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The map label for this gene is pepA

Identifier: 154245409

GI number: 154245409

Start: 1671840

End: 1673336

Strand: Reverse

Name: pepA

Synonym: Xaut_1462

Alternate gene names: 154245409

Gene position: 1673336-1671840 (Counterclockwise)

Preceding gene: 154245410

Following gene: 154245406

Centisome position: 31.52

GC content: 69.14

Gene sequence:

>1497_bases
ATGTCCGAACCCGTCACCCTCTCGTTCGCACGGCTCACCGCCGCCCCCAAGGGCGTGCTGATCGTGTTGACCGACGAGAC
CCTCGCCTTCGGCGCGCAGACGCAGAAGCTGCTGAAGGGCGCCGATGCCGCCATCACCCGCGCCTTCGACGCCGAGCGCT
ACAAGGGCAAGGCCTGGAGCACCATCGACCTGCTCGCTCCCGCCGGCCTCGATGCGCCGCGCCTGGTGGTGATCTCCGTG
GGCAAGGCCGGGGAGCTGAAGCCTGCCGATTTCCTCAAGCTGGGCGGCGTGGCGGCGGGCAAGATCCCCTCCTCCGCCCG
CGAGGCGACGGTCGTGCTCGACCTGCCGGGCGCCAAGATCGGCCCCGAGTCGGCGGCTGAAGTCGCCCTCGGCATCCGCC
TGCGCACCTACAGCTTCGACCGCTACAAGACCAAAAAGAAGGACGACACCGAGCGCGGCGCACTCGCCATGACTTTGCTG
GTGTCCGACGAGGCCGGCACCAAGCGCGCGGCGACGACGGCCGATGCGGTGGGCGACGGCGTGCTGTTCGCCCGCGACCT
GGTGAACGAGCCCGCCAACGTGCTCGACCCGCCTGAGTTCGCCCGCCGCGCCGAGGAGCACCTGTCGTCCGTGGGCGTTG
AGATCGAGGTGCTGGACGACGCCGGCCTCGCCCGCGCCGGCATGCACACGCTGCTGGGCGTCGGCCAGGGCTCCATCAAG
GAGAGCCGCGTCGTCATCATGCGCTGGAACGGCGGGCCGGCCGGCGAACCGCCTGTGGCCTTCATCGGCAAGGGCGTGAC
CTTCGACACCGGCGGCATCTCCATCAAGCCGGCGGCCGGCATGGAGGACATGAAGGGCGACATGGGCGGCGCCGCCTGCG
TCACCGGCCTCATGTATGCCCTCGCCGCCCGCAAGGCGAAGGTGAATGCGGTGGGCCTCATCGGCCTGGTGGAAAACATG
CCCGACGGCGCCGCCCAGCGCCCCGGCGACATCGTCACCTCCCTGTCGGGCCAGACCATCGAGATCATCAACACCGATGC
CGAGGGCCGGCTCGTGCTCTGCGACGTGCTCTGGTACGCCAAGGAGCAGTTCAAGCCCAAGTTCATGATCGACCTCGCCA
CCCTCACCGGGGCCATCCTGGTGGCGCTGGGGTCGGAATATGCCGGCCTGTTCTCCAACGACGACACCCTGAGCGAGCGC
CTGACCAAGACCGGCCAGGAGACCGGCGAGCGGGTGTGGCGCATGCCGCTCGGCCCGGAATACGACAAGCTGGTGGATTC
CAAGTTCGCCGACATGAAGAACACCGGCGGCCGCCATGCCGGCTCCATCACCGCCGCCCAGTTCCTCCAGCGCTTCGTGG
ACAAGACCCCCTGGGCGCATCTGGACATCGCCGGCACCGCCATGTCGTCGCCGGCCTCCGACATCAACAAGAGCTGGGGC
TCGGGCTGGGGCGTGCGCCTGCTGAACCAGCTGGTGAAGGACCACTACGAGGGGTGA

Upstream 100 bases:

>100_bases
TCGGGCGCGGCGGCATGGGCGGTTCCACCCACGCGCCAGCCGGTCTAGAGAAAGAGGCGACAGACCGATTCCTTGAAGCC
TTTCCTGCCCGGAGCGCCGC

Downstream 100 bases:

