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The map label for this gene is fabF [H]

Identifier: 154245208

GI number: 154245208

Start: 1449359

End: 1450642

Strand: Reverse

Name: fabF [H]

Synonym: Xaut_1260

Alternate gene names: 154245208

Gene position: 1450642-1449359 (Counterclockwise)

Preceding gene: 154245209

Following gene: 154245207

Centisome position: 27.32

GC content: 68.93

Gene sequence:

>1284_bases
ATGACGCAGGCGCATCTGGACAAGTTCGGCCGCCCCATCGTGGTGGTGACAGGCATCGGCATCGTCACCTCCCTGGGCCA
GGGCAAGGAAGACAACTGGCGCCGCCTCACCGCTGGCGAATCGGGCATCCACACCATCACGCGCTTCCCCATCGAGGGCA
TGCGCACCACCATCGCCGGCACGGTGGACTTCCTGTTCGACGGCCGCGTCGCCGCCCCGAACCTGTCCGAGAAGCTGGCG
ACGCTGGCGGCGGAAGAGGCCATCGCCGAAGCCGCCATTGGCTCGGACGGGGATTTTCCCGGCCCGCTGTTCGCGGCAGT
GCCCCCCGTGGAGCTGGAATGGCCCGAGCGGCGGCAGCTGGCCGATGCCGTGGGTCACTACCCCATCGTCTATCATGACC
TGCTCGGCGCAGCGGCCTCCGGCAAGTTCCGTCCCTGGCACGAGCGCTTCCTGTTCGGCTCGGTGGCGGATCGGCTCGCC
GACCGCTTCGGCACCCGCGGCCAGCCCATCTCGCTGTCCACCGCCTGCGCCTCGGGAGCGACCGCCATCCAGCTCGGCGT
CGAGGCCATCCGCCGCGGCGAGACCGATGTGGCGCTCTCCCTCGGCACCGATGGCTCGGTGCACCCGGAAGCGCTGATCC
GCTTCTCGCTACTGTCGGCGCTGACCACCGCCAACGACAATCCGGAGGGCGCCGCCCGCCCCTTCGCCAAGAATCGCGAC
GGCTTCGTCATGGCCGAGGGCGCCGCCGCCCTGGTGCTGGAGAGCTATGAGCATGCGGTTGCGCGCGGGGCGAAGATCCT
CGGCGTGCTGGAAGGCTGCGGCGAGATGGCGGACAACTTCCACCGCACCCGCTCCAGCCCCGACGGCCGCCCCATCATCG
GCTGCATGACCAATGCCTTCGCCGACGCGGGTGTGACCCCGGACGACGTGGACTACATCAATGCCCACGGCACCTCGACG
CCGGAAAACGACCGCATGGAATATGTGGGCATGAAGGCGGTGTTCGGCGACGAGAAGCTGGCGCAGACCCCGATCTCGTC
CAACAAGTCCATGATCGGCCACACCCTGACGGCGGCCGGTGCCATCGAGGCGGCGGTGTCGCTGCTCACCATCGCCAACG
GCCGCATCCCGCCGACCATCAACTACAATATCCCCGACCCGGCCATTCCCCTCGACGTGGTGCCCAACGTGGCGCGCGAC
GCGAAGGTGCGGCGGGTGATCTCCAACTCCTTCGGCTTCGGCGGGCAGAATGTCTGCCTCGTGCTGGCGGGGGAGCCGGC
GTGA

Upstream 100 bases:

>100_bases
CGCCGGCACGGACGTTCGCGCAGCCGCAGTTTGCGCGAGGCCGGGGGACACCATGGACGGCGCCTGGGGCGGGCGCGCTT
CACGTAAAGGAGCCGCGAAC

Downstream 100 bases:

>100_bases
GGGGGACGGCGCGATGAGCCCCTCCGCCAAGCCCATCCTCGTCACCGGCGGCGGGCGTGGCCTTGGCGCCGCCATCGTGC
GCGCCCTGGCGGCGGCGGGC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTQAHLDKFGRPIVVVTGIGIVTSLGQGKEDNWRRLTAGESGIHTITRFPIEGMRTTIAGTVDFLFDGRVAAPNLSEKLA
TLAAEEAIAEAAIGSDGDFPGPLFAAVPPVELEWPERRQLADAVGHYPIVYHDLLGAAASGKFRPWHERFLFGSVADRLA
DRFGTRGQPISLSTACASGATAIQLGVEAIRRGETDVALSLGTDGSVHPEALIRFSLLSALTTANDNPEGAARPFAKNRD
GFVMAEGAAALVLESYEHAVARGAKILGVLEGCGEMADNFHRTRSSPDGRPIIGCMTNAFADAGVTPDDVDYINAHGTST
PENDRMEYVGMKAVFGDEKLAQTPISSNKSMIGHTLTAAGAIEAAVSLLTIANGRIPPTINYNIPDPAIPLDVVPNVARD
AKVRRVISNSFGFGGQNVCLVLAGEPA

Sequences:

