Click here to switch to the map view.

The map label for this gene is bla [H]

Identifier: 154245388

GI number: 154245388

Start: 1653553

End: 1654392

Strand: Reverse

Name: bla [H]

Synonym: Xaut_1441

Alternate gene names: 154245388

Gene position: 1654392-1653553 (Counterclockwise)

Preceding gene: 154245389

Following gene: 154245387

Centisome position: 31.16

GC content: 71.9

Gene sequence:

>840_bases
ATGGCTGCGCGCCGGACCGGAGCCGCCCTGTCGCGCGCCGGGCTCGGCCTTCTCCTCGCCCTCGCCGCCGCGATATCCGC
CGCGCCGGCGCGGGCGGCGGAAGACTGCTTCCTCGCCACCGATCTCGAAAGCGGGCGGGTGCTGGCCAAGCAGGGCCTGT
GCGCCGCCCGCCATCCGCCCAACTCCACCTTCAAGATCGCCCTCGCCCTCATGGGCTATGATGCCGGCCTGCTGAAAAAC
GAGACCCAGCCGGTGTTCGACCCGCCCGAGGGCGCGGATCTCTCGCGGCCGCAGACGCGCGGGCCGCAGACGCCGCGCTC
CTGGATGGTGAATTCCGTGGTCTGGTATTCCCAGGTCCTCGCCCGCCAGCTGGGGCCCGAGCGCATCGCCGGGTATCTGA
AAGGCTTCGCCTACGGCAACGAGAACATGGGCGGCCTGAAGGGTGAGGACGAGCCTTTGGCCCGCTTCTGGCTCTCCTCG
TCCCTGCGCATCTCGCCGCGCGAGCAGATCGATTTCCTGCGCCGCATGCTGAAGGGCGCCCTGCCCGTCTCGGCCGAAGC
GGTCACCGCCACCGAGCGGCTCATGGCCATTGAGGAGCAGCCCGCCGGCTGGCTGGTGTTCGGCAAGACCGGAACCGGCA
GCGGCCGGCACGCCGACGGCAGCCTGGACCTCTCGCGGCCGTTCGGCTGGTTCGTGGGCTTCGCCCGCAAGGGCGCTCAC
ACCGTGGTGTTCGTGCGCTTCACCAGCCTCGACATGGCGCCCCCCGAGCCCCTCGGCCCGCTGGCGCGGCGGCAGTCCAT
CGCCATCCTCGCCCCGGTGCTGGCGGCGCAGGCGCCCTGA

Upstream 100 bases:

>100_bases
CGGTGGCAAGCTACGCCGACGAGGTGCGCGCCCGCACCTTCCCCGCCGCCGAGCACACCTACGCCCCGCGCCTCGTCGAG
AAGCCGGCGAAAGCCTCCTG

Downstream 100 bases:

>100_bases
TCAGGCGGCCTTCCCTCCCCCTTCCCGCTCCCGCCCAGACCCATTCAGCCAAGGACAGGCCCCGTGCGCGTCTCCGTCAT
CGTTTCCGCCTTCGTCGCGG

Product: Beta-lactamase

Products: NA

Alternate protein names: Penicillinase [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MAARRTGAALSRAGLGLLLALAAAISAAPARAAEDCFLATDLESGRVLAKQGLCAARHPPNSTFKIALALMGYDAGLLKN
ETQPVFDPPEGADLSRPQTRGPQTPRSWMVNSVVWYSQVLARQLGPERIAGYLKGFAYGNENMGGLKGEDEPLARFWLSS
SLRISPREQIDFLRRMLKGALPVSAEAVTATERLMAIEEQPAGWLVFGKTGTGSGRHADGSLDLSRPFGWFVGFARKGAH
TVVFVRFTSLDMAPPEPLGPLARRQSIAILAPVLAAQAP

Sequences:

>Translated_279_residues
MAARRTGAALSRAGLGLLLALAAAISAAPARAAEDCFLATDLESGRVLAKQGLCAARHPPNSTFKIALALMGYDAGLLKN
ETQPVFDPPEGADLSRPQTRGPQTPRSWMVNSVVWYSQVLARQLGPERIAGYLKGFAYGNENMGGLKGEDEPLARFWLSS
SLRISPREQIDFLRRMLKGALPVSAEAVTATERLMAIEEQPAGWLVFGKTGTGSGRHADGSLDLSRPFGWFVGFARKGAH
TVVFVRFTSLDMAPPEPLGPLARRQSIAILAPVLAAQAP
>Mature_278_residues
AARRTGAALSRAGLGLLLALAAAISAAPARAAEDCFLATDLESGRVLAKQGLCAARHPPNSTFKIALALMGYDAGLLKNE
TQPVFDPPEGADLSRPQTRGPQTPRSWMVNSVVWYSQVLARQLGPERIAGYLKGFAYGNENMGGLKGEDEPLARFWLSSS
LRISPREQIDFLRRMLKGALPVSAEAVTATERLMAIEEQPAGWLVFGKTGTGSGRHADGSLDLSRPFGWFVGFARKGAHT
VVFVRFTSLDMAPPEPLGPLARRQSIAILAPVLAAQAP

Specific function: Has a broad substrate profile, hydrolyzes amoxicillin, ticarcillin, cephalothin, ceftazidime, cefotaxime, and aztreonam, but not imipenem or cephamycins [H]

COG id: COG2602

COG function: function code V; Beta-lactamase class D

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-D beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR002137
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 29819; Mature: 29687

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS00337 BETA_LACTAMASE_D

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARRTGAALSRAGLGLLLALAAAISAAPARAAEDCFLATDLESGRVLAKQGLCAARHPP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEEECCCCCCEEHHCCCCCCCCCC
NSTFKIALALMGYDAGLLKNETQPVFDPPEGADLSRPQTRGPQTPRSWMVNSVVWYSQVL
CCHHEEEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ARQLGPERIAGYLKGFAYGNENMGGLKGEDEPLARFWLSSSLRISPREQIDFLRRMLKGA
HHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
LPVSAEAVTATERLMAIEEQPAGWLVFGKTGTGSGRHADGSLDLSRPFGWFVGFARKGAH
CCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCE
TVVFVRFTSLDMAPPEPLGPLARRQSIAILAPVLAAQAP
EEEEEEEEECCCCCCCCCCHHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure 
AARRTGAALSRAGLGLLLALAAAISAAPARAAEDCFLATDLESGRVLAKQGLCAARHPP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEEECCCCCCEEHHCCCCCCCCCC
NSTFKIALALMGYDAGLLKNETQPVFDPPEGADLSRPQTRGPQTPRSWMVNSVVWYSQVL
CCHHEEEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ARQLGPERIAGYLKGFAYGNENMGGLKGEDEPLARFWLSSSLRISPREQIDFLRRMLKGA
HHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
LPVSAEAVTATERLMAIEEQPAGWLVFGKTGTGSGRHADGSLDLSRPFGWFVGFARKGAH
CCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCE
TVVFVRFTSLDMAPPEPLGPLARRQSIAILAPVLAAQAP
EEEEEEEEECCCCCCCCCCHHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9333046 [H]