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The map label for this gene is atoC [H]

Identifier: 154244982

GI number: 154244982

Start: 1185026

End: 1186411

Strand: Reverse

Name: atoC [H]

Synonym: Xaut_1032

Alternate gene names: 154244982

Gene position: 1186411-1185026 (Counterclockwise)

Preceding gene: 154244983

Following gene: 154244981

Centisome position: 22.35

GC content: 68.69

Gene sequence:

>1386_bases
ATGGCCGCGAAGATACTCATCGTCGACGACGAGGTCCGCCATGGGGAGGTGCTGGAGGCAGCCCTCGCCGAGCGCGGCTT
CGAGGCGACTTCGACCAACACCGTCGCCAAGGCGCTGACCTATTGCACCAGCCACGCGGTGGACCTGGTGCTGAGCGACC
TGCGCATGCCCGGCCAGGGCGGCAGCGACCTGCTGAAGGCGCTTAAGGAGCAGCAGCCCGAGCTGCCGGTGATCATCATG
ACCGCCTACGCCACGGTGCGCGGTGCGGTGGACCTGGTGAAGGACGGCGCCTTCGACTATGTGGCCAAGCCCCTCGACCT
CGACGACGTGGTCGCCACCATGGCCCGCGCGCTGCGACTGAAGGCGGTGGAAAGCGAAAACGCGCGCCTGCGCTCCGAGC
TGGAGGGGCGCTACCGCTTCGACAATCTGGTGGGCGACAGCCCGGCCTTCCGCGACGTGCTGCGCCAGGTGACCGAGGTG
GCGCCGAGCCGGGCCAGCGTGCTGCTTCTTGGCGAGAGCGGCACCGGCAAGGAACTGGTGGCCCGCGCCATCCACTACAA
CAGCCCGCGGCGGGACCTGCCCTTCGTCGCCGTCAACTGCGCCGCCATTCCCGAGACCCTGATCGAAAGCGAGCTGTTCG
GCCATGTGAAGGGCGCCTTCACCGGCGCCACCGGCGCCCGCGAGGGCCGCTTCGCGGCTGCCGACCATGGCACGCTGTTC
CTCGACGAGATCGCCGACATGCCGTTGCCGGTGCAGGCCAAGGTGCTGCGCGCCCTGCAGGAGCAAAGCTTCGAGCCGGT
GGGCAGCAGCAAGAGCGTATCGGTGGACGTGCGGATTATCGCCGCCACCCACAAGGACCTGCAGAAGGAGATCGCTGCCG
GCACCTTCCGCATGGACCTTTACTATCGCCTCGCGGTGTTCCCCATCTCGCTGCCGCCGCTGCGCGAGCGCACCGACGAT
ATCGTGCTGCTCGCCAACCATTTCCTCGCTGCCGCGGCGCGGGACATGGGCAAGCGCATCAAGGGTCTCACCCCCGAGGC
GCAGGCCATGCTGACGCGCTACCGCTGGCCGGGAAACGTGCGCGAACTGCAGAACTGCATGGAGCGCGCCGCCATCGTCG
CGCGGGGCGACCTCGTGGGTGAAGGCGACCTGCTGCTGTTCGAGGCGACCGGCGATGCCGCCGCGATGCCGCACACGCTC
GACGGCGACCTCGACGGCGAGCTCGCCCGCATCGAGCGCGAGTTTGTGCTGAAAGCGCTCAAGGACAACGGCGGCGTGCA
GGCCCGCGCCGCCGAGAAGCTCGGCATCACCGAGCGCAGCCTGTGGCACCGCATCAAGAAGCTGGGCATCAAGATCGACA
AGGTGGCGGGGGCCGGCGATGGTTAG

Upstream 100 bases:

>100_bases
CAGAGGCGCACGGCGGCGCGGTGAGCCATGCCGACGCACCGGGCGGCGGCGCCATCTTCACCCTCCGCCTCCCCCTCGGC
AAACAGGGCTGATGCCGCAC

Downstream 100 bases:

>100_bases
GCGCTTCGTCCTCCTCCTGATGCTGGCGGTATCGGCGCTGCCGTGGGACGCGCGAGGGCAGGACACCGGTTCCGCCGCCA
CCTCCGCGACCGATGCCGCG

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MAAKILIVDDEVRHGEVLEAALAERGFEATSTNTVAKALTYCTSHAVDLVLSDLRMPGQGGSDLLKALKEQQPELPVIIM
TAYATVRGAVDLVKDGAFDYVAKPLDLDDVVATMARALRLKAVESENARLRSELEGRYRFDNLVGDSPAFRDVLRQVTEV
APSRASVLLLGESGTGKELVARAIHYNSPRRDLPFVAVNCAAIPETLIESELFGHVKGAFTGATGAREGRFAAADHGTLF
LDEIADMPLPVQAKVLRALQEQSFEPVGSSKSVSVDVRIIAATHKDLQKEIAAGTFRMDLYYRLAVFPISLPPLRERTDD
IVLLANHFLAAAARDMGKRIKGLTPEAQAMLTRYRWPGNVRELQNCMERAAIVARGDLVGEGDLLLFEATGDAAAMPHTL
DGDLDGELARIEREFVLKALKDNGGVQARAAEKLGITERSLWHRIKKLGIKIDKVAGAGDG

Sequences:

>Translated_461_residues
MAAKILIVDDEVRHGEVLEAALAERGFEATSTNTVAKALTYCTSHAVDLVLSDLRMPGQGGSDLLKALKEQQPELPVIIM
TAYATVRGAVDLVKDGAFDYVAKPLDLDDVVATMARALRLKAVESENARLRSELEGRYRFDNLVGDSPAFRDVLRQVTEV
APSRASVLLLGESGTGKELVARAIHYNSPRRDLPFVAVNCAAIPETLIESELFGHVKGAFTGATGAREGRFAAADHGTLF
LDEIADMPLPVQAKVLRALQEQSFEPVGSSKSVSVDVRIIAATHKDLQKEIAAGTFRMDLYYRLAVFPISLPPLRERTDD
IVLLANHFLAAAARDMGKRIKGLTPEAQAMLTRYRWPGNVRELQNCMERAAIVARGDLVGEGDLLLFEATGDAAAMPHTL
DGDLDGELARIEREFVLKALKDNGGVQARAAEKLGITERSLWHRIKKLGIKIDKVAGAGDG
>Mature_460_residues
AAKILIVDDEVRHGEVLEAALAERGFEATSTNTVAKALTYCTSHAVDLVLSDLRMPGQGGSDLLKALKEQQPELPVIIMT
AYATVRGAVDLVKDGAFDYVAKPLDLDDVVATMARALRLKAVESENARLRSELEGRYRFDNLVGDSPAFRDVLRQVTEVA
PSRASVLLLGESGTGKELVARAIHYNSPRRDLPFVAVNCAAIPETLIESELFGHVKGAFTGATGAREGRFAAADHGTLFL
DEIADMPLPVQAKVLRALQEQSFEPVGSSKSVSVDVRIIAATHKDLQKEIAAGTFRMDLYYRLAVFPISLPPLRERTDDI
VLLANHFLAAAARDMGKRIKGLTPEAQAMLTRYRWPGNVRELQNCMERAAIVARGDLVGEGDLLLFEATGDAAAMPHTLD
GDLDGELARIEREFVLKALKDNGGVQARAAEKLGITERSLWHRIKKLGIKIDKVAGAGDG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=45.2328159645233, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=46.5168539325843, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1790299, Length=472, Percent_Identity=44.4915254237288, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI1788905, Length=430, Percent_Identity=41.3953488372093, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI87082117, Length=351, Percent_Identity=44.7293447293447, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1789087, Length=404, Percent_Identity=43.5643564356436, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=45.3125, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI87082152, Length=321, Percent_Identity=44.2367601246106, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=42.3676012461059, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1786524, Length=333, Percent_Identity=41.1411411411411, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1787583, Length=316, Percent_Identity=38.6075949367089, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI1789828, Length=237, Percent_Identity=39.662447257384, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI87081858, Length=368, Percent_Identity=29.6195652173913, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789809, Length=121, Percent_Identity=31.404958677686, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786784, Length=116, Percent_Identity=29.3103448275862, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50011; Mature: 49880

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKILIVDDEVRHGEVLEAALAERGFEATSTNTVAKALTYCTSHAVDLVLSDLRMPGQG
CCEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GSDLLKALKEQQPELPVIIMTAYATVRGAVDLVKDGAFDYVAKPLDLDDVVATMARALRL
CHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHH
KAVESENARLRSELEGRYRFDNLVGDSPAFRDVLRQVTEVAPSRASVLLLGESGTGKELV
HHHCCCCHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHH
ARAIHYNSPRRDLPFVAVNCAAIPETLIESELFGHVKGAFTGATGAREGRFAAADHGTLF
HHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEE
LDEIADMPLPVQAKVLRALQEQSFEPVGSSKSVSVDVRIIAATHKDLQKEIAAGTFRMDL
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHCCEEHHH
YYRLAVFPISLPPLRERTDDIVLLANHFLAAAARDMGKRIKGLTPEAQAMLTRYRWPGNV
EEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
RELQNCMERAAIVARGDLVGEGDLLLFEATGDAAAMPHTLDGDLDGELARIEREFVLKAL
HHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
KDNGGVQARAAEKLGITERSLWHRIKKLGIKIDKVAGAGDG
HCCCCEEEEHHHHHCCCHHHHHHHHHHHCCEEEECCCCCCC
>Mature Secondary Structure 
AAKILIVDDEVRHGEVLEAALAERGFEATSTNTVAKALTYCTSHAVDLVLSDLRMPGQG
CEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GSDLLKALKEQQPELPVIIMTAYATVRGAVDLVKDGAFDYVAKPLDLDDVVATMARALRL
CHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHH
KAVESENARLRSELEGRYRFDNLVGDSPAFRDVLRQVTEVAPSRASVLLLGESGTGKELV
HHHCCCCHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHH
ARAIHYNSPRRDLPFVAVNCAAIPETLIESELFGHVKGAFTGATGAREGRFAAADHGTLF
HHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEE
LDEIADMPLPVQAKVLRALQEQSFEPVGSSKSVSVDVRIIAATHKDLQKEIAAGTFRMDL
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHCCEEHHH
YYRLAVFPISLPPLRERTDDIVLLANHFLAAAARDMGKRIKGLTPEAQAMLTRYRWPGNV
EEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
RELQNCMERAAIVARGDLVGEGDLLLFEATGDAAAMPHTLDGDLDGELARIEREFVLKAL
HHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
KDNGGVQARAAEKLGITERSLWHRIKKLGIKIDKVAGAGDG
HCCCCEEEEHHHHHCCCHHHHHHHHHHHCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]