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The map label for this gene is 154245283

Identifier: 154245283

GI number: 154245283

Start: 1531556

End: 1532938

Strand: Direct

Name: 154245283

Synonym: Xaut_1335

Alternate gene names: NA

Gene position: 1531556-1532938 (Clockwise)

Preceding gene: 154245281

Following gene: 154245285

Centisome position: 28.85

GC content: 67.97

Gene sequence:

>1383_bases
ATGGCTGAAGGCCGCGCATTCGCATGCTTCTCCCGTGCGGTGGGACTGCCGTGCTGTCCGCAATTGCTACTCCCGCGGAC
GGATTTCGGTCGCCCGGAGTGCTCCCTTGGGGGCGGCCACGCTTCTCCCAGCGAGGGCCACGCGGTGGCACGCACGGTGC
AGGAGCGCCGGCGCAACGACGACGCGACAGCGGCAGGACGCATCATGAAGCTTGGCAACGCAGTATCCATCGTCGGCTGG
GGCCATTCGCCCTTCGGCCGGCTGGCCCACATGGACATGGAGGCGCTCATCGCAGCGGTCTGCCACGAAGCGCTGGTTCA
TTCCGGCTTCCCGGCCGAGCGCATGGACGGCGTCTGGCTCGGCAATCTCAACGGCGGCTTCGTGCCGGAGATCTTCTGCT
CGTCCCTGCCCATGAATGGCGAGCCGGGCCTGCGCTGGAAGCCGGCGACGCGGGTCGAGAACGCCTGTGCCTCCGGGGCC
GGGGCCATCTTCGCCGCCTGTGACGCCATCCAGTCCGGCCGCGCGCGCCTCGCCCTCGTGGTGGGTGCGGAGAAAATGAC
CGCGGTCTCCGGCGAGGAGGTGACGCGCATCCTCGGCTCGGCCTCCTACGTCAAGGAGGAGGCGAACTGCGGCAAGACCT
TCCCGTCCATCTTCGGGGAGATCGCCGGCGCCTATTTCGAGCGTTATGGCGACCATGCGCAGGCGCTGGCGAAGATCGCG
GTGAAAAACCACGCCAACGGTGTGTCCAACCCCTTCGCGCAGATGCGCAAGGCGCTCGATTTCGAATTCTGCAATACCGT
CTCGGAGAAGAACCCGGTCATTGCCGGGCCGCTGCGCAAGACCGACTGCTCGCTGGTTTCGGACGGCGCGGCGGCCGTGG
TGCTCGCATCCGACGATCTCATCGGCGAGGCACAGCGCGCCGTGCGCATTCGTGCCCGGGCGCAGGTGAACGACCTTTTG
CCCATGTCGCGCCGCGATCCGGTGCGCTTCGAGGGGCCGCGACGCGCCTTCGCCGCGGCCTTCGCCGAGGCCGGCATAAC
GGTCGGCGATCTCTCATTTGCCGAGGTCCACGACTGCTTCACCATCGCGGAGCTTTTGGCCTACGAGGCCATGGGGCTCG
CTCCGGAAGGGCAGGGGGCGCGGGTGCTGGAGGATGGAACGGTAGCCCGTGGCGGCCGTCTCCCGGTGAACGTCTCTGGC
GGCCTCAAGGCGAAGGGCCACCCCATCGGCGCCACCGGCGTGTCCATGCACGTCCTGTCCGCCATGCAGCTCACCGGCAC
CGCCGGCGACATGCAGGTTCCCGGTGCCAGCCTTGGCGGGGTGTTCAACATGGGTGGCTCAGCGGTGGCGAACTATGTGA
GCGTGCTTGAGCCGGTGAAGTGA

Upstream 100 bases:

>100_bases
CAGACCCTTCATGAGGGATCTCCCTTTCCAGTGTCGTTGAATTGGCGGCACGCGGGACAACGGCCGCTTTCCGCGCCGCC
TCCTCGGCAAAACAGATGCC

Downstream 100 bases:

>100_bases
GGCGAGGCCGCGCGGCGGTGTCGCCGCGCGGCTTCACGAGGCGGCAGCGGCGGGCCGGCCCTTGCCCAGCCTCACGGAAT
TGATGTGCCAGGCGTCGGTC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MAEGRAFACFSRAVGLPCCPQLLLPRTDFGRPECSLGGGHASPSEGHAVARTVQERRRNDDATAAGRIMKLGNAVSIVGW
GHSPFGRLAHMDMEALIAAVCHEALVHSGFPAERMDGVWLGNLNGGFVPEIFCSSLPMNGEPGLRWKPATRVENACASGA
GAIFAACDAIQSGRARLALVVGAEKMTAVSGEEVTRILGSASYVKEEANCGKTFPSIFGEIAGAYFERYGDHAQALAKIA
VKNHANGVSNPFAQMRKALDFEFCNTVSEKNPVIAGPLRKTDCSLVSDGAAAVVLASDDLIGEAQRAVRIRARAQVNDLL
PMSRRDPVRFEGPRRAFAAAFAEAGITVGDLSFAEVHDCFTIAELLAYEAMGLAPEGQGARVLEDGTVARGGRLPVNVSG
GLKAKGHPIGATGVSMHVLSAMQLTGTAGDMQVPGASLGGVFNMGGSAVANYVSVLEPVK