>100_bases
GGCGCAAGCCTCTCCCACTTAAGCCGCTTCCGCCCAAGCCTCTCCCACCGTCGCCCTCCGGCTTGACCGGAGGACCCATT
TCCCGGCCGGCGCAGCCGCG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSEPVTLSFARLTAAPKGVLIVLTDETLAFGAQTQKLLKGADAAITRAFDAERYKGKAWSTIDLLAPAGLDAPRLVVISV
GKAGELKPADFLKLGGVAAGKIPSSAREATVVLDLPGAKIGPESAAEVALGIRLRTYSFDRYKTKKKDDTERGALAMTLL
VSDEAGTKRAATTADAVGDGVLFARDLVNEPANVLDPPEFARRAEEHLSSVGVEIEVLDDAGLARAGMHTLLGVGQGSIK
ESRVVIMRWNGGPAGEPPVAFIGKGVTFDTGGISIKPAAGMEDMKGDMGGAACVTGLMYALAARKAKVNAVGLIGLVENM
PDGAAQRPGDIVTSLSGQTIEIINTDAEGRLVLCDVLWYAKEQFKPKFMIDLATLTGAILVALGSEYAGLFSNDDTLSER
LTKTGQETGERVWRMPLGPEYDKLVDSKFADMKNTGGRHAGSITAAQFLQRFVDKTPWAHLDIAGTAMSSPASDINKSWG
SGWGVRLLNQLVKDHYEG

Sequences:

>Translated_498_residues
MSEPVTLSFARLTAAPKGVLIVLTDETLAFGAQTQKLLKGADAAITRAFDAERYKGKAWSTIDLLAPAGLDAPRLVVISV
GKAGELKPADFLKLGGVAAGKIPSSAREATVVLDLPGAKIGPESAAEVALGIRLRTYSFDRYKTKKKDDTERGALAMTLL
VSDEAGTKRAATTADAVGDGVLFARDLVNEPANVLDPPEFARRAEEHLSSVGVEIEVLDDAGLARAGMHTLLGVGQGSIK
ESRVVIMRWNGGPAGEPPVAFIGKGVTFDTGGISIKPAAGMEDMKGDMGGAACVTGLMYALAARKAKVNAVGLIGLVENM
PDGAAQRPGDIVTSLSGQTIEIINTDAEGRLVLCDVLWYAKEQFKPKFMIDLATLTGAILVALGSEYAGLFSNDDTLSER
LTKTGQETGERVWRMPLGPEYDKLVDSKFADMKNTGGRHAGSITAAQFLQRFVDKTPWAHLDIAGTAMSSPASDINKSWG
SGWGVRLLNQLVKDHYEG
>Mature_497_residues
SEPVTLSFARLTAAPKGVLIVLTDETLAFGAQTQKLLKGADAAITRAFDAERYKGKAWSTIDLLAPAGLDAPRLVVISVG
KAGELKPADFLKLGGVAAGKIPSSAREATVVLDLPGAKIGPESAAEVALGIRLRTYSFDRYKTKKKDDTERGALAMTLLV
SDEAGTKRAATTADAVGDGVLFARDLVNEPANVLDPPEFARRAEEHLSSVGVEIEVLDDAGLARAGMHTLLGVGQGSIKE
SRVVIMRWNGGPAGEPPVAFIGKGVTFDTGGISIKPAAGMEDMKGDMGGAACVTGLMYALAARKAKVNAVGLIGLVENMP
DGAAQRPGDIVTSLSGQTIEIINTDAEGRLVLCDVLWYAKEQFKPKFMIDLATLTGAILVALGSEYAGLFSNDDTLSERL
TKTGQETGERVWRMPLGPEYDKLVDSKFADMKNTGGRHAGSITAAQFLQRFVDKTPWAHLDIAGTAMSSPASDINKSWGS
GWGVRLLNQLVKDHYEG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=359, Percent_Identity=41.7827298050139, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI47155554, Length=316, Percent_Identity=32.5949367088608, Blast_Score=137, Evalue=3e-32,
Organism=Escherichia coli, GI1790710, Length=450, Percent_Identity=38.6666666666667, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=38.871473354232, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=313, Percent_Identity=34.8242811501597, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=400, Percent_Identity=26.25, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI20129969, Length=309, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI161077148, Length=289, Percent_Identity=35.6401384083045, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI20130057, Length=289, Percent_Identity=35.6401384083045, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21355725, Length=290, Percent_Identity=36.551724137931, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24662227, Length=307, Percent_Identity=32.2475570032573, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24661038, Length=282, Percent_Identity=37.9432624113475, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI19922386, Length=349, Percent_Identity=33.2378223495702, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21355645, Length=289, Percent_Identity=31.4878892733564, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24662223, Length=289, Percent_Identity=31.4878892733564, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI20129963, Length=348, Percent_Identity=33.0459770114943, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI221379063, Length=315, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI221379062, Length=315, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI21357381, Length=315, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24646701, Length=257, Percent_Identity=27.6264591439689, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646703, Length=257, Percent_Identity=27.6264591439689, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21358201, Length=257, Percent_Identity=27.6264591439689, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_XANP2 (A7IFB7)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001416367.1
- ProteinModelPortal:   A7IFB7
- SMR:   A7IFB7
- STRING:   A7IFB7
- MEROPS:   M17.003
- GeneID:   5421066
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_1462
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   ELHKPCE
- ProtClustDB:   PRK00913
- BioCyc:   XAUT78245:XAUT_1462-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52598; Mature: 52467