>Translated_427_residues
MTQAHLDKFGRPIVVVTGIGIVTSLGQGKEDNWRRLTAGESGIHTITRFPIEGMRTTIAGTVDFLFDGRVAAPNLSEKLA
TLAAEEAIAEAAIGSDGDFPGPLFAAVPPVELEWPERRQLADAVGHYPIVYHDLLGAAASGKFRPWHERFLFGSVADRLA
DRFGTRGQPISLSTACASGATAIQLGVEAIRRGETDVALSLGTDGSVHPEALIRFSLLSALTTANDNPEGAARPFAKNRD
GFVMAEGAAALVLESYEHAVARGAKILGVLEGCGEMADNFHRTRSSPDGRPIIGCMTNAFADAGVTPDDVDYINAHGTST
PENDRMEYVGMKAVFGDEKLAQTPISSNKSMIGHTLTAAGAIEAAVSLLTIANGRIPPTINYNIPDPAIPLDVVPNVARD
AKVRRVISNSFGFGGQNVCLVLAGEPA
>Mature_426_residues
TQAHLDKFGRPIVVVTGIGIVTSLGQGKEDNWRRLTAGESGIHTITRFPIEGMRTTIAGTVDFLFDGRVAAPNLSEKLAT
LAAEEAIAEAAIGSDGDFPGPLFAAVPPVELEWPERRQLADAVGHYPIVYHDLLGAAASGKFRPWHERFLFGSVADRLAD
RFGTRGQPISLSTACASGATAIQLGVEAIRRGETDVALSLGTDGSVHPEALIRFSLLSALTTANDNPEGAARPFAKNRDG
FVMAEGAAALVLESYEHAVARGAKILGVLEGCGEMADNFHRTRSSPDGRPIIGCMTNAFADAGVTPDDVDYINAHGTSTP
ENDRMEYVGMKAVFGDEKLAQTPISSNKSMIGHTLTAAGAIEAAVSLLTIANGRIPPTINYNIPDPAIPLDVVPNVARDA
KVRRVISNSFGFGGQNVCLVLAGEPA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=431, Percent_Identity=36.8909512761021, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI223972627, Length=150, Percent_Identity=42, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI41872631, Length=274, Percent_Identity=31.3868613138686, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1787337, Length=269, Percent_Identity=43.4944237918216, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1788663, Length=431, Percent_Identity=35.7308584686775, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71983541, Length=279, Percent_Identity=35.1254480286738, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=35.8778625954198, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI212642053, Length=281, Percent_Identity=29.8932384341637, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=268, Percent_Identity=28.7313432835821, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=29.6629213483146, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24644341, Length=432, Percent_Identity=37.2685185185185, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI19920632, Length=279, Percent_Identity=29.0322580645161, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI221330659, Length=279, Percent_Identity=29.0322580645161, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24581345, Length=277, Percent_Identity=29.6028880866426, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45019; Mature: 44888

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAHLDKFGRPIVVVTGIGIVTSLGQGKEDNWRRLTAGESGIHTITRFPIEGMRTTIAG
CCCHHHHHCCCCEEEEECCHHHHHCCCCCCCCCEEEECCCCCCCHHEECCCHHHHHHHHH
TVDFLFDGRVAAPNLSEKLATLAAEEAIAEAAIGSDGDFPGPLFAAVPPVELEWPERRQL
HHHHEECCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCHHHHH
ADAVGHYPIVYHDLLGAAASGKFRPWHERFLFGSVADRLADRFGTRGQPISLSTACASGA
HHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCC
TAIQLGVEAIRRGETDVALSLGTDGSVHPEALIRFSLLSALTTANDNPEGAARPFAKNRD
HHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GFVMAEGAAALVLESYEHAVARGAKILGVLEGCGEMADNFHRTRSSPDGRPIIGCMTNAF
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHH
ADAGVTPDDVDYINAHGTSTPENDRMEYVGMKAVFGDEKLAQTPISSNKSMIGHTLTAAG
HCCCCCCCCCCEEECCCCCCCCCCCCHHEEEEEEECCHHHHCCCCCCCCHHHHHHHHHHH
AIEAAVSLLTIANGRIPPTINYNIPDPAIPLDVVPNVARDAKVRRVISNSFGFGGQNVCL
HHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCEEE
VLAGEPA
EEECCCC
>Mature Secondary Structure 
TQAHLDKFGRPIVVVTGIGIVTSLGQGKEDNWRRLTAGESGIHTITRFPIEGMRTTIAG
CCHHHHHCCCCEEEEECCHHHHHCCCCCCCCCEEEECCCCCCCHHEECCCHHHHHHHHH
TVDFLFDGRVAAPNLSEKLATLAAEEAIAEAAIGSDGDFPGPLFAAVPPVELEWPERRQL
HHHHEECCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCHHHHH
ADAVGHYPIVYHDLLGAAASGKFRPWHERFLFGSVADRLADRFGTRGQPISLSTACASGA
HHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCC
TAIQLGVEAIRRGETDVALSLGTDGSVHPEALIRFSLLSALTTANDNPEGAARPFAKNRD
HHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GFVMAEGAAALVLESYEHAVARGAKILGVLEGCGEMADNFHRTRSSPDGRPIIGCMTNAF
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHH
ADAGVTPDDVDYINAHGTSTPENDRMEYVGMKAVFGDEKLAQTPISSNKSMIGHTLTAAG
HCCCCCCCCCCEEECCCCCCCCCCCCHHEEEEEEECCHHHHCCCCCCCCHHHHHHHHHHH
AIEAAVSLLTIANGRIPPTINYNIPDPAIPLDVVPNVARDAKVRRVISNSFGFGGQNVCL
HHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCEEE
VLAGEPA
EEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]