Sequences:

>Translated_460_residues
MAEGRAFACFSRAVGLPCCPQLLLPRTDFGRPECSLGGGHASPSEGHAVARTVQERRRNDDATAAGRIMKLGNAVSIVGW
GHSPFGRLAHMDMEALIAAVCHEALVHSGFPAERMDGVWLGNLNGGFVPEIFCSSLPMNGEPGLRWKPATRVENACASGA
GAIFAACDAIQSGRARLALVVGAEKMTAVSGEEVTRILGSASYVKEEANCGKTFPSIFGEIAGAYFERYGDHAQALAKIA
VKNHANGVSNPFAQMRKALDFEFCNTVSEKNPVIAGPLRKTDCSLVSDGAAAVVLASDDLIGEAQRAVRIRARAQVNDLL
PMSRRDPVRFEGPRRAFAAAFAEAGITVGDLSFAEVHDCFTIAELLAYEAMGLAPEGQGARVLEDGTVARGGRLPVNVSG
GLKAKGHPIGATGVSMHVLSAMQLTGTAGDMQVPGASLGGVFNMGGSAVANYVSVLEPVK
>Mature_459_residues
AEGRAFACFSRAVGLPCCPQLLLPRTDFGRPECSLGGGHASPSEGHAVARTVQERRRNDDATAAGRIMKLGNAVSIVGWG
HSPFGRLAHMDMEALIAAVCHEALVHSGFPAERMDGVWLGNLNGGFVPEIFCSSLPMNGEPGLRWKPATRVENACASGAG
AIFAACDAIQSGRARLALVVGAEKMTAVSGEEVTRILGSASYVKEEANCGKTFPSIFGEIAGAYFERYGDHAQALAKIAV
KNHANGVSNPFAQMRKALDFEFCNTVSEKNPVIAGPLRKTDCSLVSDGAAAVVLASDDLIGEAQRAVRIRARAQVNDLLP
MSRRDPVRFEGPRRAFAAAFAEAGITVGDLSFAEVHDCFTIAELLAYEAMGLAPEGQGARVLEDGTVARGGRLPVNVSGG
LKAKGHPIGATGVSMHVLSAMQLTGTAGDMQVPGASLGGVFNMGGSAVANYVSVLEPVK

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=389, Percent_Identity=32.6478149100257, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI302344760, Length=318, Percent_Identity=35.2201257861635, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI302344767, Length=313, Percent_Identity=35.4632587859425, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI302344762, Length=299, Percent_Identity=34.4481605351171, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI55956775, Length=267, Percent_Identity=34.0823970037453, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17537653, Length=388, Percent_Identity=31.1855670103093, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI19921506, Length=324, Percent_Identity=32.4074074074074, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24585051, Length=393, Percent_Identity=30.7888040712468, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 48032; Mature: 47901

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEGRAFACFSRAVGLPCCPQLLLPRTDFGRPECSLGGGHASPSEGHAVARTVQERRRND
CCCCCEEHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
DATAAGRIMKLGNAVSIVGWGHSPFGRLAHMDMEALIAAVCHEALVHSGFPAERMDGVWL
CHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEE
GNLNGGFVPEIFCSSLPMNGEPGLRWKPATRVENACASGAGAIFAACDAIQSGRARLALV
ECCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEE
VGAEKMTAVSGEEVTRILGSASYVKEEANCGKTFPSIFGEIAGAYFERYGDHAQALAKIA
ECCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
VKNHANGVSNPFAQMRKALDFEFCNTVSEKNPVIAGPLRKTDCSLVSDGAAAVVLASDDL
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEECCCCEEEEEECCCH
IGEAQRAVRIRARAQVNDLLPMSRRDPVRFEGPRRAFAAAFAEAGITVGDLSFAEVHDCF
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHH
TIAELLAYEAMGLAPEGQGARVLEDGTVARGGRLPVNVSGGLKAKGHPIGATGVSMHVLS
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHH
AMQLTGTAGDMQVPGASLGGVFNMGGSAVANYVSVLEPVK
HHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AEGRAFACFSRAVGLPCCPQLLLPRTDFGRPECSLGGGHASPSEGHAVARTVQERRRND
CCCCEEHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
DATAAGRIMKLGNAVSIVGWGHSPFGRLAHMDMEALIAAVCHEALVHSGFPAERMDGVWL
CHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEE
GNLNGGFVPEIFCSSLPMNGEPGLRWKPATRVENACASGAGAIFAACDAIQSGRARLALV
ECCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEE
VGAEKMTAVSGEEVTRILGSASYVKEEANCGKTFPSIFGEIAGAYFERYGDHAQALAKIA
ECCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
VKNHANGVSNPFAQMRKALDFEFCNTVSEKNPVIAGPLRKTDCSLVSDGAAAVVLASDDL
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEECCCCEEEEEECCCH
IGEAQRAVRIRARAQVNDLLPMSRRDPVRFEGPRRAFAAAFAEAGITVGDLSFAEVHDCF
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHH
TIAELLAYEAMGLAPEGQGARVLEDGTVARGGRLPVNVSGGLKAKGHPIGATGVSMHVLS
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHH
AMQLTGTAGDMQVPGASLGGVFNMGGSAVANYVSVLEPVK
HHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]