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 276-276 ACT_SITE 350-350

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPVTLSFARLTAAPKGVLIVLTDETLAFGAQTQKLLKGADAAITRAFDAERYKGKAWS
CCCCEEEEHHHHHCCCCCEEEEEECCHHHHCHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
TIDLLAPAGLDAPRLVVISVGKAGELKPADFLKLGGVAAGKIPSSAREATVVLDLPGAKI
EEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHCCEECCCCCCCCCCEEEEEECCCCCC
GPESAAEVALGIRLRTYSFDRYKTKKKDDTERGALAMTLLVSDEAGTKRAATTADAVGDG
CCCHHHHEEEEEEEEEEECHHHCCCCCCCCCCCEEEEEEEEECCCCCCHHCCHHHHCCCC
VLFARDLVNEPANVLDPPEFARRAEEHLSSVGVEIEVLDDAGLARAGMHTLLGVGQGSIK
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCCC
ESRVVIMRWNGGPAGEPPVAFIGKGVTFDTGGISIKPAAGMEDMKGDMGGAACVTGLMYA
CCEEEEEEECCCCCCCCCCEEEECCEEECCCCEEECCCCCHHHHCCCCCHHHHHHHHHHH
LAARKAKVNAVGLIGLVENMPDGAAQRPGDIVTSLSGQTIEIINTDAEGRLVLCDVLWYA
HHHHHCCCCEEEEEEHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEHHHHHH
KEQFKPKFMIDLATLTGAILVALGSEYAGLFSNDDTLSERLTKTGQETGERVWRMPLGPE
HHHCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCC
YDKLVDSKFADMKNTGGRHAGSITAAQFLQRFVDKTPWAHLDIAGTAMSSPASDINKSWG
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCC
SGWGVRLLNQLVKDHYEG
CCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEPVTLSFARLTAAPKGVLIVLTDETLAFGAQTQKLLKGADAAITRAFDAERYKGKAWS
CCCEEEEHHHHHCCCCCEEEEEECCHHHHCHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
TIDLLAPAGLDAPRLVVISVGKAGELKPADFLKLGGVAAGKIPSSAREATVVLDLPGAKI
EEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHCCEECCCCCCCCCCEEEEEECCCCCC
GPESAAEVALGIRLRTYSFDRYKTKKKDDTERGALAMTLLVSDEAGTKRAATTADAVGDG
CCCHHHHEEEEEEEEEEECHHHCCCCCCCCCCCEEEEEEEEECCCCCCHHCCHHHHCCCC
VLFARDLVNEPANVLDPPEFARRAEEHLSSVGVEIEVLDDAGLARAGMHTLLGVGQGSIK
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCCC
ESRVVIMRWNGGPAGEPPVAFIGKGVTFDTGGISIKPAAGMEDMKGDMGGAACVTGLMYA
CCEEEEEEECCCCCCCCCCEEEECCEEECCCCEEECCCCCHHHHCCCCCHHHHHHHHHHH
LAARKAKVNAVGLIGLVENMPDGAAQRPGDIVTSLSGQTIEIINTDAEGRLVLCDVLWYA
HHHHHCCCCEEEEEEHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEHHHHHH
KEQFKPKFMIDLATLTGAILVALGSEYAGLFSNDDTLSERLTKTGQETGERVWRMPLGPE
HHHCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCC
YDKLVDSKFADMKNTGGRHAGSITAAQFLQRFVDKTPWAHLDIAGTAMSSPASDINKSWG
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCC
SGWGVRLLNQLVKDHYEG
CCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA