GTDSFWTLQFARDKVPYFYIALGLLVVVWLVTYLIENSRWGFWWRAVKDDPEAAESLGVEVFRSKLAAAAVSAFFTAVGG
GFYAAFVSYIDPESVMSFRFSLLFALPAVLGGIGTLWGAPLGAAILIPLTEITRSYLGGSGSGLDLIIYGALIMVVALAK
PEGLLSLFTRKSGGKA
>Mature_335_residues
TDSTLTSLKLRGDAFIAKRRRQLVVAAAVFAAVACLPLGIRDVYLQNVLILTLLYAAVSQSWNILGGYCGQISLGHALYF
GIGAYAASVLYVNYDIVPWFGMVVGGLLSAALAVALGFMTFRLKGHYFAIATLVIAEIGLVLVHNWDFVGGALGIQWPFG
TDSFWTLQFARDKVPYFYIALGLLVVVWLVTYLIENSRWGFWWRAVKDDPEAAESLGVEVFRSKLAAAAVSAFFTAVGGG
FYAAFVSYIDPESVMSFRFSLLFALPAVLGGIGTLWGAPLGAAILIPLTEITRSYLGGSGSGLDLIIYGALIMVVALAKP
EGLLSLFTRKSGGKA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=305, Percent_Identity=27.8688524590164, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 36096; Mature: 35965

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSTLTSLKLRGDAFIAKRRRQLVVAAAVFAAVACLPLGIRDVYLQNVLILTLLYAAVS
CCCCHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QSWNILGGYCGQISLGHALYFGIGAYAASVLYVNYDIVPWFGMVVGGLLSAALAVALGFM
CCCCCCCHHCCCHHHHHHHHHHHHHHHHEEHEEECCHHHHHHHHHHHHHHHHHHHHHHHH
TFRLKGHYFAIATLVIAEIGLVLVHNWDFVGGALGIQWPFGTDSFWTLQFARDKVPYFYI
HHHCCCHHHHHHHHHHHHHCCCEEECCCEECCCEEEECCCCCCCEEEEEEHHCCCCHHHH
ALGLLVVVWLVTYLIENSRWGFWWRAVKDDPEAAESLGVEVFRSKLAAAAVSAFFTAVGG
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GFYAAFVSYIDPESVMSFRFSLLFALPAVLGGIGTLWGAPLGAAILIPLTEITRSYLGGS
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
GSGLDLIIYGALIMVVALAKPEGLLSLFTRKSGGKA
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TDSTLTSLKLRGDAFIAKRRRQLVVAAAVFAAVACLPLGIRDVYLQNVLILTLLYAAVS
CCCHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QSWNILGGYCGQISLGHALYFGIGAYAASVLYVNYDIVPWFGMVVGGLLSAALAVALGFM
CCCCCCCHHCCCHHHHHHHHHHHHHHHHEEHEEECCHHHHHHHHHHHHHHHHHHHHHHHH
TFRLKGHYFAIATLVIAEIGLVLVHNWDFVGGALGIQWPFGTDSFWTLQFARDKVPYFYI
HHHCCCHHHHHHHHHHHHHCCCEEECCCEECCCEEEECCCCCCCEEEEEEHHCCCCHHHH
ALGLLVVVWLVTYLIENSRWGFWWRAVKDDPEAAESLGVEVFRSKLAAAAVSAFFTAVGG
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GFYAAFVSYIDPESVMSFRFSLLFALPAVLGGIGTLWGAPLGAAILIPLTEITRSYLGGS
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
GSGLDLIIYGALIMVVALAKPEGLLSLFTRKSGGKA
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]